From inhaler to lung: clinical implications of the formulations of ciclesonide and other inhaled corticosteroids

References

• GINA [webpage on the Internet]From the Global Strategy for Asthma Management and PreventionGlobal Initiative for Asthma (GINA)2012 Available from: http://www.ginasthma.org/guidelines-gina-report-global-strategy-for-asthma.htmlAccessed January 18, 2013
   Google Scholar
• NaveRClinical pharmacokinetic and pharmacodynamic profile of inhaled ciclesonideClin Pharmacokinet200948424325219492869
   PubMed Web of Science ®Google Scholar
• AllenDBBieloryLDerendorfHDluhyRColiceGLSzeflerSJInhaled corticosteroids: past lessons and future issuesJ Allergy Clin Immunol2003112Suppl 3S1S4014515117
   PubMedGoogle Scholar
• DahlRSystemic side effects of inhaled corticosteroids in patients with asthmaRespir Med200610081307131716412623
   PubMed Web of Science ®Google Scholar
• BergerWAerosol devices and asthma therapyCurr Drug Deliv200961384919418954
   PubMedGoogle Scholar
• EverardMLDevadasonSGLe SouëfPNFlow early in the inspiratory manoeuvre affects the aerosol particle size distribution from a TurbuhalerRespir Med199791106246289488896
   PubMed Web of Science ®Google Scholar
• RohatagiSAppajosyulaSDerendorfHRisk-benefit value of inhaled glucocorticoids: a pharmacokinetic/pharmacodynamic perspectiveJ Clin Pharmacol2004441374714681340
   PubMed Web of Science ®Google Scholar
• LeachCColiceGLLuskinAParticle size of inhaled corticosteroids: does it matter?J Allergy Clin Immunol2009124Suppl 6S88S9319962042
   PubMed Web of Science ®Google Scholar
• de VriesTWRottierBLGjaltemaDHagedoornPFrijlinkHWde BoerAHComparative in vitro evaluation of four corticosteroid metered dose inhalers: consistency of delivered dose and particle size distributionRespir Med200910381167117319269801
   PubMed Web of Science ®Google Scholar
• BethkeTDDrollmanAHaunsBBioequivalence of two ciclesonide dosing regimen (4 puffs of 200μg versus 16 puffs of 50μg using a MDI)Eur Respir J200220Suppl 38109s
   Google Scholar
• WeibelERPrinciples and methods for the morphometric study of the lung and other organsLab Invest19631213115513999512
   PubMed Web of Science ®Google Scholar
• MartinRJTherapeutic significance of distal airway inflammation in asthmaJ Allergy Clin Immunol2002109Suppl 2S447S46011842317
   PubMed Web of Science ®Google Scholar
• ContoliMBousquetJFabbriLMThe small airways and distal lung compartment in asthma and COPD: a time for reappraisalAllergy201065214115119909298
   PubMed Web of Science ®Google Scholar
• VirchowJCAsthma – a small airway disease: concepts and evidencePneumologie200963Suppl 2S96S10120013542
   PubMedGoogle Scholar
• TulicMKHamidQContribution of the distal lung to the pathologic and physiologic changes in asthma: potential therapeutic target Roger S. Mitchell lectureChest2003123Suppl 3348S355S12628971
   PubMed Web of Science ®Google Scholar
• MitchellJPNagelMWWiersemaKJDoyleCCAerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 Aerodynamic Particle Sizer aerosol spectrometerAAPS Pharm Sci Tech200344E54
   Google Scholar
• CrippsARiebeMSchulzeMWoodhouseRPharmaceutical transition to non-CFC pressurized metered dose inhalersRespir Med200094Suppl BS3S910919679
   PubMed Web of Science ®Google Scholar
• NewmanSSalmonANaveRDrollmannAHigh lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthmaRespir Med2006100337538416275052
   PubMed Web of Science ®Google Scholar
• YangTTLiSWykaBKenyonDDrug delivery performance of the mometasone furoate dry powder inhalerJ Aerosol Med200114448749411791689
   PubMedGoogle Scholar
• LeachCLDavidsonPJBoudreauRJImproved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasoneEur Respir J1998126134613539877489
   PubMed Web of Science ®Google Scholar
• LeachCLBethkeTDBoudreauRJTwo-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: a nonrandomized study in healthy volunteersJ Aerosol Med200619211712616796536
   PubMedGoogle Scholar
• UsmaniOSBiddiscombeMFBarnesPJRegional lung deposition and bronchodilator response as a function of beta2-agonist particle sizeAm J Respir Crit Care Med2005172121497150416192448
   PubMed Web of Science ®Google Scholar
• HirstPHBaconREPitcairnGRSilvastiMNewmanSPA comparison of the lung deposition of budesonide from Easyhaler, Turbuhaler and pMDI plus spacer in asthmatic patientsRespir Med200195972072711575892
   PubMed Web of Science ®Google Scholar
• LeachCLDavidsonPJHasselquistBEBoudreauRJLung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteersChest2002122251051612171824
   PubMed Web of Science ®Google Scholar
• BuhlRLocal oropharyngeal side effects of inhaled corticosteroids in patients with asthmaAllergy200661551852616629778
   PubMed Web of Science ®Google Scholar
• MutchENaveRMcCrackenNZechKWilliamsFMThe role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissueBiochem Pharmacol200773101657166417331475
   PubMed Web of Science ®Google Scholar
• NaveRMcCrackenNMetabolism of ciclesonide in the upper and lower airways: review of available dataJ Asthma Allergy20081111821436981
   PubMedGoogle Scholar
• NaveRWatzHHoffmannHBossHMagnussenHDeposition and metabolism of inhaled ciclesonide in the human lungEur Respir J20103651113111920351025
   PubMed Web of Science ®Google Scholar
• RichterKKanniessFBibergerCNaveRMagnussenHComparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthmaJ Clin Pharmacol200545214615215647406
   PubMed Web of Science ®Google Scholar
• NaveRZechKBethkeTDLower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjectsEur J Clin Pharmacol200561320320815824911
   PubMed Web of Science ®Google Scholar
• ThongngarmTSilkoffPEKossackWSNelsonHSHydrofluoroalkane- 134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthmaJ Asthma200542425726316032934
   PubMed Web of Science ®Google Scholar
• HoshinoMComparison of effectiveness in ciclesonide and fluticasone propionate on small airway function in mild asthmaAllergol Int2010591596620035146
   PubMedGoogle Scholar
• HarrisonTWWisniewskiAHonourJTattersfieldAEComparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjectsThorax200156318619111182010
   PubMed Web of Science ®Google Scholar
• NaveRZechKBliesathHBethkeTDifferences between pharmacokinetics of ciclesonide-active principle and budesonide following repeated dose inhalationsEur Respir J200322S45
   Google Scholar
• RohatagiSLuoYShenLProtein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonideAm J Ther200512320120915891262
   PubMedGoogle Scholar
• BrutscheMHBrutscheICMunawarMComparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover studyLancet2000356922955656110950233
   PubMed Web of Science ®Google Scholar
• NaveRGunawardenaKAZechKBethkeTDPharmacokinetic disposition of inhaled ciclesonide and its metabolite desisobutyryl-ciclesonide in healthy subjects and patients with asthma are similarInt J Clin Pharmacol Ther20064411716425964
   PubMed Web of Science ®Google Scholar
• NaveRBethkeTDvan MarleSPZechKPharmacokinetics of [14C]ciclesonide after oral and intravenous administration to healthy subjectsClin Pharmacokinet200443747948615139796
   PubMed Web of Science ®Google Scholar
• RohatagiSAppajosyulaSDerendorfHRisk-benefit value of inhaled glucocorticoids: a pharmacokinetic/pharmacodynamic perspectiveJ Clin Pharmacol2004441374714681340
   PubMed Web of Science ®Google Scholar
• Daley-YatesPTPriceACSissonJRPereiraADallowNBeclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in manBr J Clin Pharmacol200151540040911421996
   PubMed Web of Science ®Google Scholar
• NaveRDetermination of lung deposition following inhalation of ciclesonide using different bioanalytical proceduresBioanalysis20102480781421083275
   PubMed Web of Science ®Google Scholar
• HochrainerDHölzHKreherCScaffidiLSpallekMWachtelHComparison of the aerosol velocity and spray duration of Respimat Soft Mist inhaler and pressurized metered dose inhalersJ Aerosol Med200518327328216181002
   PubMedGoogle Scholar
• GabrioBJSteinSWVelasquezDJA new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalersInt J Pharm1999186131210469919
   PubMed Web of Science ®Google Scholar
• ChapmanKRVoshaarTHVirchowJCInhaler choice in primary practiceEur Respir Rev20111496117122
   Google Scholar
• KhassawnehBYAl-AliMKAlzoubiKHHandling of inhaler devices in actual pulmonary practice: metered-dose inhaler versus dry powder inhalersRespir Care200853332432818291048
   PubMed Web of Science ®Google Scholar
• DrollmannANaveRSteinijansVWBaumgärtnerEBethkeTDEquivalent pharmacokinetics of the active metabolite of ciclesonide with and without use of the AeroChamber Plus spacer for inhalationClin Pharmacokinet200645772973616802853
   PubMed Web of Science ®Google Scholar
• BossHMinicPNaveRSimilar results in children with asthma for steady state pharmockinetic parameters of ciclesonide inhaled with or without spacerClinical Medicine Insights: Pediatrics20104110
   Google Scholar
• WilliamsRO3rdPatelAMBarronMKRogersTLInvestigation of some commercially available spacer devices for the delivery of glucocorticoid steroids from a pMDIDrug Dev Ind Pharm200127540141211448047
   PubMed Web of Science ®Google Scholar
• PedersenSPotterPDachevSEfficacy and safety of three ciclesonide doses vs placebo in children with asthma: the RAINBOW studyRespir Med2010104111618162820619624
   PubMed Web of Science ®Google Scholar
• van den BergeMTen HackenNHTvan der WielEPostmaDSTreatment of the bronchial tree from beginning to end: Targeting small airways inflammation in asthmaAllergy2013681162623210509
   PubMed Web of Science ®Google Scholar