Fabrication of novel vesicles of triptolide for antirheumatoid activity with reduced toxicity in vitro and in vivo

References

• KupchanSMCourtWADaileyRGJrGilmoreCJBryanRFTriptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordiiJ Am Chem Soc19729420719471955072337
   PubMed Web of Science ®Google Scholar
• HanRRostami-YazdiMGerdesSMrowietzUTriptolide in the treatment of psoriasis and other immune-mediated inflammatory diseasesBr J Clin Pharmacol201274342443622348323
   PubMed Web of Science ®Google Scholar
• MattaRWangXGeHRayWNelinLDLiuYTriptolide induces anti-inflammatory cellular responsesAm J Transl Res20091326728219956437
   PubMed Web of Science ®Google Scholar
• TaoXCushJJGarretMLipskyPEA phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritisJ Rheumatol200128102160216711669150
   PubMed Web of Science ®Google Scholar
• CibereJDengZLinYA randomized double blind, placebo controlled trial of topical Tripterygium wilfordii in rheumatoid arthritis: reanalysis using logistic regression analysisJ Rheumatol200330346546712610802
   PubMedGoogle Scholar
• TaoXYoungerJFanFZWangBLipskyPEBenefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled studyArthritis Rheum20024671735174312124856
   PubMedGoogle Scholar
• LuYWangWJLengJHChengLFFengLYaoHPInhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblastsInflamm Res200857626026518516710
   PubMedGoogle Scholar
• XuLPanJChenQIn vivo evaluation of the safety of triptolide-loaded hydrogel-thickened microemulsionFood Chem Toxicol200846123792379918952137
   PubMedGoogle Scholar
• XueMZhaoYLiXJComparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in ratsEur J Pharm Sci201247471371722677813
   PubMed Web of Science ®Google Scholar
• TsaiKLChangHFWuSNThe inhibition of inwardly rectifying K+ channels by memantine in macrophages and microglial cellsCell Pysiol Biochem2013316938951
   Google Scholar
• SoECLoYCChenLTKaoCAWuSNHigh effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cellsEur J Pharmacol201473833234124927992
   PubMed Web of Science ®Google Scholar
• ChenFGaoXShilatifardAStably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolideGenes Dev2015291394725561494
   PubMed Web of Science ®Google Scholar
• TitovDVGilmanBHeQLXPB, a subunit of TFIIH, is a target of the natural product triptolideNat Chem Biol20117318218821278739
   PubMed Web of Science ®Google Scholar
• ZhouJXiCWangWTriptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathwaysToxicol Lett2014230345446625169008
   PubMedGoogle Scholar
• ParkBSungBYadavVRChaturvediMMAggarwalBBTriptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathwayBiochem Pharmacol20118291134114421820422
   PubMedGoogle Scholar
• ZhangYMaXTriptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein αJ Immunol201018473866387720194724
   PubMedGoogle Scholar
• LiXJJiangZZZhangLYTriptolide: progress on research in pharmacodynamics and toxicologyJ Ethnopharmacol20141551677924933225
   PubMed Web of Science ®Google Scholar
• JinJSunXZhaoZActivation of the farnesoid X receptor attenuates triptolide-induced liver toxicityPhytomedicine2015221089490126321738
   PubMed Web of Science ®Google Scholar
• WuSXGuoNRClinical observation on effect of triptolide tablet in treating patients with psoriasis vulgarisChin J Integr Med200511214714816150204
   PubMedGoogle Scholar
• SinglaNChallanaSReproductive toxicity of triptolide in male house rat, Rattus rattusScientific World Journal2014201487940525374942
   PubMedGoogle Scholar
• WangXJiangZXingMInterleukin-17 mediates triptolide-induced liver injury in miceFood Chem Toxicol201471334124949944
   PubMedGoogle Scholar
• LiJShenFGuanCActivation of Nrf2 protects against triptolide-induced hepatotoxicityPLoS One201497e10068524988078
   PubMed Web of Science ®Google Scholar
• LingDXiaHParkWpH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinomaACS Nano2014888027803925093274
   PubMed Web of Science ®Google Scholar
• HouDZXieCSYangXLXuHBPingQNMicrostructure of novel solid lipid nanoparticle loaded triptolideYao Xue Xue Bao200742442943317633214
   PubMedGoogle Scholar
• XuLQiuYXuHAoWLamWYangXAcute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodentsFood Chem Toxicol20135737137923583804
   PubMed Web of Science ®Google Scholar
• ZhangLGengXZhouJFabrication of poly(gamma-glutamic acid)-based biopolymer as the targeted drug delivery system with enhanced cytotoxicity to APN/CD13 over-expressed cellsJ Drug Target201523545346125648136
   PubMed Web of Science ®Google Scholar
• GengXYeHFengZSynthesis and characterization of cisplatin-loaded, EGFR-targeted biopolymer and in vitro evaluation for targeted deliveryJ Biomed Mater Res A2012100102839284822678850
   PubMedGoogle Scholar
• AkagiTHigashiMKanekoTKidaTAkashiMHydrolytic and enzymatic degradation of nanoparticles based on amphiphilic poly(gamma-glutamic acid)-graft-L-phenylalanine copolymersBiomacromolecules20067129730316398528
   PubMed Web of Science ®Google Scholar
• AkagiTKanekoTKidaTAkashiMPreparation and characterization of biodegradable nanoparticles based on poly(gamma-glutamic acid) with L-phenylalanine as a protein carrierJ Control Release20051082–322623616125267
   PubMedGoogle Scholar
• MishraPRAl ShaalLMüllerRHKeckCMProduction and characterization of Hesperetin nanosuspensions for dermal deliveryInt J Pharm20093711–218218919162147
   PubMed Web of Science ®Google Scholar
• DuncanRVicentMJGrecoFNicholsonRIPolymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancerEndocr Relat Cancer200512Suppl 1S189S19916113096
   PubMed Web of Science ®Google Scholar
• ReddyKRControlled-release, pegylation, liposomal formulations: new mechanisms in the delivery of injectable drugsAnn Pharmacother2000347–891592310928404
   PubMed Web of Science ®Google Scholar
• PhamCTNanotherapeutic approaches for the treatment of rheumatoid arthritisWiley Interdiscip Rev Nanomed Nanobiotechnol20113660761921837725
   PubMed Web of Science ®Google Scholar
• van den HovenJMVan TommeSRMetselaarJMNuijenBBeijnenJHStormGLiposomal drug formulations in the treatment of rheumatoid arthritisMol Pharm2011841002101521634436
   PubMed Web of Science ®Google Scholar
• MetselaarJMvan den BergWBHolthuysenAEWaubenMHStormGvan LentPLLiposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritisAnn Rheum Dis200463434835315020326
   PubMed Web of Science ®Google Scholar
• HofkensWStormGvan den BergWBvan LentPLLiposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritisInt J Pharm2011416248649221382458
   PubMedGoogle Scholar
• ParkKDrug delivery of the future: chasing the invisible gorillaJ Control Release2015S0168–3659153021430215
   Google Scholar
• ChoyEUnderstanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritisRheumatology201251Suppl 5v3v1122718924
   PubMed Web of Science ®Google Scholar
• UmarSHedayaOSinghAKAhmedSThymoquinone inhibits TNF-alpha-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulationToxicol Appl Pharmacol2015287329930526134265
   PubMedGoogle Scholar
• McInnesIBSchettGCytokines in the pathogenesis of rheumatoid arthritisNat Rev Immunol20077642944217525752
   PubMed Web of Science ®Google Scholar
• RamiroSLandeweRvan der HeijdeDHarrisonDCollierDMichaudKDiscontinuation rates of biologics in patients with rheumatoid arthritis: are TNF inhibitors different from non-TNF inhibitors?RMD Open201511e00015526629366
   PubMedGoogle Scholar
• CroftMBenedictCAWareCFClinical targeting of the TNF and TNFR superfamiliesNat Rev Drug Discov201312214716823334208
   PubMed Web of Science ®Google Scholar
• LuYZhangYLiLTAB1: a target of triptolide in macrophagesChem Biol201421224625624462677
   PubMedGoogle Scholar
• ParkBTriptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cellsBiochimie201410512913625047443
   PubMed Web of Science ®Google Scholar
• Gali-MuhtasibHHmadiRKarehMTohmeRDarwicheNCell death mechanisms of plant-derived anticancer drugs: beyond apoptosisApoptosis201520121531156226362468
   PubMed Web of Science ®Google Scholar
• MeiZLiXWuQHuSYangXThe research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticlePharmacol Res200551434535115683748
   PubMed Web of Science ®Google Scholar
• FidlerJMKuGYPiazzaDXuRJinRChenZImmunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. III. Suppression of graft-versus-host disease in murine allogeneic bone marrow transplantation by the PG27 extractTransplantation200274444545712352901
   PubMedGoogle Scholar
• QuLQuFJiaZWangCWuCZhangJIntegrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolideJ Ethnopharmacol2015170283825978956
   PubMedGoogle Scholar