265
Views
101
CrossRef citations to date
0
Altmetric
Original Research

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

, , , , &
Pages 3813-3824 | Published online: 08 Aug 2016

References

  • BarryBWNovel mechanisms and devices to enable successful transdermal drug deliveryEur J Pharm Sci200114210111411500256
  • Honeywell-NguyenPLBouwstraJAVesicles as a tool for transdermal and dermal deliveryDrug Discov Today Technol200521677424981757
  • RanadeVVCannonJBDrug Delivery Systems3rd edBoca Raton, FLCRC Press2011
  • BarryBWDermatological Formulations: Percutaneous AbsorptionNew YorkMarcel Dekker1983
  • KarandePMitragotriSEnhancement of transdermal drug delivery via synergistic action of chemicalsBiochim Biophys Acta20091788112362237319733150
  • ElsayedMMAbdallahOYNaggarVFKhalafallahNMLipid vesicles for skin delivery of drugs: reviewing three decades of researchInt J Pharm20073321–211617222523
  • CevcGBlumeGLipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration forceBiochim Biophys Acta1992110412262321550849
  • CevcGSchätzleinARichardsenHUltradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurementsBiochim Biophys Acta200215641213012100992
  • CevcGBlumeGNew, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, transfersomesBiochim Biophys Acta20011514219120511557020
  • CevcGBlumeGBiological activity and characteristics of triamcinolone-acetonide formulated with the self-regulating drug carriers, transfersomes®Biochim Biophys Acta20031614215616412896808
  • CevcGBlumeGHydrocortisone and dexamethasone in very deformable drug carriers have increased biological potency, prolonged effect, and reduced therapeutic dosageBiochim Biophys Acta200416631–2617315157608
  • El MaghrabyGMWilliamsACBarryBWSkin delivery of oestradiol from deformable and traditional liposomes: mechanistic studiesJ Pharm Pharmacol199951101123113410579683
  • El MaghrabyGMWilliamsACBarryBWSkin delivery of 5-fluorouracil from ultradeformable and standard liposomes in-vitroJ Pharm Pharmacol20015381069107711518016
  • CevcGGebauerDStieberJSchätzleinABlumeGUltraflexible vesicles, transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skinBiochim Biophys Acta1998136822012159459598
  • ElsayedMMAbdallahOYNaggarVFKhalafallahNMDeformable liposomes and ethosomes as carriers for skin delivery of ketotifenPharmazie200762213313717341034
  • RenJFangZYaoLA micelle-like structure of poloxamer-methotrexate conjugates as nanocarrier for methotrexate deliveryInt J Pharm20154871–217718625865570
  • ChoiSJOhJMChungHEHongSHKimIHChoyJHIn vivo anticancer activity of methotrexate-loaded layered double hydroxide nanoparticlesCurr Pharm Des201319417196720223489199
  • StagniGShuklaCPharmacokinetics of methotrexate in rabbit skin and plasma after iv-bolus and iontophoretic administrationsJ Control Release200393328329214644578
  • YangFKamiyaNGotoMTransdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrierEur J Pharm Biopharm201282115816322713517
  • DubeyVMishraDDuttaTNaharMSarafDKJainNKDermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomesJ Control Release2007123214815417884226
  • GargNKTyagiRKSinghBNanostructured lipid carrier mediates effective delivery of methotrexate to induce apoptosis of rheumatoid arthritis via NF-κB and FOXO1Int J Pharm20164991–230132026768725
  • PintoMFMouraCCNunesCSegundoMACosta LimaSAReisSA new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriersInt J Pharm20144771–251952625445970
  • ChenAZChenLQWangSBWangYQZhaJZStudy of magnetic silk fibroin nanoparticles for massage-like transdermal drug deliveryInt J Nanomedicine20151014639465126229467
  • NagleAGoyalAKKesarlaRMurthyRREfficacy study of vesicular gel containing methotrexate and menthol combination on parakeratotic rat skin modelJ Liposome Res201121213414020557280
  • SamahNAWilliamsNHeardCMNanogel particulates located within diffusion cell receptor phases following topical application demonstrates uptake into and migration across skinInt J Pharm20104011–2727820817080
  • SingkaGSSamahNAZulfakarMHYurdasiperAHeardCMEnhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogelEur J Pharm Biopharm201076227528120600884
  • El ZaafaranyGMAwadGAHolayelSMMortadaNDRole of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin deliveryInt J Pharm20103971–216417220599487
  • LiGFanYFanCTacrolimus-loaded ethosomes: physicochemical characterization and in vivo evaluationEur J Pharm Biopharm2012821495722705640
  • RuoziBBellettiDTombesiAAFM, ESEM, TEM, and CLSM in liposomal characterization: a comparative studyInt J Nanomedicine2011655756321468358
  • van den BerghBAWertzPWJungingerHEBouwstraJAElasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurementsInt J Pharm20012171–2132411292538
  • LvQYuAXiYDevelopment and evaluation of penciclovir-loaded solid lipid nanoparticles for topical deliveryInt J Pharm20093721–219119819429280
  • El MaghrabyGMWilliamsACBarryBWOestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentrationInt J Pharm20001961637410675708
  • ZhuWYuAWangWDongRWuJZhaiGFormulation design of microemulsion for dermal delivery of penciclovirInt J Pharm20083601–218419018541394
  • LeiMWangJMaMYuMTanFLiNDual drug encapsulation in a novel nano-vesicular carrier for the treatment of cutaneous melanoma: characterization and in vitro/in vivo evaluationRSC Adv20155262046720478
  • TouitouEGodinBDayanNWeissCPiliponskyALevi-SchafferFIntracellular delivery mediated by an ethosomal carrierBiomaterials200122223053305911575480
  • WangJGuoFMaMLeiMTanFLiNNanovesicular system containing tretinoin for dermal targeting delivery and rosacea treatment: a comparison of hexosomes, glycerosomes and ethosomesRSC Adv20144854545845466
  • ObataYUtsumiSWatanabeHInfrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancersInt J Pharm20103891–2182320079819
  • CilurzoFVistoliGSelminFAn insight into the skin penetration enhancement mechanism of N-methylpyrrolidoneMol Pharm20141131014102124446970
  • ElsayedMMAbdallahOYNaggarVFKhalafallahNMDeformable liposomes and ethosomes: mechanism of enhanced skin deliveryInt J Pharm20063221–2606616806755
  • LeeEHKimAOhYKKimCKEffect of edge activators on the formation and transfection efficiency of ultradeformable liposomesBiomaterials200526220521015207467
  • El MaghrabyGMWilliamsACBarryBWSkin delivery of oestradiol from lipid vesicles: importance of liposome structureInt J Pharm20002041–215916911012000
  • PerezAPAltubeMJSchilrreffPTopical amphotericin B in ultradeformable liposomes: formulation, skin penetration study, antifungal and antileishmanial activity in vitroColloids Surf B Biointerfaces201613919019826709977
  • CevcGRational design of new product candidates: the next generation of highly deformable bilayer vesicles for noninvasive, targeted therapyJ Control Release2012160213514622266051
  • TasiLMLiuDZChenWYMicrocalorimetric investigation of the interaction of polysorbate surfactants with unilamellar phosphatidylcholines liposomesColloids Surf A Physicochem Eng Asp20032131714
  • DuangjitSPamornpathomkulBOpanasopitPRole of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomesInt J Nanomedicine201492005201724851047
  • YangTCuiFDChoiMKEnhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluationInt J Pharm20073381–231732617368984
  • OhYKKimMYShinJYSkin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte modelsJ Pharm Pharmacol200658216116616451743
  • KangMJEumJYJeongMSFacilitated skin permeation of oregonin by elastic liposomal formulations and suppression of atopic dermatitis in NC/Nga miceBiol Pharm Bull201033110010620045944
  • JainSJainPUmamaheshwariRJainNTransfersomes-a novel vesicular carrier for enhanced transdermal delivery: development, characterization, and performance evaluationDrug Dev Ind Pharm20032991013102614606665
  • DubeyVMishraDAsthanaAJainNKTransdermal delivery of a pineal hormone: melatonin via elastic liposomesBiomaterials200627183491349616513163
  • CevcGSchätzleinABlumeGTransdermal drug carriers: basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptidesJ Control Release1995361–2316
  • CevcGGebauerDHydration-driven transport of deformable lipid vesicles through fine pores and the skin barrierBiophys J2003842 pt 11010102412547782
  • Honeywell-NguyenPLArenjaSBouwstraJASkin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulationsPharm Res200320101619162514620517
  • VermaDDVermaSBlumeGFahrALiposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy studyEur J Pharm Biopharm200355327127712754000
  • VaddiHKHoPCChanYWChanSYTerpenes in ethanol: haloperidol permeation and partition through human skin and stratum corneum changesJ Control Release2002811–212113311992685
  • CuiLLLiangYYDongFJStructure of rat skin after application of electret characterized by DSCJ Phys Conf Ser20113011012027
  • DreherFWaldePWaltherPWehrliEInteraction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transportJ Control Release1997452131140
  • DubeyVMishraDJainNKMelatonin loaded ethanolic liposomes: physicochemical characterization and enhanced transdermal deliveryEur J Pharm Biopharm200767239840517452098