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Original Research

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile

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Pages 3607-3619 | Published online: 01 Aug 2016

References

  • DaviesAHRobertsAKShoneCCAcharyaKRSuper toxins from a super bug: structure and function of Clostridium difficile toxinsBiochem J2011436351752621615333
  • McFarlandLVElmerGWSurawiczCMBreaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile diseaseAm J Gastroenterol20029771769177512135033
  • CammarotaGIaniroGGasbarriniAFecal microbiota transplantation for the treatment of Clostridium difficile infection: a systematic reviewJ Clin Gastroenterol201448869370224440934
  • SteglichMNitscheAVon MüllerLTracing the spread of Clostridium difficile ribotype 027 in Germany based on bacterial genome sequencesPLoS One20151010e013981126444881
  • GillilandCWeaverJStevensonMAssociation of Clostridium difficile ribotype 078 with detectable toxin in human stool specimensJ Med Microbiol201564111341134526354090
  • CarlsonPEWalkSTBourgisAEThe relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolatesAnaerobe20132410911623608205
  • Archbald-PannoneLRBooneJHCarmanRJLyerlyDMGuerrantRLClostridium difficile ribotype 027 is most prevalent among inpatients admitted from long-term care facilitiesJ Hosp Infect201488421822125228227
  • BaiHXueXHouZZhouYMengJLuoXAntisense antibiotics: a brief review of novel target discovery and deliveryCurr Drug Discov Technol201072768520836761
  • ClatworthyAEPiersonEHungDTTargeting virulence: a new paradigm for antimicrobial therapyNat Chem Biol20073954154817710100
  • RasmussenLCSperling-PetersenHUMortensenKKHitting bacteria at the heart of the central dogma: sequence-specific inhibitionMicrob Cell Fact2007612417692125
  • DinanAMLoftusBJ(Non-)translational medicine: targeting bacterial RNAFront Genet20134v23024265632
  • JiYLeiTAntisense RNA regulation and application in the development of novel antibiotics to combat multidrug resistant bacteriaSci Prog2013961436023738437
  • JärverPCoursindelTAndaloussiSEGodfreyCWoodMJGaitMJPeptide-mediated cell and in vivo delivery of antisense oligonucleotides and siRNAMol Ther Nucleic Acids201216e2723344079
  • HansenAMBonkeGLarsenCJYavariNNielsenPEFranzykHAntibacterial peptide nucleic acid – antimicrobial peptide (PNA-AMP) conjugates: antisense targeting of fatty acid biosynthesisBioconjug Chem201627486386726938833
  • GellerBLMarshall-BattyKSchnellFJMcKnightMMIversenPLGreenbergDEGene-silencing antisense oligomers inhibit Acinetobacter growth in vitro and in vivoJ Infect Dis2013208101553156024130069
  • WangHMengJJiaMoprM as a new target for reversion of multidrug resistance in Pseudomonas aeruginosa by antisense phosphorothioate oligodeoxynucleotidesFEMS Immunol Med Microbiol201060327528220955466
  • MengJDaFMaXAntisense growth inhibition of methicillin-resistant Staphylococcus aureus by locked nucleic acid conjugated with cell-penetrating peptide as a novel FtsZ inhibitorAntimicrob Agents Chemother201559291492225421468
  • PatengeNPappeschRKrawackFInhibition of growth and gene expression by PNA-peptide conjugates in streptococcus pyogenesMol Ther Nucleic Acids20132Aprile13224193033
  • HegartyJPSangsterWHarrisLRDurdachMStewartDBTargeted silencing of essential C. difficile genes using antisense morpholino-peptide conjugatesPresented at: 2015 American Society for Microbiology. 115th General Meeting2015New Orleans, LA01151
  • ZhaoXBPanFZhangZQNanostructure of polyplexes formed between cationic diblock copolymer and antisense oligodeoxynucleotide and its influence on cell transfection efficiencyBiomacromolecules20078113493350217939715
  • ChenZHuYMengJEfficient transfection of phosphorothioate oligodeoxyribonucleotides by lipofectamine 2000 into different bacteriaCurr Drug Deliv20151218
  • ZhangLPornpattananangkuDHuC-MJHuangC-MDevelopment of nanoparticles for antimicrobial drug deliveryCurr Med Chem201017658559420015030
  • KhamenehBDiabRGhazviniKFazly BazzazBSBreakthroughs in bacterial resistance mechanisms and the potential ways to combat themMicrob Pathog201695324226911646
  • ForierKRaemdonckKDe SmedtSCDemeesterJCoenyeTBraeckmansKLipid and polymer nanoparticles for drug delivery to bacterial biofilmsJ Control Release201419060762324794896
  • HongCANamYSFunctional nanostructures for effective delivery of small interfering RNA therapeuticsTheranostics20144121211123225285170
  • KhanMAngCYWiradharmaNDiaminododecane-based cationic bolaamphiphile as a non-viral gene delivery carrierBiomaterials201233184673468022440050
  • LyrawatiDTrounsonACramDExpression of GFP in the mitochondrial compartment using DQAsome-mediated delivery of an artificial mini-mitochondrial genomePharm Res201128112848286221833794
  • WeissigVLaschJErdosGMeyerHRoweTHughesJDQAsomes: a novel potential drug and gene delivery system made from dequaliniumPharm Res19981523343379523323
  • WeissigVLizanoCTorchilinVPSelective DNA release from DQAsome/DNA complexes at mitochondria-like membranesDrug Deliv2000711510895413
  • WeissigVLizanoCGanellinCTorchilinVDNA binding cationic bolasomes with delocalized charge center – a structure-activity relationship studySTP Pharma Sci20011119196
  • WeissigVFrom serendipity to mitochondria-targeted nanocarriersPharm Res201128112657266821833792
  • GrinbergSSternAGuidottiMSteric environment around acetylcholine head groups of bolaamphiphilic nanovesicles influences the release rate of encapsulated compoundsInt J Nanomedicine2014956124531296
  • SchlameMCardiolipin synthesis for the assembly of bacterial and mitochondrial membranesJ Lipid Res20084981607162018077827
  • GuanZKatzianerDZhuJGoldfineHClostridium difficile contains plasmalogen species of phospholipids and glycolipidsBiochim Biophys Acta20141841101353135924983203
  • YooBHBochkarevaEBochkarevAMouT-CGrayDM2′-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitroNucleic Acids Res20043262008201615064360
  • NiemietzCChandhokGSchmidtHTherapeutic oligonucleotides targeting liver disease: TTR amyloidosisMolecules20152010179441797526437390
  • ChanJHLimSWongWFAntisense oligonucleotides: from design to therapeutic applicationClin Exp Pharmacol Physiol2006335–653354016700890
  • StewartDBBergASHegartyJPSingle nucleotide polymorphisms of the tcdC gene and presence of the binary toxin gene predict recurrent episodes of Clostridium difficile infectionAnn Surg2014260229930424374512
  • StubbsSLBrazierJSO’NeillGLDuerdenBIPCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypesJ Clin Microbiol19993724614639889244
  • RupnikMAvesaniVJancMVon Eichel-StreiberCDelméeMA novel toxinotyping scheme and correlation of toxinotypes with serogroups of Clostridium difficile isolatesJ Clin Microbiol1998368224022479665999
  • AdeyAMorrisonHGAsanRapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transpositionGenome Biol20101112R11921143862
  • DembekMBarquistLBoinettCJHigh-throughput analysis of gene essentiality and sporulation in Clostridium difficileMBio201562e0238325714712
  • LimaWFVickersTANicholsJLiCCrookeSTDefining the factors that contribute to on-target specificity of antisense oligonucleotidesPLoS One201497e10175225072142
  • ReuterJSMathewsDHRNAstructure: software for RNA secondary structure prediction and analysisBMC Bioinformatics201011112920230624
  • ZukerMMfold web server for nucleic acid folding and hybridization predictionNucleic Acids Res200331133406341512824337
  • GishWAltschulSFLipmanDJMillerWMyersEWBasic local alignment search toolJ Mol Biol199021534034102231712
  • ShaoYWuYChanCYMcDonoughKDingYRational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulationNucleic Acids Res200634195660566917038332
  • ZaherHSGreenRIn vitro synthesis of proteins in bacterial extractsMethods Enzymol201453931524581435
  • WeissigVDQAsomes as the prototype of mitochondria-targeted pharmaceutical nanocarriers: preparation, characterization, and useMethods Mol Biol2015126511125634263
  • Márquez-MirandaVPeñalozaJPAraya-DuránIEffect of terminal groups of dendrimers in the complexation with antisense oligonucleotides and cell uptakeNanoscale Res Lett20161116626847692
  • European Society of Clinical Microbiology and Infectious DiseasesDetermination of minimum inhibitory concentrations (MICs) of antibacterial agents by broth dilutionClin Microbiol Infect2003981712691538
  • JerchelDOstWKlausTQuaternary derivatives of 1,2,3,4-tetra-hydro-9-amino-acridineUS patent35196311970
  • WeissigVTorchilinVPMitochondriotropic cationic vesicles: a strategy towards mitochondrial gene therapyCurr Pharm Biotechnol20001432534611467330
  • ZhaoQ-QChenJ-LLvT-FN/P ratio significantly influences the transfection efficiency and cytotoxicity of a polyethylenimine/chitosan/DNA complexBiol Pharm Bull200932470671019336909
  • BaiHZhouYHouZXueXMengJLuoXTargeting bacterial RNA polymerase: promises for future antisense antibiotics developmentInfect Disord Drug Targets201111217518721470098