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Original Research

Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster

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Pages 1621-1637 | Published online: 28 Feb 2017

References

  • EPAU.S. Environmental Protection AgencyNanotechnology White Paper2007 Available from: https://www.epa.gov/sites/production/files/2015-01/documents/nanotechnology_whitepaper.pdfAccessed October, 2016
  • JonesNRayBRanjitKTMannaACAntibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganismsFEMS Microbiol Lett20082791717618081843
  • ReportBuyerGlobal Nanomaterials Market – Segmented by Product Type, End-User Industry, and Geography – Trends and Forecasts (2015–2020)2015 Available from: https://www.reportbuyer.com/product/3281799/global-nanometals-market-segmented-by-type-application-and-geography-2015-2020.htmlAccessed Octomber, 2016
  • ReportLinkerNanotechnology Market Outlook 20202015 Available from: http://www.reportlinker.com/p02162665/Nanotechnology-Market-Outlook.htmlAccessed October, 2016
  • LyeJCRichardsCDDechenKSystematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogasterJ Exp Biol2012215Pt 183254326522693027
  • KimYRParkJILeeEJToxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley ratsInt J Nanomedicine20149Suppl 2109126
  • XieYHeYIrwinPLJinTShiXAntibacterial activity and mechanism of action of zinc oxide nanoparticles against Campylobacter jejuniAppl Environ Microbiol20117772325233121296935
  • ColvinVLThe potential environmental impact of engineered nanomaterialsNat Biotechnol200321101166117014520401
  • De AngelisIBaroneFZijnoAComparative study of ZnO and TiO(2) nanoparticles: physicochemical characterisation and toxicological effects on human colon carcinoma cellsNanotoxicology2013781361137223078188
  • JohnsonBMFraiettaJAGraciasDTAcute exposure to ZnO nanoparticles induces autophagic immune cell deathNanotoxicology20159673774825378273
  • SinghNManshianBJenkinsGJNanoGenotoxicology: the DNA damaging potential of engineered nanomaterialsBiomaterials20093023–243891391419427031
  • SongWZhangJGuoJRole of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticlesToxicol Lett2010199338939720934491
  • WahabRSiddiquiMASaquibQZnO nanoparticles induced oxidative stress and apoptosis in HepG2 and MCF-7 cancer cells and their antibacterial activityColloids Surf B Biointerfaces201411726727624657613
  • NamvarFRahmanHSMohamadRCytotoxic effects of biosynthesized zinc oxide nanoparticles on murine cell linesEvid Based Complement Alternat Med2015201559301425784947
  • WongSWLeungPTDjurisicABLeungKMToxicities of nano zinc oxide to five marine organisms: influences of aggregate size and ion solubilityAnal Bioanal Chem2010396260961819902187
  • HsiaoILHuangYJEffects of various physicochemical characteristics on the toxicities of ZnO and TiO nanoparticles toward human lung epithelial cellsSci Total Environ201140971219122821255821
  • LeeJKangBSHicksBThe control of cell adhesion and viability by zinc oxide nanorodsBiomaterials200829273743374918550161
  • AsatiASantraSKaittanisCPerezJMSurface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticlesACS Nano2010495321533120690607
  • HuaJVijverMGRichardsonMKAhmadFPeijnenburgWJParticle-specific toxic effects of differently shaped zinc oxide nanoparticles to zebrafish embryos (Danio rerio)Environ Toxicol Chem201433122859286825244315
  • ZhaoXWangSWuYYouHLvLAcute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafishAquat Toxicol2013136–1374959
  • AlarabyMAnnangiBHernandezACreusAMarcosRA comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo modelJ Hazard Mater201529616617425917694
  • WanRMoYFengLChienSTollerudDJZhangQDNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATMChem Res Toxicol20122571402141122559321
  • DemirECreusAMarcosRGenotoxicity and DNA repair processes of zinc oxide nanoparticlesJ Toxicol Environ Health A201477211292130325268556
  • OsmanIFBaumgartnerACemeliEFletcherJNAndersonDGenotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cellsNanomedicine (Lond)2010581193120321039197
  • SharmaVShuklaRKSaxenaNParmarDDasMDhawanADNA damaging potential of zinc oxide nanoparticles in human epidermal cellsToxicol Lett2009185321121819382294
  • SharmaVSinghSKAndersonDTobinDJDhawanAZinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytesJ Nanosci Nanotechnol20111153782378821780369
  • BeckettWSChalupaDFPauly-BrownAComparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation studyAm J Respir Crit Care Med2005171101129113515735058
  • Adamcakova-DoddAStebounovaLVKimJSToxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation modelsPart Fibre Toxicol2014111524684892
  • ColonGWardBCWebsterTJIncreased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2J Biomed Mater Res A200678359560416752397
  • RyuHJSeoMYJungSKZinc oxide nanoparticles: a 90-day repeated-dose dermal toxicity study in ratsInt J Nanomedicine20149Suppl 213714425565832
  • CarmonaERInostroza-BlancheteauCRubioLMarcosRGenotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogasterToxicol Ind Health201632121987200126419260
  • BakandSHayesADechsakulthornFNanoparticles: a review of particle toxicology following inhalation exposureInhal Toxicol201224212513522260506
  • DengHKerppolaTKVisualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activationDevelopment2014141163277328825063457
  • KongLGaoXZhuJChengKTangMMechanisms involved in reproductive toxicity caused by nickel nanoparticle in female ratsEnviron Toxicol201631111674168327257140
  • SainiPSahaSKRoyPChowdhuryPSinha BabuSPEvidence of reactive oxygen species (ROS) mediated apoptosis in Setaria cervi induced by green silver nanoparticles from Acacia auriculiformis at a very low doseExp Parasitol2016160394826627139
  • LeeHMKimCWHwangKAChoiDWChoiKCThree components of cigarette smoke altered the growth and apoptosis of metastatic colon cancer cells via inducing the synthesis of reactive oxygen species and endoplasmic reticulum stressEnviron Toxicol Pharmacol201645808927262990
  • WuLLChiouCCChangPYWuJTUrinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabeticsClin Chim Acta20043391–21914687888
  • OngCYungLYCaiYBayBHBaegGHDrosophila melanogaster as a model organism to study nanotoxicityNanotoxicology20159339640325051331
  • KalyanaramanBDarley-UsmarVDaviesKJMeasuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitationsFree Radic Biol Med20125211622027063
  • BryanHKOlayanjuAGoldringCEParkBKThe Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulationBiochem Pharmacol201385670571723219527
  • DaviesTGWixtedWECoyleJEMonoacidic inhibitors of the Kelch-like ECH-associated protein 1: nuclear factor erythroid 2-related factor 2 (KEAP1:NRF2) protein-protein interaction with high cell potency identified by fragment-based discoveryJ Med Chem20165983991400627031670
  • LiuYKernJTWalkerJRJohnsonJASchultzPGLueschHA genomic screen for activators of the antioxidant response elementProc Natl Acad Sci U S A2007104125205521017360324
  • ItohKWakabayashiNKatohYKeap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainGenes Dev199913176869887101
  • NguyenTSherrattPJHuangHCYangCSPickettCBIncreased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasomeJ Biol Chem20032784536454112446695
  • KaoYYChenYCChengTJChiungYMLiuPSZinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicityToxicol Sci2012125246247222112499
  • BrunnerTJWickPManserPIn vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubilityEnviron Sci Technol200640144374438116903273
  • FranklinNMRogersNJApteSCBatleyGEGaddGECaseyPSComparative toxicity of nanoparticulate ZnO, bulk ZnO, and ZnCl2 to a freshwater microalga (Pseudokirchneriella subcapitata): the importance of particle solubilityEnviron Sci Technol200741248484849018200883
  • HeinlaanMIvaskABlinovaIDubourguierHCKahruAToxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurusChemosphere20087171308131618194809
  • MaHBertschPMGlennTCKabengiNJWilliamsPLToxicity of manufactured zinc oxide nanoparticles in the nematode Caenorhabditis elegansEnviron Toxicol Chem20092861324133019192952
  • SirelkhatimAMahmudSSeeniAReview on zinc oxide nanoparticles: antibacterial activity and toxicity mechanismNano-Micro Letters201573219242
  • StarkGFunctional consequences of oxidative membrane damageJ Membr Biol2005205111616245038
  • RyuWParkYBaeHCZnO nanoparticle induces apoptosis by ROS triggered mitochondrial pathway in human keratinocytesMol Cell Toxicol2014104387391
  • SharmaVAndersonDDhawanAZinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)Apoptosis201217885287022395444
  • YuKNYoonTJMinai-TehraniAZinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generationToxicol In Vitro20132741187119523458966
  • GuoDBiHLiuBWuQWangDCuiYReactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cellsToxicol In Vitro201327273173823232460
  • McCulloughKDMartindaleJLKlotzLOAwTYHolbrookNJGadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateMol Cell Biol20012141249125911158311
  • OyadomariSKoizumiATakedaKTargeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesJ Clin Invest2002109452553211854325
  • SensiSLTon-ThatDSullivanPGModulation of mitochondrial function by endogenous Zn2+ poolsProc Natl Acad Sci U S A2003100106157616212724524
  • ShoreGCPapaFROakesSASignaling cell death from the endoplasmic reticulum stress responseCurr Opin Cell Biol201123214314921146390
  • HanDLernerAGVande WalleLIRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fatesCell2009138356257519665977
  • UptonJPWangLHanDIRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2Science2012338610881882223042294
  • OngCLeeQYCaiYSilver nanoparticles disrupt germline stem cell maintenance in the Drosophila testisSci Rep201662063226847594
  • VecchioGA fruit fly in the nanoworld: once again Drosophila contributes to environment and human healthNanotoxicology20159135137
  • ApidianakisYRahmeLGDrosophila melanogaster as a model for human intestinal infection and pathologyDis Model Mech201141213021183483
  • ChangYZhangMXiaLZhangJXingGThe toxic effects and mechanisms of CuO and ZnO nanoparticlesMaterials201251228502871
  • LiCHShenCCChengYWOrgan biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in miceNanotoxicology20126774675621950449
  • VandebrielRJDe JongWHA review of mammalian toxicity of ZnO nanoparticlesNanotechnol Sci Appl20125617124198497