Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective

References

• Ochwang’iDOKimweleCNOdumaJAGathumbiPKMbariaJMKiamaSGMedicinal plants used in treatment and management of cancer in Kakamega County, KenyaJ Ethnopharmacol201415131040105524362078
   PubMed Web of Science ®Google Scholar
• JemalASiegelRXuJWardECancer statistics, 2010CA Cancer J Clin201060527730020610543
   PubMed Web of Science ®Google Scholar
• NagavarmaBYadavHKAyazAVasudhaLShivakumarHDifferent techniques for preparation of polymeric nanoparticles – a reviewAsian J Pharm Clin Res2012531623
   Google Scholar
• HedeSHuilgolN“Nano”: the new nemesis of cancerJ Cancer Res Ther20062418617998702
   PubMedGoogle Scholar
• WangXWangYChenZGShinDMAdvances of cancer therapy by nanotechnologyCancer Res Treat200941111119688065
   PubMed Web of Science ®Google Scholar
• BrandlMLiposomes as drug carriers: a technological approachBiotechnol Annu Rev20017598511686049
   PubMedGoogle Scholar
• MatsumuraYHamaguchiTUraTPhase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicinBr J Cancer200491101775178115477860
   PubMed Web of Science ®Google Scholar
• MallickSChoiJSLiposomes: versatile and biocompatible nanovesicles for efficient biomolecules deliveryJ Nanosci Nanotechnol201414175576524730295
   PubMed Web of Science ®Google Scholar
• ZhangLGuFChanJWangALangerRFarokhzadONanoparticles in medicine: therapeutic applications and developmentsClin Pharmacol Ther200883576176917957183
   PubMed Web of Science ®Google Scholar
• RasouliHFarzaeiMHMansouriKMohammadzadehSKhodarahmiRPlant cell cancer: may natural phenolic compounds prevent onset and development of plant cell malignancy? A literature reviewMolecules20162191104
   PubMed Web of Science ®Google Scholar
• Hosein FarzaeiMBahramsoltaniRRahimiRPhytochemicals as adjunctive with conventional anticancer therapiesCurr Pharm Des201622274201421827262332
   PubMedGoogle Scholar
• DanhierFAnsorenaESilvaJMCocoRLe BretonAPréatVPLGA-based nanoparticles: an overview of biomedical applicationsJ Control Release2012161250552222353619
   PubMed Web of Science ®Google Scholar
• Beck-BroichsitterMRyttingELebhardtTWangXKisselTPreparation of nanoparticles by solvent displacement for drug delivery: a shift in the “ouzo region” upon drug loadingEur J Pharm Sci201041224425320600881
   PubMed Web of Science ®Google Scholar
• ReisCPNeufeldRJRibeiroAJVeigaFNanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticlesNanomedicine20062182117292111
   PubMed Web of Science ®Google Scholar
• KumariAYadavSKYadavSCBiodegradable polymeric nanoparticles based drug delivery systemsColloids Surf B Biointerfaces201075111819782542
   PubMed Web of Science ®Google Scholar
• Tahmasebi BirganiMErfani-MoghadamVBabaeiEDendrosomal nano-curcumin; the novel formulation to improve the anti-cancer properties of curcuminProg Biol Sci201552143158
   Google Scholar
• PaleosCMTsiourvasDSideratouZPantosAFormation of artificial multicompartment vesosome and dendrosome as prospected drug and gene delivery carriersJ Control Release2013170114115223707326
   PubMedGoogle Scholar
• MohantyCAcharyaSMohantyAKDilnawazFSahooSKCurcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapyNanomedicine20105343344920394536
   PubMedGoogle Scholar
• PrabaharanMGrailerJJSteeberDAGongSStimuli-responsive chitosan-graft-poly(N-vinylcaprolactam) as a promising material for controlled hydrophobic drug deliveryMacromol Biosci20088984385118504806
   PubMedGoogle Scholar
• LoftssonTMassonMBrewsterMESelf-association of cyclodextrins and cyclodextrin complexesJ Pharm Sci20049351091109915067686
   PubMed Web of Science ®Google Scholar
• ChenLBerryRMTamKCSynthesis of β-Cyclodextrin-modified cellulose nanocrystals (CNCs)@ Fe3O4@ SiO2 superparamagnetic nanorodsACS Sustain Chem Eng201424951958
   Google Scholar
• HemrazUDCampbellKABurdickJSCklessKBolukYSunaseeRCationic poly(2-aminoethylmethacrylate) and poly(N-(2-aminoethylmethacrylamide) modified cellulose nanocrystals: synthesis, characterization, and cytotoxicityBiomacromolecules201416131932525436513
   PubMedGoogle Scholar
• PhanQTLeMHLeTTHTranTHHXuanPNHaPTCharacteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA: PEG ratiosInt J Pharm20165071324027150945
   PubMedGoogle Scholar
• SinhaVBansalKKaushikRKumriaRTrehanAPoly-ε-caprolactone microspheres and nanospheres: an overviewInt J Pharm2004278112315158945
   PubMed Web of Science ®Google Scholar
• CasadioFLeonaMLombardiJRVan DuyneRIdentification of organic colorants in fibers, paints, and glazes by surface enhanced Raman spectroscopyAcc Chem Res201043678279120420359
   PubMed Web of Science ®Google Scholar
• ChouhanRBajpaiAReal time in vitro studies of doxorubicin release from PHEMA nanoparticlesJ Nanobiotechnology200971119351396
   PubMedGoogle Scholar
• DoktorovovaSGokceEOzyaziciMSoutoELipid matrix nanoparticles: pharmacokinetics and biopharmaceuticsCurr Nanosci200953358371
   Web of Science ®Google Scholar
• MehnertWMäderKSolid lipid nanoparticles: production, characterization and applicationsAdv Drug Deliv Rev200147216519611311991
   PubMed Web of Science ®Google Scholar
• BeltingMSandgrenSWittrupANuclear delivery of macromolecules: barriers and carriersAdv Drug Deliv Rev200557450552715722161
   PubMed Web of Science ®Google Scholar
• BairagiSHSalaskarPPLokeSDSurveNNTandelDVDusaraMDMedicinal significance of coumarinsInt J Pharm Res2012421619
   Google Scholar
• BeythRMilliganPGageBRisk factors for bleeding in patients taking coumarinsCurr Hematol Rep200211414912901124
   PubMedGoogle Scholar
• LealLFerreiraABezerraGMatosFVianaGAntinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative studyJ Ethnopharmacol200070215115910771205
   PubMed Web of Science ®Google Scholar
• CastilhoROKaplanMACChemosystematics of the rosifloraeBraz J Biol200868363364018833486
   PubMedGoogle Scholar
• BhattacharyyaSSPaulSDeAPoly(lactide-co-glycolide) acid nanoencapsulation of a synthetic coumarin: cytotoxicity and bio-distribution in mice, in cancer cell line and interaction with calf thymus DNA as targetToxicol Appl Pharmacol2011253327028121549736
   PubMedGoogle Scholar
• AasZBabaeiEFeiziMAHDehghanGAnti-proliferative and apoptotic effects of dendrosomal farnesiferol c on gastric cancer cellsAsian Pac J Cancer Prev201516135325532926225673
   PubMedGoogle Scholar
• PanahiYBadeliRKaramiGRSahebkarAInvestigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorderPhytother Res2015291172125091591
   PubMed Web of Science ®Google Scholar
• ZamanMSChauhanNYallapuMMCurcumin nanoformulation for cervical cancer treatmentSci Rep201662005126837852
   PubMed Web of Science ®Google Scholar
• WuGHuangHGarcia AbreuJHeXInhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6PLoS One200941e492619293931
   PubMedGoogle Scholar
• RushworthSATargeting the oncogenic role of miRNA in human cancer using naturally occurring compoundsBr J Pharmacol2011162234634821192341
   PubMedGoogle Scholar
• ZhangBPanXCobbGPAndersonTAmicroRNAs as oncogenes and tumor suppressorsDev Biol2007302111216989803
   PubMed Web of Science ®Google Scholar
• XieMFanDZhaoZNano-curcumin prepared via super-critical: improved anti-bacterial, anti-oxidant and anti-cancer efficacyInt J Pharm2015496273274026570985
   PubMed Web of Science ®Google Scholar
• YallapuMMGuptaBKJaggiMChauhanSCFabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cellsJ Colloid Interface Sci20103511192920627257
   PubMed Web of Science ®Google Scholar
• YallapuMMMaherDMSundramVBellMCJaggiMChauhanSCCurcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growthJ Ovarian Res201031120157422
   PubMedGoogle Scholar
• PunfaWYodkeereeSPitchakarnPAmpasavateCLimtrakulPEnhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cellsActa Pharmacol Sin201233682383122580738
   PubMed Web of Science ®Google Scholar
• YuYZhangXQiuLThe anti-tumor efficacy of curcumin when delivered by size/charge-changing multistage polymeric micelles based on amphiphilic poly(β-amino ester) derivatesBiomaterials201435103467347924439418
   PubMed Web of Science ®Google Scholar
• RejinoldNSSreerekhaPChennazhiKNairSJayakumarRBiocompatible, biodegradable and thermo-sensitive chitosan-g-poly(N-isopropylacrylamide) nanocarrier for curcumin drug deliveryInt J Biol Macromol201149216117221536066
   PubMed Web of Science ®Google Scholar
• NtoutoumeGMNGranetRMbakidiJPDevelopment of curcumin–cyclodextrin/cellulose nanocrystals complexes: new anticancer drug delivery systemsBioorg Med Chem Lett201626394194526739777
   PubMedGoogle Scholar
• ShiriSAlizadehAMBaradaranBDendrosomal curcumin suppresses metastatic breast cancer in mice by changing m1/m2 macrophage balance in the tumor microenvironmentAsian Pac J Cancer Prev20151693917392225987060
   PubMedGoogle Scholar
• JiGYangJChenJPreparation of novel curcumin-loaded multifunctional nanodroplets for combining ultrasonic development and targeted chemotherapyInt J Pharm2014466131432024657138
   PubMedGoogle Scholar
• MilanoFMariLvan de LuijtgaardenWParikhKCalpeSKrishnadathKKNano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune responseFront Oncol2013313711123755374
   PubMedGoogle Scholar
• AdahounMAAl-AkhrasMHJaafarMSBououdinaMEnhanced anti-cancer and antimicrobial activities of curcumin nanoparticlesArtif Cells Nanomed Biotechnol20174519810726747522
   PubMed Web of Science ®Google Scholar
• BondìMCraparoEPiconePCurcumin entrapped into lipid nanosystems inhibits neuroblastoma cancer cell growth and activates Hsp70 proteinCurr Nanosci201065439445
   Web of Science ®Google Scholar
• MancarellaSGrecoVBaldassarreFVergaraDMaffiaMLeporattiSPolymer-coated magnetic nanoparticles for curcumin delivery to cancer cellsMacromol Biosci201515101365137426085082
   PubMed Web of Science ®Google Scholar
• YanJWangYZhangXLiuSTianCWangHTargeted nanomedicine for prostate cancer therapy: docetaxel and curcumin co-encapsulated lipid–polymer hybrid nanoparticles for the enhanced anti-tumor activity in vitro and in vivoDrug Deliv20162351757176226203689
   PubMed Web of Science ®Google Scholar
• OchiMMAmoabedinyGRezayatSMAkbarzadehAEbrahimiBIn vitro co-delivery evaluation of novel pegylated nano-liposomal herbal drugs of silibinin and glycyrrhizic acid (Nano-phytosome) to hepatocellular carcinoma cellsCell J201618213514827540518
   PubMed Web of Science ®Google Scholar
• YamazakiKIwashinaTKitajimaJGamouYYoshidaATannowaTExternal and internal flavonoids from Madagascarian Uncarina species (Pedaliaceae)Biochem Syst Ecol20073511743749
   Google Scholar
• TouréAXuemingXFlaxseed lignans: source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefitsCompr Rev Food Sci Food Saf201093261269
   PubMed Web of Science ®Google Scholar
• AdlercreutzHLignans and human healthCrit Rev Clin Lab Sci2007445–648352517943494
   PubMed Web of Science ®Google Scholar
• KalmanDSFeldmanSFeldmanRSchwartzHIKriegerDRGarrisonREffect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trialNutr J200871118194542
   PubMedGoogle Scholar
• QiuNCaiLLXieDSynthesis, structural and in vitro studies of well-dispersed monomethoxy-poly(ethylene glycol)-honokiol conjugate micellesBiomed Mater20105606500620966535
   PubMedGoogle Scholar
• AkgunIErkucukAPilavtepeMYesil-CeliktasOOptimization of total alkannin yields of Alkanna tinctoria by using sub-and supercritical carbon dioxide extractionJ Supercrit Fluids20115713137
   Google Scholar
• SharmaRSMishraVSinghRSethNBabuCAntifungal activity of some Himalayan medicinal plants and cultivated ornamental speciesFitoterapia200879758959118672040
   PubMedGoogle Scholar
• LucenaGMMatheusFCFerreiraVMEffects of ethanolic extract and naphthoquinones obtained from the bulbs of cipura paludosa on short-term and long-term memory: involvement of adenosine A1 and A2A receptorsBasic Clin Pharmacol Toxicol2013112422923523057724
   PubMedGoogle Scholar
• XuT-PShenHLiuL-XShuY-QPlumbagin from Plumbago Zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF-κB inactivationAsian Pac J Cancer Prev20131442325233123725135
   PubMedGoogle Scholar
• IsraelsenWJVander HeidenMGPyruvate kinase: function, regulation and role in cancerPaper presented at: Seminars in Cell & Developmental Biology2015
   Google Scholar
• DuraipandyNLakraRKunnavakkam VinjimurSSamantaDSaiPKiranMSCaging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosisMetallomics20146112025203325188862
   PubMed Web of Science ®Google Scholar
• RivièreCPawlusADMérillonJ-MNatural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in VitaceaeNat Prod Rep201229111317133323014926
   PubMed Web of Science ®Google Scholar
• SannaVSiddiquiIASechiMMukhtarHResveratrol-loaded nanoparticles based on poly(epsiloncaprolactone) and poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) blend for prostate cancer treatmentMol Pharm201310103871388123968375
   PubMedGoogle Scholar
• CarlettoBBertonJFerreiraTNResveratrol-loaded nanocapsules inhibit murine melanoma tumor growthColloids Surf B Biointerfaces2016144657227070053
   PubMed Web of Science ®Google Scholar
• ShaoJLiXLuXEnhanced growth inhibition effect of resveratrol incorporated into biodegradable nanoparticles against glioma cells is mediated by the induction of intracellular reactive oxygen species levelsColloids Surf B Biointerfaces2009721404719395246
   PubMed Web of Science ®Google Scholar
• GuoLPengYLiYCell death pathway induced by resveratrol-bovine serum albumin nanoparticles in a human ovarian cell lineOncol Lett2015931359136325663913
   PubMed Web of Science ®Google Scholar
• MohanANarayananSSethuramanSKrishnanUMNovel resveratrol and 5-fluorouracil coencapsulated in PEGylated nanoliposomes improve chemotherapeutic efficacy of combination against head and neck squamous cell carcinomaBiomed Res Int2014201442423925114900
   PubMed Web of Science ®Google Scholar
• WilliamsCAGrayerRJAnthocyanins and other flavonoidsNat Prod Rep200421453957315282635
   PubMed Web of Science ®Google Scholar
• ParhizHRoohbakhshASoltaniFRezaeeRIranshahiMAntioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental modelsPhytother Res201529332333125394264
   PubMed Web of Science ®Google Scholar
• Leyva-LópezNGutierrez-GrijalvaEPAmbriz-PerezDLHerediaJBFlavonoids as cytokine modulators: a possible therapy for inflammation-related diseasesInt J Mol Sci2016176921
   PubMed Web of Science ®Google Scholar
• PelusoIMiglioCMorabitoGIoannoneFSerafiniMFlavonoids and immune function in human: a systematic reviewCrit Rev Food Sci Nutr201555338339524915384
   PubMed Web of Science ®Google Scholar
• SakKCytotoxicity of dietary flavonoids on different human cancer typesPharmacogn Rev201481612225125885
   PubMedGoogle Scholar
• AyoubMde CamargoACShahidiFAntioxidants and bioactivities of free, esterified and insoluble-bound phenolics from berry seed mealsFood Chem201619722123226616944
   PubMedGoogle Scholar
• SerafiniMBugianesiRMaianiGValtuenaSDe SantisSCrozierAPlasma antioxidants from chocolateNature200369521013
   PubMedGoogle Scholar
• Le MarchandLCancer preventive effects of flavonoids – a reviewBiomed Pharmacother200256629630112224601
   PubMed Web of Science ®Google Scholar
• XieYSongXSunXIdentification of baicalein as a ferroptosis inhibitor by natural product library screeningBiochem Biophys Res Commun2016473477578027037021
   PubMed Web of Science ®Google Scholar
• LiuAWangWFangHBaicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in miceEur J Pharmacol2015748455325533331
   PubMed Web of Science ®Google Scholar
• AnandhiRAnnaduraiTAnithaTSAntihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-1339-induced hypercholesterolemic ratsJ Physiol Biochem201369231332323104078
   PubMed Web of Science ®Google Scholar
• RashidSNafeesSVafaAInhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stageArch Biochem Biophys20166061927403965
   PubMed Web of Science ®Google Scholar
• LiXHuangJ-MWangJ-NXiongX-KYangX-FZouFCombination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53Chem Biol Interact2015232122025770930
   PubMed Web of Science ®Google Scholar
• ShinYSKangSUParkJKAnti-cancer effect of (–)- epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-cateninPhytomedicine201623121344135527765354
   PubMed Web of Science ®Google Scholar
• ShafieiSSSolati-HashjinMSamadikuchaksaraeiAKalantarinejadRAsadi-EydivandMAbu OsmanNAEpigallocatechin gallate/layered double hydroxide nanohybrids: preparation, characterization, and in vitro anti-tumor studyPLoS One2015108e013653026317853
   PubMed Web of Science ®Google Scholar
• SiddiquiIABharaliDJNihalMExcellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivoNanomedicine20141081619162624965756
   PubMed Web of Science ®Google Scholar
• NarayananSMonyUVijaykumarDKKoyakuttyMPaul-PrasanthBMenonDSequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cellsNanomedicine20151161399140625888278
   PubMed Web of Science ®Google Scholar
• AbdolahadMJanmalekiMMohajerzadehSAkhavanOAbbasiSPolyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cellsMater Sci Eng C Mater Biol Appl20133331498150523827601
   PubMed Web of Science ®Google Scholar
• MengGChaiKLiXZhuYHuangWLuteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathwayChem Biol Interact2016257263427474067
   PubMedGoogle Scholar
• SabzichiMHamishehkarHRamezaniFLuteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signallingAsian Pac J Cancer Prev201415135311531625040994
   PubMedGoogle Scholar
• MajumdarDJungKHZhangHLuteolin nanoparticle in chemoprevention: in vitro and in vivo anticancer activityCancer Prev Res (Phila)201471657324403290
   PubMed Web of Science ®Google Scholar
• MurakamiAAshidaHTeraoJMultitargeted cancer prevention by quercetinCancer Lett2008269231532518467024
   PubMed Web of Science ®Google Scholar
• MinaeiASabzichiMRamezaniFHamishehkarHSamadiNCo-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cellsMol Biol Rep20164329910526748999
   PubMed Web of Science ®Google Scholar
• Rezaei-SadabadyREidiAZarghamiNBarzegarAIntracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomesArtif Cells Nanomed Biotechnol201644112813424959911
   PubMed Web of Science ®Google Scholar
• JafariSSaeidniaSAbdollahiMRole of natural phenolic compounds in cancer chemoprevention via regulation of the cell cycleCurr Pharm Biotechnol201415440942125312621
   PubMedGoogle Scholar
• SaeidniaSAbdollahiMAntioxidants: friends or foe in prevention or treatment of cancer: the debate of the centuryToxicol Appl Pharmacol20132711496323680455
   PubMed Web of Science ®Google Scholar
• MostafalouSMohammadiHRamazaniAAbdollahiMDifferent biokinetics of nanomedicines linking to their toxicity: an overviewDaru2013211123351326
   PubMedGoogle Scholar
• KoopaeiNNAbdollahiMOpportunities and obstacles to the development of nanopharmaceuticals for human useDaru20162412327716350
   PubMedGoogle Scholar
• PourmandAAbdollahiMCurrent opinion on nanotoxicologyDaru2012201123226110
   PubMedGoogle Scholar
• DonnenbergVSDonnenbergADMultiple drug resistance in cancer revisited: the cancer stem cell hypothesisJ Clin Pharmacol200545887287716027397
   PubMedGoogle Scholar
• LiangX-JChenCZhaoYWangPCCircumventing tumor resistance to chemotherapy by nanotechnologyMethods Mol Biol201059646748819949937
   PubMedGoogle Scholar
• GuptaSAfaqFMukhtarHInvolvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cellsOncogene200221233727373812032841
   PubMed Web of Science ®Google Scholar
• EmiMKimRTanabeKUchidaYTogeTTargeted therapy against Bcl-2-related proteins in breast cancer cellsBreast Cancer Res200576115642174
   PubMedGoogle Scholar
• FangX-BZhangJ-MXieXpH-sensitive micelles based on acid-labile pluronic F68–curcumin conjugates for improved tumor intracellular drug deliveryInt J Pharm20165021–2283726784981
   PubMed Web of Science ®Google Scholar
• RaveendranRBhuvaneshwarGSSharmaCPHemocompatible curcumin–dextran micelles as pH sensitive pro-drugs for enhanced therapeutic efficacy in cancer cellsCarbohydr Polym201613749750726686156
   PubMed Web of Science ®Google Scholar
• GhoshDChoudhurySTGhoshSNanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in ratChem Biol Interact2012195320621422197969
   PubMed Web of Science ®Google Scholar
• KumarSSDSurianarayananMVijayaraghavanRMandalABMacfarlaneDRCurcumin loaded poly(2-hydroxyethyl methacrylate) nanoparticles from gelled ionic liquid – in vitro cytotoxicity and anti-cancer activity in SKOV-3 cellsEur J Pharm Sci2014511344424012589
   PubMedGoogle Scholar
• MilanoFMariLvan de LuijtgaardenWParikhKCalpeSKrishnadathKKNano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune responseFront Oncol2013313723755374
   PubMedGoogle Scholar