Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment

References

• World Health Organization. Cancer Today. World Health Organization; 2021.
   Google Scholar
• Arnold M, Sierra MS, Laversanne M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683–691. doi:10.1136/gutjnl-2015-310912
   PubMed Web of Science ®Google Scholar
• Wong MC, Ding H, Wang J, Chan PS, Huang J. Prevalence and risk factors of colorectal cancer in Asia. Intest Res. 2019;17:317–329. doi:10.5217/ir.2019.00021
   PubMed Web of Science ®Google Scholar
• Sihvola S, Kuosmanen L, Kvist T. Resilience and related factors in colorectal cancer patients: a systematic review. Eur J Oncol Nurs. 2022;56:102079. doi:10.1016/j.ejon.2021.102079
   PubMed Web of Science ®Google Scholar
• Yang C, Merlin D. Lipid-based drug delivery nanoplatforms for colorectal cancer therapy. Nanomaterials. 2020;10:1424. doi:10.3390/nano10071424
   Web of Science ®Google Scholar
• Tian Q, Liu Y, Zhang Y, et al. THBS2 is a biomarker for AJCC stages and a strong prognostic indicator in colorectal cancer. J Buon. 2018;23:1331–1336.
   PubMed Web of Science ®Google Scholar
• Bennedsgaard K, Ventzel L, Themistocleous AC, et al. Long‐term symptoms of polyneuropathy in breast and colorectal cancer patients treated with and without adjuvant chemotherapy. Cancer Med. 2020;9:5114–5123. doi:10.1002/cam4.3129
   PubMed Web of Science ®Google Scholar
• Duran G, Cruz R, Simoes AR, et al. Efficacy and toxicity of adjuvant chemotherapy on colorectal cancer patients: how much influence from the genetics? J Chemother. 2020;32:310–322. doi:10.1080/1120009X.2020.1764281
   PubMed Web of Science ®Google Scholar
• Yang X, Xie Y. Recent advances in polymeric core–shell nanocarriers for targeted delivery of chemotherapeutic drugs. Int J Pharm. 2021;608:121094. doi:10.1016/j.ijpharm.2021.121094
   PubMed Web of Science ®Google Scholar
• Arumov A, Trabolsi A, Schatz JH. Potency meets precision in nano-optimized chemotherapeutics. Trends Biotechnol. 2021;39:974–977. doi:10.1016/j.tibtech.2021.03.004
   PubMed Web of Science ®Google Scholar
• Mitchell MJ, Billingsley MM, Haley RM, et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20:101–124. doi:10.1038/s41573-020-0090-8
   PubMed Web of Science ®Google Scholar
• Kundu M, Chatterjee S, Ghosh N, et al. Tumor targeted delivery of umbelliferone via a smart mesoporous silica nanoparticles controlled-release drug delivery system for increased anticancer efficiency. Mater Sci Eng C. 2020;116:111239. doi:10.1016/j.msec.2020.111239
   PubMed Web of Science ®Google Scholar
• Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chem Rev. 2016;116:2602–2663. doi:10.1021/acs.chemrev.5b00346
   PubMed Web of Science ®Google Scholar
• Kuen CY, Masarudin MJ. Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment. Molecules. 2022;27:473. doi:10.3390/molecules27020473
   PubMed Web of Science ®Google Scholar
• Jurczyk M, Jelonek K, Musiał-Kulik M, et al. Single- versus dual-targeted nanoparticles with folic acid and biotin for anticancer drug delivery. Pharmaceutics. 2021;13:326. doi:10.3390/pharmaceutics13030326
   PubMed Web of Science ®Google Scholar
• Mohanty A, Uthaman S, Park IK. Utilization of polymer-lipid hybrid nanoparticles for targeted anti-cancer therapy. Molecules. 2020;25:4377. doi:10.3390/molecules25194377
   PubMed Web of Science ®Google Scholar
• Martinez MN, Amidon GL. A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol. 2002;42:620–643. doi:10.1177/00970002042006005
   PubMed Web of Science ®Google Scholar
• Helander HF, Fändriks L. Surface area of the digestive tract-revisited. Scand J Gastroenterol. 2014;49:681–689. doi:10.3109/00365521.2014.898326
   PubMed Web of Science ®Google Scholar
• Shreya AB, Raut SY, Managuli RS, Udupa N, Mutalik S, Marosi G. Active targeting of drugs and bioactive molecules via oral administration by ligand-conjugated lipidic nanocarriers: recent advances. AAPS PharmSciTech. 2018;20:1–12. doi:10.1208/s12249-018-1201-2
   PubMed Web of Science ®Google Scholar
• Homayun B, Lin X, Choi HJ. Challenges and recent progress in oral drug delivery systems for biopharmaceuticals. Pharmaceutics. 2019;11:129. doi:10.3390/pharmaceutics11030129
   PubMed Web of Science ®Google Scholar
• El Moukhtari SH, Rodríguez-Nogales C, Blanco-Prieto MJ. Oral lipid nanomedicines: current status and future perspectives in cancer treatment. Adv Drug Deliv Rev. 2021;173:238–251. doi:10.1016/j.addr.2021.03.004
   PubMed Web of Science ®Google Scholar
• Ying K, Bai B, Gao X, et al. Orally administrable therapeutic nanoparticles for the treatment of colorectal cancer. Front Bioeng Biotechnol. 2021;9:480. doi:10.3389/fbioe.2021.670124
   Web of Science ®Google Scholar
• Prasanth VV, Jayaprakash R, Mathew ST. Colon specific drug delivery systems: a review on various pharmaceutical approaches. J Appl Pharm Sci. 2012;2:163–169.
   Google Scholar
• Coupe AJ, Davis SS, Wilding IR. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm Res. 1991;8:360–364. doi:10.1023/A:1015849700421
   PubMed Web of Science ®Google Scholar
• Amidon S, Brown JE, Dave VS. Colon-targeted oral drug delivery systems: design trends and approaches. AAPS PharmSciTech. 2015;16:731–741. doi:10.1208/s12249-015-0350-9
   PubMed Web of Science ®Google Scholar
• Dmour I, Taha MO. Natural and semisynthetic polymers in pharmaceutical nanotechnology. In: Organic Materials as Smart Nanocarriers for Drug Delivery. William Andrew Publishing; 2018:35–100. doi:10.1016/B978-0-12-813663-8.00002-6
   Google Scholar
• Naskar S, Das SK, Sharma S, Kuotsu K. A review on designing poly (lactic-co-glycolic acid) nanoparticles as drug delivery systems. Pharm Nanotechnol. 2020;9:36–50. doi:10.2174/2211738508666201214103010
   Google Scholar
• Choukaife H, Doolaanea AA, Alfatama M. Alginate nanoformulation: influence of process and selected variables. Pharmaceuticals. 2020;13:1–35. doi:10.3390/ph13110335
   Web of Science ®Google Scholar
• Ravishankar K, Dhamodharan R. Advances in chitosan-based hydrogels: evolution from covalently crosslinked systems to ionotropically crosslinked superabsorbents. React Funct Polym. 2020;149:104517. doi:10.1016/j.reactfunctpolym.2020.104517
   Web of Science ®Google Scholar
• Seyam S, Nordin NA, Alfatama M. Recent progress of chitosan and chitosan derivatives-based nanoparticles: pharmaceutical perspectives of oral insulin delivery. Pharmaceuticals. 2020;13:307. doi:10.3390/ph13100307
   Web of Science ®Google Scholar
• Harkin C, Mehlmer N, Woortman DV, Brück TB, Brück WM. Nutritional and additive uses of chitin and chitosan in the food industry. In: Sustainable Agriculture Reviews. Vol. 36. Cham: Springer; 2019:1–43. doi:10.1007/978-3-030-16581-9_1
   Google Scholar
• Feng P, Luo Y, Ke C, et al. Chitosan-based functional materials for skin wound repair: mechanisms and applications. Front Bioeng Biotechnol. 2021;9:111. doi:10.3389/fbioe.2021.650598
   Web of Science ®Google Scholar
• Tang G, Tan Z, Zeng W, et al. Recent advances of chitosan-based injectable hydrogels for bone and dental tissue regeneration. Front Bioeng Biotechnol. 2020;8:1084. doi:10.3389/fbioe.2020.587658
   Web of Science ®Google Scholar
• Chuan D, Jin T, Fan R, Zhou L, Guo G. Chitosan for gene delivery: methods for improvement and applications. Adv Colloid Interface Sci. 2019;268:25–38. doi:10.1016/j.cis.2019.03.007
   PubMed Web of Science ®Google Scholar
• Gulbake A, Jain SK. Chitosan: a potential polymer for colon-specific drug delivery system. Expert Opin Drug Deliv. 2012;9:713–729. doi:10.1517/17425247.2012.682148
   PubMed Web of Science ®Google Scholar
• Patil P, Killedar S. Formulation and characterization of gallic acid and quercetin chitosan nanoparticles for sustained release in treating colorectal cancer. J Drug Deliv Sci Technol. 2021;63:102523. doi:10.1016/j.jddst.2021.102523
   Web of Science ®Google Scholar
• Kankala RK, Liu CG, Yang DY, Wang S, Chen AZ. Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance. Chem Eng J. 2020;383:123138. doi:10.1016/j.cej.2019.123138
   Web of Science ®Google Scholar
• Badran MM, Mady MM, Ghannam MM, Shakeel F. Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer. Int J Biol Macromol. 2017;95:643–649. doi:10.1016/j.ijbiomac.2016.11.098
   PubMed Web of Science ®Google Scholar
• Ding S, Wang Y, Li J, Chen S. Progress and prospects in chitosan derivatives: modification strategies and medical applications. J Mater Sci Technol. 2021;89:209–224. doi:10.1016/j.jmst.2020.12.008
   Web of Science ®Google Scholar
• Adhikari HS, Yadav PN. Anticancer activity of chitosan, chitosan derivatives, and their mechanism of action. Int J Biomater. 2018;2018. doi:10.1155/2018/2952085
   PubMed Web of Science ®Google Scholar
• Anitha A, Deepa N, Chennazhi KP, Lakshmanan VK, Jayakumar R. Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment. Biochim Biophys Acta. 2014;1840:2730–2743. doi:10.1016/j.bbagen.2014.06.004
   PubMed Web of Science ®Google Scholar
• Alkhader E, Roberts CJ, Rosli R, et al. Pharmacokinetic and anti-colon cancer properties of curcumin-containing chitosan-pectinate composite nanoparticles. J Biomater Sci Polym. 2018;29:2281–2298. doi:10.1080/09205063.2018.1541500
   PubMed Web of Science ®Google Scholar
• Wang Y, Ma J, Qiu T, et al. In vitro and in vivo combinatorial anticancer effects of oxaliplatin- and resveratrol-loaded N,O-carboxymethyl chitosan nanoparticles against colorectal cancer. Eur J Pharm Sci. 2021;163:105864. doi:10.1016/j.ejps.2021.105864
   PubMed Web of Science ®Google Scholar
• Samprasit W, Opanasopit P, Chamsai B. Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible colon-targeted delivery. Pharm Dev Technol. 2021;26:362–372. doi:10.1080/10837450.2021.1873370
   PubMed Web of Science ®Google Scholar
• Haider M, Zaki KZ, El Hamshary MR, et al. Polymeric nanocarriers: a promising tool for early diagnosis and efficient treatment of colorectal cancer. J Adv Res. 2021;39:237–255. doi:10.1016/j.jare.2021.11.008
   PubMed Web of Science ®Google Scholar
• Shwter AN, Abdullah NA, Alshawsh MA, et al. Chemopreventive effect of Phaleria macrocarpa on colorectal cancer aberrant crypt foci in vivo. J Ethnopharmacol. 2016;193:195–206. doi:10.1016/j.jep.2016.08.002
   PubMed Web of Science ®Google Scholar
• Zhao R, Huang H, Choi BY, et al. Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer. Phytomedicine. 2019;61:152813. doi:10.1016/j.phymed.2018.12.036
   PubMed Web of Science ®Google Scholar
• Greene FL, Stewart AK, Norton HJ. A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50,042 patients. Ann Surg. 2002;236:416. doi:10.1097/00000658-200210000-00003
   PubMed Web of Science ®Google Scholar
• Hodges N, Mackenzie H, D’Souza N, Brown G, Miskovic D. Survival outcomes for right-versus left-sided colon cancer and rectal cancer in England: a propensity-score matched population-based cohort study. Eur J Surg Oncol. 2021;48:841–849. doi:10.1016/j.ejso.2021.10.007
   PubMed Web of Science ®Google Scholar
• Norcic G. Liquid biopsy in colorectal cancer-current status and potential clinical applications. Micromachines. 2018;9:300. doi:10.3390/mi9060300
   PubMed Web of Science ®Google Scholar
• Butler TM. Updated Screening Strategies for Colorectal Cancer. Physician Assist Clin. 2021;6:625–635. doi:10.1016/j.cpha.2021.05.007
   Web of Science ®Google Scholar
• Amin MB, Greene FL, Edge SB, et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67:93–99. doi:10.3322/caac.21388
   PubMed Web of Science ®Google Scholar
• Qiu Y, Zhang X, Deng X, et al. Circulating tumor cell-associated white blood cell cluster is associated with poor survival of patients with gastric cancer following radical gastrectomy. Eur J Surg Oncol. 2021;48:1039–1045. doi:10.1016/j.ejso.2021.11.115
   PubMed Web of Science ®Google Scholar
• Wislez M, Domblides C, Greillier L, et al. Circulating tumor DNA in advanced non-small-cell lung cancer patients with HIV is associated with shorter overall survival: results from a Phase II trial (IFCT-1001 CHIVA). Lung Cancer. 2021;157:124–130. doi:10.1016/j.lungcan.2021.05.013
   PubMed Web of Science ®Google Scholar
• Hasanain A, Javed AA, van Oosten F, et al. Presence of transitional circulating tumor cells following resection is associated with worse survival in patients with delayed initiation of adjuvant therapy. HPB. 2020;22:S5. doi:10.1016/j.hpb.2020.04.790
   Google Scholar
• Chalfin HJ, Glavaris SA, Gorin MA, et al. Circulating tumor cell and circulating tumor DNA assays reveal complementary information for patients with metastatic urothelial cancer. Eur Urol Oncol. 2021;4:310–314. doi:10.1016/j.euo.2019.08.004
   PubMed Web of Science ®Google Scholar
• Ghafouri-Fard S, Hussen BM, Badrlou E, Abak A, Taheri M. MicroRNAs as important contributors in the pathogenesis of colorectal cancer. Biomed Pharmacother. 2021;140:111759. doi:10.1016/j.biopha.2021.111759
   PubMed Web of Science ®Google Scholar
• Neumann MHD, Bender S, Krahn T, Schlange T. ctDNA and CTCs in liquid biopsy – current status and where we need to progress. Comput Struct Biotechnol J. 2018;16:190–195. doi:10.1016/j.csbj.2018.05.002
   PubMed Web of Science ®Google Scholar
• Pal M, Muinao T, Boruah HPD, Mahindroo N. Current advances in prognostic and diagnostic biomarkers for solid cancers: detection techniques and future challenges. Biomed Pharmacother. 2022;146:112488. doi:10.1016/j.biopha.2021.112488
   PubMed Web of Science ®Google Scholar
• Armaghany T, Wilson JD, Chu Q, Mills G. Genetic alterations in colorectal cancer. Gastrointest Cancer Res. 2012;5:19–27.
   PubMedGoogle Scholar
• Chiu H-M, Chang L-C, Hsu W-F, Chou C-K, Wu M-S. Non-invasive screening for colorectal cancer in Asia. Best Pract Res Clin Gastroenterol. 2015;29:953–965. doi:10.1016/j.bpg.2015.09.015
   PubMed Web of Science ®Google Scholar
• Pickhardt PJ, Pooler BD, Kim DH, et al. The natural history of colorectal polyps: overview of predictive static and dynamic features. Gastroenterol Clin. 2018;47:515–536. doi:10.1016/j.gtc.2018.04.004
   Google Scholar
• Lu B, Jan Hendriks A, Nolte TM. A generic model based on the properties of nanoparticles and cells for predicting cellular uptake. Colloids Surfaces B Biointerfaces. 2022;209:112155. doi:10.1016/j.colsurfb.2021.112155
   PubMed Web of Science ®Google Scholar
• Nalli M, Puxeddu M, La Regina G, Gianni S, Silvestri R. Emerging therapeutic agents for colorectal cancer. Molecules. 2021;26:7463. doi:10.3390/molecules26247463
   PubMed Web of Science ®Google Scholar
• Hilberg F, Tontsch-Grunt U, Baum A, et al. Triple angiokinase inhibitor nintedanib directly inhibits tumor cell growth and induces tumor shrinkage via blocking oncogenic receptor tyrosine kinases. J Pharmacol Exp Ther. 2018;364:494–503. doi:10.1124/jpet.117.244129
   PubMed Web of Science ®Google Scholar
• Grothey A, Prager G, Yoshino T. The mechanism of action of regorafenib in colorectal cancer: a guide for the community physician. Clin Adv Hematol Oncol. 2019;17:16–19.
   Web of Science ®Google Scholar
• Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016;79:629–661. doi:10.1021/acs.jnatprod.5b01055
   PubMed Web of Science ®Google Scholar
• Huang X, Yang Z-J, Xie Q, et al. Natural products for treating colorectal cancer: a mechanistic review. Biomed Pharmacother. 2019;117:109142. doi:10.1016/j.biopha.2019.109142
   PubMed Web of Science ®Google Scholar
• Kim EJ, Park SY, Lee J-Y, Park JHY. Fucoidan present in brown algae induces apoptosis of human colon cancer cells. BMC Gastroenterol. 2010;10:1–11. doi:10.1186/1471-230X-10-96
   PubMed Web of Science ®Google Scholar
• Ji Q, Liu X, Fu X, et al. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One. 2013;8:e78700. doi:10.1371/journal.pone.0078700
   PubMed Web of Science ®Google Scholar
• Engelbrecht A-M, Mattheyse M, Ellis B, et al. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett. 2007;258:144–153. doi:10.1016/j.canlet.2007.08.020
   PubMed Web of Science ®Google Scholar
• Su -C-C, Lin J-G, Li T-M, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res. 2006;26:4379–4389.
   PubMed Web of Science ®Google Scholar
• Su M, Qin B, Liu F, Chen Y, Zhang R. Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway. Drug Des Devel Ther. 2017;11:3333. doi:10.2147/DDDT.S140354
   PubMed Web of Science ®Google Scholar
• Nauroth JM, Liu YC, Van Elswyk M, et al. Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo. Lipids. 2010;45:375–384. doi:10.1007/s11745-010-3406-3
   PubMed Web of Science ®Google Scholar
• Hossain Z, Hosokawa M, Takahashi K. Growth inhibition and induction of apoptosis of colon cancer cell lines by applying marine phospholipid. Nutr Cancer. 2008;61:123–130. doi:10.1080/01635580802395725
   Web of Science ®Google Scholar
• Hua S. Advances in oral drug delivery for regional targeting in the gastrointestinal tract - influence of physiological, pathophysiological and pharmaceutical factors. Front Pharmacol. 2020;11:524. doi:10.3389/fphar.2020.00524
   PubMed Web of Science ®Google Scholar
• Bratten J, Jones MP. New directions in the assessment of gastric function: clinical applications of physiologic measurements. Dig Dis. 2006;24:252–259. doi:10.1159/000092878
   PubMed Web of Science ®Google Scholar
• Ibekwe VC, Fadda HM, McConnell EL, et al. Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems. Pharm Res. 2008;25:1828–1835. doi:10.1007/s11095-008-9580-9
   PubMed Web of Science ®Google Scholar
• Brunton LL, Knollmann BC, Hilal-Dandan R. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. McGraw-Hill; 2018.
   Google Scholar
• Prabu SL, Suriyaprakash TNK, Ruckmani K. Biopharmaceutics and pharmacokinetics. In: Basic Pharmacokinetic Concepts and Some Clinical Applications. IntechOpen; 2015. doi10.5772/61160
   Google Scholar
• Reinus JF, Simon D. Gastrointestinal anatomy and physiology: the essentials. In: Gastrointestinal Anatomy and Physiology: The Essentials. Wiley Blackwell; 2014:1–188. doi:10.1002/9781118833001
   Google Scholar
• Huttenhower C. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207–214.
   PubMed Web of Science ®Google Scholar
• Macfarlane GT, Macfarlane S. Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics. J Clin Gastroenterol. 2011;45:S120–S127. doi:10.1097/MCG.0b013e31822fecfe
   PubMed Web of Science ®Google Scholar
• Sartor RB. Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis. Gastroenterology. 2010;139:1816–1819. doi:10.1053/j.gastro.2010.10.036
   PubMed Web of Science ®Google Scholar
• Gately NM, Kennedy JE. The development of a melt-extruded shellac carrier for the targeted delivery of probiotics to the colon. Pharmaceutics. 2017;9:38. doi:10.3390/pharmaceutics9040038
   PubMed Web of Science ®Google Scholar
• Shahdadi Sardo H, Saremnejad F, Bagheri S, et al. A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems. Int J Pharm. 2019;558:367–379. doi:10.1016/j.ijpharm.2019.01.022
   PubMed Web of Science ®Google Scholar
• Aidy SE, van den Bogert B, Kleerebezem M. The small intestine microbiota, nutritional modulation and relevance for health. Curr Opin Biotechnol. 2015;32:14–20. doi:10.1016/j.copbio.2014.09.005
   PubMed Web of Science ®Google Scholar
• Booijink GM, El-Aidy S, Rajilić-Stojanović M, et al. High temporal and inter-individual variation detected in the human ileal microbiota. Environ Microbiol. 2010;12:3213–3227. doi:10.1111/j.1462-2920.2010.02294.x
   PubMed Web of Science ®Google Scholar
• Kagan L, Hoffman A. Systems for region selective drug delivery in the gastrointestinal tract: biopharmaceutical considerations. Expert Opin Drug Deliv. 2008;5:681–692. doi:10.1517/17425247.5.6.681
   PubMed Web of Science ®Google Scholar
• Hu Z, Mawatari S, Shibata N, et al. Application of a biomagnetic measurement system (BMS) to the evaluation of gastrointestinal transit of intestinal pressure-controlled colon delivery capsules (PCDCs) in human subjects. Pharm Res. 2000;17:160–167. doi:10.1023/A:1007561129221
   PubMed Web of Science ®Google Scholar
• Rao KA, Yazaki E, Evans DF, Carbon R. Objective evaluation of small bowel and colonic transit time using pH telemetry in athletes with gastrointestinal symptoms. Br J Sports Med. 2004;38:482–487. doi:10.1136/bjsm.2003.006825
   PubMed Web of Science ®Google Scholar
• Buhmann S, Kirchhoff C, Ladurner R, et al. Assessment of colonic transit time using MRI: a feasibility study. Eur Radiol. 2006;17:669–674. doi:10.1007/s00330-006-0414-z
   PubMed Web of Science ®Google Scholar
• Johansson MEV, Sjövall H, Hansson GC. The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol. 2013;10:352–361. doi:10.1038/nrgastro.2013.35
   PubMed Web of Science ®Google Scholar
• Yang L. Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora. J Control Release. 2008;125:77–86. doi:10.1016/j.jconrel.2007.10.026
   PubMed Web of Science ®Google Scholar
• Van Citters GW, Lin HC. Ileal brake: neuropeptidergic control of intestinal transit. Curr Gastroenterol Rep. 2006;8:367–373. doi:10.1007/s11894-006-0021-9
   PubMedGoogle Scholar
• Lombardo D, Kiselev MA, Caccamo MT. Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J Nanomater. 2019;2019:1–26. doi:10.1155/2019/3702518
   Web of Science ®Google Scholar
• Zeeshan A, Farhan M, Siddiqui A. Nanomedicine and drug delivery: a mini review. Int Nano Lett. 2014;4:1–7.
   Google Scholar
• Korrapati PS, Karthikeyan K, Satish A, et al. Recent advancements in nanotechnological strategies in selection, design and delivery of biomolecules for skin regeneration. Mater Sci Eng C. 2016;67:747–765. doi:10.1016/j.msec.2016.05.074
   PubMed Web of Science ®Google Scholar
• Pavitra E, Dariya B, Srivani G, et al. Engineered nanoparticles for imaging and drug delivery in colorectal cancer. Semin Cancer Biol. 2021;69:293–306. doi:10.1016/j.semcancer.2019.06.017
   PubMed Web of Science ®Google Scholar
• Indoria S, Singh V, Hsieh MF. Recent advances in theranostic polymeric nanoparticles for cancer treatment: a review. Int J Pharm. 2020;582:119314. doi:10.1016/j.ijpharm.2020.119314
   PubMed Web of Science ®Google Scholar
• Chandran SP, Natarajan SB, Chandraseharan S, Mohd Shahimi MSB. Nano drug delivery strategy of 5-fluorouracil for the treatment of colorectal cancer. J Cancer Res Pract. 2017;4:45–48. doi:10.1016/j.jcrpr.2017.02.002
   Google Scholar
• Philip AK, Philip B. Colon targeted drug delivery systems: a review on primary and novel approaches. Oman Med J. 2010;25:70–78. doi:10.5001/omj.2010.24
   Google Scholar
• Xiao B, Merlin D. Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opin Drug Deliv. 2012;9:1393–1407. doi:10.1517/17425247.2012.730517
   PubMed Web of Science ®Google Scholar
• Hua S, Marks E, Schneider JJ, Keely S. Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue. Nanomed Nanotechnol Biol Med. 2015;11:1117–1132. doi:10.1016/j.nano.2015.02.018
   PubMed Web of Science ®Google Scholar
• Peterson CG, Eklund E, Taha Y, Raab Y, Carlson M. A new method for the quantification of neutrophil and eosinophil cationic proteins in feces: establishment of normal levels and clinical application in patients with inflammatory bowel disease. Am J Gastroenterol. 2002;97:1755–1762. doi:10.1111/j.1572-0241.2002.05837.x
   PubMed Web of Science ®Google Scholar
• Coco R, Plapied L, Pourcelle V, et al. Drug delivery to inflamed colon by nanoparticles: comparison of different strategies. Int J Pharm. 2013;440:3–12. doi:10.1016/j.ijpharm.2012.07.017
   PubMed Web of Science ®Google Scholar
• Maroni A, Zema L, Loreti G, Palugan L, Gazzaniga A. Film coatings for oral pulsatile release. Int J Pharm. 2013;457:362–371. doi:10.1016/j.ijpharm.2013.03.010
   PubMed Web of Science ®Google Scholar
• Shia J, Klimstra DS, Nitzkorski JR, et al. Immunohistochemical expression of folate receptor α in colorectal carcinoma: patterns and biological significance. Hum Pathol. 2008;39:498–505. doi:10.1016/j.humpath.2007.09.013
   PubMed Web of Science ®Google Scholar
• Xiong S, Yu B, Wu J, Li H, Lee RJ. Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-PEG-CHEMS. Biomed Pharmacother. 2011;65:2–8. doi:10.1016/j.biopha.2010.10.003
   PubMed Web of Science ®Google Scholar
• Handali S, Moghimipour E, Rezaei M, et al. A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes. Biomed Pharmacother. 2018;108:1259–1273. doi:10.1016/j.biopha.2018.09.128
   PubMed Web of Science ®Google Scholar
• Yu M, Jambhrunkar S, Thorn P, et al. Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanoscale. 2012;5:178–183. doi:10.1039/C2NR32145A
   PubMed Web of Science ®Google Scholar
• Tesauro D, Accardo A, Diaferia C, et al. Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives. Molecules. 2019;24:351. doi:10.3390/molecules24020351
   PubMed Web of Science ®Google Scholar
• Xiao B, Han MK, Viennois E, et al. Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy. Nanoscale. 2015;7:17745–17755. doi:10.1039/C5NR04831A
   PubMed Web of Science ®Google Scholar
• Ghosh D, Peng X, Leal J, Mohanty RP. Peptides as drug delivery vehicles across biological barriers. J Pharm Investig. 2017;48:89–111. doi:10.1007/s40005-017-0374-0
   PubMedGoogle Scholar
• Jiang Z, Guan J, Qian J, Zhan C. Peptide ligand-mediated targeted drug delivery of nanomedicines. Biomater Sci. 2019;7:461–471. doi:10.1039/C8BM01340C
   PubMed Web of Science ®Google Scholar
• Al-azzawi S, Masheta D. Designing a drug delivery system for improved tumor treatment and targeting by functionalization of a cell-penetrating peptide. J Pharm Investig. 2019;49:643–654. doi:10.1007/s40005-018-00424-w
   Google Scholar
• Ren Y, Mu Y, Song Y, et al. A new peptide ligand for colon cancer targeted delivery of micelles. Drug Deliv. 2016;23:1763–1772. doi:10.3109/10717544.2015.1077293
   PubMed Web of Science ®Google Scholar
• Nguyen MNU, Van Vo T, Tran PHL, Tran TTD. Zein-based solid dispersion for potential application in targeted delivery. J Pharm Investig. 2017;47:357–364. doi:10.1007/s40005-017-0314-z
   Google Scholar
• Zhu J, Zhong L, Chen W, et al. Preparation and characterization of pectin/chitosan beads containing porous starch embedded with doxorubicin hydrochloride: a novel and simple colon targeted drug delivery system. Food Hydrocoll. 2019;95:562–570. doi:10.1016/j.foodhyd.2018.04.042
   Web of Science ®Google Scholar
• Barclay TG, Day CM, Petrovsky N, Garg S. Review of polysaccharide particle-based functional drug delivery. Carbohydr Polym. 2019;221:94–112. doi:10.1016/j.carbpol.2019.05.067
   PubMed Web of Science ®Google Scholar
• Lopes PP, Tanabe EH, Bertuol DA. Chitosan as biomaterial in drug delivery and tissue engineering. In: Handbook of Chitin and Chitosan. Vol. 3. Elsevier; 2020:407–431.
   Google Scholar
• Nurhayati Y, Manaf Ali A. Production of Chitosan Oligosaccharides using β-glycosidic degrading enzyme: optimization using response surface methodology. Malaysian J Appl Sci. 2020;5:30–44. doi:10.37231/myjas.2020.5.2.261
   Google Scholar
• Aizat MA, Aziz F. Chitosan nanocomposite application in wastewater treatments. In: Nanotechnology in Water and Wastewater Treatment. Elsevier; 2019:243–265. doi:10.1016/B978-0-12-813902-8.00012-5
   Google Scholar
• Hosseinnejad M, Jafari SM. Evaluation of different factors affecting antimicrobial properties of chitosan. Int J Biol Macromol. 2016;85:467–475. doi:10.1016/j.ijbiomac.2016.01.022
   PubMed Web of Science ®Google Scholar
• Nilsen-Nygaard J, Strand SP, Vårum KM, Draget KI, Nordgård CT. Chitosan: gels and interfacial properties. Polymers. 2015;7:552–579.
   Web of Science ®Google Scholar
• Moine L, Canali MM, Porporatto C, Correa SG. Reviewing the biological activity of chitosan in the mucosa: focus on intestinal immunity. Int J Biol Macromol. 2021;189:324–334. doi:10.1016/j.ijbiomac.2021.08.098
   PubMed Web of Science ®Google Scholar
• Grgac SF, Tarbuk A, Dekanic T, Sujka W, Draczynski Z. The chitosan implementation into cotton and polyester/cotton blend fabrics. Materials. 2020;13:1616. doi:10.3390/ma13071616
   PubMed Web of Science ®Google Scholar
• Aibani N, Rai R, Patel P, Cuddihy G, Wasan EK. Chitosan nanoparticles at the biological interface: implications for drug delivery. Pharmaceutics. 2021;13:1686. doi:10.3390/pharmaceutics13101686
   PubMed Web of Science ®Google Scholar
• Petrou G, Crouzier T. Mucins as multifunctional building blocks of biomaterials. Biomater Sci. 2018;6:2282–2297. doi:10.1039/C8BM00471D
   PubMed Web of Science ®Google Scholar
• Lee S, Müller M, Rezwan K, Spencer ND. Porcine Gastric Mucin (PGM) at the Water/Poly(Dimethylsiloxane) (PDMS) interface: influence of pH and ionic strength on its conformation, adsorption, and aqueous lubrication properties. Langmuir. 2005;21:8344–8353. doi:10.1021/la050779w
   PubMed Web of Science ®Google Scholar
• Collado-González M, Espinosa YG, Goycoolea FM. Interaction between chitosan and mucin: fundamentals and applications. Biomimetics. 2019;4:32. doi:10.3390/biomimetics4020032
   PubMed Web of Science ®Google Scholar
• Jayakumar R, Prabaharan M. Chitosan for Biomaterials III: Structure-Property Relationships. Cham: Springer; 2021. doi:10.1007/978-3-030-83807-2
   Google Scholar
• Gavini E, Rassu G, Sanna V, et al. Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide: in-vitro/ex-vivo studies. J Pharm Pharmacol. 2010;57:287–294. doi:10.1211/0022357055623
   Web of Science ®Google Scholar
• Garg U, Chauhan S, Nagaich U, Jain N. Current advances in chitosan nanoparticles based drug delivery and targeting. Adv Pharm Bull. 2019;9:195. doi:10.15171/apb.2019.023
   PubMed Web of Science ®Google Scholar
• Lin C, Kuo TC, Lin JC, Ho YC, Mi FL. Delivery of polysaccharides from Ophiopogon japonicus (OJPs) using OJPs/chitosan/whey protein co-assembled nanoparticles to treat defective intestinal epithelial tight junction barrier. Int J Biol Macromol. 2020;160:558–570. doi:10.1016/j.ijbiomac.2020.05.151
   PubMed Web of Science ®Google Scholar
• Dou T, Wang J, Han C, et al. Cellular uptake and transport characteristics of chitosan modified nanoparticles in Caco-2 cell monolayers. Int J Biol Macromol. 2019;138:791–799. doi:10.1016/j.ijbiomac.2019.07.168
   PubMed Web of Science ®Google Scholar
• Da Silva FLO, Marques MB, Kato KC, Carneiro G. Nanonization techniques to overcome poor water-solubility with drugs. Expert Opin Drug Discov. 2020;15:853–864. doi:10.1080/17460441.2020.1750591
   PubMed Web of Science ®Google Scholar
• Yao Y, Zhou Y, Liu L, et al. Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Front Mol Biosci. 2020;7:193. doi:10.3389/fmolb.2020.00193
   PubMed Web of Science ®Google Scholar
• De Jong WH, Paul JB. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3:133–149. doi:10.2147/IJN.S596
   PubMed Web of Science ®Google Scholar
• Afzal M, Alharbi KS. Nanomedicine in treatment of breast cancer – a challenge to conventional therapy. Semin Cancer Biol. 2021;69:279–292. doi:10.1016/j.semcancer.2019.12.016
   PubMed Web of Science ®Google Scholar
• White BD, Duan C, Townley HE. Nanoparticle activation methods in cancer treatment. Biomolecules. 2019;9:202. doi:10.3390/biom9050202
   PubMed Web of Science ®Google Scholar
• Sutradhar KB, Amin ML. Nanotechnology in cancer drug delivery and selective targeting. ISRN Nanotechnol. 2014;2014:1–12. doi:10.1155/2014/939378
   Google Scholar
• Sen K, Banerjee S, Mandal M. Dual drug loaded liposome bearing apigenin and 5-fluorouracil for synergistic therapeutic efficacy in colorectal cancer. Colloids Surf B Biointerfaces. 2019;180:9–22. doi:10.1016/j.colsurfb.2019.04.035
   PubMed Web of Science ®Google Scholar
• Vigneshwaran R, Ezhilarasan D, Rajeshkumar S. Inorganic titanium dioxide nanoparticles induces cytotoxicity in colon cancer cells. Inorg Chem Commun. 2021;133:108920. doi:10.1016/j.inoche.2021.108920
   Web of Science ®Google Scholar
• Abouaitah K, Hassan HA, Swiderska-Sroda A, et al. Targeted nano-drug delivery of colchicine against colon cancer cells by means of mesoporous silica nanoparticles. Cancers. 2020;12:12. doi:10.3390/cancers12010144
   Web of Science ®Google Scholar
• Zielinska A, Carreiró F, Oliveira AM, et al. Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology. Molecules. 2020;25:3731. doi:10.3390/molecules25163731
   PubMed Web of Science ®Google Scholar
• Begines B, Ortiz T, Pérez-Aranda M, et al. Polymeric nanoparticles for drug delivery: recent developments and future prospects. Nanomaterials. 2020;10:1–41. doi:10.3390/nano10071403
   Web of Science ®Google Scholar
• Herdiana Y, Wathoni N, Shamsuddin S, Joni IM, Muchtaridi M. Chitosan-based nanoparticles of targeted drug delivery system in breast cancer treatment. Polymers. 2021;13:1717. doi:10.3390/polym13111717
   PubMed Web of Science ®Google Scholar
• Shi Y, van der Meel R, Chen X, Lammers T. The EPR effect and beyond: strategies to improve tumor targeting and cancer nanomedicine treatment efficacy. Theranostics. 2020;10:7921–7924. doi:10.7150/thno.49577
   PubMed Web of Science ®Google Scholar
• Morshed M, Chowdhury EH. Gene delivery and clinical applications. In: Encyclopedia of Biomedical Engineering. Vol. 1–3. Elsevier; 2019:345–351.
   Google Scholar
• Shah MR, Imran M, Ullah S. Nanocarrier-based targeted pulmonary delivery: novel approaches for effective lung cancer treatment. Nanocarriers Cancer Diagnosis Target Chemother. 2019;129–161. doi:10.1016/B978-0-12-816773-1.00006-7
   Google Scholar
• Bose A, Wong TW. Oral colon cancer targeting by chitosan nanocomposites. Appl Nanocomposite Mater Drug Deliv. 2018;409–429. doi:10.1016/B978-0-12-813741-3.00018-2
   Google Scholar
• Salahpour anarjan F. Active targeting drug delivery nanocarriers: ligands. Nano Struct Nano Objects. 2019;19:100370. doi:10.1016/j.nanoso.2019.100370
   Google Scholar
• Sen P, Saha M, Ghosh SS. Nanoparticle mediated alteration of EMT dynamics: an approach to modulate cancer therapeutics. Mater Adv. 2020;1:2614–2630. doi:10.1039/D0MA00455C
   Web of Science ®Google Scholar
• Zhang Y, Li M, Gao X, Chen Y, Liu T. Nanotechnology in cancer diagnosis: progress, challenges and opportunities. J Hematol Oncol. 2019;12:137. doi:10.1186/s13045-019-0833-3
   PubMed Web of Science ®Google Scholar
• Hwang J, Sullivan MO, Kiick KL. Targeted drug delivery via the use of ECM-mimetic materials. Front Bioeng Biotechnol. 2020;8:69. doi:10.3389/fbioe.2020.00069
   PubMed Web of Science ®Google Scholar
• Senthil Kumar C, Thangam R, Mary SA, et al. Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells. Carbohydr Polym. 2020;231:115682. doi:10.1016/j.carbpol.2019.115682
   PubMed Web of Science ®Google Scholar
• Safdar R, Omar AA, Arunagiri A, Regupathi I, Thanabalan M. Potential of Chitosan and its derivatives for controlled drug release applications – a review. J Drug Deliv Sci Technol. 2019;49:642–659. doi:10.1016/j.jddst.2018.10.020
   Web of Science ®Google Scholar
• Qin C, Li H, Xiao Q, et al. Water-solubility of chitosan and its antimicrobial activity. Carbohydr Polym. 2006;63:367–374. doi:10.1016/j.carbpol.2005.09.023
   Web of Science ®Google Scholar
• Muzzarelli RAA, Tanfani F. The N-permethylation of chitosan and the preparation of N-trimethyl chitosan iodide. Carbohydr Polym. 1985;5:297–307. doi:10.1016/0144-8617(85)90037-2
   Web of Science ®Google Scholar
• Jintapattanakit A, Mao S, Kissel T, Junyaprasert VB. Physicochemical properties and biocompatibility of N-trimethyl chitosan: effect of quaternization and dimethylation. Eur J Pharm Biopharm. 2008;70:563–571. doi:10.1016/j.ejpb.2008.06.002
   PubMed Web of Science ®Google Scholar
• Mourya VK, Inamdar NN. Trimethyl chitosan and its applications in drug delivery. J Mater Sci Mater Med. 2008;20:1057–1079. doi:10.1007/s10856-008-3659-z
   PubMed Web of Science ®Google Scholar
• Chen G, Svirskis D, Lu W, et al. N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic effects of gemcitabine. Carbohydr Polym. 2021;273:118592. doi:10.1016/j.carbpol.2021.118592
   PubMed Web of Science ®Google Scholar
• Kotzé AF, Lueßen HL, De leeuw BJ, et al. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release. 1998;51:35–46. doi:10.1016/S0168-3659(97)00154-5
   PubMed Web of Science ®Google Scholar
• Kotze AF, Thanou MM, Lueßen HL, et al. Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). Eur J Pharm Biopharm. 1999;47:269–274. doi:10.1016/S0939-6411(99)00006-5
   PubMed Web of Science ®Google Scholar
• Shariatinia Z. Carboxymethyl chitosan: properties and biomedical applications. Int J Biol Macromol. 2018;120:1406–1419. doi:10.1016/j.ijbiomac.2018.09.131
   PubMed Web of Science ®Google Scholar
• Rahmani S, Mohammadi Z, Amini M, et al. Methylated 4-N,N dimethyl aminobenzyl N,O carboxymethyl chitosan as a new chitosan derivative: synthesis, characterization, cytotoxicity and antibacterial activity. Carbohydr Polym. 2016;149:131–139. doi:10.1016/j.carbpol.2016.04.116
   PubMed Web of Science ®Google Scholar
• Muñoz Ruiz GA, Fabio H, Corrales Z. Chitosan, chitosan derivatives and their biomedical applications. In: Biological Activities and Application of Marine Polysaccharides. IntechOpen; 2017. doi10.5772/66527
   Google Scholar
• Moghaddam AS, Khonakdar HA, Sarikhani E, et al. Fabrication of carboxymethyl chitosan nanoparticles to deliver paclitaxel for melanoma treatment. ChemNanoMat. 2020;6:1373–1385. doi:10.1002/cnma.202000229
   Web of Science ®Google Scholar
• Pan X, Chen J, Yang M, et al. Enzyme/pH dual-responsive polymer prodrug nanoparticles based on 10-hydroxycamptothecin-carboxymethyl chitosan for enhanced drug stability and anticancer efficacy. Eur Polym J. 2019;117:372–381. doi:10.1016/j.eurpolymj.2019.04.050
   Web of Science ®Google Scholar
• Yan C, Chen D, Gu J, et al. Preparation of N-Succinyl-chitosan and their physical-chemical properties as a novel excipient. Yakugaku Zasshi. 2006;126:789–793. doi:10.1248/yakushi.126.789
   PubMed Web of Science ®Google Scholar
• Raizaday A, Yadav HK, Jayanth A, Kaushi SR, Mathew M, Zachariah AB. Formulation and evaluation of pH sensitive microspheres of N-succinyl chitosan for the treatment of diverticulitis. Cell Chem Technol. 2015;49:41–50.
   Web of Science ®Google Scholar
• Bashir S, Teo YY, Ramesh S, Ramesh K, Khan AA. N-succinyl chitosan preparation, characterization, properties and biomedical applications: a state of the art review. Rev Chem Eng. 2015;31:563–597.
   Web of Science ®Google Scholar
• Kato Y, Onishi H, Machida Y. N-succinyl-chitosan as a drug carrier: water-insoluble and water-soluble conjugates. Biomaterials. 2004;25:907–915. doi:10.1016/S0142-9612(03)00598-2
   PubMed Web of Science ®Google Scholar
• Wang Y, Karmakar T, Ghosh N, Basak S, Gopal Sahoo N. Targeting mangiferin loaded N-succinyl chitosan-alginate grafted nanoparticles against atherosclerosis – a case study against diabetes mediated hyperlipidemia in rat. Food Chem. 2022;370:131376. doi:10.1016/j.foodchem.2021.131376
   PubMed Web of Science ®Google Scholar
• Ghaffari SB, Sarrafzadeh MH, Salami M, Khorramizadeh MR. A pH-sensitive delivery system based on N-succinyl chitosan-ZnO nanoparticles for improving antibacterial and anticancer activities of curcumin. Int J Biol Macromol. 2020;151:428–440. doi:10.1016/j.ijbiomac.2020.02.141
   PubMed Web of Science ®Google Scholar
• Bashir S, Teo YY, Naeem S, Ramesh S, Ramesh K. pH responsive N-succinyl chitosan/poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil. PLoS One. 2017;12:e0179250. doi:10.1371/journal.pone.0179250
   PubMed Web of Science ®Google Scholar
• Cristallini C, Barbani N, Bianchi S. Injectable hydrogel based on dialdehyde galactomannan and N-succinyl chitosan: a suitable platform for cell culture. J Mater Sci Mater Med. 2019;31:1–13. doi:10.1007/s10856-019-6328-5
   PubMed Web of Science ®Google Scholar
• Zhu Y, Kruglikov IL, Akgul Y, Scherer PE. Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism. Matrix Biol. 2019;78–79:284–291. doi:10.1016/j.matbio.2018.02.012
   PubMed Web of Science ®Google Scholar
• Luo Z, Dai Y, Gao H. Development and application of hyaluronic acid in tumor targeting drug delivery. Acta Pharm Sin B. 2019;9:1099–1112. doi:10.1016/j.apsb.2019.06.004
   PubMed Web of Science ®Google Scholar
• Jain A, Jain SK. Optimization of chitosan nanoparticles for colon tumors using experimental design methodology. Artif Cells Nanomedicine Biotechnol. 2015;44:1917–1926. doi:10.3109/21691401.2015.1111236
   PubMed Web of Science ®Google Scholar
• Liang Y, Wang Y, Wang L, et al. Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer. Bioact Mater. 2021;6:433–446. doi:10.1016/j.bioactmat.2020.08.019
   PubMed Web of Science ®Google Scholar
• Chiesa E, Dorati R, Conti B, et al. Hyaluronic acid-decorated chitosan nanoparticles for CD44-targeted delivery of everolimus. Int J Mol Sci. 2018;19:2310. doi:10.3390/ijms19082310
   PubMed Web of Science ®Google Scholar
• Serrano-Sevilla I, Artiga Á, Mitchell SG, De Matteis L, de la Fuente JM. Natural polysaccharides for siRNA delivery: nanocarriers based on chitosan, hyaluronic acid, and their derivatives. Molecules. 2019;24:2570. doi:10.3390/molecules24142570
   PubMed Web of Science ®Google Scholar
• Sionkowska A, Gadomska M, Musiał K, Piatek J. Hyaluronic acid as a component of natural polymer blends for biomedical applications: a review. Molecules. 2020;25:4035.
   PubMed Web of Science ®Google Scholar
• Mohapatra A, Uthaman S, Park I-K. Polyethylene glycol nanoparticles as promising tools for anticancer therapeutics. Tool Anti Cancer Ther. 2019;205–231. doi:10.1016/B978-0-12-816963-6.00010-8
   Google Scholar
• Gorochovceva N, Makuška R. Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers. Eur Polym J. 2004;40:685–691. doi:10.1016/j.eurpolymj.2003.12.005
   Web of Science ®Google Scholar
• Casettari L, Vllasaliu D, Castagnino E, et al. PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Prog Polym Sci. 2012;37:659–685. doi:10.1016/j.progpolymsci.2011.10.001
   Web of Science ®Google Scholar
• Bozuyuk U, Gokulu IS, Dogan NO, Kizilel S. A novel method for PEGylation of chitosan nanoparticles through photopolymerization. RSC Adv. 2019;9:14011–14015. doi:10.1039/C9RA00780F
   PubMed Web of Science ®Google Scholar
• Andrade F, Goycoolea F, Chiappetta DA, et al. Chitosan-grafted copolymers and chitosan-ligand conjugates as matrices for pulmonary drug delivery. Int J Carbohydr Chem. 2011;2011:1–14. doi:10.1155/2011/865704
   Google Scholar
• Shad PM, Karizi SZ, Javan RS, et al. Folate conjugated hyaluronic acid coated alginate nanogels encapsulated oxaliplatin enhance antitumor and apoptosis efficacy on colorectal cancer cells (HT29 cell line). Toxicol Vitr. 2020;65:104756. doi:10.1016/j.tiv.2019.104756
   PubMed Web of Science ®Google Scholar
• Soleymani J, Hasanzadeh M, Shadjou N, Somi MH, Jouyban A. The role of nanomaterials on the cancer cells sensing based on folate receptor: analytical approach. Trends Anal Chem. 2020;125:115834. doi:10.1016/j.trac.2020.115834
   Google Scholar
• Ghaz-Jahanian MA, Abbaspour-Aghdam F, Anarjan N, Berenjian A, Jafarizadeh-Malmiri H. Application of chitosan-based nanocarriers in tumor-targeted drug delivery. Mol Biotechnol. 2015;57:201–218. doi:10.1007/s12033-014-9816-3
   PubMed Web of Science ®Google Scholar
• Cheng L, Ma H, Shao M. Synthesis of folate‑chitosan nanoparticles loaded with ligustrazine to target folate receptor positive cancer cells. Mol Med Rep. 2017;16:1101–1108. doi:10.3892/mmr.2017.6740
   PubMed Web of Science ®Google Scholar
• Xu W, Jiang X, Huang L. RNA interference technology. In: Comprehensive Biotechnology. Third ed. Elsevier; 2019:560–575. doi:10.1016/B978-0-444-64046-8.00282-2
   Google Scholar
• Mahmoodi Chalbatani G, Dana H, Gharagouzloo E, et al. Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach. Int J Nanomedicine. 2019;14:3111. doi:10.2147/IJN.S200253
   PubMed Web of Science ®Google Scholar
• Sadreddini S, Safaralizadeh R, Baradaran B, et al. Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer. Immunol Lett. 2017;181:79–86. doi:10.1016/j.imlet.2016.11.013
   PubMed Web of Science ®Google Scholar
• Gomathysankar S, Halim AS, Yaacob NS. Proliferation of keratinocytes induced by adipose-derived stem cells on a chitosan scaffold and its role in wound healing, a review. Arch Plast Surg. 2014;41:452–457. doi:10.5999/aps.2014.41.5.452
   PubMedGoogle Scholar
• Sabra R, Billa N, Roberts CJ. An augmented delivery of the anticancer agent, curcumin, to the colon. React Funct Polym. 2018;123:54–60. doi:10.1016/j.reactfunctpolym.2017.12.012
   Web of Science ®Google Scholar
• Sabra R, Billa N, Roberts CJ. Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer. Int J Pharm. 2019;572:118775. doi:10.1016/j.ijpharm.2019.118775
   PubMed Web of Science ®Google Scholar
• Bhattacharya S. Fabrication and characterization of chitosan-based polymeric nanoparticles of Imatinib for colorectal cancer targeting application. Int J Biol Macromol. 2020;151:104–115. doi:10.1016/j.ijbiomac.2020.02.151
   PubMed Web of Science ®Google Scholar
• Liu W, Zhu Y, Wang F, et al. Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery. R Soc Open Sci. 2018;5:181027. doi:10.1098/rsos.181027
   PubMed Web of Science ®Google Scholar
• Chen G, Zhao Y, Xu Y, et al. Chitosan nanoparticles for oral photothermally enhanced photodynamic therapy of colon cancer. Int J Pharm. 2020;589:119763. doi:10.1016/j.ijpharm.2020.119763
   PubMed Web of Science ®Google Scholar
• Gouda M, Ibrahim HIM, Negm A. Chitosan containing nano Zn-organic framework: synthesis, characterization and biological activity. Polym. 2022;14:1276. doi:10.3390/polym14071276
   PubMed Web of Science ®Google Scholar
• Kamel KM, Khalil IA, Rateb ME, Elgendy H, Elhawary S. Chitosan-coated cinnamon/oregano-loaded solid lipid nanoparticles to augment 5-fluorouracil cytotoxicity for colorectal cancer: extract standardization, nanoparticle optimization, and cytotoxicity evaluation. J Agric Food Chem. 2017;65:7966–7981. doi:10.1021/acs.jafc.7b03093
   PubMed Web of Science ®Google Scholar
• Udompornmongkol P, Chiang BH. Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications. J Biomater Appl. 2015;30:537–546. doi:10.1177/0885328215594479
   PubMed Web of Science ®Google Scholar
• Yusefi M, Chan H-Y, Teow S-Y, et al. 5-fluorouracil encapsulated chitosan-cellulose fiber bionanocomposites: synthesis, characterization and in vitro analysis towards colorectal cancer cells. Nanomaterials. 2021;11:1691. doi:10.3390/nano11071691
   Web of Science ®Google Scholar
• Han W, Xie B, Li Y, et al. Orally deliverable nanotherapeutics for the synergistic treatment of colitis-associated colorectal cancer. Theranostics. 2019;9:7458. doi:10.7150/thno.38081
   PubMed Web of Science ®Google Scholar
• Yang SJ, Lin F-H, Tsai K-C, et al. Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin ix accumulation in colorectal cancer cells. Bioconjug Chem. 2010;21:679–689. doi:10.1021/bc9004798
   PubMed Web of Science ®Google Scholar
• Jain A, Jain SK, Ganesh N, Barve J, Beg AM. Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer. Nanomed Nanotechnol Biol Med. 2010;6:179–190. doi:10.1016/j.nano.2009.03.002
   PubMed Web of Science ®Google Scholar
• Soe ZC, Poudel BK, Nguyen HT, et al. Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells. Asian J Pharm Sci. 2019;14:40–51. doi:10.1016/j.ajps.2018.09.004
   PubMed Web of Science ®Google Scholar
• Guo XY, Wang P, Du QG, et al. Paclitaxel and gemcitabine combinational drug-loaded mucoadhesive delivery system in the treatment of colon cancers. Drug Res. 2015;65:199–204.
   PubMedGoogle Scholar
• Sun L, Li Z, Li Z, et al. Improving antitumor activity with N -trimethyl chitosan entrapping camptothecin in colon cancer and lung cancer. J Nanosci Nanotechnol. 2015;15:6397–6404. doi:10.1166/jnn.2015.10736
   PubMed Web of Science ®Google Scholar
• Abu Elella MH, Mohamed RR, Abdel-Aziz MM, Sabaa MW. Green synthesis of antimicrobial and antitumor N,N,N-trimethyl chitosan chloride/poly (acrylic acid)/silver nanocomposites. Int J Biol Macromol. 2018;111:706–716. doi:10.1016/j.ijbiomac.2018.01.055
   PubMed Web of Science ®Google Scholar
• Rahmati A, Homayouni Tabrizi M, Karimi E, Zarei B. Fabrication and assessment of folic acid conjugated-chitosan modified PLGA nanoparticle for delivery of alpha terpineol in colon cancer. Journal of Biomaterials Science, Polymer Edition. 2022;33:1289–1307. doi:10.1080/09205063.2022.2051693
   PubMed Web of Science ®Google Scholar
• Lazer LM, Kesavan Y, Gor R, et al. Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles. Colloids Surfaces B Biointerfaces. 2022;217:112612. doi:10.1016/j.colsurfb.2022.112612
   PubMed Web of Science ®Google Scholar
• Mary lazer L, Sadhasivam B, Palaniyandi K, et al. Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin. Int J Biol Macromol. 2018;107:1988–1998. doi:10.1016/j.ijbiomac.2017.10.064
   PubMed Web of Science ®Google Scholar
• Ullah S, Azad AK, Nawaz A, et al. 5-fluorouracil-loaded folic-acid-fabricated chitosan nanoparticles for site-targeted drug delivery cargo. Polymers. 2022;14:2010. doi:10.3390/polym14102010
   PubMed Web of Science ®Google Scholar
• Anirudhan TS, Sekhar VC, Nair SS. Polyelectrolyte complexes of carboxymethyl chitosan/alginate based drug carrier for targeted and controlled release of dual drug. J Drug Deliv Sci Technol. 2019;51:569–582. doi:10.1016/j.jddst.2019.03.036
   Web of Science ®Google Scholar
• Bhaskaran NA, Jitta SR, Cheruku S, et al. Orally delivered solid lipid nanoparticles of irinotecan coupled with chitosan surface modification to treat colon cancer: preparation, in-vitro and in-vivo evaluations. Int J Biol Macromol. 2022;211:301–315. doi:10.1016/j.ijbiomac.2022.05.060
   PubMed Web of Science ®Google Scholar
• Samprasit W, Opanasopit P, Chamsai B. Alpha-mangostin and resveratrol, dual-drugs-loaded mucoadhesive thiolated chitosan-based nanoparticles for synergistic activity against colon cancer cells. J Biomed Mater Res Part B Appl Biomater. 2022;110:1221–1233. doi:10.1002/jbm.b.34992
   PubMed Web of Science ®Google Scholar
• Siahmansouri H, Somi MH, Babaloo Z, et al. Effects of HMGA2 siRNA and doxorubicin dual delivery by chitosan nanoparticles on cytotoxicity and gene expression of HT-29 colorectal cancer cell line. J Pharm Pharmacol. 2016;68:1119–1130. doi:10.1111/jphp.12593
   PubMed Web of Science ®Google Scholar
• Yan L, Gao S, Shui S, et al. Small interfering RNA-loaded chitosan hydrochloride/carboxymethyl chitosan nanoparticles for ultrasound-triggered release to hamper colorectal cancer growth in vitro. Int J Biol Macromol. 2020;162:1303–1310. doi:10.1016/j.ijbiomac.2020.06.246
   PubMed Web of Science ®Google Scholar
• Nikkhoo A, Rostami N, Farhadi S, et al. Codelivery of STAT3 siRNA and BV6 by carboxymethyl dextran trimethyl chitosan nanoparticles suppresses cancer cell progression. Int J Pharm. 2020;581:119236. doi:10.1016/j.ijpharm.2020.119236
   PubMed Web of Science ®Google Scholar