Preparation of Budesonide-Loaded Liposomal Nanoparticles for Pulmonary Delivery and Their Therapeutic Effect in OVA-Induced Asthma in Mice

References

• Pavord ID, Beasley R, Agusti A, et al. After asthma: redefining airways diseases. Lancet. 2018;391(10118):350–400. doi:10.1016/s0140-6736(17)30879-6
   PubMed Web of Science ®Google Scholar
• Papi A, Brightling C, Pedersen SE, et al. Asthma. Lancet. 2018;391(10122):783–800. doi:10.1016/s0140-6736(17)33311-1
   PubMed Web of Science ®Google Scholar
• Ahmad A. Pharmacological strategies and recent advancement in nano-drug delivery for targeting asthma. Life. 2022;12(4):596. doi:10.3390/life12040596
   PubMedGoogle Scholar
• Cevhertas L, Ogulur I, Maurer DJ, et al. Advances and recent developments in asthma in 2020. Allergy. 2020;75(12):3124–3146. doi:10.1111/all.14607
   PubMed Web of Science ®Google Scholar
• Bleecker ER, Menzies-Gow AN, Price DB, et al. Systematic literature review of systemic corticosteroid use for asthma management. Am J Respir Crit Care Med. 2020;201(3):276–293. doi:10.1164/rccm.201904-0903SO
   PubMed Web of Science ®Google Scholar
• Liang Z, Ni R, Zhou J, et al. Recent advances in controlled pulmonary drug delivery. Drug Discov Today. 2015;20(3):380–389. doi:10.1016/j.drudis.2014.09.020
   PubMed Web of Science ®Google Scholar
• Oh YJ, Lee J, Seo JY, et al. Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model. J Control Release. 2011;150(1):56–62. doi:10.1016/j.jconrel.2010.11.001
   PubMed Web of Science ®Google Scholar
• Visaggi P, Barberio B, Del Corso G, et al. Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis. Gut. 2023;72(11):2019–2030. doi:10.1136/gutjnl-2023-329873
   PubMed Web of Science ®Google Scholar
• Pozzoli M, Rogueda P, Zhu B, et al. Dry powder nasal drug delivery: challenges, opportunities and a study of the commercial Teijin Puvlizer Rhinocort device and formulation. Drug Dev Ind Pharm. 2016;42(10):1660–1668. doi:10.3109/03639045.2016.1160110
   PubMed Web of Science ®Google Scholar
• Napp J, Markus MA, Heck JG, et al. Therapeutic fluorescent hybrid nanoparticles for traceable delivery of glucocorticoids to inflammatory sites. Theranostics. 2018;8(22):6367–6383. doi:10.7150/thno.28324
   PubMed Web of Science ®Google Scholar
• Zuo X, Guo X, Gu Y, et al. Recent advances in nanomaterials for asthma treatment. Int J Mol Sci. 2022;23(22). doi:10.3390/ijms232214427
   Web of Science ®Google Scholar
• Ortiz M, de Sa Coutinho D, Ciambarella BT, et al. Intranasal administration of budesonide-loaded nanocapsule microagglomerates as an innovative strategy for asthma treatment. Drug Deliv Transl Res. 2020;10(6):1700–1715. doi:10.1007/s13346-020-00813-5
   PubMed Web of Science ®Google Scholar
• Lokugamage MP, Vanover D, Beyersdorf J, et al. Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs. Nat Biomed Eng. 2021;5(9):1059–1068. doi:10.1038/s41551-021-00786-x
   PubMed Web of Science ®Google Scholar
• Arber Raviv S, Alyan M, Egorov E, et al. Lung targeted liposomes for treating ARDS. J Control Release. 2022;346:421–433. doi:10.1016/j.jconrel.2022.03.028
   PubMed Web of Science ®Google Scholar
• Dymek M, Sikora E. Liposomes as biocompatible and smart delivery systems- the current state. Adv Colloid Interface Sci. 2022;309:102757. doi:10.1016/j.cis.2022.102757
   PubMed Web of Science ®Google Scholar
• Liu J, Wu Z, Liu Y, et al. ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling. J Nanobiotechnology. 2022;20(1):213. doi:10.1186/s12951-022-01435-4
   PubMed Web of Science ®Google Scholar
• Zhao J, Su J, Qin L, et al. Exploring the influence of inhaled liposome membrane fluidity on its interaction with pulmonary physiological barriers. Biomater Sci. 2020;8(23):6786–6797. doi:10.1039/d0bm01529f
   PubMed Web of Science ®Google Scholar
• Li H, Liu S, Dai W, et al. Pressure-sensitive multivesicular liposomes as a smart drug-delivery system for high-altitude pulmonary edema. J Control Release. 2023;365:301–316. doi:10.1016/j.jconrel.2023.11.039
   PubMed Web of Science ®Google Scholar
• Tang H, Chen J, Wang L, et al. Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer. Int J Pharm. 2020;573:118806. doi:10.1016/j.ijpharm.2019.118806
   PubMed Web of Science ®Google Scholar
• Wang J, Xu L, Liu X, et al. A facile adenosine triphosphate-responsive nanoplatform for efficacious therapy of esophageal cancer. Oncol Lett. 2020;20(4):108. doi:10.3892/ol.2020.11969
   PubMed Web of Science ®Google Scholar
• Guan X, Yuan Y, Wang G, et al. Ginsenoside Rg3 ameliorates acute exacerbation of COPD by suppressing neutrophil migration. Int Immunopharmacol. 2020;83:106449. doi:10.1016/j.intimp.2020.106449
   PubMed Web of Science ®Google Scholar
• Guan X, Lu Y, Wang G, et al. The role of regulatory T Cell in nontypeable Haemophilus influenzae-induced acute exacerbation of chronic obstructive pulmonary disease. Mediators Inflamm. 2018;2018:8387150. doi:10.1155/2018/8387150
   PubMed Web of Science ®Google Scholar
• Dunican EM, Elicker BM, Gierada DS, et al. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018;128(3):997–1009. doi:10.1172/jci95693
   PubMed Web of Science ®Google Scholar
• Aegerter H, Lambrecht BN. The pathology of asthma: what is obstructing our view? Annu Rev Pathol. 2023;18:387–409. doi:10.1146/annurev-pathol-042220-015902
   PubMed Web of Science ®Google Scholar
• Chen D, Liu J, Wu J, et al. Enhancing nanoparticle penetration through airway mucus to improve drug delivery efficacy in the lung. Expert Opin Drug Deliv. 2021;18(5):595–606. doi:10.1080/17425247.2021.1854222
   PubMed Web of Science ®Google Scholar
• Schuster BS, Suk JS, Woodworth GF, et al. Nanoparticle diffusion in respiratory mucus from humans without lung disease. Biomaterials. 2013;34(13):3439–3446. doi:10.1016/j.biomaterials.2013.01.064
   PubMed Web of Science ®Google Scholar
• Aalbers R, Vogelmeier C, Kuna P. Achieving asthma control with ICS/LABA: a review of strategies for asthma management and prevention. Respir Med. 2016;111:1–7. doi:10.1016/j.rmed.2015.11.002
   PubMed Web of Science ®Google Scholar
• Espinosa V, Rivera A. First line of defense: innate cell-mediated control of pulmonary aspergillosis. Front Microbiol. 2016;7:272. doi:10.3389/fmicb.2016.00272
   PubMed Web of Science ®Google Scholar
• Kuerban K, Gao X, Zhang H, et al. Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer. Acta Pharm Sin B. 2020;10(8):1534–1548. doi:10.1016/j.apsb.2020.02.002
   PubMed Web of Science ®Google Scholar
• Williams AH, Hebert AM, Boehm RC, et al. Bioscaffold stiffness mediates aerosolized nanoparticle uptake in lung epithelial cells. ACS Appl Mater Interfaces. 2021;13(43):50643–50656. doi:10.1021/acsami.1c09701
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang X, Li Y, et al. Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacol Res. 2022;176:106083. doi:10.1016/j.phrs.2022.106083
   PubMed Web of Science ®Google Scholar
• Cao Y, Chen J, Ren G, et al. Punicalagin prevents inflammation in LPS-induced RAW264.7 macrophages by inhibiting FoxO3a/autophagy signaling pathway. Nutrients. 2019;11(11):2794.
   PubMed Web of Science ®Google Scholar
• Bianco A, Contoli M, Di Marco F, et al. As-needed anti-inflammatory reliever therapy for asthma management: evidence and practical considerations. Clin Exp Allergy. 2021;51(7):873–882. doi:10.1111/cea.13795
   PubMed Web of Science ®Google Scholar
• Almeida B, Nag OK, Rogers KE, et al. Recent progress in bioconjugation strategies for liposome-mediated drug delivery. Molecules. 2020;25(23). doi:10.3390/molecules25235672
   Web of Science ®Google Scholar
• Woodrow JS, Sheats MK, Cooper B, et al. Asthma: the use of animal models and their translational utility. Cells. 2023;12(7). doi:10.3390/cells12071091
   PubMed Web of Science ®Google Scholar
• Kim NY, Lee CH, Jin KN, et al. Clinical deterioration and lung function change in patients with concomitant asthma and bronchiectasis. J Allergy Clin Immunol Pract. 2022;10(10):2607–2613.e4. doi:10.1016/j.jaip.2022.05.026
   PubMed Web of Science ®Google Scholar
• Hayes D, Collins PB, Khosravi M, et al. Bronchoconstriction triggered by breathing hot humid air in patients with asthma: role of cholinergic reflex. Am J Respir Crit Care Med. 2012;185(11):1190–1196. doi:10.1164/rccm.201201-0088OC
   PubMed Web of Science ®Google Scholar
• Busse WW. The relationship of airway hyperresponsiveness and airway inflammation: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest. 2010;138(2 Suppl):4s–10s. doi:10.1378/chest.10-0100
   PubMed Web of Science ®Google Scholar
• Hochgerner M, Sturm EM, Schnoegl D, et al. Low oxygen levels decrease adaptive immune responses and ameliorate experimental asthma in mice. Allergy. 2022;77(3):870–882. doi:10.1111/all.15020
   PubMed Web of Science ®Google Scholar
• Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–1485. doi:10.1016/j.cell.2021.02.016
   PubMed Web of Science ®Google Scholar
• Athari SS. Targeting cell signaling in allergic asthma. Signal Transduct Target Ther. 2019;4:45. doi:10.1038/s41392-019-0079-0
   PubMed Web of Science ®Google Scholar
• Reddel HK, O’Byrne PM, FitzGerald JM, et al. Efficacy and safety of as-needed budesonide-formoterol in adolescents with mild asthma. J Allergy Clin Immunol Pract. 2021;9(8):3069–3077.e6. doi:10.1016/j.jaip.2021.04.016
   PubMed Web of Science ®Google Scholar
• Chipps BE, Israel E, Beasley R, et al. Albuterol-budesonide pressurized metered dose inhaler in patients with mild-to-moderate asthma: results of the DENALI double-blind randomized controlled trial. Chest. 2023;164(3):585–595. doi:10.1016/j.chest.2023.03.035
   PubMed Web of Science ®Google Scholar
• Bassetti M, Vena A, Russo A, et al. Inhaled liposomal antimicrobial delivery in lung infections. Drugs. 2020;80(13):1309–1318. doi:10.1007/s40265-020-01359-z
   PubMed Web of Science ®Google Scholar