Dexamethasone-Loaded Lipid Calcium Phosphate Nanoparticles Treat Experimental Colitis by Regulating Macrophage Polarization in Inflammatory Sites

References

• Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756–1770. doi:10.1016/S0140-6736(16)32126-2
   PubMed Web of Science ®Google Scholar
• Espaillat MP, Kew RR, Obeid LM. Sphingolipids in neutrophil function and inflammatory responses: mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis. Adv Bio Regul. 2017;63:140–155. doi:10.1016/j.jbior.2016.11.001
   PubMedGoogle Scholar
• Iwamuro M, Takahashi T, Watanabe N, et al. Enriched CD45RA(-)CD62L(+) central memory T and decreased CD3(+)CD56(+) natural killer T lymphocyte subsets in the rectum of ulcerative colitis patients. Inter J Immuno Pharmacol. 2022;2022:36.
   Google Scholar
• Zhang JX, Zhao YG, Hou TL, et al. Macrophage-based nanotherapeutic strategies in ulcerative colitis. J Control Release. 2020;320:363–380. doi:10.1016/j.jconrel.2020.01.047
   PubMed Web of Science ®Google Scholar
• Kaymak I, Williams KS, Cantor JR, Jones RG. Immunometabolic Interplay in the Tumor Microenvironment. Cancer Cell. 2021;39(1):28–37. doi:10.1016/j.ccell.2020.09.004
   PubMed Web of Science ®Google Scholar
• Rubin PH, Friedman S, Harpaz N, et al. Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps. Gastroenterology. 1999;117(6):1295–1300. doi:10.1016/S0016-5085(99)70279-9
   PubMed Web of Science ®Google Scholar
• Kaluzna A, Olczyk P, Komosinska-Vassev K. The role of innate and adaptive immune cells in the pathogenesis and development of the inflammatory response in ulcerative colitis. J Clin Med. 2022;11:2. doi:10.3390/jcm11020400
   Web of Science ®Google Scholar
• Pan XH, Zhu Q, Pan LL, Sun J. Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy. Pharmacol Ther. 2022;2022:238.
   Google Scholar
• Kuhl AA, Erben U, Kredel LI, Siegmund B. Diversity of intestinal Macrophages in inflammatory Bowel Diseases. Front Immunol. 2015;6. doi:10.3389/fimmu.2015.00006
   PubMed Web of Science ®Google Scholar
• Ma SJ, Zhang JX, Liu HS, Li S, Wang Q. The role of tissue-resident macrophages in the development and treatment of inflammatory bowel disease. Front Cell Dev Biol. 2022;2022:10.
   Google Scholar
• Tugal D, Liao XD, Jain MK. Transcriptional control of macrophage polarization. Arteriosclerosis Thrombosis Vasc Biol. 2013;33(6):1135–1144. doi:10.1161/ATVBAHA.113.301453
   PubMed Web of Science ®Google Scholar
• Lissner D, Schumann M, Batra A, et al. Monocyte and M1 macrophage-induced barrier defect contributes to chronic intestinal inflammation in IBD. Inflammat Bowel Dis. 2015;21(6):1297–1305. doi:10.1097/MIB.0000000000000384
   PubMed Web of Science ®Google Scholar
• Ning LQ, Ye NY, Ye B, et al. Qingre Xingyu recipe exerts inhibiting effects on ulcerative colitis development by inhibiting TNF alpha/NLRP3/Caspase-1/IL-1 beta pathway and macrophage M1 polarization. Cell Death Discovery. 2023;9:1. doi:10.1038/s41420-023-01361-w
   PubMed Web of Science ®Google Scholar
• Monajemi M, Pang YCF, Bjornson S, Menzies SC, van Rooijen N, Sly LM. Malt1 blocks IL-1 beta production by macrophages in vitro and limits dextran sodium sulfate-induced intestinal inflammation in vivo. J Leukocy Biol. 2018;104(3):557–572. doi:10.1002/JLB.3VMA0118-019R
   PubMed Web of Science ®Google Scholar
• Nicaise P, Gleizes A, Sandre C, et al. The intestinal microflora regulates cytokine production positively in spleen-derived macrophages but negatively in bone marrow-derived macrophages. European Cytokine Network. 1999;10(3):365–372.
   PubMed Web of Science ®Google Scholar
• Sommer K, Wiendl M, Muller TM, et al. Intestinal mucosal wound healing and barrier integrity in IBD-crosstalk and trafficking of cellular players. Front Med. 2021;2021:8.
   Google Scholar
• Pan F, Tang W, Zhou Z, Gilkeson G, Lang R, Jiang W. Intestinal macrophages in mucosal immunity and their role in systemic lupus erythematosus disease. Lupus. 2018;27(12):1898–1902. doi:10.1177/0961203318797417
   PubMed Web of Science ®Google Scholar
• Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1756–U1782. doi:10.1053/j.gastro.2011.02.016
   PubMed Web of Science ®Google Scholar
• Zhu W, Yu JB, Nie Y, et al. Disequilibrium of M1 and M2 macrophages correlates with the development of experimental inflammatory bowel diseases. Immunol Invest. 2014;43(7):638–652. doi:10.3109/08820139.2014.909456
   PubMed Web of Science ®Google Scholar
• Lai WM, Xian CX, Chen MX, et al. Single-cell and bulk transcriptomics reveals M2d macrophages as a potential therapeutic strategy for mucosal healing in ulcerative colitis. Int Immunopharmacol. 2023;2023:121.
   Google Scholar
• Wang K, Mao TY, Lu XY, et al. A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals. Front Immunol. 2023;2023:14.
   Google Scholar
• Greifer MK, Markowitz JF. Update in the treatment of paediatric ulcerative colitis. Expert Opinion Pharmacoth. 2006;7(14):1907–1918. doi:10.1517/14656566.7.14.1907
   PubMed Web of Science ®Google Scholar
• Farrell RJ, Kelleher D. Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol. 2003;178(3):339–346. doi:10.1677/joe.0.1780339
   PubMed Web of Science ®Google Scholar
• Sutherland L, MacDonald JK. Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2006;2006:2.
   Google Scholar
• Mao EJ, Hazlewood GS, Kaplan GG, Peyrin-Biroulet L, Ananthakrishnan AN. Systematic review with meta-analysis: comparative efficacy of immunosuppressants and biologics for reducing hospitalisation and surgery in Crohn’s disease and ulcerative colitis. Aliment Pharmacol Ther. 2017;45(1):3–13. doi:10.1111/apt.13847
   PubMed Web of Science ®Google Scholar
• George LA, Cross RK. Treatment of ulcerative colitis with steroids (in Whom, How Long, What Dose, What Form). Gastroenterol Clin North Am. 2020;49(4):705–716. doi:10.1016/j.gtc.2020.08.001
   PubMed Web of Science ®Google Scholar
• Bitton A. Medical management of ulcerative proctitis, proctosigmoiditis, and left-sided colitis. Semin Gastrointl Dis. 2001;12(4):263–274.
   PubMedGoogle Scholar
• Meduri GU, Muthiah MP, Carratu P, Eltorky M, Chrousos GP. Nuclear factor-kappa B- and glucocorticoid receptor alpha-mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome - Evidence for inflammation-induced target tissue resistance to glucocorticoids. Neuroimmunomodulation. 2005;12(6):321–338. doi:10.1159/000091126
   PubMed Web of Science ®Google Scholar
• Hermoso M, Cidlowski J. Putting the brake on inflammatory responses: the role of glucocorticoids. Iubmb Life. 2003;55(9):497–504. doi:10.1080/15216540310001642072
   PubMed Web of Science ®Google Scholar
• Liu W, Fan Z, Han Y, et al. Activation Of Nf-Kappa B signaling pathway in Hsv-1-induced mouse facial palsy: possible relation to therapeutic effect of glucocorticoids. Neuroscience. 2015;289:251–261. doi:10.1016/j.neuroscience.2014.12.062
   PubMed Web of Science ®Google Scholar
• Choi JH, Brummer E, Kang YJ, Jones PP, Stevens DA. Inhibitor kappa B and nuclear factor kappa B in granulocyte-macrophage colony-stimulating factor antagonism of dexamethasone suppression of the macrophage response to Aspergillus fumigatus conidia. J Infect Dis. 2006;193(7):1023–1028. doi:10.1086/500948
   PubMed Web of Science ®Google Scholar
• Jiang KY, Weaver JD, Li YJY, Chen XJ, Liang JP, Stabler CL. Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages. Biomaterials. 2017;114:71–81. doi:10.1016/j.biomaterials.2016.11.004
   PubMed Web of Science ®Google Scholar
• Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci Landm. 2008;13:453–461. doi:10.2741/2692
   PubMed Web of Science ®Google Scholar
• Tu GW, Shi Y, Zheng YJ, et al. Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage. J Transl Med;2017. 15. doi:10.1186/s12967-016-1116-1
   PubMed Web of Science ®Google Scholar
• Urbanska J, Karewicz A, Nowakowska M. Polymeric delivery systems for dexamethasone. Life Sci. 2014;96(1–2):1–6. doi:10.1016/j.lfs.2013.12.020
   PubMed Web of Science ®Google Scholar
• Qu Z, Wong KY, Moniruzzaman M, et al. One-Pot Synthesis of pH-responsive eudragit-mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease. Adv Therap. 2021;4:2. doi:10.1002/adtp.202000165
   Google Scholar
• Wang N, Shao LY, Lu WJ, et al. 5-aminosalicylic acid pH sensitive core-shell nanoparticles targeting ulcerative colitis. J Drug Delivery Sci Technol. 2022;2022:74.
   Google Scholar
• Qiu C, Wu YY, Guo QY, et al. Preparation and application of calcium phosphate nanocarriers in drug delivery. Mater Today Bio. 2022;2022:17.
   Google Scholar
• Khalifehzadeh R, Arami H. Biodegradable calcium phosphate nanoparticles for cancer therapy. Adv Colloid Interface Sci. 2020;2020:279.
   Google Scholar
• Jeong J, Kim JH, Shim JH, Hwang NS, Heo CY. Bioactive calcium phosphate materials and applications in bone regeneration. Biomater Res. 2019;23:1. doi:10.1186/s40824-018-0149-3
   PubMedGoogle Scholar
• Al-Sanabani JS, Madfa AA, Al-Sanabani FA. Application of calcium phosphate materials in dentistry. Int J Biomater. 2013;2013:876132. doi:10.1155/2013/876132
   PubMedGoogle Scholar
• Xu XC, Li ZH, Zhao XQ, Keen L, Kong XD. Calcium phosphate nanoparticles-based systems for siRNA delivery. Regenerat Biomat. 2016;3(3):187–195. doi:10.1093/rb/rbw010
   PubMed Web of Science ®Google Scholar
• Maitra A. Calcium phosphate nanoparticles: second-generation nonviral vectors in gene therapy. Expert Rev Molecul Diagnost. 2005;5(6):893–905. doi:10.1586/14737159.5.6.893
   PubMed Web of Science ®Google Scholar
• Sokolova V, Epple M. Biological and medical applications of calcium phosphate nanoparticles. Chemistry. 2021;27(27):7471–7488. doi:10.1002/chem.202005257
   PubMed Web of Science ®Google Scholar
• Ridi F, Meazzini I, Castroflorio B, Bonini M, Berti D, Baglioni P. Functional calcium phosphate composites in nanomedicine. Adv Colloid Interface Sci. 2017;244:281–295. doi:10.1016/j.cis.2016.03.006
   PubMed Web of Science ®Google Scholar
• An JL, Zhang YX, Ying ZW, et al. The formation, structural characteristics, absorption pathways and bioavailability of calcium-peptide chelates. Foods. 2022;11:18. doi:10.3390/foods11182762
   Web of Science ®Google Scholar
• Huang JL, Chen HZ, Gao XL. Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery. J Drug Target. 2018;26(5–6):398–406. doi:10.1080/1061186X.2017.1419360
   PubMed Web of Science ®Google Scholar
• Shi XP, Yan Y, Wang PC, et al. In vitro and in vivo study of pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres used for ulcerative colitis therapy. Eur. J. Pharm. Biopharm. 2018;122:70–77. doi:10.1016/j.ejpb.2017.10.003
   PubMed Web of Science ®Google Scholar
• Zeng AG, Dong K, Wang ML, et al. Investigation of the colon-targeting, improvement on the side-effects and therapy on the experimental colitis in mouse of a resin microcapsule loading dexamethasone sodium phosphate. Drug Delivery. 2016;23(6):1.
   PubMed Web of Science ®Google Scholar
• You YC, Dong LY, Dong K, et al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr. Polym. 2015;130:243–253. doi:10.1016/j.carbpol.2015.03.075
   PubMed Web of Science ®Google Scholar
• Dorozhkin SV. Amorphous calcium (ortho)phosphates. Acta Biomater. 2010;6(12):4457–4475. doi:10.1016/j.actbio.2010.06.031
   PubMed Web of Science ®Google Scholar
• Wang S, Zhang J, Zhou H, et al. The role of protein Corona on nanodrugs for organ-targeting and its prospects of application. J Controll Rele. 2023;360:15–43. doi:10.1016/j.jconrel.2023.06.014
   PubMed Web of Science ®Google Scholar
• Waggoner LE, Miyasaki KF, Kwon EJ. Analysis of PEG-lipid anchor length on lipid nanoparticle pharmacokinetics and activity in a mouse model of traumatic brain injury. Biomater Sci. 2023;11(12):4238–4253. doi:10.1039/D2BM01846B
   PubMed Web of Science ®Google Scholar
• Lunov O, Syrovets T, Rocker C, et al. Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes. Biomaterials. 2010;31(34):9015–9022. doi:10.1016/j.biomaterials.2010.08.003
   PubMed Web of Science ®Google Scholar
• Li X, Naguib YW, Valdes S, Hufnagel S, Cui ZR. Reverse microemulsion-based synthesis of (Bis)phosphonate-metal materials with controllable physical properties: an example using zoledronic acid-calcium complexes. ACS Appl. Mater. Interfaces. 2017;9(16):14478–14489. doi:10.1021/acsami.6b15006
   PubMed Web of Science ®Google Scholar
• Van den Bossche J, Baardman J, de Winther MPJ. Metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time extracellular flux analysis. J Visual Experim. 2015;2015:105.
   Google Scholar
• Caer C, Wick MJ, Hu L, Qiu L, Zhu L. Human intestinal mononuclear phagocytes in health and inflammatory bowel disease. Front Immunol. 2020;11:11. doi:10.3389/fimmu.2020.00011
   PubMed Web of Science ®Google Scholar
• Polinska B, Matowicka-Karna J, Kemona H. The cytokines in inflammatory bowel disease. Postepy Hig Med Dosw (Online). 2009;63:389–394.
   PubMedGoogle Scholar
• Yang ZH, Lin SS, Feng WY, et al. A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: macrophage polarization. Front Pharmacol. 2022;2022:13.
   Google Scholar
• Zguris J, Pishko MV. pH sensitive fluorescent poly(ethylene) glycol hydrogel microstructures for monitoring in cell culture systems. Sens Lett. 2005;3(3):206–210. doi:10.1166/sl.2005.027
   Google Scholar
• Kim YJ, Lee S, Jin J, Woo H, Choi YK, Park KG. Cassiaside C Inhibits M1 polarization of macrophages by downregulating glycolysis. Int J Mol Sci. 2022;23:3.
   Web of Science ®Google Scholar
• Zhou HC, Yan XY, Yu WW, et al. Lactic acid in macrophage polarization: the significant role in inflammation and cancer. Internat Rev Immunol. 2022;41(1):4–18. doi:10.1080/08830185.2021.1955876
   PubMed Web of Science ®Google Scholar
• Park SY, Kim IS. Identification of macrophage genes responsive to extracellular acidification. Inflamm Res. 2013;62(4):399–406. doi:10.1007/s00011-013-0591-6
   PubMed Web of Science ®Google Scholar
• Tedesco S, Bolego C, Toniolo A, et al. Phenotypic activation and pharmacological outcomes of spontaneously differentiated human monocyte-derived macrophages. Immunobiology. 2015;220(5):545–554. doi:10.1016/j.imbio.2014.12.008
   PubMed Web of Science ®Google Scholar
• Tuckermann JP, Kleiman A, McPherson KG, Reichardt HM. Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Crit Rev Clin Laborat Sci. 2005;42(1):71–104. doi:10.1080/10408360590888983
   PubMed Web of Science ®Google Scholar
• Fretwurst T, Garaicoa-Pazmino C, Nelson K, et al. Characterization of macrophages infiltrating peri-implantitis lesions. Clin Oral Implants Res. 2020;31(3):274–281. doi:10.1111/clr.13568
   PubMed Web of Science ®Google Scholar
• Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell. Signalling. 2001;13(2):85–94. doi:10.1016/S0898-6568(00)00149-2
   PubMed Web of Science ®Google Scholar
• Atreya I, Atreya R, Neurath MF. NF-kappa B in inflammatory bowel disease. J Internal Med. 2008;263(6):591–596. doi:10.1111/j.1365-2796.2008.01953.x
   Google Scholar
• Saklatvala J. Glucocorticoids: do we know how they work? Arthritis Res. 2002;4(3):146–150. doi:10.1186/ar398
   PubMedGoogle Scholar
• Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of I-Kappa-B-alpha in mediation of immunosuppression by glucocorticoids. Science. 1995;270(5234):283–286. doi:10.1126/science.270.5234.283
   PubMed Web of Science ®Google Scholar
• De Vera ME, Taylor BS, Wang Q, Shapiro RA, Billiar TR, Geller DA. Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B. Am J Physiol Gastrointest Liver Physiol. 1997;273(6):G1290–G1296. doi:10.1152/ajpgi.1997.273.6.G1290
   Web of Science ®Google Scholar
• Dong K, Deng SJ, He BY, et al. Mucoadhesive nanoparticles enhance the therapeutic effect of dexamethasone on experimental ulcerative colitis by the local administration as an enema. Drug Des Devel Ther. 2023;17:191–207. doi:10.2147/DDDT.S390274
   PubMed Web of Science ®Google Scholar
• Carlson M, Raab Y, Seveus L, Xu S, Hallgren R, Venge P. Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis. Gut. 2002;50(4):501–506. doi:10.1136/gut.50.4.501
   PubMed Web of Science ®Google Scholar
• Li QZ, Hu XL, Bai YP, et al. The oxidative damage and inflammatory response induced by lead sulfide nanoparticles in rat lung. Food Chem Toxicol. 2013;60:213–217. doi:10.1016/j.fct.2013.07.046
   PubMed Web of Science ®Google Scholar
• Szandruk M, Merwid-Lad A, Szelag A. The impact of mangiferin from Belamcanda chinensis on experimental colitis in rats. Inflammopharmacology. 2018;26(2):571–581. doi:10.1007/s10787-017-0337-0
   PubMed Web of Science ®Google Scholar
• Moret-Tatay I, Iborra M, Cerrillo E, Tortosa L, Nos P, Beltran B. Possible biomarkers in blood for crohn’s disease: oxidative stress and MicroRNAs-current evidences and further aspects to unravel. Oxid Med Cell Longev. 2016;2016:1.
   Web of Science ®Google Scholar
• Liu YX, Liu X, Hua WW, et al. Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-kappa B signaling pathway to protect against DSS-induced colitis. Int Immunopharmacol. 2018;57:121–131. doi:10.1016/j.intimp.2018.01.049
   PubMed Web of Science ®Google Scholar
• Gren ST, Grip O. Role of monocytes and intestinal macrophages in crohn’s disease and ulcerative colitis. Inflammat Bowel Dis. 2016;22(8). doi:10.1097/MIB.0000000000000824
   PubMed Web of Science ®Google Scholar
• Randhawa PK, Singh K, Singh N, Jaggi AS. A review on chemical-induced inflammatory bowel disease models in rodents. Korean J Physiol Pharmacol. 2014;18(4):279–288. doi:10.4196/kjpp.2014.18.4.279
   PubMed Web of Science ®Google Scholar
• Katsandegwaza B, Horsnell W, Smith K. Inflammatory bowel disease: a review of pre-clinical murine models of human disease. Int J Mol Sci. 2022;23:16. doi:10.3390/ijms23169344
   Google Scholar
• Li CP, Luo XY, Li LF, Cai Y, Kang XH, Li PW. Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings. Int J Biol Macromol. 2022;209:344–355. doi:10.1016/j.ijbiomac.2022.04.025
   PubMed Web of Science ®Google Scholar