Utilization of Nitrogen-Doped Graphene Quantum Dots to Neutralize ROS and Modulate Intracellular Antioxidant Pathways to Improve Dry Eye Disease Therapy

References

• Tavakoli A, Flanagan JL. Dry eye disease: an (in)convenient truth. Clin Exp Optom. 2022;105(2):222–229. doi:10.1080/08164622.2021.1945410
   PubMed Web of Science ®Google Scholar
• Louie HH, Mugisho OO, Chamley LW, Rupenthal ID. Extracellular vesicles as biomarkers and therapeutics for inflammatory eye diseases. Mol Pharm. 2023;20(1):23–40. doi:10.1021/acs.molpharmaceut.2c00414
   PubMedGoogle Scholar
• Huang L, Gao H, Wang Z, Zhong Y, Hao L, Du Z. Combination nanotherapeutics for dry eye disease treatment in a rabbit model. Int J Nanomed. 2021;16:3613–3631. doi:10.2147/IJN.S301717
   PubMed Web of Science ®Google Scholar
• Lu YT, Wu YQ, Zhou XJ, et al. Editorial: advances in the pathophysiology, diagnosis, and treatment of dry eye disease. Front Med-Lausanne. 2022;9:1 doi:10.3389/fmed.2022.925876.
   Web of Science ®Google Scholar
• Lou Q, Pan L, Xiang S, et al. Suppression of NLRP3/Caspase-1/GSDMD mediated corneal epithelium pyroptosis using melatonin-loaded liposomes to inhibit benzalkonium chloride-induced dry eye disease. Int J Nanomed. 2023;18:2447–2463. doi:10.2147/IJN.S403337
   PubMed Web of Science ®Google Scholar
• Luo L-J, Jian H-J, Harroun SG, Lai J-Y, Unnikrishnan B, Huang C-C. Targeting nanocomposites with anti-oxidative/inflammatory/angiogenic activities for synergistically alleviating macular degeneration. Appl Mater Today. 2021;24:1 doi:10.1016/j.apmt.2021.101156.
   Web of Science ®Google Scholar
• Tzong-Yun G, Tzong-Yun G, Tzong-Yun G, Lai J-Y. Biofunctionalization of nanoceria with sperminated hyaluronan enhances drug delivery performance for corneal alkali burn therapy. Chem Eng J. 2023;476:146864. doi:10.1016/j.cej.2023.146864
   Web of Science ®Google Scholar
• Yang C-J, Anand A, Huang C-C, Lai J-Y. Unveiling the power of gabapentin-loaded nanoceria with multiple therapeutic capabilities for the treatment of dry eye disease. ACS Nano. 2023;17(24):25118–25135. doi:10.1021/acsnano.3c07817
   PubMed Web of Science ®Google Scholar
• Wu DD, Lim BXH, Seah I, et al. Impact of microplastics on the ocular surface. Int J Mat Sci. 2023;24:1 doi:10.3390/ijms24043928.
   Web of Science ®Google Scholar
• Jung SJ, Mehta JS, Tong L. Effects of environment pollution on the ocular surface. Ocul Surf. 2018;16(2):198–205. doi:10.1016/j.jtos.2018.03.001
   PubMed Web of Science ®Google Scholar
• Li S, Lu Z, Huang Y, et al. Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle. Adv Sci (Weinh). 2022;9(17):e2200435. doi:10.1002/advs.202200435
   PubMedGoogle Scholar
• Le Gal K, Schmidt EE, Sayin VI. Cellular redox homeostasis. Antioxidants. 2021;11(1):10. doi:10.3390/antiox11010010
   Google Scholar
• Yang CJ, Nguyen DD, Lai JY. Poly(l-histidine)-mediated on-demand therapeutic delivery of roughened ceria nanocages for treatment of chemical eye injury. Adv Sci. 2023;10(26):e2302174. doi:10.1002/advs.202302174
   Web of Science ®Google Scholar
• Lin PH, Jian HJ, Li YJ, et al. Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels. Acta Biomater. 2022;141:140–150. doi:10.1016/j.actbio.2022.01.044
   PubMed Web of Science ®Google Scholar
• Lim JC, Suzuki-Kerr H, Nguyen TX. Redox homeostasis in ocular tissues: circadian regulation of glutathione in the lens? Antioxidants. 2022;12(1):11. doi:10.3390/antiox12010011
   Google Scholar
• Nguyen DD, Luo LJ, Yang CJ, Lai JY. Highly retina-permeating and long-acting resveratrol/metformin nanotherapeutics for enhanced treatment of macular degeneration. ACS Nano. 2023;17(1):168–183. doi:10.1021/acsnano.2c05824
   PubMed Web of Science ®Google Scholar
• Awwad S, Ahmed AHAM, Sharma G, et al. Principles of pharmacology in the eye. Brit J Pharmacol. 2017;174(23):4205–4223. doi:10.1111/bph.14024
   PubMed Web of Science ®Google Scholar
• Li YJ, Luo LJ, Harroun SG, et al. Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease. Nanoscale. 2019;11(12):5580–5594. doi:10.1039/C9NR00376B
   PubMed Web of Science ®Google Scholar
• Luo LJ, Nguyen DD, Lai JY. Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease. Mater Sci Eng C Mater Biol Appl. 2020;115:111095. doi:10.1016/j.msec.2020.111095
   PubMed Web of Science ®Google Scholar
• Nguyen DD, Luo LJ, Lai JY. Thermogels containing sulfated hyaluronan as novel topical therapeutics for treatment of ocular surface inflammation. Mater Today Bio. 2022;13:100183. doi:10.1016/j.mtbio.2021.100183
   PubMedGoogle Scholar
• Seen S, Tong L. Dry eye disease and oxidative stress. Acta Ophthalmol. 2018;96(4):E412–E420. doi:10.1111/aos.13526
   PubMed Web of Science ®Google Scholar
• Wu Z, Pan T, Lin D, et al. Biocompatible tumor-targeted GQDs nanocatalyst for chemodynamic tumor therapy. J Mater Chem B. 2022;10(18):3567–3576. doi:10.1039/D1TB02734D
   PubMed Web of Science ®Google Scholar
• Jian H-J, Ren-Siang W, Lin T-Y, et al. Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis. ACS nano. 2017;11(7):6703–6716. doi:10.1021/acsnano.7b01023
   PubMed Web of Science ®Google Scholar
• Lin H-Y, Wang S-W, Mao J-Y, et al. Carbonized nanogels for simultaneous antibacterial and antioxidant treatment of bacterial keratitis. Chem Eng J. 2021;411:1 doi:10.1016/j.cej.2021.128469.
   Web of Science ®Google Scholar
• Dehvari K, Chiu SH, Lin JS, Girma WM, Ling YC, Chang JY. Heteroatom doped carbon dots with nanoenzyme like properties as theranostic platforms for free radical scavenging, imaging, and chemotherapy. Acta Biomater. 2020;114:343–357. doi:10.1016/j.actbio.2020.07.022
   PubMed Web of Science ®Google Scholar
• Zhao L, Wang YM, Li Y. Antioxidant activity of graphene quantum dots prepared in different electrolyte environments. Nanomaterials-Basel. 2019;9:1 doi:10.3390/nano9121708.
   Web of Science ®Google Scholar
• Ruiz V, Yate L, Garcia I, Cabanero G, Grande HJ. Tuning the antioxidant activity of graphene quantum dots: protective nanomaterials against dye decoloration. Carbon. 2017;116:366–374. doi:10.1016/j.carbon.2017.01.090
   Web of Science ®Google Scholar
• Choudhary P, Biswas S, Kandoth N, et al. Graphene quantum dots alleviate ROS-mediated gastric damage. iScience. 2022;25(4):104062. doi:10.1016/j.isci.2022.104062
   PubMed Web of Science ®Google Scholar
• Wang HB, Zhang ML, Ma YR, et al. Carbon dots derived from citric acid and glutathione as a highly efficient intracellular reactive oxygen species scavenger for alleviating the lipopolysaccharide-induced inflammation in macrophages. Acs Appl Mater Inter. 2020;12(37):41088–41095. doi:10.1021/acsami.0c11735
   PubMed Web of Science ®Google Scholar
• Ho TC, Yeh SI, Chen SL, Tsao YP. Integrin alphav and vitronectin prime macrophage-related inflammation and contribute the development of dry eye disease. Int J Mol Sci. 2021;23(1):22. doi:10.3390/ijms23010022
   PubMedGoogle Scholar
• Chen L, Deng J, Ailing Y, et al. Drug-peptide supramolecular hydrogel boosting transcorneal permeability and pharmacological activity via ligand-receptor interaction. Bioact Mater. 2022;10:420–429. doi:10.1016/j.bioactmat.2021.09.006
   PubMed Web of Science ®Google Scholar
• Pierschbacher MD, Ruoslahti E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature. 1984;309(5963):30–33. doi:10.1038/309030a0
   PubMed Web of Science ®Google Scholar
• Ensign LM, Tang BC, Wang YY, et al. Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci Transl Med. 2012;4:1 doi:10.1126/scitranslmed.3003453.
   Web of Science ®Google Scholar
• Mert O, Lai SK, Ensign L, et al. A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles. J Control Release. 2012;157(3):455–460. doi:10.1016/j.jconrel.2011.08.032
   PubMed Web of Science ®Google Scholar
• Yu MR, Xu L, Tian FL, et al. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nat Commun. 2018;9:1 doi:10.1038/s41467-018-05061-3.
   PubMed Web of Science ®Google Scholar
• Li L, Li SH, Wang S, et al. Antioxidant and anti-glycated TAT-modified platinum nanoclusters as eye drops for non-invasive and painless relief of diabetic cataract in rats. Chem Eng J. 2020;398:1 doi:10.1016/j.cej.2020.125436.
   Web of Science ®Google Scholar
• Qi L, Th P, Ll O, et al. Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage. Commun Biol. 2021;4(1):4. doi:10.1038/s42003-020-01536-6
   PubMed Web of Science ®Google Scholar
• Liu XF, Hao JL, Xie T, et al. Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress. Aging Cell. 2017;16(5):934–942. doi:10.1111/acel.12645
   PubMed Web of Science ®Google Scholar
• Ayu Y, Zm L, Gt C, Sd H, Hs Y. Bamboo leaf flavonoids extracts alleviate oxidative stress in HepG2 cells via naturally modulating reactive oxygen species production and Nrf2-mediated antioxidant defense responses. J Food Sci. 2019;84(6):1609–1620. doi:10.1111/1750-3841.14609
   PubMed Web of Science ®Google Scholar