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REVIEW

Macrophage-Derived Exosomes as Advanced Therapeutics for Inflammation: Current Progress and Future Perspectives

ORCID Icon, ORCID Icon, , , & ORCID Icon
Pages 1597-1627 | Received 22 Nov 2023, Accepted 10 Feb 2024, Published online: 18 Feb 2024

References

  • Tian Y, Cheng C, Wei Y, Yang F, Li G. The role of exosomes in inflammatory diseases and tumor-related inflammation. Cells. 2022;11(6):1005. doi:10.3390/cells11061005
  • Gupta S, Sarangi PP. Inflammation driven metabolic regulation and adaptation in macrophages. Clin Immunol. 2023;246:109216. doi:10.1016/j.clim.2022.109216
  • Zhong J, Shi G. Editorial: regulation of inflammation in chronic disease. Front Immunol. 2019;10:737. doi:10.3389/fimmu.2019.00737
  • Panigrahy D, Gilligan MM, Serhan CN, Kashfi K. Resolution of inflammation: an organizing principle in biology and medicine. Pharmacol Ther. 2021;227:107879. doi:10.1016/j.pharmthera.2021.107879
  • Feehan KT, Gilroy DW. Is resolution the end of inflammation? Trends Mol Med. 2019;25(3):198–214. doi:10.1016/j.molmed.2019.01.006
  • Miao L, Liu C, Cheong MS, et al. Exploration of natural flavones’ bioactivity and bioavailability in chronic inflammation induced-type-2 diabetes mellitus. Crit Rev Food Sci Nutr. 2023;63(33):11640–11667. doi:10.1080/10408398.2022.2095349
  • Custodero C, Mankowski RT, Lee SA, et al. Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis. Ageing Res Rev. 2018;46:42–59. doi:10.1016/j.arr.2018.05.004
  • Wang S, Lei B, Zhang E, et al. Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics. Int j Nanomed. 2022;17:1757–1781. doi:10.2147/ijn.S355366
  • Jordan F, Quinn TJ, McGuinness B, et al. Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia. Cochrane Database Syst Rev. 2020;4(4):Cd011459. doi:10.1002/14651858.CD011459.pub2
  • Fragoulis GE, Nikiphorou E, Dey M, et al. 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases. Ann Rheumatic Dis. 2023;82(6):742–753. doi:10.1136/ard-2022-223335
  • Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2–13. doi:10.1016/j.mce.2010.04.005
  • Chen S, Zhang M, Li J, et al. β-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis. J Extracell Vesicles. 2022;11(3):e12203. doi:10.1002/jev2.12203
  • Arya SB, Collie SP, Parent CA. The ins-and-outs of exosome biogenesis, secretion, and internalization. Trends Cell Biol. 2023. doi:10.1016/j.tcb.2023.06.006
  • Ozansoy M, Mikati H, Velioglu HA, Yulug B. Exosomes: a missing link between chronic systemic inflammation and Alzheimer’s disease? Biomed Pharmacother. 2023;159:114161. doi:10.1016/j.biopha.2022.114161
  • Chen Z, Larregina AT, Morelli AE. Impact of extracellular vesicles on innate immunity. Curr Opinion Organ Transpl. 2019;24(6):670–678. doi:10.1097/mot.0000000000000701
  • Yahara Y, Barrientos T, Tang YJ, et al. Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. Nat Cell Biol. 2020;22(1):49–59. doi:10.1038/s41556-019-0437-8
  • Bian Z, Gong Y, Huang T, et al. Deciphering human macrophage development at single-cell resolution. Nature. 2020;582(7813):571–576. doi:10.1038/s41586-020-2316-7
  • Li F, Okreglicka KM, Piattini F, Pohlmeier LM, Schneider C, Kopf M. Gene therapy of Csf2ra deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and function. JCI Insight. 2022;7(7):e152271.
  • Lee JW, Lee IH, Iimura T, Kong SW. Two macrophages, osteoclasts and microglia: from development to pleiotropy. Bone Res. 2021;9(1):11. doi:10.1038/s41413-020-00134-w
  • Chauhan A, Sheriff L, Hussain MT, et al. The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in Acetaminophen induced acute liver failure. Nat Commun. 2020;11(1):1939. doi:10.1038/s41467-020-15584-3
  • Shan X, Zhang C, Mai C, et al. The biogenesis, biological functions, and applications of macrophage-derived exosomes. Front Mol Biosci. 2021;8:715461. doi:10.3389/fmolb.2021.715461
  • Li J, Xue H, Li T, et al. Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE(-/-) mice via miR-let7 mediated infiltration and polarization of M2 macrophage. Biochem Biophys Res Commun. 2019;510(4):565–572. doi:10.1016/j.bbrc.2019.02.005
  • Baig MS, Roy A, Rajpoot S, et al. Tumor-derived exosomes in the regulation of macrophage polarization. Inflammation Res. 2020;69(5):435–451. doi:10.1007/s00011-020-01318-0
  • Dini L, Tacconi S, Carata E, Tata AM, Vergallo C, Panzarini E. Microvesicles and exosomes in metabolic diseases and inflammation. Cytokine Growth Factor Rev. 2020;51:27–39. doi:10.1016/j.cytogfr.2019.12.008
  • Fu SP, Chen SY, Pang QM, et al. Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury. Front Immunol. 2022;13:1014013. doi:10.3389/fimmu.2022.1014013
  • Yao Y, Xu XH, Jin L. Macrophage polarization in physiological and pathological pregnancy. Front Immunol. 2019;10:792. doi:10.3389/fimmu.2019.00792
  • Kim W, Lee EJ, Bae IH, et al. Lactobacillus plantarum-derived extracellular vesicles induce anti-inflammatory M2 macrophage polarization in vitro. J Extracell Vesicles. 2020;9(1):1793514. doi:10.1080/20013078.2020.1793514
  • Sedighzadeh SS, Khoshbin AP, Razi S, Keshavarz-Fathi M, Rezaei N. A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications. Transl Lung Cancer Res. 2021;10(4):1889–1916. doi:10.21037/tlcr-20-1241
  • Wu Y, Li J, Zeng Y, et al. Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies. Int J Oral Sci. 2022;14(1):40. doi:10.1038/s41368-022-00187-z
  • Ma X, Liu B, Fan L, et al. Native and engineered exosomes for inflammatory disease. Nano Res. 2023;16(5):6991–7006. doi:10.1007/s12274-022-5275-5
  • Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750. doi:10.1080/20013078.2018.1535750
  • Gharavi AT, Hanjani NA, Movahed E, Doroudian M. The role of macrophage subtypes and exosomes in immunomodulation. Cell Mol Biol Lett. 2022;27(1):83. doi:10.1186/s11658-022-00384-y
  • Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75(2):193–208. doi:10.1007/s00018-017-2595-9
  • Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signaling. 2021;19(1):47. doi:10.1186/s12964-021-00730-1
  • Nail HM, Chiu CC, Leung CH, Ahmed MMM, Wang HD. Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments. J Biomed Sci. 2023;30(1):69. doi:10.1186/s12929-023-00964-w
  • de Rivero Vaccari JP, Brand F, Adamczak S, et al. Exosome-mediated inflammasome signaling after central nervous system injury. J Neurochemistry. 2016;136(1):39–48. doi:10.1111/jnc.13036
  • Pang H, Luo S, Xiao Y, et al. Emerging roles of exosomes in T1DM. Front Immunol. 2020;11:593348. doi:10.3389/fimmu.2020.593348
  • Xiong YY, Gong ZT, Tang RJ, Yang YJ. The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics. 2021;11(3):1046–1058. doi:10.7150/thno.53326
  • Liang Y, Duan L, Lu J, Xia J. Engineering exosomes for targeted drug delivery. Theranostics. 2021;11(7):3183–3195. doi:10.7150/thno.52570
  • Isaac R, Reis FCG, Ying W, Olefsky JM. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021;33(9):1744–1762. doi:10.1016/j.cmet.2021.08.006
  • Gao J, Dong X, Wang Z. Generation, purification and engineering of extracellular vesicles and their biomedical applications. Methods. 2020;177:114–125. doi:10.1016/j.ymeth.2019.11.012
  • Li M, Rai AJ, DeCastro GJ, et al. An optimized procedure for exosome isolation and analysis using serum samples: application to cancer biomarker discovery. Methods. 2015;87:26–30. doi:10.1016/j.ymeth.2015.03.009
  • Zhang J, Li S, Li L, et al. Exosome and exosomal microRNA: trafficking, sorting, and function. Genom Proteom Bioinform. 2015;13(1):17–24. doi:10.1016/j.gpb.2015.02.001
  • Li KL, Huang HY, Ren H, Yang XL. Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease. Neural regenerat res. 2022;17(9):1898–1906. doi:10.4103/1673-5374.335143
  • Yang S, Liang X, Song J, et al. A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6. Stem Cell Res Ther. 2021;12(1):315. doi:10.1186/s13287-021-02404-8
  • Ren J, Zhu B, Gu G, et al. Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury. Cell Death Dis. 2023;14(1):70. doi:10.1038/s41419-023-05607-4
  • Zhang B, Yang Y, Xiang L, Zhao Z, Ye R. Adipose-derived exosomes: a novel adipokine in obesity-associated diabetes. J Cell Physiol. 2019;234(10):16692–16702. doi:10.1002/jcp.28354
  • Mathieu M, Névo N, Jouve M, et al. Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9. Nat Commun. 2021;12(1):4389. doi:10.1038/s41467-021-24384-2
  • Mashouri L, Yousefi H, Aref AR, Ahadi AM, Molaei F, Alahari SK. Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance. Mol Cancer. 2019;18(1):75. doi:10.1186/s12943-019-0991-5
  • Jeppesen DK, Fenix AM, Franklin JL, et al. Reassessment of Exosome Composition. Cell. 2019;177(2):428–445.e18. doi:10.1016/j.cell.2019.02.029
  • Gurunathan S, Kang MH, Jeyaraj M, Qasim M, Kim JH. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells. 2019;8(4). doi:10.3390/cells8040307
  • Chang W, Wang J. Exosomes and their noncoding RNA Cargo are emerging as new modulators for diabetes mellitus. Cells. 2019;8(8). doi:10.3390/cells8080853
  • Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int j Nanomed. 2020;15:6917–6934. doi:10.2147/ijn.S264498
  • Li P, Kaslan M, Lee SH, Yao J, Gao Z. Progress in exosome isolation techniques. Theranostics. 2017;7(3):789–804. doi:10.7150/thno.18133
  • Wu R, Gao W, Yao K, Ge J. Roles of exosomes derived from immune cells in cardiovascular diseases. Front Immunol. 2019;10:648. doi:10.3389/fimmu.2019.00648
  • Rehman FU, Liu Y, Zheng M, Shi B. Exosomes based strategies for brain drug delivery. Biomaterials. 2023;293:121949. doi:10.1016/j.biomaterials.2022.121949
  • Zhang M, Hu S, Liu L, et al. Engineered exosomes from different sources for cancer-targeted therapy. Signal Transd Target Ther. 2023;8(1):124. doi:10.1038/s41392-023-01382-y
  • Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478). doi:10.1126/science.aau6977
  • Funes SC, Rios M, Escobar-Vera J, Kalergis AM. Implications of macrophage polarization in autoimmunity. Immunology. 2018;154(2):186–195. doi:10.1111/imm.12910
  • Liu J, Wu F, Zhou H. Macrophage-derived exosomes in cancers: biogenesis, functions and therapeutic applications. Immunol Lett. 2020;227:102–108. doi:10.1016/j.imlet.2020.08.003
  • Liu S, Chen J, Shi J, et al. M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment. Basic Res Cardiol. 2020;115(2):22. doi:10.1007/s00395-020-0781-7
  • Nguyen MA, Karunakaran D, Geoffrion M, et al. Extracellular vesicles secreted by atherogenic macrophages transfer MicroRNA to inhibit cell migration. Arteriosclerosis Thrombosis Vasc Biol. 2018;38(1):49–63. doi:10.1161/atvbaha.117.309795
  • Tian F, Tang P, Sun Z, et al. miR-210 in exosomes derived from macrophages under high glucose promotes mouse diabetic obesity pathogenesis by suppressing NDUFA4 expression. J Diabetes Res. 2020;2020:6894684. doi:10.1155/2020/6894684
  • Wang B, Wang ZM, Ji JL, et al. Macrophage-derived exosomal Mir-155 regulating cardiomyocyte pyroptosis and hypertrophy in uremic cardiomyopathy. JACC. 2020;5(2):148–166. doi:10.1016/j.jacbts.2019.10.011
  • Ye C, Li H, Bao M, Zhuo R, Jiang G, Wang W. Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury. Aging. 2020;12(7):6120–6128. doi:10.18632/aging.103010
  • Yang R, Liao Y, Wang L, et al. Exosomes derived from M2b macrophages attenuate DSS-induced colitis. Front Immunol. 2019;10:2346. doi:10.3389/fimmu.2019.02346
  • Wang C, Zhang C, Liu L, et al. Macrophage-derived mir-155-containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury. Mol Ther. 2017;25(1):192–204. doi:10.1016/j.ymthe.2016.09.001
  • Osada-Oka M, Shiota M, Izumi Y, et al. Macrophage-derived exosomes induce inflammatory factors in endothelial cells under hypertensive conditions. Hypertens Res. 2017;40(4):353–360. doi:10.1038/hr.2016.163
  • Lee KS, Lee J, Lee P, et al. Exosomes released from Shiga toxin 2a-treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells. Cell Microbiol. 2020;22(11):e13249. doi:10.1111/cmi.13249
  • Bhatnagar S, Shinagawa K, Castellino FJ, Schorey JS. Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood. 2007;110(9):3234–3244. doi:10.1182/blood-2007-03-079152
  • Yuan D, Zhao Y, Banks WA, et al. Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. Biomaterials. 2017;142:1–12. doi:10.1016/j.biomaterials.2017.07.011
  • Meng M, Lu M, Feng J, et al. Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis. Inflammation Res. 2023;72(8):1567–1581. doi:10.1007/s00011-023-01765-5
  • Sun X, Liu Y, Wang J, Zhang M, Wang M. Cardioprotection of M2 macrophages-derived exosomal microRNA-24-3p/Tnfsf10 axis against myocardial injury after sepsis. Mol Immunol. 2022;141:309–317. doi:10.1016/j.molimm.2021.11.003
  • Li C, Deng C, Zhou T, et al. MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis. Int J Bio Sci. 2021;17(7):1795–1807. doi:10.7150/ijbs.59715
  • Gao ZS, Zhang CJ, Xia N, et al. Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy. Acta Biomater. 2021;126:211–223. doi:10.1016/j.actbio.2021.03.018
  • Li D, Zhang C, Gao Z, et al. Curcumin-loaded macrophage-derived exosomes effectively improve wound healing. Mol Pharmaceut. 2023;20(9):4453–4467. doi:10.1021/acs.molpharmaceut.3c00062
  • Cui Y, Hong S, Xia Y, et al. Melatonin engineering M2 macrophage-derived exosomes mediate endoplasmic reticulum stress and immune reprogramming for periodontitis therapy. Adv Sci. 2023;10(27):e2302029. doi:10.1002/advs.202302029
  • Huo Q, Shi Y, Qi Y, Huang L, Sui H, Zhao L. Biomimetic silibinin-loaded macrophage-derived exosomes induce dual inhibition of Aβ aggregation and astrocyte activation to alleviate cognitive impairment in a model of Alzheimer’s disease. Mater Sci Eng C Mater Biol Appl. 2021;129:112365. doi:10.1016/j.msec.2021.112365
  • Li H, Feng Y, Zheng X, et al. M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization. J Control Release. 2022;341:16–30. doi:10.1016/j.jconrel.2021.11.019
  • Zhao C, Song W, Ma J, Wang N. Macrophage-derived hybrid exosome-mimic nanovesicles loaded with black phosphorus for multimodal rheumatoid arthritis therapy. Biomater Sci. 2022;10(23):6731–6739. doi:10.1039/d2bm01274j
  • Bhatnagar S, Schorey JS. Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory. J Biol Chem. 2007;282(35):25779–25789. doi:10.1074/jbc.M702277200
  • Imamiya R, Shinohara A, Yakura D, et al. Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes. mBio. 2023;14(1):e0305122. doi:10.1128/mbio.03051-22
  • Cui X, Lai W, Zhao Y, Chen C. The exosome-mediated cascade reactions for the transfer and inflammatory responses of fine atmospheric particulate matter in macrophages. Environ Sci Technol. 2023;57(21):7891–7901. doi:10.1021/acs.est.3c01436
  • Zhu M, Sun X, Qi X, Xia L, Wu Y. Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-κB signaling pathway in vitro and in vivo. Int Immunopharmacol. 2020;84:106551. doi:10.1016/j.intimp.2020.106551
  • Liu Y, Li X, Zhao M, et al. Macrophage-derived exosomes promote activation of NLRP3 inflammasome and autophagy deficiency of mesangial cells in diabetic nephropathy. Life Sci. 2023;330:121991. doi:10.1016/j.lfs.2023.121991
  • Holder B, Jones T, Sancho Shimizu V, et al. Macrophage exosomes induce placental inflammatory cytokines: a novel mode of maternal-placental messaging. Traffic. 2016;17(2):168–178. doi:10.1111/tra.12352
  • Jin Y, Wu R, Li L, Shen L, Gu Y, Sun C. Exosomes from Inflamed macrophages promote the progression of parkinson’s disease by inducing neuroinflammation. Mol Neurobiol. 2023;60(4):1914–1928. doi:10.1007/s12035-022-03179-6
  • Chen F, Li J, She J, Chen T, Yuan Z. Exosomal microRNA-16-5p from macrophage exacerbates atherosclerosis via modulating mothers against decapentaplegic homolog 7. Microvascular Res. 2022;142:104368. doi:10.1016/j.mvr.2022.104368
  • Singhto N, Kanlaya R, Nilnumkhum A, Thongboonkerd V. Roles of Macrophage Exosomes in Immune Response to Calcium Oxalate Monohydrate Crystals. Front Immunol. 2018;9:316. doi:10.3389/fimmu.2018.00316
  • Singhto N, Thongboonkerd V. Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix. J Proteom. 2018;185:64–76. doi:10.1016/j.jprot.2018.06.015
  • Jiao Y, Li Z, Loughran PA, et al. Frontline science: macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. J Leukocyte Biol. 2018;103(2):175–183. doi:10.1189/jlb.3HI0517-173R
  • Esser J, Gehrmann U, D’Alexandri FL, et al. Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration. J Allergy Clin Immunol. 2010;126(5):1032–40, 1040.e1–e4. doi:10.1016/j.jaci.2010.06.039
  • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Ann Rev Physiol. 2010;72:219–246. doi:10.1146/annurev-physiol-021909-135846
  • Liu YC, Zou XB, Chai YF, Yao YM. Macrophage polarization in inflammatory diseases. Int J Bio Sci. 2014;10(5):520–529. doi:10.7150/ijbs.8879
  • Bachwich PR, Chensue SW, Larrick JW, Kunkel SL. Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem Biophys Res Commun. 1986;136(1):94–101. doi:10.1016/0006-291x(86)90881-8
  • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006;124(2):263–266. doi:10.1016/j.cell.2006.01.007
  • Li M, Wang T, Tian H, Wei G, Zhao L, Shi Y. Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model. Artif Cells Nanomed Biotechnol. 2019;47(1):3793–3803. doi:10.1080/21691401.2019.1669617
  • Zhang B, Lin F, Dong J, Liu J, Ding Z, Xu J. Peripheral macrophage-derived exosomes promote repair after spinal cord injury by inducing local anti-inflammatory type microglial polarization via increasing autophagy. Int J Bio Sci. 2021;17(5):1339–1352. doi:10.7150/ijbs.54302
  • Xu M, Feng T, Liu B, et al. Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies. Theranostics. 2021;11(18):8926–8944. doi:10.7150/thno.62330
  • Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harbor Perspect Biol. 2009;1(6):a001651. doi:10.1101/cshperspect.a001651
  • McDonald MK, Tian Y, Qureshi RA, et al. Functional significance of macrophage-derived exosomes in inflammation and pain: erratum. Pain. 2022;163(2):e383–e384. doi:10.1097/j.pain.0000000000002533
  • Zheng Y, He R, Wang P, Shi Y, Zhao L, Liang J. Exosomes from LPS-stimulated macrophages induce neuroprotection and functional improvement after ischemic stroke by modulating microglial polarization. Biomater Sci. 2019;7(5):2037–2049. doi:10.1039/c8bm01449c
  • Ji G, Feng S, Ren H, Chen W, Chen R. Exosomes released from macrophages infected with Talaromyces marneffei activate the innate immune responses and decrease the replication. Immun inflam dis. 2023;11(6):e881. doi:10.1002/iid3.881
  • Phu TA, Ng M, Vu NK, Bouchareychas L, Raffai RL. IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity. Mol Ther. 2022;30(6):2274–2297. doi:10.1016/j.ymthe.2022.03.008
  • Bouchareychas L, Duong P, Covarrubias S, et al. Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA Cargo. Cell Rep. 2020;32(2):107881. doi:10.1016/j.celrep.2020.107881
  • Hwang HS, Kim H, Han G, et al. Extracellular vesicles as potential therapeutics for inflammatory diseases. Int J Mol Sci. 2021;22(11):5487.
  • Sil S, Dagur RS, Liao K, et al. Strategies for the use of extracellular vesicles for the delivery of therapeutics. J Neuroimmune Pharmacol. 2020;15(3):422–442. doi:10.1007/s11481-019-09873-y
  • Tang TT, Wang B, Lv LL, Liu BC. Extracellular vesicle-based nanotherapeutics: emerging frontiers in anti-inflammatory therapy. Theranostics. 2020;10(18):8111–8129. doi:10.7150/thno.47865
  • Gámbaro F, Li Calzi M, Fagúndez P, et al. Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner. RNA Biol. 2020;17(8):1168–1182. doi:10.1080/15476286.2019.1708548
  • Mehryab F, Rabbani S, Shahhosseini S, et al. Exosomes as a next-generation drug delivery system: an update on drug loading approaches, characterization, and clinical application challenges. Acta Biomater. 2020;113:42–62. doi:10.1016/j.actbio.2020.06.036
  • Xi XM, Xia SJ, Lu R. Drug loading techniques for exosome-based drug delivery systems. Die Pharmazie. 2021;76(2):61–67. doi:10.1691/ph.2021.0128
  • Vader P, Mol EA, Pasterkamp G, Schiffelers RM. Extracellular vesicles for drug delivery. Adv Drug Delivery Rev. 2016;106(Pt A):148–156. doi:10.1016/j.addr.2016.02.006
  • Haney MJ, Klyachko NL, Zhao Y, et al. Exosomes as drug delivery vehicles for Parkinson’s disease therapy. J Control Release. 2015;207:18–30. doi:10.1016/j.jconrel.2015.03.033
  • Xia W, Liu Y, Jiang X, et al. Lean adipose tissue macrophage derived exosome confers immunoregulation to improve wound healing in diabetes. J Nanobiotechnol. 2023;21(1):128. doi:10.1186/s12951-023-01869-4
  • Zhou M, Li B, Liu C, et al. M2 Macrophage-derived exosomal miR-501 contributes to pubococcygeal muscle regeneration. Int Immunopharmacol. 2021;101(Pt B):108223. doi:10.1016/j.intimp.2021.108223
  • Chen X, Wan Z, Yang L, et al. Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA. J Nanobiotechnol. 2022;20(1):110. doi:10.1186/s12951-022-01314-y
  • Liu K, Luo X, Lv ZY, et al. Macrophage-derived exosomes promote bone mesenchymal stem cells towards osteoblastic fate through microRNA-21a-5p. Front Bioeng Biotechnol. 2021;9:801432. doi:10.3389/fbioe.2021.801432
  • Deng F, Yan J, Lu J, et al. M2 macrophage-derived exosomal miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1/YAP/ β-Catenin signalling axis. J Crohn’s Colitis. 2021;15(4):665–677. doi:10.1093/ecco-jcc/jjaa214
  • Ban J, Liu F, Zhang Q, Chang S, Zeng X, Chen J. Macrophage-derived exosomal lncRNA MSTRG.91634.7 inhibits fibroblasts activation by targeting PINK1 in silica-induced lung fibrosis. Toxicol Lett. 2023;372:36–44. doi:10.1016/j.toxlet.2022.10.004
  • Wang P, Wang H, Huang Q, et al. Exosomes from M1-polarized macrophages enhance paclitaxel antitumor activity by activating macrophages-mediated inflammation. Theranostics. 2019;9(6):1714–1727. doi:10.7150/thno.30716
  • Wu G, Zhang J, Zhao Q, et al. Molecularly engineered macrophage-derived exosomes with inflammation tropism and intrinsic heme biosynthesis for atherosclerosis treatment. Angew Chem. 2020;59(10):4068–4074. doi:10.1002/anie.201913700
  • Piffoux M, Volatron J, Cherukula K, et al. Engineering and loading therapeutic extracellular vesicles for clinical translation: a data reporting frame for comparability. Adv Drug Delivery Rev. 2021;178:113972. doi:10.1016/j.addr.2021.113972
  • Silva AM, Lázaro-Ibáñez E, Gunnarsson A, et al. Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution. J Extracell Vesicles. 2021;10(10):e12130. doi:10.1002/jev2.12130
  • Elsharkasy OM, Nordin JZ, Hagey DW, et al. Extracellular vesicles as drug delivery systems: why and how? Adv Drug Delivery Rev. 2020;159:332–343. doi:10.1016/j.addr.2020.04.004
  • Cheng L, Wang Y, Huang L. Exosomes from M1-polarized macrophages potentiate the cancer vaccine by creating a pro-inflammatory microenvironment in the lymph node. Mol Ther. 2017;25(7):1665–1675. doi:10.1016/j.ymthe.2017.02.007
  • Zeng J, Gu C, Sun Y, Chen X. Engineering of M2 macrophages-derived exosomes via click chemistry for spinal cord injury repair. Adv Healthcare Mater. 2023;12(11):e2203391. doi:10.1002/adhm.202203391
  • Zeng J, Sun Z, Zeng F, Gu C, Chen X. M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing. Mater Today Bio. 2023;20:100649. doi:10.1016/j.mtbio.2023.100649
  • He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8(1):237–255. doi:10.7150/thno.21945
  • Deb A, Gupta S, Mazumder PB. Exosomes: a new horizon in modern medicine. Life Sci. 2021;264:118623. doi:10.1016/j.lfs.2020.118623
  • Ashrafizadeh M, Kumar AP, Aref AR, Zarrabi A, Mostafavi E. Exosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complications. Int j Nanomed. 2022;17:1229–1253. doi:10.2147/ijn.S350250
  • Zhang Y, Liu Y, Liu H, Tang WH. Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019;9:19. doi:10.1186/s13578-019-0282-2
  • Wang C, Xu M, Fan Q, Li C, Zhou X. Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases. Asian J Pharm Sci. 2023;18(1):100772. doi:10.1016/j.ajps.2022.100772
  • Taylor DD, Shah S. Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes. Methods. 2015;87:3–10. doi:10.1016/j.ymeth.2015.02.019
  • Lai JJ, Chau ZL, Chen SY, et al. Exosome Processing and Characterization Approaches for Research and Technology Development. Adv Sci. 2022;9(15):e2103222. doi:10.1002/advs.202103222
  • Batrakova EV, Kim MS. Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 2015;219:396–405. doi:10.1016/j.jconrel.2015.07.030
  • Wang C, Li Z, Liu Y, Yuan L. Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets. Theranostics. 2021;11(8):3996–4010. doi:10.7150/thno.56035
  • Lv K, Wang Y, Lou P, et al. Extracellular vesicles as advanced therapeutics for the resolution of organ fibrosis: current progress and future perspectives. Front Immunol. 2022;13:1042983. doi:10.3389/fimmu.2022.1042983
  • DiStefano TJ, Vaso K, Danias G, Chionuma HN, Weiser JR, Iatridis JC. Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations. Adv Healthcare Mater. 2022;11(5):e2100596. doi:10.1002/adhm.202100596
  • Witwer KW, Buzás EI, Bemis LT, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. 2013;2. doi:10.3402/jev.v2i0.20360
  • Mateescu B, Kowal EJ, van Balkom BW, et al. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. J Extracell Vesicles. 2017;6(1):1286095. doi:10.1080/20013078.2017.1286095