Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization

References

• Biesemann N, Margerie D, Asbrand C, et al. Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis. Sci Transl Med. 2023;15(681):eabq4419.
   PubMed Web of Science ®Google Scholar
• Yang Y, Guo L, Wang Z, et al. Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization. Biomaterials. 2021;264:120390.
   PubMed Web of Science ®Google Scholar
• Hoes JN, Jacobs JW, Buttgereit F, Bijlsma JW. Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis. Nat Rev Rheumatol. 2010;6(12):693–702.
   PubMed Web of Science ®Google Scholar
• Luo TT, Wu YJ, Yin Q, Chen WG, Zuo J. The Involvement of Glucose and Lipid Metabolism Alteration in Rheumatoid Arthritis and Its Clinical Implication. J Inflamm Res. 2023;16:1837–1852.
   PubMed Web of Science ®Google Scholar
• Liu D, Yuan N, Yu G, Song G, Chen Y. Can rheumatoid arthritis ever cease to exist: a review of various therapeutic modalities to maintain drug-free remission? Am J Transl Res. 2017;9(8):3758–3775.
   PubMed Web of Science ®Google Scholar
• Zhang S, Liu Y, Jing W, et al. Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice. Nat Commun. 2023;14(1):817.
   PubMed Web of Science ®Google Scholar
• Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol. 2011;12(11):1035–1044.
   PubMed Web of Science ®Google Scholar
• Kang S, Nakanishi Y, Kioi Y, et al. Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization. Nat Immunol. 2018;19(6):561–570.
   PubMed Web of Science ®Google Scholar
• Kim H, Back JH, Han G, et al. Extracellular vesicle-guided in situ reprogramming of synovial macrophages for the treatment of rheumatoid arthritis. Biomaterials. 2022;286:121578.
   PubMed Web of Science ®Google Scholar
• Cheng L, Wang Y, Wu R, et al. New Insights From Single-Cell Sequencing Data: synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis. Front Immunol. 2021;12:709178.
   PubMed Web of Science ®Google Scholar
• Smiljanovic B, Radzikowska A, Kuca-Warnawin E, et al. Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint. Ann Rheum Dis. 2018;77(2):300–308.
   PubMed Web of Science ®Google Scholar
• Alivernini S, MacDonald L, Elmesmari A, et al. Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nat Med. 2020;26(8):1295–1306.
   PubMed Web of Science ®Google Scholar
• Kurowska-Stolarska M, Alivernini S. Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nat Rev Rheumatol. 2022;18(7):384–397.
   PubMed Web of Science ®Google Scholar
• Culemann S, Gruneboom A, Nicolas-Avila JA, et al. Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019;572(7771):670–675.
   PubMed Web of Science ®Google Scholar
• Movsesian M. Novel approaches to targeting PDE3 in cardiovascular disease. Pharmacol Ther. 2016;163:74–81.
   PubMed Web of Science ®Google Scholar
• Degerman E, Ahmad F, Chung YW, et al. From PDE3B to the regulation of energy homeostasis. Curr Opin Pharmacol. 2011;11(6):676–682.
   PubMed Web of Science ®Google Scholar
• Ahmad F, Degerman E, Manganiello VC. Cyclic nucleotide phosphodiesterase 3 signaling complexes. Horm Metab Res. 2012;44(10):776–785.
   PubMed Web of Science ®Google Scholar
• Zuo Y, Xu H, Li Y, Zhang Z, Tao R, Wang M. Hsa_circ_0007707 participates in PDE3B-mediated apoptosis inhibition and inflammation promotion in fibroblast-like synoviocytes. Int Immunopharmacol. 2023;119:110157.
   PubMed Web of Science ®Google Scholar
• Wang R, Sun Y, Jin X, Wen W, Cao Y. Diosgenin Inhibits Excessive Proliferation and Inflammatory Response of Synovial Fibroblasts in Rheumatoid Arthritis by Targeting PDE3B. Inflammation. 2021;44(3):946–955.
   PubMed Web of Science ®Google Scholar
• Leuschner F, Dutta P, Gorbatov R, et al. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011;29(11):1005–1010.
   PubMed Web of Science ®Google Scholar
• Chen Q, Gao M, Li Z, et al. Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy. J Control Release. 2020;323:179–190.
   PubMed Web of Science ®Google Scholar
• Yan L, Hou C, Liu J, et al. Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization. Sci China Life Sci. 2023.
   Web of Science ®Google Scholar
• Wang Y, Zhang L, Wu GR, et al. MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program. Sci Adv. 2021;7(1).
   Web of Science ®Google Scholar
• Wu GR, Zhou M, Wang Y, et al. Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production. Front Immunol. 2022;13:930103.
   PubMed Web of Science ®Google Scholar
• Ngoune R, Contini C, Hoffmann MM, von Elverfeldt D, Winkler K, Putz G. Optimizing Antitumor Efficacy and Adverse Effects of Pegylated Liposomal Doxorubicin by Scheduled Plasmapheresis: impact of Timing and Dosing. Curr Drug Deliv. 2018;15(9):1261–1270.
   PubMed Web of Science ®Google Scholar
• Chen J, Chen J, Tan J, et al. HIF-1alpha dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo. J Orthop Translat. 2023;40:49–57.
   PubMed Web of Science ®Google Scholar
• Chen J, Tan J, Li J, et al. Genetically Engineered Biomimetic Nanoparticles for Targeted Delivery of mRNA to Treat Rheumatoid Arthritis. Small Methods. 2023;7(11):e2300678.
   PubMed Web of Science ®Google Scholar
• Chen J, Zeng S, Xue Q, et al. Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis. Proc Natl Acad Sci U S A. 2022;119(43):e2213373119.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang C, Meng J, et al. A Targeted Exosome Therapeutic Confers Both Cfdna Scavenging and Macrophage Polarization for Ameliorating Rheumatoid Arthritis. Adv Mater. 2023;e2302503.
   PubMed Web of Science ®Google Scholar
• Deng C, Zhang Q, He P, et al. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis. Nat Commun. 2021;12(1):2174.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang J, Zou Y, et al. Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus. Cell Death Differ. 2021;28(6):1880–1899.
   PubMed Web of Science ®Google Scholar
• Yuan Q, Zhao B, Cao YH, et al. BCR-Associated Protein 31 Regulates Macrophages Polarization and Wound Healing Function via Early Growth Response 2/C/EBPbeta and IL-4Ralpha/C/EBPbeta Pathways. J Immunol. 2022;209(6):1059–1070.
   PubMed Web of Science ®Google Scholar
• Zhang H, Kong Q, Wang J, Jiang Y, Hua H. Complex roles of cAMP-PKA-CREB signaling in cancer. Exp Hematol Oncol. 2020;9(1):32.
   PubMed Web of Science ®Google Scholar
• Hsu CG, Fazal F, Rahman A, Berk BC, Yan C. Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation. J Immunol. 2021;206(12):3010–3020.
   PubMed Web of Science ®Google Scholar
• Page CP, Spina D. Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol. 2012;12(3):275–286.
   PubMed Web of Science ®Google Scholar
• Movsesian M, Ahmad F, Hirsch E. Functions of PDE3 Isoforms in Cardiac Muscle. J Cardiovasc Dev Dis. 2018;5(1).
   PubMed Web of Science ®Google Scholar
• Wang Y, Han CC, Cui D, Li Y, Ma Y, Wei W. Is macrophage polarization important in rheumatoid arthritis? Int Immunopharmacol. 2017;50:345–352.
   PubMed Web of Science ®Google Scholar
• Peng Y, Zhou M, Yang H, et al. Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases. Mediators Inflamm. 2023;2023:8821610.
   PubMed Web of Science ®Google Scholar
• Liu PS, Wang H, Li X, et al. alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18(9):985–994.
   PubMed Web of Science ®Google Scholar
• Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov. 2014;13(4):290–314.
   PubMed Web of Science ®Google Scholar
• Bolger GB. The PDE-Opathies: diverse Phenotypes Produced by a Functionally Related Multigene Family. Trends Genet. 2021;37(7):669–681.
   PubMed Web of Science ®Google Scholar
• Ruffell D, Mourkioti F, Gambardella A, et al. A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci U S A. 2009;106(41):17475–17480.
   PubMed Web of Science ®Google Scholar
• Apparailly F, Jorgensen C. siRNA-based therapeutic approaches for rheumatic diseases. Nat Rev Rheumatol. 2013;9(1):56–62.
   PubMed Web of Science ®Google Scholar
• Kulkarni JA, Witzigmann D, Chen S, Cullis PR, van der Meel R. Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics. Acc Chem Res. 2019;52(9):2435–2444.
   PubMed Web of Science ®Google Scholar