Magnetic Graphene Oxide Nanocomposites Boosts Craniomaxillofacial Bone Regeneration by Modulating circAars/miR-128-3p/SMAD5 Signaling Axis

References

• ElHawary H, Baradaran A, Abi-Rafeh J, Vorstenbosch J, Xu L, Efanov JI. Bone healing and inflammation: principles of fracture and repair. Sem Plast Surg. 2021;35(3):198–203. doi:10.1055/s-0041-1732334
   PubMed Web of Science ®Google Scholar
• Chen Y, Xu J, Huang Z, et al. An innovative approach for enhancing bone defect healing using PLGA Scaffolds Seeded with extracorporeal-shock-wave-treated Bone Marrow Mesenchymal Stem Cells (BMSCs). Sci Rep. 2017;7(1):44130. doi:10.1038/srep44130
   PubMedGoogle Scholar
• Roseti L, Parisi V, Petretta M, et al. Scaffolds for bone tissue engineering: state of the art and new perspectives. Mater Sci Eng C Mater Biol Appl. 2017;78:1246–1262. doi:10.1016/j.msec.2017.05.017
   PubMed Web of Science ®Google Scholar
• Eini E, Ghaemi A, Rahim F. Bone using stem cells for maxillofacial bone disorders: a systematic review and meta-analysis. In: Advances in Experimental Medicine and Biology. Springer; 2022.
   Google Scholar
• Ma R, Su Y, Cao R, Wang K, Yang P. Enhanced osteogenic activity and bone repair ability of PLGA/MBG scaffolds doped with ZIF-8 nanoparticles loaded with BMP-2. Int J Nanomed. 2023;18:5055–5072. doi:10.2147/IJN.S423985
   PubMed Web of Science ®Google Scholar
• Dong Y, Yao L, Cai L, et al. Antimicrobial and pro-osteogenic coaxially electrospun magnesium oxide nanoparticles-polycaprolactone/parathyroid hormone-polycaprolactone composite barrier membrane for guided bone regeneration. Int J Nanomed. 2023;18:369–383. doi:10.2147/IJN.S395026
   PubMed Web of Science ®Google Scholar
• He Y, Yi C, Zhang XL, Zhao W, Yu DS. Magnetic graphene oxide: synthesis approaches, physicochemical characteristics, and biomedical applications. Trac-Trends Anal Chem. 2021;136:116191. doi:10.1016/j.trac.2021.116191
   Web of Science ®Google Scholar
• Zhang W, Yang G, Wang X, et al. Magnetically controlled growth-factor-immobilized multilayer cell sheets for complex tissue regeneration. Adv Mater. 2017;29(43). doi:10.1002/adma.201703795
   Web of Science ®Google Scholar
• Zhang H, Li S, Liu Y, et al. Fe(3)O(4)@GO magnetic nanocomposites protect mesenchymal stem cells and promote osteogenic differentiation of rat bone marrow mesenchymal stem cells. Biomater Sci. 2020;8(21):5984–5993. doi:10.1039/D0BM00906G
   PubMed Web of Science ®Google Scholar
• He Y, Chen G, Li Y, et al. Effect of magnetic graphene oxide on cellular behaviors and osteogenesis under a moderate static magnetic field, Nanomedicine. Nanotechnol Biol Med. 2021;37:102435. doi:10.1016/j.nano.2021.102435
   PubMed Web of Science ®Google Scholar
• Hombach S, Kretz M. Non-coding RNAs: classification, biology and functioning. Adv Exp Med Biol. 2016;937:3–17.
   PubMed Web of Science ®Google Scholar
• Yuan YG, Zhang YX, Liu SZ, et al. Multiple RNA profiling reveal epigenetic toxicity effects of oxidative stress by graphene oxide silver nanoparticles in-vitro. Int J Nanomed. 2023;18:2855–2871. doi:10.2147/IJN.S373161
   PubMed Web of Science ®Google Scholar
• Chen X, Peng Y, Xue H, Liu G, Wang N, Shao Z. MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models. J Nanobiotechnol. 2022;20(1):309. doi:10.1186/s12951-022-01516-4
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs, Nature reviews. Genetics. 2019;20(11):675–691. doi:10.1038/s41576-019-0158-7
   PubMed Web of Science ®Google Scholar
• Guo Z, Zhao L, Ji S, et al. CircRNA-23525 regulates osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-30a-3p. Cell Tissue Res. 2021;383(2):795–807. doi:10.1007/s00441-020-03305-7
   PubMed Web of Science ®Google Scholar
• Yang J, Cheng M, Gu B, Wang J, Yan S, Xu D. CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis. Cell Death Dis. 2020;11(10):833. doi:10.1038/s41419-020-03038-z
   PubMed Web of Science ®Google Scholar
• Huang HB, Luo HT, Wei NN, et al. Integrative analysis reveals a lineage-specific circular RNA landscape for adipo-osteogenesis of human mesenchymal stem cells. Stem Cell Res Ther. 2022;13(1):106. doi:10.1186/s13287-022-02792-5
   PubMed Web of Science ®Google Scholar
• Zhao X, Sun W, Guo B, Cui L. Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment. Stem Cell Res Ther. 2022;13(1):417. doi:10.1186/s13287-022-03093-7
   PubMed Web of Science ®Google Scholar
• Wang T, Li C, Shi M, Zhou S, Chen J, Wang F. Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis. Diabetol Metab Syndr. 2022;14(1):14. doi:10.1186/s13098-022-00787-z
   PubMed Web of Science ®Google Scholar
• Wang Y, Jiang Z, Yu M, Yang G. Roles of circular RNAs in regulating the self-renewal and differentiation of adult stem cells. Differentiation. 2020;113:10–18. doi:10.1016/j.diff.2020.03.001
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Okholm TLH, Veno MT, Kjems J. Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biol. 2018;15(2):280–291. doi:10.1080/15476286.2017.1409931
   PubMed Web of Science ®Google Scholar
• Liu CX, Li X, Nan F, et al. Structure and degradation of circular RNAs regulate PKR activation in innate immunity. Cell. 2019;177(4):865–880.e21. doi:10.1016/j.cell.2019.03.046
   PubMed Web of Science ®Google Scholar
• Chen X, Yang T, Wang W, et al. Circular RNAs in immune responses and immune diseases. Theranostics. 2019;9(2):588–607. doi:10.7150/thno.29678
   PubMed Web of Science ®Google Scholar
• Min X, Liu DL, Xiong XD. Circular RNAs as competing endogenous RNAs in cardiovascular and cerebrovascular diseases: molecular mechanisms and clinical implications. Front Cardiovasc Med. 2021;8:682357. doi:10.3389/fcvm.2021.682357
   PubMed Web of Science ®Google Scholar
• Zhang D, Ni N, Wang Y, et al. CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression. Cell Death Differ. 2020;28(1):283–302. doi:10.1038/s41418-020-0600-6
   PubMed Web of Science ®Google Scholar
• Panda AC. Circular RNAs act as miRNA sponges. Adv Exper Med Biol. 2018;1087:67–79.
   PubMed Web of Science ®Google Scholar
• Ping J, Li L, Dong Y, et al. The role of long non-coding RNAs and circular RNAs in bone regeneration: modulating miRNAs function. J Tissue Eng Regener Med. 2021;16(3):227–243. doi:10.1002/term.3277
   Web of Science ®Google Scholar
• Liu B, Mao N. Smad5: signaling roles in hematopoiesis and osteogenesis. Int J Biochem Cell Biol. 2004;36(5):766–770. doi:10.1016/S1357-2725(03)00250-4
   PubMed Web of Science ®Google Scholar
• Gu M, Wang X, Ding X. Pseudogene MSTO2P Interacts with miR-128-3p to regulate coptisine sensitivity of Non-Small-Cell Lung Cancer (NSCLC) through TGF-β signaling and VEGFC. J Oncol. 2022;2022:9864411. doi:10.1155/2022/9864411
   PubMed Web of Science ®Google Scholar
• Qian G, Zhang L, Li X, Shuai C, Wang X. Construction of Fe(3)O(4)-loaded mesoporous carbon systems for controlled drug delivery. ACS Appl Bio Mater. 2021;4(6):5304–5311. doi:10.1021/acsabm.1c00422
   PubMedGoogle Scholar
• Qian G, Mao Y, Zhao H, Zhang L, Xiong L, Long Z. pH-Responsive nanoplatform synergistic gas/photothermal therapy to eliminate biofilms in poly(L-lactic acid) scaffolds. J Mater Chem B. 2024;12(5):1379–1392. doi:10.1039/D3TB02600K
   PubMed Web of Science ®Google Scholar
• Qian G, Mao Y, Shuai Y, Zeng Z, Peng S, Shuai C. Enhancing bone scaffold interfacial reinforcement through in situ growth of metal-organic frameworks (MOFs) on strontium carbonate: achieving high strength and osteoimmunomodulation. J Colloid Interface Sci. 2024;655:43–57. doi:10.1016/j.jcis.2023.10.133
   PubMed Web of Science ®Google Scholar
• He Y, Shi F, Hu J, et al. Magnetic graphene oxide nanocomposites induce cytotoxicity in ADSCs via GPX4 regulating ferroptosis. Ecotoxicol Environ Saf. 2023;269:115745. doi:10.1016/j.ecoenv.2023.115745
   PubMed Web of Science ®Google Scholar
• Liu CH, Chen YJ, Wu WC, Lin YH. Magnetic graphene oxide nanoflakes for dual RNA interfering delivery and gene knockdown in prostate and liver cancers. Int J Biol Macromol. 2023;253(Pt 8):127357. doi:10.1016/j.ijbiomac.2023.127357
   PubMedGoogle Scholar
• Ma J, Zhang M, Ji M, et al. Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes. Int J Biol Macromol. 2021;193(Pt B):2221–2231. doi:10.1016/j.ijbiomac.2021.11.054
   PubMedGoogle Scholar
• Zhou P, Yan B, Wei B, et al. Quercetin-solid lipid nanoparticle-embedded hyaluronic acid functionalized hydrogel for immunomodulation to promote bone reconstruction. Regen Biomater. 2023;10:rbad025. doi:10.1093/rb/rbad025
   PubMed Web of Science ®Google Scholar
• Halling Linder C, Ek-Rylander B, Krumpel M, et al. Bone alkaline phosphatase and tartrate-resistant acid phosphatase: potential co-regulators of bone mineralization. Calcif Tissue Int. 2017;101(1):92–101. doi:10.1007/s00223-017-0259-2
   PubMed Web of Science ®Google Scholar
• Guan H, Kong N, Tian R, et al. Melatonin increases bone mass in normal, perimenopausal, and postmenopausal osteoporotic rats via the promotion of osteogenesis. J Transl Med. 2022;20(1):132. doi:10.1186/s12967-022-03341-7
   PubMed Web of Science ®Google Scholar
• He Y, Li Y, Chen G, et al. Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide. J Biomed Mater Res Part A. 2019;108(1):50–60. doi:10.1002/jbm.a.36791
   PubMed Web of Science ®Google Scholar
• Misir S, Wu N, Yang BB. Specific expression and functions of circular RNAs. Cell Death Differ. 2022;29(3):481–491. doi:10.1038/s41418-022-00948-7
   PubMed Web of Science ®Google Scholar
• Zhang S, Sun J, Gu M, Wang G, Wang X. Circular RNA: a promising new star for the diagnosis and treatment of colorectal cancer. Cancer Med. 2021;10(24):8725–8740. doi:10.1002/cam4.4398
   PubMed Web of Science ®Google Scholar
• Rong Z, Xu J, Shi S, et al. Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment. Theranostics. 2021;11(6):2755–2769. doi:10.7150/thno.56174
   PubMed Web of Science ®Google Scholar
• Huang W, Wu Y, Qiao M, et al. CircRNA-miRNA networks in regulating bone disease. J Cell Physiol. 2021;237(2):1225–1244. doi:10.1002/jcp.30625
   PubMed Web of Science ®Google Scholar
• Chen Z, Lin W, Zhao S, et al. Identification of circRNA expression profiles in BMSCs from glucocorticoid-induced osteoporosis model. Stem Cells Int. 2022;2022:3249737. doi:10.1155/2022/3249737
   PubMed Web of Science ®Google Scholar
• Zhang M, He Y, Zhang X, et al. Engineered cell-overexpression of circular RNA hybrid hydrogels promotes healing of calvarial defects. Biomater Sci. 2023;11(5):1665–1676. doi:10.1039/D2BM01472F
   PubMed Web of Science ®Google Scholar
• Mohanapriya R, Akshaya RL, Selvamurugan N. A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation. Biochimie. 2021;193:137–147. doi:10.1016/j.biochi.2021.11.001
   PubMed Web of Science ®Google Scholar
• Chen G, Li Y, He Y, et al. Upregulation of circular RNA circATRNL1 to sensitize oral squamous cell carcinoma to irradiation. Mol Ther Nucleic Acids. 2020;19:961–973. doi:10.1016/j.omtn.2019.12.031
   PubMedGoogle Scholar
• Ouyang Z, Tan T, Zhang X, et al. CircRNA hsa_circ_0074834 promotes the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by acting as a ceRNA for miR-942-5p. Cell Death Dis. 2019;10(12):932. doi:10.1038/s41419-019-2161-5
   PubMed Web of Science ®Google Scholar
• Chen G, Wang Q, Li Z, et al. Circular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head. Bone. 2020;133:115258. doi:10.1016/j.bone.2020.115258
   PubMed Web of Science ®Google Scholar
• Moghaddam T, Neshati Z. Role of microRNAs in osteogenesis of stem cells. J Cell Biochem. 2019;120(8):14136–14155. doi:10.1002/jcb.28689
   PubMed Web of Science ®Google Scholar
• Lv Y, Huang Y, Xu M, et al. The miR-193a-3p-MAP3k3 signaling axis regulates substrate topography-induced osteogenesis of bone marrow stem cells. Adv Sci. 2020;7(1):1901412. doi:10.1002/advs.201901412
   Web of Science ®Google Scholar
• Yan J, Lu X, Zhu X, et al. Effects of miR-26a on osteogenic differentiation of bone marrow mesenchymal stem cells by a mesoporous silica nanoparticle - PEI - Peptide System. Int J Nanomed. 2020;15:497–511. doi:10.2147/IJN.S228797
   PubMed Web of Science ®Google Scholar
• Xu T, Luo Y, Wang J, et al. Exosomal miRNA-128-3p from mesenchymal stem cells of aged rats regulates osteogenesis and bone fracture healing by targeting Smad5. J Nanobiotechnol. 2020;18(1):47. doi:10.1186/s12951-020-00601-w
   PubMed Web of Science ®Google Scholar
• Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth Factors. 2004;22(4):233–241. doi:10.1080/08977190412331279890
   PubMed Web of Science ®Google Scholar