Staphylococcus Aureus Membrane Vesicles Kill Tumor Cells Through a Caspase-1-Dependent Pyroptosis Pathway

References

• Negura I, Pavel-Tanasa M, Danciu M. Regulatory T cells in gastric cancer: key controllers from pathogenesis to therapy. Cancer Treat Rev. 2023;120:102629. doi:10.1016/j.ctrv.2023.102629
   PubMed Web of Science ®Google Scholar
• Grafanaki K, Grammatikakis I, Ghosh A, et al. Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response. Pharmacol Ther. 2023;248:108466. doi:10.1016/j.pharmthera.2023.108466
   PubMed Web of Science ®Google Scholar
• Rudnicki Y, Stapleton SM, Batra R, et al. Perianal Paget’s-an aggressive disease. Colorectal Dis. 2023;25(6):1213–1221. doi:10.1111/codi.16549
   PubMed Web of Science ®Google Scholar
• Jia Y, Wang X, Deng Y, et al. Pyroptosis provides new strategies for the treatment of cancer. J Cancer. 2023;14(1):140–151. doi:10.7150/jca.77965
   PubMed Web of Science ®Google Scholar
• Caproni E, Corbellari R, Tomasi M, et al. Anti-tumor efficacy of in situ vaccination using bacterial outer membrane vesicles. Cancers. 2023;15(13):3328. doi:10.3390/cancers15133328
   PubMed Web of Science ®Google Scholar
• Lucas MW, Versluis JM, Rozeman EA, Blank CU. Personalizing neoadjuvant immune-checkpoint inhibition in patients with melanoma. Nat Rev Clin Oncol. 2023;20(6):408–422. doi:10.1038/s41571-023-00760-3
   PubMed Web of Science ®Google Scholar
• Zhang Z, He C, Chen X. Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine. Adv Mater. 2023;1:e2308894. doi:10.1002/adma.202308894
   Google Scholar
• Toyofuku M, Nomura N, Eberl L. Types and origins of bacterial membrane vesicles. Nat Rev Microbiol. 2019;17(1):13–24. doi:10.1038/s41579-018-0112-2
   PubMed Web of Science ®Google Scholar
• Knox KW, Vesk M, Work E. Relation between excreted lipopolysaccharide complexes and surface structures of a lysine-limited culture of Escherichia coli. J Bacteriol. 1966;92(4):1206–1217. doi:10.1128/jb.92.4.1206-1217.1966
   PubMed Web of Science ®Google Scholar
• Kulp A, Kuehn MJ. Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol. 2010;64:163–184. doi:10.1146/annurev.micro.091208.073413
   PubMed Web of Science ®Google Scholar
• Kim OY, Park HT, Dinh NTH, et al. Bacterial outer membrane vesicles suppress tumor by interferon-gamma-mediated antitumor response. Nat Commun. 2017;8(1):626. doi:10.1038/s41467-017-00729-8
   PubMedGoogle Scholar
• Jiang S, Fu W, Wang S, et al. Bacterial outer membrane vesicles loaded with perhexiline suppress tumor development by regulating tumor-associated macrophages repolarization in a synergistic way. Int J Mol Sci. 2023;24(13):11222. doi:10.3390/ijms241311222
   PubMed Web of Science ®Google Scholar
• Jin L, Zhang Z, Tan X, et al. Antitumor effect of Escherichia coli-derived outer membrane vesicles on neuroblastoma in vitro and in vivo. Acta Biochim Biophys Sin. 2022;54(9):1301–1313. doi:10.3724/abbs.2022127
   Google Scholar
• Ren C, Li Y, Cong Z, et al. Bioengineered bacterial outer membrane vesicles encapsulated Polybia-mastoparan I fusion peptide as a promising nanoplatform for bladder cancer immune-modulatory chemotherapy. Front Immunol. 2023;14:1129771. doi:10.3389/fimmu.2023.1129771
   PubMed Web of Science ®Google Scholar
• Li M, Zhou H, Yang C, et al. Bacterial outer membrane vesicles as a platform for biomedical applications: an update. J Control Release. 2020;323:253–268. doi:10.1016/j.jconrel.2020.04.031
   PubMed Web of Science ®Google Scholar
• Briaud P, Carroll RK. Extracellular vesicle biogenesis and functions in Gram-positive bacteria. Infect Immun. 2020;88. doi:10.1128/IAI.00433-20
   Web of Science ®Google Scholar
• Long Q, Zheng P, Zheng X, et al. Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy. Adv Drug Deliv Rev. 2022;186:114321. doi:10.1016/j.addr.2022.114321
   PubMed Web of Science ®Google Scholar
• Wang X, Eagen WJ, Lee JC. Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles. Proc Natl Acad Sci USA. 2020;117(6):3174–3184. doi:10.1073/pnas.1915829117
   PubMed Web of Science ®Google Scholar
• Lee EY, Choi DY, Kim DK, et al. Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Proteomics. 2009;9(24):5425–5436.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Wang L, Yang B, et al. Bifidobacterium-derived membrane vesicles inhibit triple-negative breast cancer growth by inducing tumor cell apoptosis. Mol Biol Rep. 2023;50(9):7547–7556. doi:10.1007/s11033-023-08702-z
   PubMed Web of Science ®Google Scholar
• Abedi A, Tafvizi F, Jafari P, Akbari N. The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis. Sci Rep. 2024;14(1):3100. doi:10.1038/s41598-024-53773-y
   PubMed Web of Science ®Google Scholar
• Codemo M, Muschiol S, Iovino F, et al. Immunomodulatory effects of pneumococcal extracellular vesicles on cellular and humoral host defenses. mBio. 2018;9(2):e00559–18. doi:10.1128/mBio.00559-18
   PubMed Web of Science ®Google Scholar
• Yuan J, Yang J, Hu Z, et al. Safe staphylococcal platform for the development of multivalent nanoscale vesicles against viral infections. Nano Lett. 2018;18(2):725–733. doi:10.1021/acs.nanolett.7b03893
   PubMed Web of Science ®Google Scholar
• Qing S, Lyu C, Zhu L, et al. Biomineralized bacterial outer membrane vesicles potentiate safe and efficient tumor microenvironment reprogramming for anticancer therapy. Adv Mater. 2020;32(47):e2002085.
   PubMed Web of Science ®Google Scholar
• Shang W, Hu Z, Li M, et al. Optimizing a high‐sensitivity NanoLuc‐based bioluminescence system for in vivo evaluation of antimicrobial treatment. mLife. 2023. doi:10.1002/mlf2.12091
   Google Scholar
• Shang W, Rao Y, Zheng Y, et al. beta-Lactam antibiotics enhance the pathogenicity of methicillin-resistant Staphylococcus aureus via SarA-controlled lipoprotein-like cluster expression. mBio. 2019;10(3):e00880–19. doi:10.1128/mBio.00880-19
   PubMed Web of Science ®Google Scholar
• Su Y, Walker JR, Park Y, et al. Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nat Methods. 2020;17(8):852–860. doi:10.1038/s41592-020-0889-6
   PubMed Web of Science ®Google Scholar
• Chen J, Lv Y, Shang W, et al. Loaded delta-hemolysin shapes the properties of Staphylococcus aureus membrane vesicles. Front Microbiol. 2023;14:1254367. doi:10.3389/fmicb.2023.1254367
   PubMed Web of Science ®Google Scholar
• Li Y, Shen Y, Jin K, et al. The DNA repair nuclease MRE11A functions as a mitochondrial protector and prevents T cell pyroptosis and tissue inflammation. Cell Metab. 2019;30(3):477–492.e6. doi:10.1016/j.cmet.2019.06.016
   PubMed Web of Science ®Google Scholar
• Hosseini-Giv N, Basas A, Hicks C, et al. Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer. Front Cell Infect Microbiol. 2022;12:962216. doi:10.3389/fcimb.2022.962216
   PubMed Web of Science ®Google Scholar
• Milling L, Zhang Y, Irvine DJ. Delivering safer immunotherapies for cancer. Adv Drug Deliv Rev. 2017;114:79–101. doi:10.1016/j.addr.2017.05.011
   PubMed Web of Science ®Google Scholar
• Aytar Celik P, Derkus B, Erdogan K, et al. Bacterial membrane vesicle functions, laboratory methods, and applications. Biotechnol Adv. 2022;54:107869. doi:10.1016/j.biotechadv.2021.107869
   PubMed Web of Science ®Google Scholar
• Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–665. doi:10.1038/nature15514
   PubMed Web of Science ®Google Scholar
• Jan AT. Outer membrane vesicles (OMVs) of Gram-negative bacteria: a perspective update. Front Microbiol. 2017;8:1053. doi:10.3389/fmicb.2017.01053
   PubMed Web of Science ®Google Scholar
• Diep BA, Gill SR, Chang RF, et al. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet. 2006;367(9512):731–739. doi:10.1016/S0140-6736(06)68231-7
   PubMed Web of Science ®Google Scholar
• Fan R, Zhou Y, Chen X, et al. Porphyromonas gingivalis outer membrane vesicles promote apoptosis via msRNA-regulated DNA methylation in periodontitis. Microbiol Spectr. 2023;11(1):e0328822. doi:10.1128/spectrum.03288-22
   PubMed Web of Science ®Google Scholar
• Rivera J, Cordero RJB, Nakouzi AS, et al. Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins. Proc Natl Acad Sci USA. 2010;107(44):19002–19007. doi:10.1073/pnas.1008843107
   PubMed Web of Science ®Google Scholar
• Hikita T, Miyata M, Watanabe R, Oneyama C. Sensitive and rapid quantification of exosomes by fusing luciferase to exosome marker proteins. Sci Rep. 2018;8(1):14035. doi:10.1038/s41598-018-32535-7
   PubMedGoogle Scholar
• Hikita T, Miyata M, Watanabe R, Oneyama C. In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter. Sci Rep. 2020;10(1):16616. doi:10.1038/s41598-020-73580-5
   PubMed Web of Science ®Google Scholar
• Wang X, Thompson CD, Weidenmaier C, Lee JC. Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform. Nat Commun. 2018;9(1):1379. doi:10.1038/s41467-018-03847-z
   PubMedGoogle Scholar
• Munoz-Planillo R, Kuffa P, Martinez-Colon G, et al. K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 2013;38(6):1142–1153. doi:10.1016/j.immuni.2013.05.016
   PubMed Web of Science ®Google Scholar