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ORIGINAL RESEARCH

Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis

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Pages 3259-3273 | Received 28 Dec 2023, Accepted 25 Mar 2024, Published online: 05 Apr 2024

References

  • McInnes IB, Schett G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet. 2017;389(10086):2328–2337. doi:10.1016/S0140-6736(17)31472-1
  • Mateen S, Zafar A, Moin S, Khan AQ, Zubair S. Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clin Chim Acta. 2016;455:161–171. doi:10.1016/j.cca.2016.02.010
  • Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038. doi:10.1016/S0140-6736(16)30173-8
  • Zhang L, Zhang Y, Pan J. Immunopathogenic mechanisms of rheumatoid arthritis and the use of anti-inflammatory drugs. Intractable Rare Dis Res. 2021;10(3):154–164. doi:10.5582/irdr.2021.01022
  • Tardito S, Martinelli G, Soldano S, et al. Macrophage M1/M2 polarization and rheumatoid arthritis: a systematic review. Autoimmun Rev. 2019;18(11):102397. doi:10.1016/j.autrev.2019.102397
  • Zheng X, Yu X, Wang C, et al. Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy. Drug Deliv. 2022;29(1):1025–1037. doi:10.1080/10717544.2022.2057616
  • Boutet MA, Courties G, Nerviani A, et al. Novel insights into macrophage diversity in rheumatoid arthritis synovium. Autoimmun Rev. 2021;20(3):102758. doi:10.1016/j.autrev.2021.102758
  • Liu W, Zhang Y, Zhu W, et al. Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets. Front Immunol. 2018;9:2228. doi:10.3389/fimmu.2018.02228
  • Goyal A, Agrawal N. Quercetin: a Potential Candidate for the Treatment of Arthritis. Curr Mol Med. 2022;22(4):325–335. doi:10.2174/1566524021666210315125330
  • Shen P, Lin W, Deng X, et al. Potential Implications of Quercetin in Autoimmune Diseases. Front Immunol. 2021;12:689044. doi:10.3389/fimmu.2021.689044
  • Kumazawa Y, Kawaguchi K, Takimoto H. Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. Curr Pharm Des. 2006;12(32):4271–4279. doi:10.2174/138161206778743565
  • Tang M, Zeng Y, Peng W, et al. Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis. Drug Des Devel Ther. 2022;16:2043–2053. doi:10.2147/DDDT.S364759
  • Gokhale JP, Mahajan HS, Surana SJ. Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: in vivo and in vitro studies. Biomed Pharmacother. 2019;112:108622. doi:10.1016/j.biopha.2019.108622
  • Wang K, Yin C, Ye X, et al. A Metabolic Driven Bio-Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis. Small. 2023;19(21):e2207319. doi:10.1002/smll.202207319
  • Canavan M, Marzaioli V, McGarry T, et al. Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells. Clin Exp Immunol. 2020;202(2):226–238. doi:10.1111/cei.13479
  • Nakashima-Matsushita N, Homma T, Yu S, et al. Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 1999;42(8):1609–1616. doi:10.1002/1529-0131(199908)42:8
  • Nogueira E, Sárria MP, Azoia NG, et al. Internalization of Methotrexate Conjugates by Folate Receptor-α. Biochemistry. 2018;57(49):6780–6786. doi:10.1021/acs.biochem.8b00607
  • Angulo-Pachón CA, Pozo V, Miravet JF. Alkaline cations dramatically control molecular hydrogelation by an amino acid-derived anionic amphiphile. J Colloid Interface Sci. 2023;635:524–534. doi:10.1016/j.jcis.2022.12.134
  • Palsson-McDermott EM. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65–80. doi:10.1016/j.cmet.2014.12.005
  • Yao Q, Liu Y, Kou L, Tu Y, Tang X, Zhu L. Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles. Nanomedicine. 2019;19:71–80. doi:10.1016/j.nano.2019.03.012
  • Dai Z, Tu Y, Zhu L. Multifunctional Micellar Nanocarriers for Tumor-Targeted Delivery of Hydrophobic Drugs. J Biomed Nanotechnol. 2016;12(6):1199–1210. doi:10.1166/jbn.2016.2249
  • Zhang X, Xu X, Chen J, et al. Identification of HHT-9041P1: a novel potent and selective JAK1 inhibitor in a rat model of rheumatoid arthritis. Int Immunopharmacol. 2023;125(Pt A):111086. doi:10.1016/j.intimp.2023.111086
  • Yu C, Liu H, Guo C, et al. Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis. Drug Deliv. 2022;29(1):454–465. doi:10.1080/10717544.2022.2032482
  • Guo RB, Zhang XY, Yan DK, et al. Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy. Biomater Sci. 2022;10(2):499–513. doi:10.1039/d1bm01520f
  • Zhu W, Song Z, Wei P, et al. Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin. J Colloid Interface Sci. 2015;443:1–7. doi:10.1016/j.jcis.2014.11.073
  • Liu Y, Xie B, Li L, et al. PEGylated lipid microspheres loaded with cabazitaxel for intravenous administration: stability, bioavailability, antitumor efficacy, and toxicity. Drug Deliv Transl Res. 2018;8(5):1365–1379. doi:10.1007/s13346-018-0562-0
  • Yang S, Zhao M, Jia S. Macrophage: key player in the pathogenesis of autoimmune diseases. Front Immunol. 2023;14:1080310. doi:10.3389/fimmu.2023.1080310
  • Song Y, Gao N, Yang Z, et al. Characteristics, polarization and targeted therapy of mononuclear macrophages in rheumatoid arthritis. Am J Transl Res. 2023;15(3):2109–2121.
  • Kong JS, Jeong GH, Yoo SA. The use of animal models in rheumatoid arthritis research. J Yeungnam Med Sci. 2023;40(1):23–29. doi:10.12701/jyms.2022.00773
  • Jia N, Gao Y, Li M, et al. Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms. Signal Transduct Target Ther. 2023;8(1):280. doi:10.1038/s41392-023-01499-0
  • Li Y, Liang Q, Zhou L, et al. An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1α/NF-κB cascade regulation of ROS scavenging and macrophage repolarization. Acta Biomater. 2022;152:406–424. doi:10.1016/j.actbio.2022.08.054