Stem Cell-Derived Extracellular Vesicles: Promising Therapeutic Opportunities for Diabetic Wound Healing

References

• Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9(4):244–253. doi:10.1038/nrmicro2537
   PubMed Web of Science ®Google Scholar
• Mascharak S, Talbott HE, Januszyk M, et al. Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing. Cell Stem Cell. 2022;29(2):315–327.e6. doi:10.1016/j.stem.2021.12.011
   PubMed Web of Science ®Google Scholar
• Zheng Y, Ma S, Huang Q, et al. Meta-Analysis of the Efficacy and Safety of Finerenone in Diabetic Kidney Disease. Kidney Blood Press Res. 2022;47(4):219–228. doi:10.1159/000521908
   PubMed Web of Science ®Google Scholar
• Cao J, Zhao C, Gong L, et al. MiR-181 Enhances Proliferative and Migratory Potentials of Retinal Endothelial Cells in Diabetic Retinopathy by Targeting KLF6. Curr Eye Res. 2022;47(6):882–888. doi:10.1080/02713683.2022.2039206
   PubMed Web of Science ®Google Scholar
• Li J, Wang X, Mao H, et al. Precision therapy for three Chinese families with maturity-onset diabetes of the young (MODY12). Front Endocrinol (Lausanne). 2022;13(13):858096. doi:10.3389/fendo.2022.858096
   PubMedGoogle Scholar
• Zhu S, Li J, Zhao X. Comparative risk of new-onset hyperkalemia for antihypertensive drugs in patients with diabetic nephropathy: a Bayesian network meta-analysis. Int J Clin Pract. 2021;75(8). doi:10.1111/ijcp.13940
   Web of Science ®Google Scholar
• Chang M, Nguyen TT. Strategy for Treatment of Infected Diabetic Foot Ulcers. Acc Chem Res. 2021;54(5):1080–1093. doi:10.1021/acs.accounts.0c00864
   PubMed Web of Science ®Google Scholar
• Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019;10(1):68. doi:10.1186/s13287-019-1165-5
   PubMedGoogle Scholar
• Bacakova L, Zarubova J, Travnickova M, et al. Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells – a review. Biotechnol Adv. 2018;36(4):1111–1126. doi:10.1016/j.biotechadv.2018.03.011
   PubMed Web of Science ®Google Scholar
• Liu XY, Yang LP, Zhao L. Stem cell therapy for Alzheimer’s disease. World J Stem Cells. 2020;12(8):787–802. doi:10.4252/WJSC.V12.I8.787
   PubMed Web of Science ®Google Scholar
• Nguyen PK, Rhee JW, Wu JC. Adult stem cell therapy and heart failure, 2000 to 2016: a systematic review. JAMA Cardiol. 2016;1(7):831–841. doi:10.1001/jamacardio.2016.2225
   PubMed Web of Science ®Google Scholar
• Qi X, Zhang J, Yuan H, et al. Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats. Int J Biol Sci. 2016;12(7):836–849. doi:10.7150/ijbs.14809
   PubMed Web of Science ®Google Scholar
• Mazini L, Rochette L, Admou B, Amal S, Malka G. Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing. Int J Mol Sci. 2020;21(4):1306. doi:10.3390/ijms21041306
   PubMed Web of Science ®Google Scholar
• Jiang M, Jiang X, Li H, et al. The role of mesenchymal stem cell-derived EVs in diabetic wound healing. Front Immunol. 2023;14:1136098. doi:10.3389/fimmu.2023.1136098
   PubMed Web of Science ®Google Scholar
• Mulcahy LA, Pink RC, Carter DRF. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014;3. doi:10.3402/jev.v3.24641
   Google Scholar
• Watanabe Y, Tsuchiya A, Terai S. The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future. Clin Mol Hepatol. 2020;27(1):70–80. doi:10.3350/cmh.2020.0194
   PubMed Web of Science ®Google Scholar
• Zhou C, Zhang B, Yang Y, et al. Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing. Stem Cell Res Ther. 2023;14(1):107. doi:10.1186/s13287-023-03345-0
   PubMed Web of Science ®Google Scholar
• Rong Y, Wang Z, Tang P, et al. Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury. Bioact Mater. 2023;23:328–342. doi:10.1016/j.bioactmat.2022.11.011
   PubMed Web of Science ®Google Scholar
• Li S, Sun J, Yang J, et al. Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin. Biomater Res. 2023;27(1):11. doi:10.1186/s40824-023-00352-3
   PubMedGoogle Scholar
• Kou M, Huang L, Yang J, et al. Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Cell Death Dis. 2022;13(7):580. doi:10.1038/s41419-022-05034-x
   PubMed Web of Science ®Google Scholar
• Deng H, Chen Y. The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: trends and prospects. Front Endocrinol (Lausanne). 2022;13:902130. doi:10.3389/fendo.2022.902130
   PubMed Web of Science ®Google Scholar
• Xu J, Chen Q, Tian K, et al. m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation. Oncol Rep. 2020;44(3):973–986. doi:10.3892/or.2020.7665
   PubMed Web of Science ®Google Scholar
• Ding L, Lu S, Zhou Y, et al. The 3′ Untranslated Region Protects the Heart from Angiotensin II-Induced Cardiac Dysfunction via AGGF1 Expression. Mol Ther. 2020;28(4):1119–1132. doi:10.1016/j.ymthe.2020.02.002
   PubMed Web of Science ®Google Scholar
• Xiong T, Xia L, Song Q. Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients. J Clin Lab Anal. 2023;37(3):e24835. doi:10.1002/jcla.24835
   PubMed Web of Science ®Google Scholar
• Duan F, Zeng W, Zhang Y, Li D, Wu K. Lipopolysaccharide enhances HSV-1 replication and inflammatory factor release in the ARPE-19 cells. Heliyon. 2022;8(11). doi:10.1016/j.heliyon.2022.e11787
   Web of Science ®Google Scholar
• Kong X, Patel NA, Chalfant CE, Cooper DR. Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function. Cell Commun Signal. 2023;21(1):221. doi:10.1186/s12964-022-00900-9
   PubMed Web of Science ®Google Scholar
• Zhang Y, Bai X, Shen K, et al. Exosomes Derived from Adipose Mesenchymal Stem Cells Promote Diabetic Chronic Wound Healing through SIRT3/SOD2. Cells. 2022;11(16):2568. doi:10.3390/cells11162568
   PubMed Web of Science ®Google Scholar
• Ren S, Chen J, Guo J, et al. Exosomes from Adipose Stem Cells Promote Diabetic Wound Healing through the eHSP90/LRP1/AKT Axis. Cells. 2022;11(20):3229. doi:10.3390/cells11203229
   PubMed Web of Science ®Google Scholar
• Wang G, Zeng L, Gong C, Gong X, Zhu T, Zhu Y. Extracellular vesicles derived from mouse adipose-derived mesenchymal stem cells promote diabetic corneal epithelial wound healing through NGF/TrkA pathway activation involving dendritic cells. Exp Eye Res. 2023;231:109484. doi:10.1016/j.exer.2023.109484
   PubMed Web of Science ®Google Scholar
• Zhao B, Zhang X, Zhang Y, et al. Human Exosomes Accelerate Cutaneous Wound Healing by Promoting Collagen Synthesis in a Diabetic Mouse Model. Stem Cells Dev. 2021;30(18):922–933. doi:10.1089/scd.2021.0100
   PubMed Web of Science ®Google Scholar
• Wang Wen J, Zhu Zheng Y, Hu X, et al. Extracellular Vesicles Derived from Adipose-Derived Stem Cells Accelerate Diabetic Wound Healing by Suppressing the Expression of Matrix Metalloproteinase-9. Curr Pharm Biotechnol. 2022;23(6):894–901. doi:10.2174/1389201022666210719154009
   PubMed Web of Science ®Google Scholar
• Xiao S, Xiao C, Miao Y, et al. Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing. Stem Cell Res Ther. 2021;12(1):255. doi:10.1186/s13287-021-02333-6
   PubMed Web of Science ®Google Scholar
• Weng L, Ye J, Yang F, et al. TGF-β1/SMAD3 Regulates Programmed Cell Death 5 That Suppresses Cardiac Fibrosis Post-Myocardial Infarction by Inhibiting HDAC3. Circ Res. 2023;133(3):237–251. doi:10.1161/CIRCRESAHA.123.322596
   PubMed Web of Science ®Google Scholar
• Hsu HH, Wang AYL, Loh CYY, Pai AA, Kao HK. Therapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice. Pharmaceutics. 2022;14(6):1206. doi:10.3390/pharmaceutics14061206
   PubMed Web of Science ®Google Scholar
• Wang JW, Zhu YZ, Ouyang JY, et al. Adipose-Derived Stem Cell Extracellular Vesicles Improve Wound Closure and Angiogenesis in Diabetic Mice. Plast Reconstr Surg. 2023;151(2):331–342. doi:10.1097/PRS.0000000000009840
   PubMed Web of Science ®Google Scholar
• Liu W, Yuan Y, Liu D. Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway. Tissue Eng Regen Med. 2021;18(6):1035–1044. doi:10.1007/s13770-021-00383-8
   PubMed Web of Science ®Google Scholar
• Li J, He D, Bi Y, Liu S. The Emerging Roles of Exosomal miRNAs in Breast Cancer Progression and Potential Clinical Applications. Breast Cancer Targets Ther. 2023;15:825–840. doi:10.2147/BCTT.S432750
   PubMed Web of Science ®Google Scholar
• Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, Ghaffari SH. An overview of microRNAs: biology, functions, therapeutics, and analysis methods. J Cell Physiol. 2019;234(5):5451–5465. doi:10.1002/jcp.27486
   PubMed Web of Science ®Google Scholar
• Desdín-Micó G, Mittelbrunn M. Role of exosomes in the protection of cellular homeostasis. Cell Adhes Migr. 2017;11(2):127–134. doi:10.1080/19336918.2016.1251000
   PubMed Web of Science ®Google Scholar
• Lv Q, Deng J, Chen Y, Wang Y, Liu B, Liu J. Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing. Mol Pharm. 2020;17(5):1723–1733. doi:10.1021/acs.molpharmaceut.0c00177
   PubMed Web of Science ®Google Scholar
• Ge L, Wang K, Lin H, et al. Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction. Front Bioeng Biotechnol. 2023;11:1129538. doi:10.3389/fbioe.2023.1129538
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang W, Zhu W, et al. Mechanisms and functions of long non-coding RNAs at multiple regulatory levels. Int J Mol Sci. 2019;20(22):5573. doi:10.3390/ijms20225573
   PubMed Web of Science ®Google Scholar
• Yang Q, Fang D, Chen J, et al. LncRNAs associated with oxidative stress in diabetic wound healing: regulatory mechanisms and application prospects. Theranostics. 2023;13(11):3655–3674. doi:10.7150/thno.85823
   PubMed Web of Science ®Google Scholar
• Qiu J, Shu C, Li X, Ye C, Zhang WC. Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation. Diabet Res Clin Pract. 2021;180:109032. doi:10.1016/j.diabres.2021.109032
   PubMed Web of Science ®Google Scholar
• Pi L, Yang L, Fang BR. LncRNA MALAT1 from human adipose-derived stem cell exosomes accelerates wound healing via miR-378a/FGF2 axis. Regener Med. 2022;17(9):627–641. doi:10.2217/rme-2021-0170
   PubMed Web of Science ®Google Scholar
• He X, Xu T, Hu W, et al. Circular RNAs: their Role in the Pathogenesis and Orchestration of Breast Cancer. Front Cell Dev Biol. 2021;9:647736. doi:10.3389/fcell.2021.647736
   PubMed Web of Science ®Google Scholar
• Wang Z, Feng C, Liu H, et al. Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation. World J Stem Cells. 2023;15(5):476–489. doi:10.4252/wjsc.v15.i5.476
   PubMed Web of Science ®Google Scholar
• Liang ZH, Pan NF, Lin SS, et al. Exosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4/p38MAPK pathway. Stem Cell Res Ther. 2022;13(1):336. doi:10.1186/s13287-022-03015-7
   PubMed Web of Science ®Google Scholar
• Shi R, Jin Y, Hu W, et al. Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy. Am J Physiol Physiol. 2020;318(5):C848–C856. doi:10.1152/ajpcell.00041.2020
   PubMed Web of Science ®Google Scholar
• Zhang D, Lv FL, Wang GH. Effects of HIF-1α on diabetic retinopathy angiogenesis and VEGF expression. Eur Rev Med Pharmacol Sci. 2018;22(16):5071–5076. doi:10.26355/eurrev_201808_15699
   PubMed Web of Science ®Google Scholar
• Wang Z, Feng C, Liu H, et al. Hypoxic Pretreatment of Adipose-Derived Stem Cells Accelerates Diabetic Wound Healing via circ-Gcap14 and HIF-1α/VEGF Mediated Angiopoiesis. Int J Stem Cells. 2021;14(4):447–454. doi:10.15283/ijsc21050
   PubMed Web of Science ®Google Scholar
• Shi R, Jin Y, Zhao S, Yuan H, Shi J, Zhao H. Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization. Biomed Pharmacother. 2022;153:113463. doi:10.1016/j.biopha.2022.113463
   PubMed Web of Science ®Google Scholar
• Long M, De La Vega MR, Wen Q, et al. An essential role of NRF2 in diabetic wound healing. Diabetes. 2016;65(3):780–793. doi:10.2337/db15-0564
   PubMed Web of Science ®Google Scholar
• Li X, Xie X, Lian W, et al. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med. 2018;50(4):1–14. doi:10.1038/s12276-018-0058-5
   Web of Science ®Google Scholar
• Zhang L, Zhang L, Li S, et al. Overexpression of MM9_CIRC_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the MiR-153-3P/NFIC axis. Can J Physiol Pharmacol. 2021;99(11):1199–1206. doi:10.1139/cjpp-2021-0187
   PubMed Web of Science ®Google Scholar
• Huang H, Zhu W, Huang Z, Zhao D, Cao L, Gao X. Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2. J Orthop Surg Res. 2023;18(1):687. doi:10.1186/s13018-023-04165-x
   PubMed Web of Science ®Google Scholar
• Cai HA, Huang L, Zheng LJ, et al. Ginsenoside (Rg-1) promoted the wound closure of diabetic foot ulcer through iNOS elevation via miR-23a/IRF-1 axis. Life Sci. 2019;233:116525. doi:10.1016/j.lfs.2019.05.081
   PubMed Web of Science ®Google Scholar
• Zhou H, Jing S, Liu Y, et al. Identifying the key genes of Epstein–Barr virus-regulated tumour immune microenvironment of gastric carcinomas. Cell Prolif. 2023;56(3):e13373. doi:10.1111/cpr.13373
   PubMed Web of Science ®Google Scholar
• Wu M, Tu J, Huang J, Wen H, Zeng Y, Lu Y. Exosomal IRF1-loaded rat adipose-derived stem cell sheet contributes to wound healing in the diabetic foot ulcers. Mol Med. 2023;29(1):60. doi:10.1186/s10020-023-00617-6
   PubMed Web of Science ®Google Scholar
• Thangarajah H, Yao D, Chang EI, et al. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A. 2009;106(32):13505–13510. doi:10.1073/pnas.0906670106
   PubMed Web of Science ®Google Scholar
• Wang J, Wu H, Zhao Y, et al. Extracellular vesicles from hif-1α-overexpressing adipose-derived stem cells restore diabetic wounds through accelerated fibroblast proliferation and migration. Int J Nanomed. 2021;16:7943–7957. doi:10.2147/IJN.S335438
   PubMed Web of Science ®Google Scholar
• Hu C, Li L. Preconditioning influences mesenchymal stem cell properties in vitro and in vivo. J Cell Mol Med. 2018;22(3):1428–1442. doi:10.1111/jcmm.13492
   PubMed Web of Science ®Google Scholar
• Zheng Y, Xu P, Pan C, et al. Production and Biological Effects of Extracellular Vesicles from Adipose-Derived Stem Cells Were Markedly Increased by Low-Intensity Ultrasound Stimulation for Promoting Diabetic Wound Healing. Stem Cell Rev Rep. 2023;19(3):784–806. doi:10.1007/s12015-022-10487-w
   PubMed Web of Science ®Google Scholar
• Wang J, Wu H, Peng Y, et al. Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways. J Nanobiotechnology. 2021;19(1):202. doi:10.1186/s12951-021-00942-0
   PubMed Web of Science ®Google Scholar
• He X, Wang D, Yi Y, et al. δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis. Cell Death Discov. 2023;9(1):349. doi:10.1038/s41420-023-01653-1
   PubMed Web of Science ®Google Scholar
• Wang L, Cai Y, Zhang Q, Zhang Y. Pharmaceutical Activation of Nrf2 Accelerates Diabetic Wound Healing by Exosomes from Bone Marrow Mesenchymal Stem Cells. Int J Stem Cells. 2022;15(2):164–172. doi:10.15283/ijsc21067
   PubMed Web of Science ®Google Scholar
• Gondaliya P, Sayyed AA, Bhat P, et al. Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-155 Inhibitor Ameliorate Diabetic Wound Healing. Mol Pharm. 2022;19(5):1294–1308. doi:10.1021/acs.molpharmaceut.1c00669
   PubMed Web of Science ®Google Scholar
• Xu WD, Feng SY, Huang AF. Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review. Inflamm Res. 2022;71(12):1501–1517. doi:10.1007/s00011-022-01643-6
   PubMed Web of Science ®Google Scholar
• Li J, Tian H, Yang J, Gong Z. Long Noncoding RNAs Regulate Cell Growth, Proliferation, and Apoptosis. DNA Cell Biol. 2016;35(9):459–470. doi:10.1089/dna.2015.3187
   PubMed Web of Science ®Google Scholar
• Li B, Luan S, Chen J, et al. The MSC-Derived Exosomal lncRNA H19 Promotes Wound Healing in Diabetic Foot Ulcers by Upregulating PTEN via MicroRNA-152-3p. Mol Ther Nucleic Acids. 2020;19:814–826. doi:10.1016/j.omtn.2019.11.034
   PubMedGoogle Scholar
• Han ZF, Cao JH, Liu ZY, Yang Z, Qi RX, Xu HL. Exosomal lncRNA KLF3-AS1 derived from bone marrow mesenchymal stem cells stimulates angiogenesis to promote diabetic cutaneous wound healing. Diabet Res Clin Pract. 2022;183:109126. doi:10.1016/j.diabres.2021.109126
   PubMed Web of Science ®Google Scholar
• Born LJ, Chang Hua K, Shoureshi P, et al. HOTAIR‐Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing. Adv Healthc Mater. 2022;11(5):e2002070. doi:10.1002/adhm.202002070
   PubMed Web of Science ®Google Scholar
• Wang M, Chen B, Ru Z, Cong L. CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/β-catenin pathway. Biochem Biophys Res Commun. 2018;504(1):283–288. doi:10.1016/j.bbrc.2018.08.175
   PubMed Web of Science ®Google Scholar
• Chen J, Li X, Liu H, et al. Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis. Diabet Med. 2023;40(7):e15031. doi:10.1111/dme.15031
   PubMed Web of Science ®Google Scholar
• Li S, Yang K, Cao W, et al. Tanshinone IIA enhances the therapeutic efficacy of mesenchymal stem cells derived exosomes in myocardial ischemia/reperfusion injury via up-regulating miR-223-5p. J Control Release. 2023;358:13–26. doi:10.1016/j.jconrel.2023.04.014
   PubMed Web of Science ®Google Scholar
• Liu W, Yu M, Xie D, et al. Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway. Stem Cell Res Ther. 2020;11(1):259. doi:10.1186/s13287-020-01756-x
   PubMed Web of Science ®Google Scholar
• Yu M, Liu W, Li J, et al. Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway. Stem Cell Res Ther. 2020;11(1):350. doi:10.1186/s13287-020-01824-2
   PubMed Web of Science ®Google Scholar
• Hu Y, Tao R, Chen L, et al. Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis. J Nanobiotechnology. 2021;19(1):150. doi:10.1186/s12951-021-00894-5
   PubMed Web of Science ®Google Scholar
• Lu W, Du X, Zou S, et al. IFN-γ enhances the therapeutic efficacy of MSCs-derived exosome via miR-126-3p in diabetic wound healing by targeting SPRED1. J Diabetes. 2023. doi:10.1111/1753-0407.13465
   Web of Science ®Google Scholar
• Abumaree MH, Abomaray FM, Alshabibi MA, AlAskar AS, Kalionis B. Immunomodulatory properties of human placental mesenchymal stem/stromal cells. Placenta. 2017;59:87–95. doi:10.1016/j.placenta.2017.04.003
   PubMed Web of Science ®Google Scholar
• Li Q, Hu W, Huang Q, et al. MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1. Signal Transduct Target Ther. 2023;8(1):62. doi:10.1038/s41392-022-01263-w
   PubMed Web of Science ®Google Scholar
• Teng L, Maqsood M, Zhu M, et al. Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Promoting M2 Macrophage Polarization, Angiogenesis, and Collagen Deposition. Int J Mol Sci. 2022;23(18):10421. doi:10.3390/ijms231810421
   PubMed Web of Science ®Google Scholar
• Yan C, Xv Y, Lin Z, et al. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis. Front Bioeng Biotechnol. 2022;10:829868. doi:10.3389/fbioe.2022.829868
   PubMed Web of Science ®Google Scholar
• Liu L, Zheng CX, Zhao N, et al. Mesenchymal Stem Cell Aggregation-Released Extracellular Vesicles Induce CD31+EMCN+ Vessels in Skin Regeneration and Improve Diabetic Wound Healing. Adv Healthc Mater. 2023;12(20):e2300019. doi:10.1002/adhm.202300019
   PubMed Web of Science ®Google Scholar
• Ti D, Hao H, Tong C, et al. LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b. J Transl Med. 2015;13:308. doi:10.1186/s12967-015-0642-6
   PubMed Web of Science ®Google Scholar
• Wei Q, Wang Y, Ma K, et al. Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Rev Rep. 2022;18(3):1025–1040. doi:10.1007/s12015-021-10176-0
   PubMed Web of Science ®Google Scholar
• Yamasaki K, Edington HDJ, McClosky C, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest. 1998;101(5):967–971. doi:10.1172/JCI2067
   PubMed Web of Science ®Google Scholar
• Schwentker A, Billiar TR. Nitric oxide and wound repair. Surg Clin North Am. 2003;83(3):521–530. doi:10.1016/S0039-6109(02)00207-4
   PubMed Web of Science ®Google Scholar
• Zhao X, Fu L, Zou H, et al. Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair. J Nanobiotechnology. 2023;21(1):176. doi:10.1186/s12951-023-01886-3
   PubMed Web of Science ®Google Scholar
• Hu K, Xu Y, Li X, Du P, Lu Y, Lyu G. The Nocardia Rubra Cell Wall Skeleton Regulates Macrophages and Promotes Wound Healing. Curr Issues Mol Biol. 2022;44(12):5995–6005. doi:10.3390/cimb44120408
   PubMed Web of Science ®Google Scholar
• Li Q, Guo L, Wang J, Tao S. Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis. Chin J Nat Med. 2023;21(3):172–184. doi:10.1016/S1875-5364(23)60419-4
   PubMed Web of Science ®Google Scholar
• Li JY, Ren KK, Zhang WJ, et al. Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway. Stem Cell Res Ther. 2019;10(1):247. doi:10.1186/s13287-019-1366-y
   PubMed Web of Science ®Google Scholar
• Fu S, Zhang H, Li X, et al. Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs. Tissue Eng Regen Med. 2023;20(2):295–308. doi:10.1007/s13770-022-00513-w
   PubMed Web of Science ®Google Scholar
• Wei P, Zhong C, Yang X, et al. Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function. Burn Trauma. 2020;8(tkaa020). doi:10.1093/BURNST/TKAA020
   Google Scholar
• Balaji S, King A, Crombleholme TM, Keswani SG. The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: implications for Therapeutic Neovascularization and Wound Healing. Adv Wound Care. 2013;2(6):283–295. doi:10.1089/wound.2012.0398
   PubMedGoogle Scholar
• Li X, Jiang C, Zhao J. Human endothelial progenitor cells-derived exosomes accelerate cutaneous wound healing in diabetic rats by promoting endothelial function. J Diabetes Complications. 2016;30(6):986–992. doi:10.1016/j.jdiacomp.2016.05.009
   PubMed Web of Science ®Google Scholar
• Zhang J, Chen C, Hu B, et al. Exosomes derived from human endothelial progenitor cells accelerate cutaneous wound healing by promoting angiogenesis through Erk1/2 signaling. Int J Biol Sci. 2016;12(12):1472–1487. doi:10.7150/ijbs.15514
   PubMed Web of Science ®Google Scholar
• Xu J, Bai S, Cao Y, et al. MiRNA-221-3p in endothelial progenitor cell-derived exosomes accelerates skin wound healing in diabetic mice. Diabetes Metab Syndr Obes. 2020;13:1259–1270. doi:10.2147/DMSO.S243549
   PubMed Web of Science ®Google Scholar
• Li P, Hong G, Zhan W, et al. Endothelial progenitor cell derived exosomes mediated miR-182-5p delivery accelerate diabetic wound healing via down-regulating PPARG. Int J Med Sci. 2023;20(4):468–481. doi:10.7150/ijms.78790
   PubMed Web of Science ®Google Scholar
• Xiong W, Zhang X, Zhou J, et al. Astragaloside IV promotes exosome secretion of endothelial progenitor cells to regulate PI3KR2/SPRED1 signaling and inhibit pyroptosis of diabetic endothelial cells. Cytotherapy. 2023;S1465-3249(23):01045–01049. doi:10.1016/j.jcyt.2023.08.013
   Google Scholar
• Blanpain C, Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol. 2006;22:339–373. doi:10.1146/annurev.cellbio.22.010305.104357
   PubMed Web of Science ®Google Scholar
• Xu H, Yang H, Wang Z, et al. Epidermal stem cell derived exosomes alleviate excessive autophagy induced endothelial cell apoptosis by delivering miR200b-3p to diabetic wounds. J Invest Dermatol. 2023. doi:10.1016/j.jid.2023.08.030
   Google Scholar
• Wang P, Theocharidis G, Vlachos IS, et al. Exosomes Derived from Epidermal Stem Cells Improve Diabetic Wound Healing. J Invest Dermatol. 2022;142(9):2508–2517.e13. doi:10.1016/j.jid.2022.01.030
   PubMed Web of Science ®Google Scholar
• Yang H, Xu H, Wang Z, et al. Analysis of miR-203a-3p/SOCS3-mediated induction of M2 macrophage polarization to promote diabetic wound healing based on epidermal stem cell-derived exosomes. Diabet Res Clin Pract. 2023;197:110573. doi:10.1016/j.diabres.2023.110573
   PubMed Web of Science ®Google Scholar
• Li G, Cheng G, Wu J, Ma S, Sun C. New iPSC for old long QT syndrome modeling: putting the evidence into perspective. Exp Biol Med. 2014;239(2):131–140. doi:10.1177/1535370213514000
   Web of Science ®Google Scholar
• Yoshida Y, Yamanaka S. Induced Pluripotent Stem Cells 10 Years Later: for Cardiac Applications. Circ Res. 2017;120(12):1958–1968.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Ebisawa K, Kambe M, et al. Effects of exosomes derived from the induced pluripotent stem cells on skin wound healing. Nagoya J Med Sci. 2018;80(2):141–153. doi:10.18999/nagjms.80.2.141
   PubMed Web of Science ®Google Scholar
• Yang H, Feng R, Fu Q, et al. Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models. Cell Death Dis. 2019;10(10):718. doi:10.1038/s41419-019-1957-7
   PubMedGoogle Scholar
• Levy D, Abadchi SN, Shababi N, et al. Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Promote Wound Repair in a Diabetic Mouse Model via an Anti-Inflammatory Immunomodulatory Mechanism. Adv Healthc Mater. 2023;12(26):e2300879. doi:10.1002/adhm.202300879
   PubMed Web of Science ®Google Scholar
• Li YJ, Wu JY, Liu J, et al. Artificial exosomes for translational nanomedicine. J Nanobiotechnology. 2021;19(1):242. doi:10.1186/s12951-021-00986-2
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang L, Guo H, Chen L, Huang X. Dapagliflozin-Loaded Exosome Mimetics Facilitate Diabetic Wound Healing by HIF-1α-Mediated Enhancement of Angiogenesis. Adv Healthc Mater. 2023;12(7):e2202751. doi:10.1002/adhm.202202751
   PubMed Web of Science ®Google Scholar
• Ji S, Zhu Z, Sun X, Fu X. Functional hair follicle regeneration: an updated review. Signal Transduct Target Ther. 2021;6(1):66. doi:10.1038/s41392-020-00441-y
   PubMed Web of Science ®Google Scholar
• Ma Y, Lin Z, Chen X, et al. Human hair follicle-derived mesenchymal stem cells promote tendon repair in a rabbit Achilles tendinopathy model. Chin Med J (Engl). 2023;136(9):1089–1097. doi:10.1097/CM9.0000000000002542
   PubMed Web of Science ®Google Scholar
• Yang H, Zhang Y, Du Z, Wu T, Yang C. Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing. Aging (Albany NY). 2023;15(3):791–809. doi:10.18632/aging.204513
   PubMedGoogle Scholar
• Huang YZ, He T, Cui J, et al. Urine-Derived Stem Cells for Regenerative Medicine: basic Biology, Applications, and Challenges. Tissue Eng - Part B Rev. 2022;28(5):978–994. doi:10.1089/ten.teb.2021.0142
   PubMed Web of Science ®Google Scholar
• Müller H, Hu J, Popp R, et al. Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis. Arterioscler Thromb Vasc Biol. 2012;32(2):442–448. doi:10.1161/ATVBAHA.111.239830
   PubMed Web of Science ®Google Scholar
• Chen CY, Rao SS, Ren L, et al. Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis. Theranostics. 2018;8(6):1607–1623. doi:10.7150/thno.22958
   PubMed Web of Science ®Google Scholar
• Kong Y, Shao Y, Ren C, Yang G. Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis. Stem Cell Res Ther. 2021;12(1):474. doi:10.1186/s13287-021-02526-z
   PubMed Web of Science ®Google Scholar
• Dalirfardouei R, Jamialahmadi K, Jafarian AH, Mahdipour E. Promising effects of exosomes isolated from menstrual blood‐derived mesenchymal stem cell on wound‐healing process in diabetic mouse model. J Tissue Eng Regen Med. 2019;13(4):555–568. doi:10.1002/term.2799
   PubMed Web of Science ®Google Scholar
• Wang DR, Pan J. Extracellular vesicles: emerged as a promising strategy for regenerative medicine. World J Stem Cells. 2023;15(4):165–181. doi:10.4252/wjsc.v15.i4.165
   PubMed Web of Science ®Google Scholar
• Nallakumarasamy A, Jeyaraman M, Maffulli N, et al. Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Wound Healing. Life. 2022;12(11):1733. doi:10.3390/life12111733
   PubMedGoogle Scholar
• Xiong M, Zhang Q, Hu W, et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacol Res. 2021;166:105490. doi:10.1016/j.phrs.2021.105490
   PubMed Web of Science ®Google Scholar
• Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750. doi:10.1080/20013078.2018.1535750
   PubMed Web of Science ®Google Scholar
• Yu H, Wu Y, Zhang B, et al. Exosomes Derived from E2F1–/– adipose-Derived Stem Cells Promote Skin Wound Healing via miR-130b-5p/TGFBR3 Axis. Int J Nanomed. 2023;18:6275–6292. doi:10.2147/IJN.S431725
   PubMed Web of Science ®Google Scholar
• Yang D, Zhang W, Zhang H, et al. Progress, opportunity, and perspective on exosome isolation - Efforts for efficient exosome-based theranostics. Theranostics. 2020;10(8):3684–3707. doi:10.7150/thno.41580
   PubMed Web of Science ®Google Scholar
• Vyas KS, Kaufman J, Munavalli GS, Robertson K, Behfar A. Exosomes: the latest in regenerative aesthetics. Regener Med. 2023;18(2):181–194. doi:10.2217/rme-2022-0134
   PubMed Web of Science ®Google Scholar
• Buzas EI. The roles of extracellular vesicles in the immune system. Nat Rev Immunol. 2023;23(4):236–250. doi:10.1038/s41577-022-00763-8
   PubMed Web of Science ®Google Scholar
• Rybkowska P, Radoszkiewicz K, Kawalec M, et al. The Metabolic Changes between Monolayer (2D) and Three-Dimensional (3D) Culture Conditions in Human Mesenchymal Stem/Stromal Cells Derived from Adipose Tissue. Cells. 2023;12(1):178. doi:10.3390/cells12010178
   PubMed Web of Science ®Google Scholar
• Dong Y, S A, Rodrigues M, et al. Injectable and Tunable Gelatin Hydrogels Enhance Stem Cell Retention and Improve Cutaneous Wound Healing. Adv Funct Mater. 2017;27(24):1606619. doi:10.1002/adfm.201606619
   Web of Science ®Google Scholar
• Xu Q, Sigen A, Gao Y, et al. A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing. Acta Biomater. 2018;75:63–74. doi:10.1016/j.actbio.2018.05.039
   PubMed Web of Science ®Google Scholar
• Patra JK, Das G, Fraceto LF, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018;16(1):71. doi:10.1186/s12951-018-0392-8
   PubMed Web of Science ®Google Scholar
• Fan Z, Jiang C, Wang Y, et al. Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine. Nanoscale Horiz. 2022;7(7):682–714. doi:10.1039/d2nh00070a
   PubMed Web of Science ®Google Scholar
• Wu P, Zhang B, Ocansey DKW, Xu W, Qian H. Extracellular vesicles: a bright star of nanomedicine. Biomaterials. 2021;269. doi:10.1016/j.biomaterials.2020.120467
   Web of Science ®Google Scholar
• Chen J, Zhao Q, Peng J, Yang X, Yu D, Zhao W. Antibacterial and mechanical properties of reduced graphene-silver nanoparticle nanocomposite modified glass ionomer cements. J Dent. 2020;96:103332. doi:10.1016/j.jdent.2020.103332
   PubMed Web of Science ®Google Scholar
• Xiao R, Ding J, Chen J, et al. Citric acid coated ultrasmall superparamagnetic iron oxide nanoparticles conjugated with lactoferrin for targeted negative MR imaging of glioma. J Biomater Appl. 2021;36(1):15–25. doi:10.1177/0885328220975570
   PubMed Web of Science ®Google Scholar
• Wang H, Ding L, Xu F, et al. Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging. J Biomater Appl. 2021;36(4):613–625. doi:10.1177/08853282211011766
   PubMed Web of Science ®Google Scholar
• Gibello L, D’Antico S, Salafia M, et al. First pilot case-control interventional study using autologous extracellular vesicles to treat chronic venous ulcers unresponsive to conventional treatments. Pharmacol Res. 2023;190:106718. doi:10.1016/j.phrs.2023.106718
   PubMed Web of Science ®Google Scholar
• Yang T, Dong Y, Wan J, et al. Sustained Release of BMSC-EVs from 3D Printing Gel/HA/nHAP Scaffolds for Promoting Bone Regeneration in Diabetic Rats. Adv Healthc Mater. 2023;12(18):e2203131. doi:10.1002/adhm.202203131
   PubMed Web of Science ®Google Scholar