Size-Optimized Layered Double Hydroxide Nanoparticles Promote Neural Progenitor Cells Differentiation of Embryonic Stem Cells Through the Regulation of M⁶A Methylation

References

• Li Y, Mao X, Zhou X, et al. An optimized method for neuronal differentiation of embryonic stem cells in vitro. J Neurosci Methods. 2020;330:108486. doi:10.1016/j.jneumeth.2019.108486
   PubMed Web of Science ®Google Scholar
• Wang Z, Yang H, Bai Y, et al. rBMSC osteogenic differentiation enhanced by graphene quantum dots loaded with immunomodulatory layered double hydroxide nanoparticles. Biomed Mater. 2022;17(2):024101. doi:10.1088/1748-605X/ac4324
   Web of Science ®Google Scholar
• Ogawa Y, Sawamoto K, Miyata T, et al. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res. 2002;69(6):925–933. doi:10.1002/jnr.10341
   PubMed Web of Science ®Google Scholar
• Iwai H, Shimada H, Nishimura S, et al. Allogeneic neural stem/progenitor cells derived from embryonic stem cells promote functional recovery after transplantation into injured spinal cord of nonhuman primates. Stem Cells Transl Medi. 2015;4(7):708–719. doi:10.5966/sctm.2014-0215
   PubMed Web of Science ®Google Scholar
• Chang DJ, Oh SH, Lee N, et al. Contralaterally transplanted human embryonic stem cell-derived neural precursor cells (ENStem-A) migrate and improve brain functions in stroke-damaged rats. Exp Mol Med. 2013;45(11):e53. doi:10.1038/emm.2013.93
   PubMedGoogle Scholar
• Zeevaert K, Elsafi Mabrouk MH, Wagner W, et al. Cell mechanics in embryoid bodies. Cells. 2020;9(10):2270. doi:10.3390/cells9102270
   PubMed Web of Science ®Google Scholar
• Shparberg RA, Glover HJ, Morris MB. Embryoid body differentiation of mouse embryonic stem cells into neurectoderm and neural progenitors. Methods Mol Biol. 2019;2019:273–285. doi:10.1007/978-1-4939-9631-5_21.
   Google Scholar
• Joshi R, Buchanan JC, Tavana H. Self-regulatory factors of embryonic stem cells in co-culture with stromal cells enhance neural differentiation. Integr Biol. 2017;9(5):418–426. doi:10.1039/C7IB00038C
   Google Scholar
• Rifes P, Isaksson M, Rathore GS, et al. Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient. Nat Biotechnol. 2020;38(11):1265–1273. doi:10.1038/s41587-020-0525-0
   PubMed Web of Science ®Google Scholar
• Zhang C, Du L, Pang K, et al. Differentiation of human embryonic stem cells into corneal epithelial progenitor cells under defined conditions. PLoS One. 2017;12(8):e0183303. doi:10.1371/journal.pone.0183303
   PubMed Web of Science ®Google Scholar
• Kang MK, Kim TJ, Kim YJ, et al. Targeted delivery of iron oxide nanoparticle-loaded human embryonic stem cell-derived spherical neural masses for treating intracerebral hemorrhage. Int J Mol Sci. 2020;21(10):3658. doi:10.3390/ijms21103658
   PubMed Web of Science ®Google Scholar
• Rahimi Darehbagh R, Mahmoodi M, Amini N, et al. The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review. Eur J Med Res. 2023;28(1):576. doi:10.1186/s40001-023-01546-0
   PubMed Web of Science ®Google Scholar
• Pinto MC, Tonelli FM, Vieira AL, et al. Studying complex system: calcium oscillations as attractor of cell differentiation. Integr Biol. 2016;8(2):130–148. doi:10.1039/c5ib00285k
   Google Scholar
• Marques BL, Maciel GF, Brito MRJ, et al. Regulatory mechanisms of stem cell differentiation: biotechnological applications for neurogenesis. Semin Cell Dev Biol. 2023;144:11–19. doi:10.1016/j.semcdb.2022.09.014
   PubMed Web of Science ®Google Scholar
• Asgari V, Landarani-Isfahani A, Salehi H, et al. The Story of Nanoparticles in Differentiation of Stem Cells into Neural Cells. Neurochem Res. 2019;44(12):2695–2707. doi:10.1007/s11064-019-02900-7
   PubMed Web of Science ®Google Scholar
• Qiu J, Liu XJ, You BA, et al. Application of nanomaterials in stem cell-based therapeutics for cardiac repair and regeneration. Small. 2023;19(11):e2206487. doi:10.1002/smll.202206487
   PubMed Web of Science ®Google Scholar
• Gupta P, Rathi P, Gupta R, et al. Neuronal maturation-dependent nano–neuro interaction and modulation. Nanoscale Horiz. 2023;8(11):1537–1555. doi:10.1039/D3NH00258F
   PubMed Web of Science ®Google Scholar
• da Silva VA, Bobotis BC, Correia FF, et al. The impact of biomaterial surface properties on engineering neural tissue for spinal cord regeneration. Int J Mol Sci. 2023;24(17):13642. doi:10.3390/ijms241713642
   PubMed Web of Science ®Google Scholar
• Sperling LE, Reis KP, Pozzobon LG, et al. Influence of random and oriented electrospun fibrous poly(lactic-co-glycolic acid) scaffolds on neural differentiation of mouse embryonic stem cells. J Biomed Mater Res A. 2017;105(5):1333–1345. doi:10.1002/jbm.a.36012
   PubMed Web of Science ®Google Scholar
• Park SJ, Kim S, Kim SY, et al. Highly efficient and rapid neural differentiation of mouse embryonic stem cells based on retinoic acid encapsulated porous nanoparticle. ACS Appl Mater Interfaces. 2017;9(40):34634–34640. doi:10.1021/acsami.7b09760
   PubMed Web of Science ®Google Scholar
• Zhang S, Hang Y, Wu J, et al. Dual pathway for promotion of stem cell neural differentiation mediated by gold nanocomposites. ACS Appl Mater Interfaces. 2020;12(19):22066–22073. doi:10.1021/acsami.9b22258
   PubMed Web of Science ®Google Scholar
• Taviot-Gueho C, Prevot V, Forano C, et al. Tailoring hybrid layered double hydroxides for the development of innovative applications. Adv Funct Mater. 2018;28(27):1703868. doi:10.1002/adfm.201703868
   Web of Science ®Google Scholar
• He X, Zhu Y, Yang L, et al. MgFe-LDH nanoparticles: a promising leukemia inhibitory factor replacement for self-renewal and pluripotency maintenance in cultured mouse embryonic stem cells. Adv Sci. 2021;8(9):2003535. doi:10.1002/advs.202003535
   Web of Science ®Google Scholar
• Zhu R, Zhu X, Zhu Y, et al. Immunomodulatory layered double hydroxide nanoparticles enable neurogenesis by targeting transforming growth factor-β Receptor 2. ACS nano. 2021;15(2):2812–2830. doi:10.1021/acsnano.0c08727
   PubMed Web of Science ®Google Scholar
• Yang L, Sun J, Liu Q, et al. Synergetic functional nanocomposites enhance immunotherapy in solid tumors by remodeling the immunoenvironment. Adv Sci. 2019;6(8):1802012. doi:10.1002/advs.201802012
   Web of Science ®Google Scholar
• Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18(1):31–42. doi:10.1038/nrm.2016.132
   PubMed Web of Science ®Google Scholar
• Yang Y, Hsu PJ, Chen YS, et al. Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res. 2018;28(6):616–624. doi:10.1038/s41422-018-0040-8
   PubMed Web of Science ®Google Scholar
• Lee M, Kim B, Kim VN. Emerging roles of RNA modification: m(6)A and U-tail. Cell. 2014;158(5):980–987. doi:10.1016/j.cell.2014.08.005
   PubMed Web of Science ®Google Scholar
• Han L, Dong L, Leung K, et al. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023;30(1):52–68.e13. doi:10.1016/j.stem.2022.12.006
   PubMed Web of Science ®Google Scholar
• Tooley JG, Catlin JP, Tooley CES. METTLing in stem cell and cancer biology. Stem Cell Rev Rep. 2023;19(1):76–91. doi:10.1007/s12015-022-10444-7
   PubMed Web of Science ®Google Scholar
• Batista PJ, Molinie B, Wang J, et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014;15(6):707–719. doi:10.1016/j.stem.2014.09.019
   PubMed Web of Science ®Google Scholar
• Geula S, Moshitch-Moshkovitz S, Dominissini D, et al. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science. 2015;347(6225):1002–1006. doi:10.1126/science.1261417
   PubMed Web of Science ®Google Scholar
• Xu W, Li J, He C, et al. METTL3 regulates heterochromatin in mouse embryonic stem cells. Nature. 2021;591(7849):317–321. doi:10.1038/s41586-021-03210-1
   PubMed Web of Science ®Google Scholar
• Wang Z, Xu Z, Jing G, et al. Layered double hydroxide eliminate embryotoxicity of chemotherapeutic drug through BMP-SMAD signaling pathway. Biomaterials. 2020;230:119602. doi:10.1016/j.biomaterials.2019.119602
   PubMed Web of Science ®Google Scholar
• Wu Y, Xu X, Qi M, et al. N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Nat Cell Biol. 2022;24(6):917–927. doi:10.1038/s41556-022-00915-x
   PubMed Web of Science ®Google Scholar
• Suter DM, Tirefort D, Julien S, et al. A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells. 2009;27(1):49–58. doi:10.1634/stemcells.2008-0319
   PubMed Web of Science ®Google Scholar
• Wang Z, Yang H, Xu X, et al. Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway. Bioact Mater. 2023;22:75–90. doi:10.1016/j.bioactmat.2022.08.023
   PubMed Web of Science ®Google Scholar
• Mao N, Zhou CH, Tong DS, et al. Exfoliation of layered double hydroxide solids into functional nanosheets. Appl Clay Sci. 2017;144(4):60–78. doi:10.1016/j.clay.2017.04.021
   Google Scholar
• Zhang T, Wang Z, Wang Z, et al. LDH-doped gelatin-chitosan scaffold with aligned microchannels improves anti-inflammation and neuronal regeneration with guided axonal growth for effectively recovering spinal cord injury. Appl Mater Today. 2023;34:101884. doi:10.1016/j.apmt.2023.101884
   Web of Science ®Google Scholar
• Qiu J, Li J, Wang S, et al. TiO2 nanorod array constructed nanotopography for regulation of mesenchymal stem cells fate and the realization of location-committed stem cell differentiation. Small. 2016;12(13):1770–1778. doi:10.1002/smll.201503946
   PubMed Web of Science ®Google Scholar
• Qiu J, Li D, Mou X, et al. Effects of graphene quantum dots on the self-renewal and differentiation of mesenchymal stem cells. Adv Healthcare Mater. 2016;5(6):702–710. doi:10.1002/adhm.201500770
   Web of Science ®Google Scholar
• Li J, Qiu J, Guo W, et al. Cellular internalization of LiNbO3 nanocrystals for second harmonic imaging and the effects on stem cell differentiation. Nanoscale. 2016;8(14):7416–7422. doi:10.1039/C6NR00785F
   PubMed Web of Science ®Google Scholar
• Zhang C, Chen Y, Sun B, et al. m(6)A modulates haematopoietic stem and progenitor cell specification. Nature. 2017;549(7671):273–276. doi:10.1038/nature23883
   PubMed Web of Science ®Google Scholar
• Zhang ZW, Teng X, Zhao F, et al. METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep. 2022;41(4):111530. doi:10.1016/j.celrep.2022.111530
   PubMedGoogle Scholar