Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles

References

• MinkoTRodriguez-RodriguezLPozharovVNanotechnology approaches for personalized treatment of multidrug resistant cancersAdv Drug Deliv Rev20136513–141880189510.1016/j.addr.2013.09.01724120655
   PubMed Web of Science ®Google Scholar
• MuraSCouvreurPNanotheranostics for personalized medicineAdv Drug Deliv Rev201264131394141610.1016/j.addr.2012.06.00622728642
   PubMed Web of Science ®Google Scholar
• WongIYBhatiaSNTonerMNanotechnology: emerging tools for biology and medicineGenes Dev201327222397240810.1101/gad.226837.11324240230
   PubMed Web of Science ®Google Scholar
• RosenholmJMMamaevaVSahlgrenCLindénMNanoparticles in targeted cancer therapy: mesoporous silica nanoparticles entering preclinical development stageNanomedicine20127111112010.2217/nnm.11.16622191780
   PubMed Web of Science ®Google Scholar
• LaitmanLEDahanSTaking inflammatory bowel disease up a NotchImmunol Res2012541–3697410.1007/s12026-012-8314-622427015
   PubMedGoogle Scholar
• SumanSDasTPAnkemMKDamodaranCTargeting Notch signaling in colorectal cancerCurr Colorectal Cancer Rep201410441141610.1007/s11888-014-0252-325395896
   PubMedGoogle Scholar
• NtziachristosPLimJSSageJAifantisIFrom fly wings to targeted cancer therapies: a centennial for notch signalingCancer Cell201425331833410.1016/j.ccr.2014.02.01824651013
   PubMed Web of Science ®Google Scholar
• LipinskiCAPoor aqueous solubility – an industry wide problem in drug discoveryAm Pharm Rev200258285
   Google Scholar
• BawarskiWEChidlowskyEBharaliDJMousaSAEmerging nanopharmaceuticalsNanomed Nanotechnol Biol Med20084427328210.1016/j.nano.2008.06.002
   PubMed Web of Science ®Google Scholar
• LarouiHWilsonDSDalmassoGNanomedicine in GIAm J Physiol Gastrointest Liver Physiol20113003G371G38310.1152/ajpgi.00466.201021148398
   PubMed Web of Science ®Google Scholar
• ShahbaziM-ASantosHAImproving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabricationCurr Drug Metab2013141285622497568
   PubMed Web of Science ®Google Scholar
• PlapiedLDuhemNdes RieuxAPréatVFate of polymeric nanocarriers for oral drug deliveryCurr Opin Colloid Interface Sci201116322823710.1016/j.cocis.2010.12.005
   Web of Science ®Google Scholar
• WilsonDSDalmassoGWangLSitaramanSVMerlinDMurthyNOrally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestinesNat Mater201091192392810.1038/nmat285920935658
   PubMed Web of Science ®Google Scholar
• LewisLLCHarrisonLLCGenerally Recognized as Safe Determination for Silicon Dioxide When Added Directly and/or Indirectly to Human Food12010 Available from: http://www.fda.gov/ucm/groups/fdagov-public/@fdagov-foods-gen/documents/document/ucm269494.pdfAccessed August 9, 2015
   Google Scholar
• IlerRKThe Chemistry of Silica: Solubility, Polymerization, Colloid and Surface Properties, and BiochemistryNew YorkJohn Wiley & Sons1979
   Google Scholar
• RigbySPFairheadMvan der WalleCFEngineering silica particles as oral drug delivery vehiclesCurr Pharm Des200814181821183118673185
   PubMedGoogle Scholar
• van SpeybroeckMMellaertsRThiTDPreventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugsJ Pharm Sci2011100114864487610.1002/jps.2270321766312
   PubMed Web of Science ®Google Scholar
• MellaertsRMolsRJammaerJAGIncreasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silicaEur J Pharm Biopharm200869122323010.1016/j.ejpb.2007.11.00618164930
   PubMed Web of Science ®Google Scholar
• GodbeyWTWuKKMikosAGSize matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicleJ Biomed Mater Res199945326827510397985
   PubMed Web of Science ®Google Scholar
• ZintchenkoAPhilippADehshahriAWagnerESimple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicityBioconjug Chem20081971448145510.1021/bc800065f18553894
   PubMed Web of Science ®Google Scholar
• MerdanTKunathKPetersenHPEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into miceBioconjug Chem200516478579210.1021/bc049743q16029019
   PubMedGoogle Scholar
• DesaiDKaramanDSPrabhakarNDesign considerations for mesoporous silica nanoparticulate systems in facilitating biomedical applicationsMesoporous Biomater201411
   Google Scholar
• KnopKHoogenboomRFischerDSchubertUSPoly(ethylene glycol) in drug delivery: pros and cons as well as potential alternativesAngew Chem Int Ed201049366288630810.1002/anie.200902672
   PubMed Web of Science ®Google Scholar
• HarrisJMChessRBEffect of pegylation on pharmaceuticalsNat Rev Drug Discov20032321422110.1038/nrd103312612647
   PubMed Web of Science ®Google Scholar
• LaiSKWangY-YHanesJMucus-penetrating nanoparticles for drug and gene delivery to mucosal tissuesAdv Drug Deliv Rev200961215817110.1016/j.addr.2008.11.00219133304
   PubMed Web of Science ®Google Scholar
• HuangYLeobandungWFossAPeppasNAMolecular aspects of muco- and bioadhesion: tethered structures and site-specific surfacesJ Control Release2000651–2637110699271
   PubMed Web of Science ®Google Scholar
• SerraLDoménechJPeppasNADesign of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systemsEur J Pharm Biopharm2006631111810.1016/j.ejpb.2005.10.01116368228
   PubMedGoogle Scholar
• YonchevaKGómezSCampaneroMAGamazoCIracheJMBioadhesive properties of pegylated nanoparticlesExpert Opin Drug Deliv20052220521810.1517/17425247.2.2.20516296748
   PubMedGoogle Scholar
• Şen KaramanDGulin-SarfrazTHedströmGDuchanoyAEklundPRosenholmJMRational evaluation of the utilization of PEG-PEI copolymers for the facilitation of silica nanoparticulate systems in biomedical applicationsJ Colloid Interface Sci201441830031010.1016/j.jcis.2013.11.08024461849
   PubMed Web of Science ®Google Scholar
• MamaevaVRosenholmJMBate-EyaLTMesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancerMol Ther J Am Soc Gene Ther20111981538154610.1038/mt.2011.105
   PubMed Web of Science ®Google Scholar
• WittigRRosenholmJMvon HaartmanEActive targeting of mesoporous silica drug carriers enhances γ-secretase inhibitor efficacy in an in vivo model for breast cancerNanomedicine20149797198710.2217/nnm.13.6223898823
   PubMed Web of Science ®Google Scholar
• RosenholmJMMeinanderAPeuhuETargeting of porous hybrid silica nanoparticles to cancer cellsACS Nano20083119720610.1021/nn800781r19206267
   PubMedGoogle Scholar
• KaramanDSDesaiDSenthilkumarRShape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalizationNanoscale Res Lett20127111410.1186/1556-276X-7-35822214494
   PubMedGoogle Scholar
• RosenholmJMDuchanoyALindénMHyperbranching surface polymerization as a tool for preferential functionalization of the outer surface of mesoporous silica†Chem Mater20082031126113310.1021/cm7021328
   Google Scholar
• PetersenHFechnerPMFischerDKisselTSynthesis, characterization, and biocompatibility of polyethylenimine-graft-poly(ethylene glycol) block copolymersMacromolecules200235186867687410.1021/ma012060a
   Google Scholar
• NakajimaNIkadaYMechanism of amide formation by carbodiimide for bioconjugation in aqueous mediaBioconjug Chem19956112313010.1021/bc00031a0157711098
   PubMed Web of Science ®Google Scholar
• ChapmanMEHuLPlatoCFKohanDEBioimpedance spectroscopy for the estimation of body fluid volumes in miceAm J Physiol Renal Physiol20102991F280F28310.1152/ajprenal.00113.201020462974
   PubMed Web of Science ®Google Scholar
• SjöbackRNygrenJKubistaMAbsorption and fluorescence properties of fluoresceinSpectrochim Acta A Mol Biomol Spectrosc1995516L7L2110.1016/0584-8539(95)01421-P
   Web of Science ®Google Scholar
• YangS-JLinF-HTsaiK-CFolic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cellsBioconjug Chem201021467968910.1021/bc900479820222677
   PubMed Web of Science ®Google Scholar
• DavdaJLabhasetwarVCharacterization of nanoparticle uptake by endothelial cellsInt J Pharm20022331–2515911897410
   PubMed Web of Science ®Google Scholar
• HatakeyamaHAkitaHHarashimaHThe polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumorsBiol Pharm Bull201336689289910.1248/bpb.b13-0005923727912
   PubMed Web of Science ®Google Scholar
• TytgatKMBüllerHAOpdamFJKimYSEinerhandAWDekkerJBiosynthesis of human colonic mucin: Muc2 is the prominent secretory mucinGastroenterology19941075135213637926500
   PubMed Web of Science ®Google Scholar
• YeungTMChiaLAKosinskiCMKuoCJRegulation of self-renewal and differentiation by the intestinal stem cell nicheCell Mol Life Sci201168152513252310.1007/s00018-011-0687-521509540
   PubMedGoogle Scholar
• van EsJHvan GijnMERiccioONotch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cellsNature2005435704495996310.1038/nature0365915959515
   PubMed Web of Science ®Google Scholar
• McConnellELFaddaHMBasitAWGut instincts: explorations in intestinal physiology and drug deliveryInt J Pharm2008364221322610.1016/j.ijpharm.2008.05.01218602774
   PubMed Web of Science ®Google Scholar
• ErmundASchütteAJohanssonMEVGustafssonJKHanssonGCStudies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer’s patchesAm J Physiol Gastrointest Liver Physiol20133055G341G34710.1152/ajpgi.00046.201323832518
   PubMed Web of Science ®Google Scholar
• JohanssonMEVSjövallHHanssonGCThe gastrointestinal mucus system in health and diseaseNat Rev Gastroenterol Hepatol201310635236110.1038/nrgastro.2013.3523478383
   PubMed Web of Science ®Google Scholar
• ZhangYWangJBaiXJiangTZhangQWangSMesoporous silica nanoparticles for increasing the oral bioavailability and permeation of poorly water soluble drugsMol Pharm20129350551310.1021/mp200287c22217205
   PubMedGoogle Scholar
• PopatAJambhrunkarSZhangJProgrammable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug deliveryChem Commun (Camb)201450425547555010.1039/c4cc00620h24603852
   PubMed Web of Science ®Google Scholar
• YonchevaKPopovaMSzegediAFunctionalized mesoporous silica nanoparticles for oral delivery of budesonideJ Solid State Chem201421115416110.1016/j.jssc.2013.12.020
   Web of Science ®Google Scholar
• KiekensFEelenSVerheydenLDaemsTMartensJVan Den MooterGUse of ordered mesoporous silica to enhance the oral bio-availability of ezetimibe in dogsJ Pharm Sci201210131136114410.1002/jps.2301622190350
   PubMed Web of Science ®Google Scholar
• DoaneTBurdaCNanoparticle mediated non-covalent drug deliveryAdv Drug Deliv Rev201365560762110.1016/j.addr.2012.05.01222664231
   PubMed Web of Science ®Google Scholar
• XuWRiikonenJLehtoV-PMesoporous systems for poorly soluble drugsInt J Pharm2013453118119710.1016/j.ijpharm.2012.09.00822990124
   PubMed Web of Science ®Google Scholar