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Review

New and improved strategies for the treatment of gout

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Pages 145-166 | Published online: 24 Nov 2010

References

  • ChoiHKMountDBReginatoAMPathogenesis of goutAnn Intern Med2005143749951616204163
  • ChoiHKCurhanGGout: epidemiology and lifestyle choicesCurr Opin Rheumatol200517334134515838248
  • NriaguJOSaturnine gout among Roman aristocrats. Did lead poisoning contribute to the fall of the Empire?N Engl J Med1983308116606636338384
  • HealeyLAPort wine and the goutArthritis Rheum197518Suppl 66596621106430
  • SteinbockRTLead ingestion in historyN Engl J Med19793015277377079
  • HakAEChoiHKLifestyle and goutCurr Opin Rheumatol200820217918618349748
  • SaagKGChoiHEpidemiology, risk factors, and lifestyle modifications for goutArthritis Res Ther20068Suppl 1S216820041
  • SaagKGMikulsTRRecent advances in the epidemiology of goutCurr Rheumatol Rep20057323524115919001
  • KahnAMEffect of diuretics on the renal handling of urateSemin Nephrol1988833053143059433
  • CaspiDLubartEGraffEHabotBYaronMSegalRThe effect of mini-dose aspirin on renal function and uric acid handling in elderly patientsArthritis Rheum200043110310810643705
  • SchumacherHRJrBeckerMAWortmannRLEffects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trialArthritis Rheum200859111540154818975369
  • SundyJSBeckerMABarafHSReduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: Results of a phase II randomized studyArthritis Rheum20085892882289118759308
  • ShermanMRSaiferMGPerez-RuizFPEG-uricase in the management of treatment-resistant gout and hyperuricemiaAdv Drug Deliv Rev2008601596817826865
  • FarkouhMEGreenbergBPAn evidence-based review of the cardiovascular risks of nonsteroidal anti-inflammatory drugsAm J Cardiol200910391227123719406264
  • EdwardsNLThe role of hyperuricemia and gout in kidney and cardiovascular diseaseCleve Clin J Med200875Suppl 5S13S1618822470
  • FeigDIKangDHJohnsonRJUric acid and cardiovascular riskN Engl J Med2008359171811182118946066
  • SchlesingerNDalbethNPerez-RuizFGout – what are the treatment options?Expert Opin Pharmacother20091081319132819463070
  • ThieleRGSchlesingerNUltrasonography shows disappearance of monosodium urate crystal deposition on hyaline cartilage after sustained normouricemia is achievedRheumatol Int201030449550319543895
  • Perez-RuizFDalbethNUrresolaAde MiguelESchlesingerNGout. Imaging of gout: findings and utilityArthritis Res Ther200911323219591633
  • LeeSJHirschJDTerkeltaubRPerceptions of disease and health-related quality of life among patients with goutRheumatology (Oxford)200948558258619307257
  • SinghJAQuality of life and quality of care for patients with goutCurr Rheumatol Rep200911215416019296889
  • SinghJAStrandVGout is associated with more comorbidities, poorer health-related quality of life and higher healthcare utilisation in US veteransAnn Rheum Dis20086791310131618178692
  • RoddyEZhangWDohertyMIs gout associated with reduced quality of life? A case-control studyRheumatology (Oxford)20074691441144417586863
  • WinzenbergTBuchbinderRCochrane Musculoskeletal Group review: acute goutSteroids or NSAIDs? Let this overview from the Cochrane Group help you decide what’s best for your patientJ Fam Pract2009587E1E419607767
  • KimSYChoiHKGout and quality of lifeJ Rheumatol200936586586819435969
  • ShultenPThomasJMillerMSmithMAhernMThe role of diet in the management of gout: a comparison of knowledge and attitudes to current evidenceJ Hum Nutr Diet200922131119192022
  • WeaverALEpidemiology of goutCleve Clin J Med200875Suppl 5S9S1218819329
  • CampionEWGlynnRJDeLabryLOAsymptomatic hyperuricemia. Risks and consequences in the Normative Aging StudyAm J Med198738234214263826098
  • MarinelloERiario-SforzaGMarcolongoRPlasma follicle-stimulating hormone, luteinizing hormone, and sex hormones in patients with goutArthritis Rheum19852821271313918542
  • RosenRTomerYCarelRWeinbergerASerum 17-beta-estradiol and testosterone levels in asymptomatic hyperuricaemic menClin Rheumatol19941322192238088062
  • RhoYHChoiSJLeeYHThe prevalence of metabolic syndrome in patients with gout: a multicenter studyJ Korean Med Sci20052061029103316361817
  • OnatAUyarelHHergencGSerum uric acid is a determinant of metabolic syndrome in a population-based studyAm J Hypertens200619101055106217027827
  • TakahashiSYamamotoTMoriwakiYTsutsumiZHigashinoKImpaired lipoprotein metabolism in patients with primary gout – influence of alcohol intake and body weightBr J Rheumatol19943387317348055199
  • GenelhuVACeloriaBMDuarteSFCabelloPHFrancischettiEANot all obese subjects of multiethnic origin are at similar risk for developing hypertension and type 2 diabetesEur J Intern Med200920328929519393496
  • ChoiHKDiet, alcohol, and gout: how do we advise patients given recent developments?Curr Rheumatol Rep20057322022615918999
  • TorralbaTPBayani-SiosonPSThe Filipino and goutSemin Arthritis Rheum1975443073201135632
  • KaplanHKlatskinGSarcoidosis, psoriasis, and gout: syndrome or coincidence?Yale J Biol Med19603233535214404387
  • YuTFSecondary gout associated with myeloproliferative diseasesArthritis Rheum1965857657715216775
  • BrutscheRLDoernerAAChronic lymphocytic leukemia; report of a case with marked uric acid crystalluriaAMA Arch Intern Med195697681781913312727
  • LudwigGDSaturnine gout; a secondary type of goutAMA Arch Intern Med1957100580281213468828
  • KangEHLeeEYLeeYJSongYWLeeEBClinical features and risk factors of postsurgical goutAnn Rheum Dis20086791271127517998214
  • RajJMSudhakarSSemsKCarlsonRWArthritis in the intensive care unitCrit Care Clin200218476778012418440
  • KurtzmanNACoexistent sarcoidosis and goutJ Lancet19658519519614290322
  • RubinMRSilverbergSJRheumatic manifestations of primary hyperparathyroidism and parathyroid hormone therapyCurr Rheumatol Rep20024217918511890884
  • KangHCChungDEKimDWKimHDEarly- and late-onset complications of the ketogenic diet for intractable epilepsyEpilepsia20044591116112315329077
  • CameronJSSimmondsHAHereditary hyperuricemia and renal diseaseSemin Nephrol200525191815660329
  • KamataniNYamanakaHTotokawaSKashiwazakiSHigurashiMDown syndrome with coexistent gout: report of six patients and possible reasons for the scarcity of descriptions of this associationAnn Rheum Dis19965596496508882140
  • SaigalRChakrabortyAYadavRNPrashantRKPartial HPRT deficiency (Kelley-Seegmiller syndrome)J Assoc Physicians India200654495216649740
  • NyhanWLInherited hyperuricemic disordersContrib Nephrol2005147223415604603
  • NakagawaTHuHZharikovSA causal role for uric acid in fructose-induced metabolic syndromeAm J Physiol Renal Physiol20062903F625F63116234313
  • SaglamFCelikASariogluSHyperuricemia influences chronic cyclosporine nephropathyTransplant Proc200840116717018261576
  • WhiteMHaddadHLeblancMHConversion from cyclosporine microemulsion to tacrolimus-based immunoprophylaxis improves cholesterol profile in heart transplant recipients with treated but persistent dyslipidemia: the Canadian multicentre randomized trial of tacrolimus vs cyclosporine microemulsionJ Heart Lung Transplant200524779880915982605
  • NoordzijTCLeunissenKMvan HooffJPRenal handling of urate and the incidence of gouty arthritis during cyclosporine and diuretic useTransplantation199152164671858156
  • NakagawaTTuttleKRShortRAJohnsonRJHypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndromeNat Clin Pract Nephrol200512808616932373
  • Sanchez-LozadaLGTapiaEBautista-GarciaPEffects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndromeAm J Physiol Renal Physiol20082944F710F71818216151
  • SiuYPLeungKTTongMKKwanTHUse of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid levelAm J Kidney Dis2006471515916377385
  • WhiteJSMisconceptions about high-fructose corn syrup: is it uniquely responsible for obesity, reactive dicarbonyl compounds, and advanced glycation endproducts?J Nutr200913961219S1227S19386820
  • WhiteJSStraight talk about high-fructose corn syrup: what it is and what it ain’tAm J Clin Nutr20088861716S1721S19064536
  • SoleimaniMDietary fructose, salt absorption and hypertension in metabolic syndrome: Toward a new paradigmActa Physiol (Oxf)2010 [Epub ahead of print]
  • AkhavanTAndersonGHEffects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young menAm J Clin Nutr20078651354136317991646
  • FesselWJRenal outcomes of gout and hyperuricemiaAm J Med19796717482463920
  • Miranda-CarusEMateosFASanzAGHerreroERamosTPuigJGPurine metabolism in patients with gout: the role of leadNephron19977533273359069456
  • FeigDIUric acid: a novel mediator and marker of risk in chronic kidney disease?Curr Opin Nephrol Hypertens200918652653019654543
  • EdwardsNLThe role of hyperuricemia in vascular disordersCurr Opin Rheumatol200921213213719339923
  • KangDHHanLOuyangXUric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporterAm J Nephrol200525542543316113518
  • NakagawaTMazzaliMKangDHHyperuricemia causes glomerular hypertrophy in the ratAm J Nephrol20032312712373074
  • NakagawaTKangDHOhashiRTubulointerstitial disease: role of ischemia and microvascular diseaseCurr Opin Nephrol Hypertens200312323324112698060
  • GibsonTRodgersVPotterCSimmondsHAAllopurinol treatment and its effect on renal function in gout: a controlled studyAnn Rheum Dis198241159657039523
  • AvramZKrishnanEHyperuricaemia – where nephrology meets rheumatologyRheumatology (Oxford)200847796096418443007
  • WheltonAMacDonaldPLloydELademacherCBeneficial relationship of serum urate (sUA) reduction and estimated glomerular filtration rate (eGFR) improvement/maintenance in hyperuricemic gout subjects treated for up to 5.5 years with febuxostat (FEB) [abstract)2008 American College of Rheumatology MeetingSan Francisco, CA2008
  • GaffoALEdwardsNLSaagKGGout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?Arthritis Res Ther200911424019725932
  • ShahAKeenanRTGout, hyperuricemia, and the risk of cardiovascular disease: cause and effect?Curr Rheumatol Rep201012211812420425020
  • RoncalCAReungjuiSSanchez-LozadaLGCombination of captopril and allopurinol retards fructose-induced metabolic syndromeAm J Nephrol200930539940419696478
  • NakagawaTMazzaliMKangDHSanchez-LozadaLGHerrera-AcostaJJohnsonRJUric acid – a uremic toxin?Blood Purif2006241677016361844
  • MasuoKKawaguchiHMikamiHOgiharaTTuckMLSerum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevationHypertension200342447448012953019
  • NagahamaKInoueTIsekiKHyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, JapanHypertens Res2004271183584115824465
  • NakanishiNOkamotoMYoshidaHMatsuoYSuzukiKTataraKSerum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workersEur J Epidemiol200318652353012908717
  • AnnemansLSpaepenEGaskinMGout in the UK and Germany: prevalence, comorbidities and management in general practice 2000–2005Ann Rheum Dis200867796096617981913
  • KrishnanEKwohCKSchumacherHRKullerLHyperuricemia and incidence of hypertension among men without metabolic syndromeHypertension200749229830317190877
  • FeigDISoletskyBJohnsonRJEffect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trialJAMA2008300892493218728266
  • TangZChengLTLiHYWangTSerum uric acid and endothelial dysfunction in continuous ambulatory peritoneal dialysis patientsAm J Nephrol200929536837318974637
  • BergaminiCCicoiraMRossiAVassanelliCOxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failureEur J Heart Fail200911544445219346534
  • MitsuhashiHYatsuyaHMatsushitaKUric acid and left ventricular hypertrophy in Japanese menCirc J200973466767219225200
  • BainbridgeSAvon Versen-HoynckFRobertsJMUric acid inhibits placental system A amino acid uptakePlacenta200930219520019058847
  • TerkeltaubRBushinskyDABeckerMARecent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeuticsArthritis Res Ther20068Suppl 1S416820043
  • BenedictJDForshamPHStettenDJrThe metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acidJ Biol Chem1949181118319315390405
  • CampoCRuilopeLMSeguraJRodicioJLGarcia-RoblesRGarcia-PuigJHyperuricemia, low urine urate excretion and target organ damage in arterial hypertensionBlood Press2003125–627728314763658
  • EnomotoAKimuraHChairoungduaAMolecular identification of a renal urate anion exchanger that regulates blood urate levelsNature2002417688744745212024214
  • EralySAVallonVRiegTMultiple organic anion transporters contribute to net renal excretion of uric acidPhysiol Genomics200833218019218270321
  • SilvermanWLocoveiSDahlGProbenecid, a gout remedy, inhibits pannexin 1 channelsAm J Physiol Cell Physiol20082953C761C76718596212
  • EnomotoANiwaTKanaiYEndouHUrate transporter and renal hypouricemiaRinsho Byori200351989289714560659
  • SoAThorensBUric acid transport and diseaseJ Clin Invest201012061791179920516647
  • LipkowitzMSLeal-PintoECohenBEAbramsonRGGalectin 9 is the sugar-regulated urate transporter/channel UATGlycoconj J2004197–949149814758072
  • ChoiHKZhuYMountDBGenetics of goutCurr Opin Rheumatol201022214415120110790
  • UranoWTaniguchiAAnzaiNSodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with goutAnn Rheum Dis20106961232123419556210
  • MatsuoHTakadaTIchidaKCommon defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese populationSci Transl Med2009155ra11
  • CheesemanCSolute carrier family 2, member 9 and uric acid homeostasisCurr Opin Nephrol Hypertens200918542843219593129
  • DahanKDevuystOSmaersMA cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulinJ Am Soc Nephrol200314112883289314569098
  • RampoldiLCaridiGSantonDAllelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamicsHum Mol Genet200312243369338414570709
  • StoreyGDAlfred Baring Garrod (1819–1907)Rheumatology (Oxford)200140101189119011600751
  • FairesJSMcCartyDJAcute arthritis in man and dog after intrasynovial injection of sodium urate crystalsLancet19622807258682685
  • PascualEJovaniVA quantitative study of the phagocytosis of urate crystals in the synovial fluid of asymptomatic joints of patients with goutBr J Rheumatol19953487247267551655
  • SimkinPAConcentration of urate by differential diffusion: a hypothesis for initial urate depositionAdv Exp Med Biol1974415475504832580
  • SoADevelopments in the scientific and clinical understanding of goutArthritis Res Ther200810522118947374
  • PillingerMHKeenanRTUpdate on the management of hyperuricemia and goutBull NYU Hosp Jt Dis200866323123918937638
  • LioteFEaHKRecent developments in crystal-induced inflammation pathogenesis and managementCurr Rheumatol Rep20079324325017531179
  • ReginatoAMOlsenBRGenetics and experimental models of crystal-induced arthritis. Lessons learned from mice and men: is it crystal clear?Curr Opin Rheumatol200719213414517278928
  • RoseDMLiu-BryanRInnate immunity in triggering and resolution of acute gouty inflammationCurr Rheumatol Rep20068320921416901079
  • KoopmanWJMorelandLWArthritis and Allied Conditions: A Textbook of Rheumatology15th edPhiladelphiaLippincott Williams & Wilkins2005
  • AbramsonSHoffsteinSTWeissmannGSuperoxide anion generation by human neutrophils exposed to monosodium urateArthritis Rheum19822521741806279115
  • TerkeltaubRADyerCAMartinJCurtissLKApolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivoJ Clin Invest199187120261985096
  • AkahoshiTMurakamiYKitasatoHRecent advances in crystal-induced acute inflammationCurr Opin Rheumatol200719214615017278929
  • McCartyDJJrPhelpsPPyensonJCrystal-induced inflammation in canine joints. I. An experimental model with quantification of the host responseJ Exp Med19661241991144287616
  • FalascaGFRamachandrulaAKelleyKAO’ConnorCRReginatoAJSuperoxide anion production and phagocytosis of crystals by cultured endothelial cellsArthritis Rheum19933611051168381009
  • TerkeltaubRZachariaeCSantoroDMartinJPeveriPMatsushimaKMonocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammationArthritis Rheum19913478949032059236
  • DuffGWAtkinsEMalawistaSEThe fever of gout: urate crystals activate endogenous pyrogen production from human and rabbit mononuclear phagocytesTrans Assoc Am Physicians1983962342456093311
  • MartinWJWaltonMHarperJResident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute goutArthritis Rheum200960128128919116939
  • MartinWJHarperJLInnate inflammation and resolution in acute goutImmunol Cell Biol2010881151919935764
  • Liu-BryanRScottPSydlaskeARoseDMTerkeltaubRInnate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammationArthritis Rheum20055292936294616142712
  • RyckmanCGilbertCde MedicisRLussierAVandalKTessierPAMonosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophilsJ Leukoc Biol200476243344015107458
  • GassePRiteauNCharronSUric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosisAm J Respir Crit Care Med20091791090391319218193
  • MartinonFMayorATschoppJThe inflammasomes: guardians of the bodyAnnu Rev Immunol20092722926519302040
  • BianchiMEDAMPs, PAMPs and alarmins: all we need to know about dangerJ Leukoc Biol20078111517032697
  • MalawistaSEDuffGWAtkinsECheungHSMcCartyDJCrystal-induced endogenous pyrogen production. A further look at gouty inflammationArthritis Rheum1985289103910462994686
  • WoodDDIhrieEJDinarelloCACohenPLIsolation of an interleukin-1-like factor from human joint effusionsArthritis Rheum19832689759836603852
  • di GiovineFSMalawistaSENukiGDuffGWInterleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1J Immunol198751513810321332183033070
  • MartinonFBurnsKTschoppJThe inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaMol Cell200210241742612191486
  • MartinonFPetrilliVMayorATardivelATschoppJGout-associated uric acid crystals activate the NALP3 inflammasomeNature2006440708123724116407889
  • SidiropoulosPIGoulielmosGVoloudakisGKPetrakiEBoumpasDTInflammasomes and rheumatic diseases: evolving conceptsAnn Rheum Dis200867101382138917921182
  • FranchiLEigenbrodTMunoz-PlanilloRNunezGThe inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesisNat Immunol200910324124719221555
  • PopeRMTschoppJThe role of interleukin-1 and the inflammasome in gout: implications for therapyArthritis Rheum200756103183318817907163
  • Liu-BryanRIntracellular innate immunity in gouty arthritis: role of NALP3 inflammasomeImmunol Cell Biol2010881202319935768
  • ChurchLDCookGPMcDermottMFPrimer: inflammasomes and interleukin 1beta in inflammatory disordersNat Clin Pract Rheumatol200841344218172447
  • PetrilliVMartinonFThe inflammasome, autoinflammatory diseases, and goutJoint Bone Spine200774657157617714972
  • Liu-BryanRPritzkerKFiresteinGSTerkeltaubRTLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generationJ Immunol200517485016502315814732
  • Liu-BryanRLioteFMonosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signalingJoint Bone Spine200572429530215990350
  • ScottPMaHViriyakosolSTerkeltaubRLiu-BryanREngagement of CD14 mediates the inflammatory potential of monosodium urate crystalsJ Immunol200617796370637817056568
  • YagnikDREvansBJFloreyOMasonJCLandisRCHaskardDOMacrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammationArthritis Rheum20045072273228015248227
  • LandisRCYagnikDRFloreyOSafe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophagesArthritis Rheum200246113026303312428246
  • MarcolongoRCalabriaAALalumeraMGerliRAlessandriniCCavalloGThe “switch-off ” mechanism of spontaneous resolution of acute gout attackJ Rheumatol19881511011092832599
  • SchumacherHRJrThe pathogenesis of goutCleve Clin J Med200875Suppl 5S2S418822468
  • FalascaGFMetabolic diseases: goutClin Dermatol200624649850817113968
  • ter BorgEJRaskerJJGout in the elderly, a separate entity?Ann Rheum Dis198746172763813677
  • O’DellJRGout in Heberden’s nodesArthritis Rheum19832611141314146639700
  • Molinos NormiellaCRey GalanCMedina VillanuevaAConcha TorreAMenendez CuervoSUric acid as a prognostic marker in critically ill patientsAn Esp Pediatr200155430530911578536
  • WeaverJSomaniNBauerTWPiliangMSimple non-staining method to demonstrate urate crystals in formalin-fixed, paraffin-embedded skin biopsiesJ Cutan Pathol200936556056419476524
  • ShidhamVChivukulaMBasirZShidhamGEvaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosisMod Pathol200114880681011504841
  • Perez-RuizFDalbethNUrresolaAde MiguelESchlesingerNImaging of gout: findings and utilityArthritis Res Ther200911323219591633
  • DalbethNMcQueenFMUse of imaging to evaluate gout and other crystal deposition disordersCurr Opin Rheumatol200921212413119339922
  • FilippucciEScireCADelle SedieAUltrasound imaging for the rheumatologist. XXV. Sonographic assessment of the knee in patients with gout and calcium pyrophosphate deposition diseaseClin Exp Rheumatol20102812520346230
  • de Avila FernandesEKubotaESSandimGBMitraudSAFerrariAJFernandesARUltrasound features of tophi in chronic tophaceous goutSkeletal Radiol2010 [Epub ahead of print]
  • ThieleRGSchlesingerNDiagnosis of gout by ultrasoundRheumatology (Oxford)20074671116112117468505
  • CarterJDKedarRPAndersonSRAn analysis of MRI and ultrasound imaging in patients with gout who have normal plain radiographsRheumatology (Oxford)200948111442144619745028
  • KunkelGKaeleyGThieleRComment on: an analysis of MRI and ultrasound imaging in patients with gout who have normal plain radiographsRheumatology (Oxford)201049510221023 author reply1023102420172992
  • NeogiTHunterDJChaissonCEAllensworth-DaviesDZhangYFrequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal studyJ Rheumatol200633110410916267879
  • TerkeltaubRAFurstDEBennettKKookKACrockettRSDavisMWHigh versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine studyArthritis Rheum20106241060106820131255
  • PharmaUColcrys Official Prescribing Information20105 Official Prescribing Information. http://colcrys.com/assets/pdf/COLCRYS_Full_Prescribing_Information.pdf. Accessed 2010 Aug 28.
  • MoladYUpdate on colchicine and its mechanism of actionCurr Rheumatol Rep20024325225612010611
  • ChenYJHuangSMLiuCYYehPHTsaiTHHepatobiliary excretion and enterohepatic circulation of colchicine in ratsInt J Pharm20083501–223023917931809
  • MontsenyJJMeyrierAGherardiRKColchicine toxicity in patients with chronic renal failureNephrol Dial Transplant19961110205520588918722
  • SchiffDDrislaneFWRapid-onset colchicine myoneuropathyArthritis Rheum19923512153515361472131
  • FiehnCZeierMSuccessful treatment of chronic tophaceous gout with infliximab (Remicade)Rheumatol Int200626327427615933855
  • TauscheAKRichterKGrasslerAHanselSRochBSchroderHESevere gouty arthritis refractory to anti-inflammatory drugs: treatment with anti-tumour necrosis factor alpha as a new therapeutic optionAnn Rheum Dis200463101351135215361402
  • MengZHHudsonAPSchumacherHRJrBakerJFBakerDGMonosodium urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumor necrosis factor-alpha expression in a mononuclear cell lineJ Rheumatol19972412238523889415647
  • di GiovineFSMalawistaSEThorntonEDuffGWUrate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distributionJ Clin Invest1991874137513812010550
  • SoAde SmedtTRevazSTschoppJA pilot study of IL-1 inhibition by anakinra in acute goutArthritis Res Ther200792R2817352828
  • SinghDHustonKKIL-1 inhibition with anakinra in a patient with refractory goutJ Clin Rheumatol200915736620009976
  • GrattonSBScalapinoKJFyeKHCase of anakinra as a steroid-sparing agent for gout inflammationArthritis Rheum20096191268127019714614
  • TerkeltaubRSundyJSSchumacherHRThe interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot studyAnn Rheum Dis200968101613161719635719
  • SoAde MeulemeesterMPikhlakACanakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: results of a multicenter, phase II, dose-ranging studyArthritis Rheum201062103064307620533546
  • Study of Tranilast Alone or in Combination With Allopurinol in Subjects With Hyperuricemia. 2010; http://clinicaltrials.gov/ct2/show/NCT01052987?intr=Tranilast&rank=2. Accessed 2010 Sep 1.
  • HiggsGIs PDE4 too difficult a drug target?Curr Opin Investig Drugs2010115495498
  • Apremilast Therapy for Acute Gouty Arthritis2010 http://clinicaltrials.gov/ct2/show/NCT00997581?term=apremilast&rank=11. Accessed 2010 Sep 1.
  • FavreLGlassonPRiondelAVallottonMBInteraction of diuretics and non-steroidal anti-inflammatory drugs in manClin Sci (Lond)19836444074156337769
  • FavreLGlassonPVallottonMBReversible acute renal failure from combined triamterene and indomethacin: a study in healthy subjectsAnn Intern Med19829633173206949485
  • VarugheseGIVargheseAIColchicine myoneuropathy: the role of rhabdomyolysisNephrology (Carlton)2006115481482 author reply 48217014570
  • LaiICChengCYChenHHChenWYChenPYColchicine myoneuropathy in chronic renal failure patients with goutNephrology (Carlton)200611214715016669978
  • KunclRWDuncanGWatsonDAldersonKRogawskiMAPeperMColchicine myopathy and neuropathyN Engl J Med198731625156215683035372
  • Uloric Full Prescribing Information2009 http://general.takedapharm.com/content/file/pi.pdf?applicationcode=6C7C39D8-5D09-453B-BF30-696A4AB88E62&FileTypeCode=ULORICPI. Accessed 2010 Aug 30.
  • KissinEYNishioJYangMSelf-directed learning of basic musculoskeletal ultrasound among rheumatologists in the United StatesArthritis Care Res (Hoboken)201062215516020191513
  • FilippucciERiverosMGGeorgescuDSalaffiFGrassiWHyaline cartilage involvement in patients with gout and calcium pyrophosphate deposition disease. An ultrasound studyOsteoarthritis Cartilage200917217818118657999
  • ChoiHKA prescription for lifestyle change in patients with hyperuricemia and goutCurr Opin Rheumatol201022216517220035225
  • DohertyMNew insights into the epidemiology of goutRheumatology (Oxford)200948Suppl 2ii2ii819447779
  • CutlerDMGlaeserELShapiroJMWhy have Americans become more obese?J Econ Perspect20031793118
  • Statistics Related to Overweight and Obesity NIH Publication Number 04-4158. 2010; http://win.niddk.nih.gov/statistics/. Accessed 2010 Aug 1.
  • ChoiHKAtkinsonKKarlsonEWCurhanGObesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up studyArch Intern Med2005165774274815824292
  • ChoiJWFordESGaoXChoiHKSugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: The Third National Health and Nutrition Examination SurveyArthritis Rheum200859110911618163396
  • ChoiHKCurhanGSoft drinks, fructose consumption, and the risk of gout in men: prospective cohort studyBMJ2008336763930931218244959
  • SchlesingerNDietary factors and hyperuricaemiaCurr Pharm Des200511324133413816375734
  • KerndtPRNaughtonJLDriscollCELoxterkampDAFasting: the history, pathophysiology and complicationsWest J Med198213753793996758355
  • ChoiHKAtkinsonKKarlsonEWWillettWCurhanGAlcohol intake and risk of incident gout in men: a prospective studyLancet200436394171277128115094272
  • JacobRASpinozziGMSimonVAConsumption of cherries lowers plasma urate in healthy womenJ Nutr200313361826182912771324
  • HowatsonGMcHughMPHillJAInfluence of tart cherry juice on indices of recovery following marathon runningScand J Med Sci Sports2009 [Epub ahead of print]
  • KelleyDSRasoolyRJacobRAKaderAAMackeyBEConsumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and womenJ Nutr2006136498198616549461
  • USDA National Nutrient Database for Standard Reference. Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/ba/bhnrc/ndl. US Department of Agriculture; 2010. http://www.ars.usda.gov/ba/bhnrc/ndl. Accessed 2010 Oct 8.
  • BlauLWCherry diet control for gout and arthritisTex Rep Biol Med19508330931114776685
  • SteinHBHasanAFoxIHAscorbic acid-induced uricosuria. A consequency of megavitamin therapyAnn Intern Med19768443853881259282
  • ChoiHKGaoXCurhanGVitamin C intake and the risk of gout in men: a prospective studyArch Intern Med2009169550250719273781
  • GaoXCurhanGFormanJPAscherioAChoiHKVitamin C intake and serum uric acid concentration in menJ Rheumatol20083591853185818464304
  • McGillNWGout and other crystal-associated arthropathiesBaillieres Best Pract Res Clin Rheumatol200014344546010985980
  • SarawateCABrewerKKYangWGout medication treatment patterns and adherence to standards of care from a managed care perspectiveMayo Clin Proc200681792593416835972
  • RiedelAANelsonMWallaceKJoseph-RidgeNClearyMFamAGPrevalence of Comorbid Conditions and Prescription Medication Use Among Patients With Gout and Hyperuricemia in a Managed Care SettingJ Clin Rheumatol200410630831417043538
  • RiedelAANelsonMJoseph-RidgeNWallaceKMacDonaldPBeckerMCompliance with allopurinol therapy among managed care enrollees with gout: a retrospective analysis of administrative claimsJ Rheumatol20043181575158115290738
  • ReindersMKHaagsmaCJansenTLA randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day in patients with goutAnn Rheum Dis200968689289718633127
  • DalbethNStampLAllopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse eventsSemin Dial200720539139517897242
  • ShalomRRimbrothSRozenmanDMarkelAAllopurinol-induced recurrent DRESS syndrome: pathophysiology and treatmentRen Fail200830332732918350453
  • FamAGLewtasJSteinJPatonTWDesensitization to allopurinol in patients with gout and cutaneous reactionsAm J Med19929332993021388001
  • LeeSSLinHYWangSRTsaiYYAllopurinol hypersensitivity syndromeZhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi19942731401479747344
  • LuptonGPOdomRBThe allopurinol hypersensitivity syndromeJ Am Acad Dermatol197914365374159913
  • RoujeauJCKellyJPNaldiLMedication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysisN Engl J Med199533324160016077477195
  • MarkelAAllopurinol-induced DRESS syndromeIsr Med Assoc J200571065666016259349
  • HungSIChungWHLiouLBHLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinolProc Natl Acad Sci U S A2005102114134413915743917
  • Zyloprim® Official Prescribing Information. 2003; http://www.prometheuspatients.com/PDF/Zyloprim.pdf. Accessed 2010 Aug 30.
  • ChaoJTerkeltaubRA critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in goutCurr Rheumatol Rep200911213514019296886
  • GaffoALSaagKGManagement of hyperuricemia and gout in CKDAm J Kidney Dis2008525994100918971014
  • MurrellGARapeportWGClinical pharmacokinetics of allopurinolClin Pharmacokinet19861153433533536254
  • HandeKRNooneRMStoneWJSevere allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiencyAm J Med198476147566691361
  • BellamyNGilbertJRBrooksPMEmmersonBTCampbellJA survey of current prescribing practices of antiinflammatory and urate lowering drugs in gouty arthritis in the province of OntarioJ Rheumatol19881512184118473265960
  • DalbethNKumarSStampLGowPDose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with goutJ Rheumatol20063381646165016783857
  • Vazquez-MelladoJMoralesEMPacheco-TenaCBurgos-VargasRRelation between adverse events associated with allopurinol and renal function in patients with goutAnn Rheum Dis2001601098198311557658
  • IfuduOTanCCDulinALDelanoBGFriedmanEAGouty arthritis in end-stage renal disease: clinical course and rarity of new casesAm J Kidney Dis19942333473518128934
  • SchreinerOWandelEHimmelsbachFGallePRMarker-HermannEReduced secretion of proinflammatory cytokines of monosodium urate crystal-stimulated monocytes in chronic renal failure: an explanation for infrequent gout episodes in chronic renal failure patients?Nephrol Dial Transplant200015564464910809805
  • GargJPChasan-TaberSBlairAEffects of sevelamer and calcium-based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: a randomized clinical trialArthritis Rheum200552129029515641045
  • StampLHaLSearleMO’DonnellJFramptonCChapmanPGout in renal transplant recipientsNephrology (Carlton)200611436737116889578
  • StampLSearleMO’DonnellJChapmanPGout in solid organ transplantation: a challenging clinical problemDrugs200565182593261116392875
  • Siegenthaler-ZuberGWhich uric acid value is in need of treatment?Schweiz Med Wochenschr1976106144874911265467
  • LiangMHFriesJFAsymptomatic hyperuricemia: the case for conservative managementAnn Intern Med1978885666670646260
  • DawsonJQuinnTWaltersMUric acid reduction: a new paradigm in the management of cardiovascular risk?Curr Med Chem200714171879188617627523
  • BeckerMASchumacherHRJrWortmannRLFebuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with goutArthritis Rheum200552391692315751090
  • BeckerMASchumacherHRJrWortmannRLFebuxostat compared with allopurinol in patients with hyperuricemia and goutN Engl J Med2005353232450246116339094
  • Febuxostat Phase 3 Clinical Trials Study NCT00174915. Takeda Pharmaceuticals; 2009. http://clinicaltrials.gov/ct2/show/results/NCT00174915?term=gout&rank=9&sect=X6015#outcome1. Accessed 2010 Jun 21.
  • TerkeltaubRAClinical practice. GoutN Engl J Med2003349171647165514573737
  • ReindersMKvan RoonENJansenTLEfficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinolAnn Rheum Dis2009681515618250112
  • LeeMHGrahamGGWilliamsKMDayROA benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?Drug Saf200831864366518636784
  • TakahashiSMoriwakiYYamamotoTTsutsumiZKaTFukuchiMEffects of combination treatment using anti-hyperuricaemic agents with fenofibrate and/or losartan on uric acid metabolismAnn Rheum Dis200362657257512759298
  • TerkeltaubRGout. Novel therapies for treatment of gout and hyperuricemiaArthritis Res Ther23200911423619664185
  • LaskoBSheedyBHingoraniVRDEA594, a novel uricosuric agent, significantly reduced serum urate levels and was well tolerated in a phase 2a pilot study in hyperuricemic gout patients2009 American College of Rheumatology Annual Scientific MeetingPhiladelphia, PA2009
  • Ardea Biosciences Announces positive results from a Phase 1 Study of RDEA594Medical News Today2009 http://www.medicalnewstoday.com/articles/135285.php. Accessed 2010 Aug 30.