References
- MunozLEJankoCSchulzeCAutoimmunity and chronic inflammation – two clearance-related steps in the etiopathogenesis of SLEAutoimmun Rev2010101384220817127
- PerniokAWedekindFHerrmannMSpeckerCSchneiderMHigh levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosusLupus1998721131189541096
- RhodesBVyseTJThe genetics of SLE: an update in the light of genome-wide association studiesRheumatology (Oxford)200847111603161118611920
- CooperGSMillerFWPandeyJPThe role of genetic factors in autoimmune disease: implications for environmental researchEnviron Health Perspect1999107Suppl 569370010502533
- EdwardsCJEnvironmental factors and lupus: are we looking too late?Lupus200514642342516038104
- Pons-EstelGJAlarconGSScofieldLReinlibLCooperGSUnderstanding the epidemiology and progression of systemic lupus erythematosusSemin Arthritis Rheum201039425726819136143
- IppolitoAWallaceDJGladmanDAutoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivityLupus201120325025521362750
- PradhanVDBadakereSSBichileLSAlmeidaAFAnti-neutrophil cytoplasmic antibodies (ANCA) in systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodiesJ Assoc Physicians India20045253353715645975
- BoutsYMWolthuisDFDirkxMFApoptosis and NET formation in the pathogenesis of SLEAutoimmunity201245859760122913420
- MunozLEGaiplUSFranzSSLE – a disease of clearance deficiency?Rheumatology (Oxford)20054491101110715928001
- LuJHTehBKWangLThe classical and regulatory functions of C1q in immunity and autoimmunityCell Mol Immunol20085192118318990
- MilesKHeaneyJSibinskaZA tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cellsProc Natl Acad Sci U S A2012109388789222207622
- RenehanAGBachSPPottenCSThe relevance of apoptosis for cellular homeostasis and tumorigenesis in the intestineCan J Gastroenterol200115316617611264570
- HensonPMHumeDAApoptotic cell removal in development and tissue homeostasisTrendsImmunol2006275244250
- RavichandranKSLorenzUEngulfment of apoptotic cells: signals for a good mealNat Rev Immunol200771296497418037898
- SavillJApoptosis in resolution of inflammationJ Leukoc Biol19976143753809103222
- LiuXZouHSlaughterCWangXDFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosisCell19978921751849108473
- SakahiraHEnariMNagataSCleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosisNature1998391666296999422513
- LazebnikYAKaufmannSHDesnoyersSPoirierGGEarnshawWCCleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICENature199437164953463478090205
- GuYSarneckiCAldapeRALivingstonDJSuMSCleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2J Biol Chem19952703218715187187642516
- ChaurioRAMunozLEMaueroderCThe progression of cell death affects the rejection of allogeneic tumors in immune-competent mice – implications for cancer therapyFront Immunol2014556025426116
- ParthasarathyGPhilippMTReview: apoptotic mechanisms in bacterial infections of the central nervous systemFront Immunol2012330623060884
- BilyyROShkandinaTTominAMacrophages discriminate glycosylation patterns of apoptotic cell-derived microparticlesJ Biol Chem2012287149650322074924
- PeterCWesselborgSHerrmannMLauberKDangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cellsApoptosis20101591007102820157780
- VollREHerrmannMRothEAStachCKaldenJRGirkontaiteIImmunosuppressive effects of apoptotic cellsNature199739066583503519389474
- FadokVAde CathelineauADalekeDLHensonPMBrattonDLLoss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblastsJ Biol Chem200127621071107710986279
- ChaurioRAJankoCMunozLEFreyBHerrmannMGaiplUSPhospholipids: key players in apoptosis and immune regulationMolecules200914124892491420032867
- WilliamsonPSchlegelRATransbilayer phospholipid movement and the clearance of apoptotic cellsBiochim Biophys Acta200215852–3536312531537
- DillonSRManciniMRosenASchlisselMSAnnexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activationJ Immunol200016431322133210640746
- FischerKVoelklSBergerJAndreesenRPomorskiTMackensenAAntigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cellsBlood2006108134094410116912227
- SegawaKSuzukiJNagataSConstitutive exposure of phosphatidylserine on viable cellsProc Natl Acad Sci U S A201110848192461925122084121
- JankoCJeremicIBiermannMCooperative binding of Annexin A5 to phosphatidylserine on apoptotic cell membranesPhys Biol201310606500624304966
- BiermannMMaueroderCBraunerJMSurface code – biophysical signals for apoptotic cell clearancePhys Biol201310606500724305041
- GregoryCDPoundJDCell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissuesJ Pathol2011223217719421125674
- KimSParkSYKimSYCross talk between engulfment receptors stabilin-2 and integrin alphavbeta5 orchestrates engulfment of phosphatidylserine-exposed erythrocytesMol Cell Biol201232142698270822566688
- KobayashiNKarisolaPPena-CruzVTIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cellsImmunity200727692794018082433
- IshimotoYOhashiKMizunoKNakanoTPromotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6J Biochem2000127341141710731712
- KruseKJankoCUrbonaviciuteVInefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other playersApoptosis20101591098111320198437
- KinchenJMRavichandranKSJourney to the grave: signaling events regulating removal of apoptotic cellsJ Cell Sci2007120Pt 132143214917591687
- BournazouIPoundJDDuffinRApoptotic human cells inhibit migration of granulocytes via release of lactoferrinJ Clin Invest20091191203219033648
- VermesIHaanenCRichelDJSchaafsmaMRKalsbeek-BatenburgEReutelingspergerCPApoptosis and secondary necrosis of lymphocytes in cultureActa Haematol19979818139210907
- WuXMolinaroCJohnsonNCasianoCASecondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for systemic autoimmunityArthritis Rheum200144112642265211710720
- KonoHRockKLHow dying cells alert the immune system to dangerNat Rev Immunol20088427928918340345
- UrbonaviciuteVFurnrohrBGMeisterSInduction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLEJ Exp Med2008205133007301819064698
- MunozLEJankoCGrossmayerGERemnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosusArthritis Rheum20096061733174219479824
- MunozLELauberKSchillerMManfrediAAHerrmannMThe role of defective clearance of apoptotic cells in systemic autoimmunityNat Rev Rheumatol20106528028920431553
- GaiplUSBeyerTDBaumannIExposure of anionic phospholipids serves as anti-inflammatory and immunosuppressive signal – implications for antiphospholipid syndrome and systemic lupus erythematosusImmunobiology20032071738112638907
- RekvigOPMortensenESImmunity and autoimmunity to dsDNA and chromatin – the role of immunogenic DNA-binding proteins and nuclease deficienciesAutoimmunity201245858859223013317
- GaiplUSBeyerTDHeyderPCooperation between C1q and DNase I in the clearance of necrotic cell-derived chromatinArthritis Rheum200450264064914872509
- KerrJFWyllieAHCurrieARApoptosis: a basic biological phenomenon with wide-ranging implications in tissue kineticsBr J Cancer19722642392574561027
- BiermannMHVeissiSMaueroderCThe role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targetsExpert Rev Clin Immunol20141091151116425081199
- Witko-SarsatVRieuPDescamps-LatschaBLesavrePHalbwachs-MecarelliLNeutrophils: molecules, functions and pathophysiological aspectsLab Invest200080561765310830774
- ScapiniPLaudannaCPinardiCNeutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP- 3alpha)/CCL20 and MIP-3beta/CCL19Eur J Immunol20013171981198811449350
- IbaTHashiguchiNNagaokaITabeYMuraiMNeutrophil cell death in response to infection and its relation to coagulationJ Intens Care20131113
- BrinkmannVReichardUGoosmannCNeutrophil extracellular traps kill bacteriaScience200430356631532153515001782
- SchornCJankoCLatzkoMChaurioRSchettGHerrmannMMonosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cellsFront Immunol2012327722969769
- PapayannopoulosVMetzlerKDHakkimAZychlinskyANeutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular trapsJ Cell Biol2010191367769120974816
- MetzlerKDFuchsTANauseefWMMyeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunityBlood2011117395395920974672
- NakashimaKHagiwaraTIshigamiAMolecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)J Biol Chem199927439277862779210488123
- NakashimaKHagiwaraTYamadaMNuclear localization of peptidylarginine deiminase V and histone deimination in granulocytesJ Biol Chem200227751495624956812393868
- VossenaarERZendmanAJvan VenrooijWJPruijnGJPAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseBioessays200325111106111814579251
- FuchsTAAbedUGoosmannCNovel cell death program leads to neutrophil extracellular trapsJ Cell Biol2007176223124117210947
- PieterseEvan der VlagJBreaking immunological tolerance in systemic lupus erythematosusFront Immunol2014516424782867
- MillerBFAbramsRDorfmanAKleinMAntibacterial properties of protamine and histoneScience194296249742843017729719
- HoffmannMHBrunsHBackdahlLThe cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and ratsAnn Rheum Dis20137271239124823172753
- LandeRGangulyDFacchinettiVNeutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosusSci Transl Med201137373ra19
- Garcia-RomoGSCaielliSVegaBNetting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosusSci Transl Med201137373ra20
- UrbonaviciuteVVollREHigh-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosusJ Int Med20112704309318
- HakkimAFurnrohrBGAmannKImpairment of neutrophil extracellular trap degradation is associated with lupus nephritisProc Natl Acad Sci U S A2010107219813981820439745
- CoitPYalavarthiSOgnenovskiMEpigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophilsJ Autoimmun201558596625638528
- SchauerCJankoCMunozLEAggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokinesNat Med201420551151724784231
- IpWKChanSYLauCSLauYLAssociation of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin geneArthritis Rheum1998419166316689751100
- RicklinDHajishengallisGYangKLambrisJDComplement: a key system for immune surveillance and homeostasisNat Immunol201011978579720720586
- JogNRFrisoniLShiQCaspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigensArthritis Rheum20126441247125622127758
- HerrmannMVollREZollerOMHagenhoferMPonnerBBKaldenJRImpaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosusArthritis Rheum1998417124112509663482
- MunozLEChaurioRAGaiplUSSchettGKernPMoMa from patients with systemic lupus erythematosus show altered adhesive activityAutoimmunity200942426927119811273
- CairnsAPCrockardADMcConnellJRCourtneyPABellALReduced expression of CD44 on monocytes and neutrophils in systemic lupus erythematosus: relations with apoptotic neutrophils and disease activityAnn Rheum Dis2001601095095511557652
- GaiplUSMunozLEGrossmayerGClearance deficiency and systemic lupus erythematosus (SLE)J Autoimmun2007282–311412117368845
- BaumannIKolowosWVollREImpaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosusArthritis Rheum200246119120111817590
- KravitzMSShoenfeldYAutoimmunity to protective molecules: is it the perpetuum mobile (vicious cycle) of autoimmune rheumatic diseases?Nat Clin Prac Rheumatol200629481490
- VollRERothEAGirkontaiteIHistone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody productionArthritis Rheum19974012216221719416853
- TheocharisSSfikakisPPLipnickRNKlippleGLSteinbergADTsokosGCCharacterization of in vivo mutated T cell clones from patients with systemic lupus erythematosusClin Immunol Immunopathol19957421351427828367
- ShivakumarSTsokosGCDattaSKT cell receptor alpha/beta expressing double-negative (CD4−/CD8−) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritisJ Immunol198914311031122525144
- CamachoSAKosco-VilboisMHBerekCThe dynamic structure of the germinal centerImmunol Today199819115115149818545
- MevorachDMascarenhasJOGershovDElkonKBComplement-dependent clearance of apoptotic cells by human macrophagesJ Exp Med199818812231323209858517
- SchroederKHerrmannMWinklerTHThe role of somatic hypermutation in the generation of pathogenic antibodies in SLEAutoimmunity201346212112723181829
- WinklerTHFehrHKaldenJRAnalysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomasEur J Immunol1992227171917281623920
- SaikiOSaekiYTanakaTDevelopment of selective IgM deficiency in systemic lupus erythematosus patients with disease of long durationArthritis Rheum19873011128912923689463
- WitteTIgM antibodies against dsDNA in SLEClin Rev Allergy Immunol200834334534718097774
- SjowallCZapfJvon LohneysenSAltered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosusLupus201424656958125389233
- MalhotraRWormaldMRRuddPMFischerPBDwekRASimRBGlycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding proteinNat Med1995132372437585040
- KanekoYNimmerjahnFRavetchJVAnti-inflammatory activity of immunoglobulin G resulting from Fc sialylationScience2006313578767067316888140
- BlancoPPaluckaAKPascualVBanchereauJDendritic cells and cytokines in human inflammatory and autoimmune diseasesCytokine Growth Factor Rev2008191415218258476
- LiaoJChangCWuHLuQCell-based therapies for systemic lupus erythematosusAutoimmun Rev2015141434825308529
- BanchereauJSteinmanRMDendritic cells and the control of immunityNature199839266732452529521319
- FransenJHvan der VlagJRubenJAdemaGJBerdenJHHilbrandsLBThe role of dendritic cells in the pathogenesis of systemic lupus erythematosusArthritis Res Ther201012220720423534
- SeitzHMMatsushimaGKDendritic cells in systemic lupus erythematosusInt Rev Immunol201029218420920367140
- DieboldSSKaishoTHemmiHAkiraSReis e SousaCInnate antiviral responses by means of TLR7-mediated recognition of single-stranded RNAScience200430356631529153114976261
- Ahmad-NejadPHackerHRutzMBauerSVabulasRMWagnerHBacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartmentsEur J Immunol20023271958196812115616
- GangulyDChamilosGLandeRSelf-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8J Exp Med200920691983199419703986
- PagnouxCPlasma exchange for systemic lupus erythematosusTransfus Aphere Sci2007362187193
- AllhornMOlinAINimmerjahnFCollinMHuman IgG/Fc gamma R interactions are modulated by streptococcal IgG glycan hydrolysisPloS One200831e141318183294
- NimmerjahnFRavetchJVThe antiinflammatory activity of IgG: the intravenous IgG paradoxJ Exp Medicine200720411115
- NgKPLeandroMJEdwardsJCEhrensteinMRCambridgeGIsenbergDARepeated B cell depletion in treatment of refractory systemic lupus erythematosusAnn Rheum Dis200665794294516269424
- LutaloPMD’CruzDPUpdate on belimumab for the management of systemic lupus erythematosusExpert Opin Biol Ther201414111701170825303323
- NeubertKMeisterSMoserKThe proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritisNat Med200814774875518542049
- IlleiGGCerveraRBurtRKCurrent state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosusAnn Rheum Dis201170122071207421873334
- NoseMWigzellHBiological significance of carbohydrate chains on monoclonal antibodiesProc Natl Acad Sci U S A19838021663266366579549
- CollinMOlsenAEndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgGEMBO J200120123046305511406581
- MerrillJTWallaceDJPetriMSafety profile and clinical activity of sifalimumab, a fully human anti-interferon alpha monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised studyAnn Rheum Dis201170111905191321798883
- McBrideJMJiangJAbbasARSafety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation studyArthritis Rheum201264113666367622833362
- LauwerysBRHachullaESpertiniFDown-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon alpha-kinoidArthritis Rheum201365244745623203821
- WallaceDJGudsoorkarVSWeismanMHVenuturupalliSRNew insights into mechanisms of therapeutic effects of antimalarial agents in SLENat Rev Rheumatol20128952253322801982
- Ruiz-IrastorzaGRamos-CasalsMBrito-ZeronPKhamashtaMAClinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic reviewAnn Rheum Dis2010691202819103632
- Linker-IsraeliMDeansRJWallaceDJPrehnJOzeri-ChenTKlinenbergJRElevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesisJ Immunol199114711171232051017