Current and emerging “at-site” pain medications: a review

References

• AnandKJSCraigKDNew perspectives on the definition of painPain1996671368895225
   PubMed Web of Science ®Google Scholar
• MelnikovaIPain marketNat Rev Drug Dis201098589590
   PubMed Web of Science ®Google Scholar
• TsangAVon KorffMLeeSCommon chronic pain conditions in developed and developing countries: gender and age differences and comorbidity with depression-anxiety disordersJ Pain200891088389118602869
   PubMed Web of Science ®Google Scholar
• GouckeRCThe management of persistent painMed J Aust2003178944444712720511
   PubMed Web of Science ®Google Scholar
• HelmsJEBaroneCPPhysiology and treatment of painCrit Care Nurse2008286384919047694
   PubMed Web of Science ®Google Scholar
• ReichlingDBLevineJDPain and death: neurodegenerative disease mechanisms in the nociceptorAnn Neurol2011691132121280072
   PubMed Web of Science ®Google Scholar
• BaronRNeuropathic pain: a clinical perspectiveHandb Exp Pharmacol200919433019655103
   PubMedGoogle Scholar
• VoscopoulosCLemaMWhen does acute pain become chronic?Br J Anaesth2010105Suppl 1i69i8521148657
   PubMed Web of Science ®Google Scholar
• MilanMJThe induction of pain: an integrative reviewProg Neurobiol199957111649987804
   PubMed Web of Science ®Google Scholar
• SchaibleHGPeripheral and central mechanisms of pain generationHandb Exp Pharmacol200717732817087118
   PubMedGoogle Scholar
• ScholzJWoolfCJCan we conquer pain?Nat Neurosci20025Suppl1062106712403987
   PubMed Web of Science ®Google Scholar
• BrasMDordevicVGrequrekRBulajicMNeurobiological and clinical relationship between psychiatric disorders and chronic painPsychiatr Danub201022222122620562750
   PubMed Web of Science ®Google Scholar
• MarazzitiDMungaiFVivarelliLPrestaSDell’OssoBPain and psychiatry: a critical analysis and pharmacological reviewClin Pract Epidemiol Ment Health200623117087832
   PubMedGoogle Scholar
• LynchMEWatsonCPNThe pharmacotherapy of chronic pain: a reviewPain Res Manage20061111138
   Google Scholar
• KroenkeKKrebsEEBairMJPharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviewsGen Hosp Psychiatry200931320621919410099
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and PreventionNational Hospital Ambulatory Medical Care Survey (NHAMCS)Atlanta, GACenters for Disease Control and Prevention Available from: http://www.cdc.gov/nchs/ahcd.htmAccessed June 18, 2011
   Google Scholar
• WoodcockJA difficult balance – pain management, drug safety, and the FDAN Eng J Med20093612221052107
   PubMed Web of Science ®Google Scholar
• TrelleSReichenbachSWandelSCardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysisBMJ2011342c708621224324
   PubMed Web of Science ®Google Scholar
• MendelsonJFlowerKPletcherMJGallowayGPAddiction to prescription opioids: characteristics of the emerging epidemic and treatment with buprenorphineExp Clin Psychopharmacol200816543544118837640
   PubMed Web of Science ®Google Scholar
• FoxABevanSTherapeutic potential of cannabinoid receptor agonists as analgesic agentsExpert Opin Investig Drugs2005146695703
   PubMed Web of Science ®Google Scholar
• PertweeRGCannabinoid receptors and painProg Neurobiol200163556961111164622
   PubMed Web of Science ®Google Scholar
• ChengYHitchcockSATargeting cannabinoid agonists for inflammatory and neuropathic painExpert Opin Investig Drugs2007167951965
   PubMed Web of Science ®Google Scholar
• GaliequeSMarySMarchandJExpression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulationsEur J Biochem1995232154617556170
   PubMedGoogle Scholar
• CurranHVBrignellCFletcherSMiddletonPHenryJCognitive, subjective dose–response effects of acute oral Δ9-tetrahydrocannabinol (THC) in infrequent cannabis usersPsychopharmacology20021641617012373420
   PubMed Web of Science ®Google Scholar
• RobinsonLGoonawardenaAVPertweeRGHampsonRERiedelGThe synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in ratsBr J Pharmacol2007151568870017502849
   PubMed Web of Science ®Google Scholar
• HerkenhamMLynnABJohnsonMRMelvinLSde CostaBRRiceKCCharacterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyJ Neurosci19911125635831992016
   PubMed Web of Science ®Google Scholar
• DevaneWAHanusLBreuerAIsolation and structure of a brain constituent that binds to the cannabinoid receptorScience19922585090194619491470919
   PubMed Web of Science ®Google Scholar
• PertweeRGPharmacological actions of cannabinoidsHandb Exp Pharmacol200516815116596770
   PubMedGoogle Scholar
• RahnEJHohmanAGCannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedsideNeurotheraptics200964713737
   PubMed Web of Science ®Google Scholar
• ThakurGATichkuleRBajajSMakriyannisALatest advances in cannabinoid receptor agonistsExpert Opin Ther Patents2009191216471673
   PubMed Web of Science ®Google Scholar
• HsiehGCPaiMChandranPCentral and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in ratsBr J Pharmacol2011162242844020880025
   PubMed Web of Science ®Google Scholar
• HanusLBreuerATchillibonSHU-308: a specific agonist for CB2, a peripheral cannabinoid receptorProc Natl Acad Sci U S A19999625142281423310588688
   PubMed Web of Science ®Google Scholar
• YaoBBMukherjeeSFanYIn vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?Br J Pharmacol2006149214515416894349
   PubMed Web of Science ®Google Scholar
• IbrahimMMDengHZvonokAActivation of CB2-cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNSProc Natl Acad Sci U S A200310018105291053312917492
   PubMed Web of Science ®Google Scholar
• FrostMDartMJTietjeKRIndol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activityJ Med Chem201053129531519921781
   PubMed Web of Science ®Google Scholar
• FrostJMDartMJTietjeKRIndol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activityJ Med Chem20085161904191218311894
   PubMed Web of Science ®Google Scholar
• ChengYAlbrechtBKBrownBDiscovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonistsJ Med Chem200851165019503418680277
   PubMed Web of Science ®Google Scholar
• GiblinGMPO’ShaughnessyCTNaylorADiscovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory painJ Med Chem200750112597260017477516
   PubMed Web of Science ®Google Scholar
• GiblinGMPBillintonABriggsMDiscovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic painJ Med Chem200952195785578819743867
   PubMed Web of Science ®Google Scholar
• El BakaliJMuccioliGGRenaultN4-Oxo-1,4-dihydropyridines as selective CB2 Cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist seriesJ Med Chem201053227918793120979417
   PubMed Web of Science ®Google Scholar
• PatapoutianATateSWoolfCJTransient receptor potential channels: targeting pain at the sourceNat Rev Drug Dis2009815568
   PubMed Web of Science ®Google Scholar
• RomanovskyAAAlmeidaMCGaramiAThe transient receptor potential vanilloid-1 channel in thermoregulation: thermosensor it is notPharmacol Rev200961322826119749171
   PubMed Web of Science ®Google Scholar
• VenkatachalamKMontellCTRP channelsAnnu Rev Biochem20077638741717579562
   PubMed Web of Science ®Google Scholar
• LevineJDHaberNATRP channels: targets for the relief of painBiochim Biophys Acta200717728989100317321113
   PubMed Web of Science ®Google Scholar
• PremkumarLSTargeting TRPV1 as an alternative approach to narcotic analgesic to treat chronic pain conditionsAAPS J201012336137020440589
   PubMed Web of Science ®Google Scholar
• JoshiNKSzallasiATRPV1 antagonists: the challenges for therapeutic targetingTrends Mol Med2009151142219097938
   PubMed Web of Science ®Google Scholar
• GunthorpeMJChizhBAClinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathwayDrug Discov Today2009141–2566719063991
   PubMed Web of Science ®Google Scholar
• RamiHKThompsonMStempGDiscovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical developmentBioorg Med Chem Lett200616123287329116580202
   PubMed Web of Science ®Google Scholar
• DohertyEMBannonAWBoYNovel vanilloid receptor-1 antagonists: 2. Structure-activity relationship of 4-oxopyrimidines leading to the selection of a clinical candidateJ Med Chem200750153515352717585750
   PubMed Web of Science ®Google Scholar
• WangHLKatonJBalanCNovel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic propertiesJ Med Chem200750153528353917585751
   PubMed Web of Science ®Google Scholar
• GomtsyanABayburtEKSchmidtRGIdentification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl) urea (ABT-102) as a potent TRPV1 antagonist for pain managementJ Med Chem200851339239518183945
   PubMed Web of Science ®Google Scholar
• HonorePChandranPHernandezGRepeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermiaPain20091421–2273519135797
   PubMed Web of Science ®Google Scholar
• RowbothamMCNothaftWDuanWROral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trialPain201115251192200021377273
   PubMed Web of Science ®Google Scholar
• WestawaySMThe potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of painJ Med Chem200750112589259617489570
   PubMed Web of Science ®Google Scholar
• ChizhBAIllesPP2X receptors and nociceptionPharmacol Rev200153455356811734618
   PubMed Web of Science ®Google Scholar
• KennedyCAssisTSCurrieJRowanEGCrossing the pain barrier: P2 receptors as targets for novel analgesicsJ Physiol2003553Pt 368369414514872
   PubMed Web of Science ®Google Scholar
• KennedyCP2X receptors: targets for novel analgesics?Neuroscientist200511434535616061521
   PubMed Web of Science ®Google Scholar
• BurnstockGPurinergic signaling and disorders of the central nervous systemNat Rev Drug Dis200878575590
   Web of Science ®Google Scholar
• SurprenantANorthRASignaling at purinergic P2X receptorsAnnu Rev Physiol20097133335918851707
   PubMed Web of Science ®Google Scholar
• HughesJPHatcherJPChessellIPThe role of P2X7 in pain and inflammationPurinergic Signal200731–216316918404430
   PubMed Web of Science ®Google Scholar
• GunosewoyoHKassiouMP2X purinergic receptor ligands: recently patented compoundsExpert Opin Ther Pat201020562564620205618
   PubMed Web of Science ®Google Scholar
• NelsonDWGreggRJKortMEStructure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonistsJ Med Chem200649123659366616759108
   PubMed Web of Science ®Google Scholar
• NelsonDWSarrisKKalvinDMStructure-activity relationship studies on N′-aryl carbohydrazide P2X7 antagonistsJ Med Chem200851103030303418438986
   PubMed Web of Science ®Google Scholar
• MedranoAPDonnelly-RobertsDLHonorePDiscovery and biological evaluation of novel cyanoguanidine P2X7 antagonists with analgesic activity in a rat model of neuropathic painJ Med Chem200952103366337619397270
   PubMed Web of Science ®Google Scholar
• FurberMAlcarazLBentJEDiscovery of potent and selective adamantane-based small-molecule P2X7 receptor antagonists/interleukin-1β inhibitorsJ Med Chem200750245882588517963373
   PubMed Web of Science ®Google Scholar
• GuileSDAlcarazLBirkinshawTNAntagonists of the P2X7 receptor. From lead identification to drug developmentJ Med Chem200952103123314119191585
   PubMed Web of Science ®Google Scholar
• WatkinsLRMaierSFTargeting glia to control clinical pain: an idea whose time has comeDrug Discov Today2004118388
   Google Scholar
• MilliganEDWatkinsLRPathological and protective roles of glia in chronic painNat Rev Neurosci2009101233619096368
   PubMed Web of Science ®Google Scholar
• McMahonSBMalcangioMCurrent challenges in glia-pain biologyNeuron2009641465419840548
   PubMed Web of Science ®Google Scholar
• SvenssonCIBrodinESpinal astrocytes in pain processing: non-neuronal cells as therapeutic targetsMol Interv2010101253820124561
   PubMedGoogle Scholar
• BeggsSSalterMWMicroglia-neuronal signaling in neuropathic pain hypersensitivity 2.0Curr Opin Neurobiol201020447448020817512
   PubMed Web of Science ®Google Scholar