CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle

References

• Crane F. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001; 20(6):591–598.
   PubMed Web of Science ®Google Scholar
• Sohal RS, Kamzalov S, Sumien N, et al. Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defences, and life of mice. Free Radic Biol Med. 2006;40:480–487.
   PubMed Web of Science ®Google Scholar
• Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: a review of essential functions and clinical trials. US Pharmacist. 2000:28–41.
   Google Scholar
• Weis M, Mortensen SA, Rassing MR, et al. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol Aspects Med. 1994;15:s273–s280.
   PubMed Web of Science ®Google Scholar
• Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A. 1994;91:10771–10778.
   PubMed Web of Science ®Google Scholar
• Alexeyev MF, LeDoux SP, Wilson GL. Mitochondrial DNA & aging. Clin Sci. 2004;107:355–364.
   PubMed Web of Science ®Google Scholar
• Powers SK, Hamilton K. Antioxidants and exercise. Clin Sports Med. 1999;18(3):525–536.
   Google Scholar
• Nair KS. Aging muscle. Am J Clin Nutr. 2005;81:953–963.
   PubMed Web of Science ®Google Scholar
• Pansarasa O, Bertorelli L, Vecchiet J, Felzani G, Marzatico F. Age- dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic Biol Med. 1999;27:617–622.
   PubMed Web of Science ®Google Scholar
• Short KL, Bigelow ML, Kahl J, et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A. 2005;102:5618–5623.
   PubMed Web of Science ®Google Scholar
• Lambertucci RH, Levada-Pires AC, Rossoni LV, Curi R, Pithon-Curi TC. Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats. Mech Ageing Dev. 2007;128:267–275.
   PubMed Web of Science ®Google Scholar
• Kwong LK, Kamzalov S, Rebrin I, et al. Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med. 2002;33:627–638.
   PubMed Web of Science ®Google Scholar
• Lass A, Sohal RS. Effect of coenzyme Q10 and (alpha)-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J. 2000;14:87–94.
   PubMed Web of Science ®Google Scholar
• Quiles JL, Ochoa JJ, Huertas JR, Mataix J. Coenzyme Q supplementation protects from age-related DNA double strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Exp Gerontol. 2004; 39:189–194.
   PubMed Web of Science ®Google Scholar
• Tomasetti M, Littarru GP, Stocker R, Alleva R. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Radic Biol Med. 1999;27:1027–1032.
   PubMed Web of Science ®Google Scholar
• Lee C-K, Pugh TD, Klopp RG, et al. The impact of [alpha]-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med. 2004;36: 1043–1057.
   PubMed Web of Science ®Google Scholar
• Linnane A, Kopsidas G, Zhang C, et al. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Free Radic Res. 2002;36:445–453.
   PubMed Web of Science ®Google Scholar
• Lass A, Agarwal S, Sohal RS. Mitochondrial ubiquinone homologues, superoxide radical generation, and longevity in different mammalian species. J Biol Chem. 1997;272:19199–19204.
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2007;22:659–661.
   PubMed Web of Science ®Google Scholar
• Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S. Coenzyme Q10 in health and disease. Eur J Clin Nutr. 1999;53:764–770.
   PubMed Web of Science ®Google Scholar
• Gollnick PD, Sjödin B, Karlsson J, Jansson E, Saltin B. Human soleus muscle: A comparison of fiber composition and enzyme activities with other leg muscles. Pflugers Arch. 1974;348:247–255.
   PubMed Web of Science ®Google Scholar
• Tang PH, Miles MV, DeGrauw A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Clin Chem. 2001;47:256–265.
   PubMed Web of Science ®Google Scholar
• Paglia DE, Valentine WN. Studies in quantitative and qualitative charaterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158–169.
   PubMed Web of Science ®Google Scholar
• Beers RF Jr, Sizer IW A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952;195:133–140.
   PubMed Web of Science ®Google Scholar
• Vijayasarathy C, Damle S, Prabu SK, Otto CM, Avadhani NG. Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia. Eur J Biochem. 2003;280:871–879.
   Google Scholar
• Takada M, Ikenoya S, Yuzuriha T, Katayama K. Studies on reduced and oxidized coenzyme Q (ubiquinones). II. The determination of oxidation-reduction levels of coenzyme Q in mitochondria, microsomes and plasma by high-performance liquid chromatography. Biochim Biophys Acta. 1982;679:308–314.
   PubMed Web of Science ®Google Scholar
• Yamashita S, Yamamoto Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem. 1997;250:66–73.
   PubMed Web of Science ®Google Scholar
• Kamzalov S, Sumien N, Forster MJ, Sohal RS. Coenzyme Q intake elevates the mitochondrial and tissue levels of coenzyme Q and {alpha}- tocopherol in young mice. J Nutr. 2003;133:3175–3180.
   PubMed Web of Science ®Google Scholar
• Niklowitz P, Sonnenschein A, Janetzky B, Andler WTM. Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. Int J Biol Sci. 2007;3:257–262.
   Google Scholar
• Sohal RS, Forster MJ. Coenzyme Q, oxidative stress and aging. Mitochondrion. 2007;7:S103–S111.
   Google Scholar
• Linnane AW, Eastwood H. Cellular redox poise modulation; the role of coenzyme Q10, gene and metabolic regulation. Mitochondrion. 2004;4:779–789.
   Google Scholar