The beneficial effects of spirulina focusing on its immunomodulatory and antioxidant properties

References

• Characterization of Spirulina biomass for CELSS diet potential. Normal, Al.: Alabama A&M University, 1988.
   Google Scholar
• Cornet JF, Dubertret G. The cyanobacterium Spirulina in the photosynthetic compartment of the MELISSA artificial ecosystem. Workshop on artificial ecological systems. 1990 October 24–26; Marseille, France: DARA-CNES.
   Google Scholar
• Vonshak A. Spirulina platensis (Arthrospira). Physiol Cell-Biol Biotechnol. London: Taylor & Francis; 1997.
   Google Scholar
• Eun HL, Ji-Eun P, Young-Ju C, Kap-Bum H, Wha-Young K. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nut Res Practice. 2008;2(4):295–300.
   Google Scholar
• Cifferi O. Spirulina as a micro organism. Microbiol Rev. 1983;47(4): 551–578.
   Google Scholar
• Wang Y, Chen-Fu C, Chou J, et al. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Experiment Neurol. 2005;193(1):75–84.
   PubMed Web of Science ®Google Scholar
• Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-Based Dietary Supplement on Cytokine Production from Allergic Rhinitis Patients. J Med Food. 2005;8(1):27–30.
   PubMed Web of Science ®Google Scholar
• Misbahuddin M, Islam AZ, Khandker S, Ifthaker-Al-Mahmud, Islam N, Anjumanara. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebocontrolled study. (Risk factors). J Toxicol: Clinic Toxicol. 2006;44(2): 135–137.
   Google Scholar
• Diaz DCB. The Discovery and Conquest of Mexico. London: Routledge; 1928:1517–1521
   Google Scholar
• Sammon AM. Dietary Linoleic acid, immune inhibition and disease. Postgrad Med J. 1999;75(881):129–132.
   PubMed Web of Science ®Google Scholar
• Simpore J, Zongo F, Kabore F, et al. Nutrition rehabilitation of undernourished children utilizing Spirulina and Misola. Nut J. 2008;(2): 20–25.
   Google Scholar
• Kulshreshtha A, Zacharia J, Jarouliya U, Bhadauriya P, Prasad GBKS, Bisen PS. Spirulina in Health Care Management. Current Pharm Biotechnol. 2008;9(5):400–405.
   PubMed Web of Science ®Google Scholar
• Johnstone RW, Ruefli AA, Lowe SW Apoptosis: a link between cancer genetics and chemotherapy. Cell. 2002;108(2):153–164.
   PubMed Web of Science ®Google Scholar
• Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis. 2000;21(3):485–495.
   PubMed Web of Science ®Google Scholar
• Vousden K, Lu X. Live or let die: the cell’s response to p53. Nature Rev Cancer. 2002;2(8):594–604.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Pan ZQ, Schreiber-Agus N, DePinho RA, Hurwitz J, Xiong Y. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc Natl Acad Sci U S A. 1998;95(4):1392–1397.
   Google Scholar
• Chen T, Wong YS, Zheng W. Induction of G1 cell cycle arrest and mitochondria-mediated apoptosis in MCF-7 human breast carcinoma cells by selenium-enriched Spirulina extract. Biomed Pharmacother. 2009;27. Epub ahead of print 2009.
   Google Scholar
• Dasgupta T, Banejee S, Yadav PK, Rao AR. Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina platensis. Mol Cell Biochem. 2001;226(1–2):27–38.
   Google Scholar
• Mathew B, Sankaranarayanan R, Nair PP, et al. Evaluation of chemo- prevention of oral cancer with Spirulina fusiformis. Nutr Cancer. 1995;24(2): 197–202.
   PubMed Web of Science ®Google Scholar
• Subhashini J, Mahipal SV, Reddy MC, Mallikarjuna Reddy M, Rachamallu A, Reddanna P. Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562. Biochem Pharmacol. 2004;68(3):453–462.
   PubMed Web of Science ®Google Scholar
• Akao Y, Ebihara T, Masuda H, et al. Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice. Cancer Sci. 2009;100 (8):1494–501. Epub 2009 May 6.
   PubMed Web of Science ®Google Scholar
• Mishima T, Murata J, Toyoshima M, et al. Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis. Clin Exp Metastasis. 1998;16(6):541–550.
   PubMed Web of Science ®Google Scholar
• Grawish ME, Zaher AR, Gaafar AI, Nasif WA. Long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study). Med Oncol. 2009. Epub 2009.
   Google Scholar
• Chen T, Wong YS. In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis. J Agric Food Chem. 2008 25;56(12):4352–4358. Epub 2008 Jun 4.
   PubMed Web of Science ®Google Scholar
• Mittal A, Kumar PV, Banerjee S, Rao AR, Kumar A. Modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice. Phytother Res. 1999;13(2):111–114.
   Google Scholar
• Hamidah A, Rustam ZA, Tamil AM, Zarina LA, Zulkifli ZS, Jamal R. Prevalence and parental perceptions of complementary and alternative medicine use by children with cancer in a multi-ethnic Southeast Asian population. Pediatr Blood Cancer. 2009;52(1):70–74.
   Google Scholar
• Schwartz J, Shklar G, Reid S, Trickler D. Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae. Nutr Cancer. 1988;11(2):127–134.
   Web of Science ®Google Scholar
• Schwartz J, Shklar G. Regression of experimental hamster cancer by beta carotene and algae extracts. J Oral Maxillofac Surg. 1987 Jun;45(6): 510–515.
   PubMed Web of Science ®Google Scholar
• Ismail MF, Ali DA, Fernando A, et al. Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina. Int J Biol Sci. 2009;5(4): 377–387.
   PubMed Web of Science ®Google Scholar
• Shklar G, Schwartz J. Tumor necrosis factor in experimental cancer regression with alphatocopherol, beta-carotene, canthaxanthin and algae extract. Eur J Cancer Clin Oncol. 1988 (5):839–850.
   Google Scholar
• Sheahan S, Bellamy CO, Harland SN, et al. TGF beta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status. BMC Cancer. 2008;8:191–201.
   Google Scholar
• Raffaella R, Marzia BG, Laura P, Elena M. Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin. Int J Bio Sci. 2009;5(4):377–387.
   Google Scholar
• Khan M, Shobha JC, Mohan IK, Naidu MU, Sundaram C, Singh S. Protective effect of Spirulina against doxorubicin-induced cardio- toxicity. Phytother Res. 2005;19(12):1030–1037.
   PubMedGoogle Scholar
• Zhang HQ, Lin AP, Sun Y. Chemo and radio protective effects of polysaccharide of spirulina platensis on haematopoietic stem cells in dog and mice. Acta Pharmacol Sin. 2001;22(12):1121–1124.
   Google Scholar
• Hayashi T, Hayashi K, Maeda M, Kojima I. Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis. J Nat Prod. 1996;59(1):83–87.
   Google Scholar
• Ayehunie S, Belay A, Baba TW, Ruprecht RM. Inhibition of HIV-1 tensis (Arthrospira platensis). JAIDS: JAcquir Immune DefSynd Human Retrovirol. 1998;18(11):7–12.
   Google Scholar
• Hayashi T, Hayashi K, Maeda M, Kojima IA. Natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platen- sis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities. AIDS Res Hum Retroviruses.1996;12(15):1463–1471.
   PubMed Web of Science ®Google Scholar
• Simpore J, Zongo F, Kabore F, Dansou D, Bere A, Nikiema JB. Nutrition Rehabilitation of HIV-Infected and HIV-Negative Undernourished Children Utilizing Spirulina”. Annal Nut Metabolism. 2005;49(6):373–380.
   PubMed Web of Science ®Google Scholar
• Park HJ, Lee YJ, Ryu HK, Kim MH, Chung HW, Kim WYA. Randomized double-blind, placebo-controlled study to establish the effects of Spirulina in elderly Koreans. Annal Nutr Metabol. 2008;52(4): 322–329.
   PubMed Web of Science ®Google Scholar
• Hosoyamada Y, Takai T, Kato T. Effects of water-soluble and insoluble fractions of Spirulina on serum lipid components and glucose tolerance in rats. Journal of Japanese Soc Nutr Food Sci. 1991;44: 273–277.
   Google Scholar
• Juarez MA, Mascher D, Torres PV, Farias JM. Effects of spirulina on vascular reactivity. J Med Food. 2009;12(1):15–20.
   Google Scholar
• Khan Z, Bhadouria P, Bisen PS. Nutritional and therapeutic potential of spirulina. Curr Pharm Biotechnol. 2005;6(5):373–379.
   PubMed Web of Science ®Google Scholar
• Lee AN, Werth VP. Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements. Arch Dermatol. 2004;140(6): 723–727.
   Google Scholar
• Remirez D, Ledon N, Gonzale R. Role of histamine in the inhibitory effects of phycocyanin in experimental models of allergic inflammatory response. MedInflamm. 2002;11(2):81–85.
   Google Scholar
• Hayashi O, Katayanagi Y, Ishii K, Kato T. Flow cytometric analysis of age-related changes in intestine intraepithelial lymphocyte subsets and their functional preservation after feeding mice on spirulina. J Med Food. 2009;12(5):982–989.
   PubMed Web of Science ®Google Scholar
• Rasool M, Sabina EP. Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study. J Nat Med. 2009; 63(2):169–175.
   Google Scholar
• Løbner M, Walsted A, Larsen R, Bendtzen K, Nielsen CH. Enhancement of human adaptive immune responses by administration of a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis. J Med Food. 2008;11(2):313–322.
   PubMed Web of Science ®Google Scholar
• Trushina EN, Gladkikh O, Gadzhieva ZM, Mustafina OK, Pozdniakov AL. The influence of Spirulina and Selen-Spirulina on some indexes of rat’s immune status Article Russian Vopr Pitan. 2007;76(2):21–25.
   Google Scholar
• Balachandran P, Pugh ND, Ma G, Pasco DS. Toll-like receptor 2- dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice. Int Immunopharmacol. 2006;6(12): 1808–1814.
   PubMed Web of Science ®Google Scholar
• Grzanna R, Polotsky A, Phan PV, Pugh N, Pasco D, Frondoza CG. Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cells. J Altern Complement Med. 2006;12(5):429–435.
   PubMed Web of Science ®Google Scholar
• Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Med. 2001;67(8):737–742.
   PubMed Web of Science ®Google Scholar
• Nemoto-Kawamura C, Hirahashi T, Nagai T, Yamada H, Katoh T, Hayashi O. Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticles. J Nutr Sci Vitaminol (Tokyo). 2004;50(2):129–136.
   Google Scholar
• Cingi C, Conk-Dalay M, Cakli H, Bal C. The effects of Spirulina on allergic rhinitis. Eur Arch Oto-Rhino-Larynol. 2008;265(10): 1219–1223.
   PubMed Web of Science ®Google Scholar
• Hirahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T. Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis. Int Immunopharmacol. 2002;2(4):423–434.
   PubMed Web of Science ®Google Scholar
• Qureshi MA, Garlich JD, Kidd MT. Dietary Spirulina platensis enhances humoral and cellmediated immune functions in chickens. Immuno- pharmacol Immunotoxicol. 1996;18(3):465–476.
   PubMed Web of Science ®Google Scholar
• Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo). 1994;40(5):431–441.
   PubMed Web of Science ®Google Scholar
• McCarty MF. Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies. Med Hypoth. 2010.
   Web of Science ®Google Scholar
• McCarty MF. Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. Med Hypoth. Epub 2010 Jan 18.
   Google Scholar
• Mendiola JA, Martín-Alvarez PJ, Señoráns FJ, et al. Design of natural food antioxidant ingredients through a chemometric approach. J Agric Food Chem. 2010;58(2):787–792.
   Web of Science ®Google Scholar
• Barmejo-Bescós P, Piñero-Estrada E, Villar DF, A. Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron- induced toxicity in SH-SY5Y neuroblastoma cells. Toxicol in Vitro. 2002;22(6):1496–1502.
   Google Scholar
• Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN. Preventative effects of Spirulina platensis on skeletal muscle damage under exercise induced oxidative stress. Eur J Appl Physiol. 2006;98(2):220–226.
   PubMed Web of Science ®Google Scholar
• Kalafati M, Jamurtas AZ, Nikolaidis MG, et al. Ergogenic and antioxidant effects of spirulina supplementation in humans. Med Sci Sports Exerc. 2010;42(1):142–151.
   PubMed Web of Science ®Google Scholar
• Vázquez-Sánchez J, Ramón-Gallegos E, Mojica-Villegas A, et al. Spirulina maxima and its protein extract protect against hydroxyurea-teratogenic insult in mice. Food Chem Toxicol. 2009;47(ll): 2785–2789.
   Google Scholar
• Bedirli A, Kerem M, Ofluoglu E, et al. Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clin Nutr. 2009;28(6):674–678.
   Google Scholar
• Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC. Diets enriched in foods with high antioxidant activity reverse age- induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. Experiment Neurol. 2002;22(14): 6114–6120.
   Google Scholar
• Robb-Nicholson C. By the way, doctor. Harvard Women ’s Health Watch 8.2006.
   Google Scholar
• Li B, Gao MH, Zhang XC, Chu XM. Molecular immune mechanism of C-phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro. Biotechnol Appi Biochem. 2006 Mar;43(Pt 3):155–164.
   Google Scholar