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ORIGINAL RESEARCH

Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population

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Pages 989-1000 | Published online: 24 Apr 2019

References

  • Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiat. 2003;60:1187–1192. doi:10.1001/archpsyc.60.12.1187
  • Stahl SM. Essential Psychopharmacology. 3rd ed. New York: Cambridge University Press; 2008.
  • Fairman WA, Amara SG. Functional diversity of excitatory amino acid transporters: ion channel and transport modes. Am J Physiol. 1999;277:481–486. doi:10.1152/ajpheart.1999.277.5.H2002
  • Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148:1301–1308. doi:10.1176/ajp.148.10.1301
  • Krystal JH, Perry EB Jr, Gueorguieva R, et al. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch Gen Psychiatry. 2005;62:985–994. doi:10.1001/archpsyc.62.9.985
  • Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry. 1994;51:199–214. doi:10.1001/archpsyc.1994.03950030035004
  • Lahti AC, Weiler MA, Tamara Michaelidis BA, Parwani A, Tamminga CA. Effects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology. 2001;25:455–467. doi:10.1016/S0893-133X(01)00243-3
  • Moghaddam B, Adams B, Verma A, Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997;17:2921–2927. doi:10.1523/JNEUROSCI.17-08-02921.1997
  • Stefansson H, Ophoff RA, Steinberg S, et al. Common variants conferring risk of schizophrenia. Nature. 2009;460(7256):744–747. doi:10.1038/nature08186
  • Ripke S, Sanders AR, Kendler KS, et al. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011;43:969–976. doi:10.1038/ng.940
  • Schijven D, Kofink D, Tragante V, et al. Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling. Schizophr Res. 2018;199:195–202. doi:10.1016/j.schres.2018.03.032
  • Ripke S, Neale BM, Corvin A, et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421–427. doi:10.1038/nature13595
  • Ohi K, Hashimoto R, Ikeda M, et al. Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes. Schizophr Bull. 2015;41(4):909–918. doi:10.1093/schbul/sbu171
  • Tarabeux J, Kebir O, Gauthier J, et al. Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Transl Psychiatry. 2011;1:e55. doi:10.1038/tp.2011.52
  • Van Horn MR, Sild M, Ruthazer ES. D-serine as a gliotrans- mitter and its roles in brain development and disease. Front Cell Neurosci. 2013;7:39.
  • Rose EM, Koo JC, Antflick JE, Ahmed SM, Angers S, Hampson DR. Glutamate transporter coupling to Na, K-ATPase. J Neurosci. 2009;29(25):8143–8155. doi:10.1523/JNEUROSCI.1081-09.2009
  • Danbolt NC. Glutamate uptake. Prog Neurobiol. 2001;65(1):1–105. doi:10.1016/S0301-0082(00)00067-8
  • Nakagawa T, Kaneko S. SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain. Curr Mol Pharmacol. 2013;6(2):66–73. doi:10.2174/18744672113069990033
  • Arriza JL, Eliasof S, Kavanaugh MP, Amara SG. Excitatory aminoacid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci USA. 1997;94:4155–4160. doi:10.1073/pnas.94.8.4155
  • Lauriat TL, Dracheva S, Chin B, Schmeidler J, McInnes LA, Haroutunian V. Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain. Neuroscience. 2006;(137):843–851. doi:10.1016/j.neuroscience.2005.10.003.
  • Sheldon AL, Robinson MB. The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int. 2007;51:333–355. doi:10.1016/j.neuint.2007.03.012
  • Rothstein JD, Martin L, Levey AI, et al. Localization of neuronal and glial glutamate transporters. Neuron. 1994;13:713–725. doi:10.1016/0896-6273(94)90038-8
  • Domercq M, Etxebarria E, Perez-Samartin A, Matute C. Excitotoxic oligodendrocyte death and axonal damage induced by glutamate transporter inhibition. Glia. 2005;52:36–46. doi:10.1002/glia.20221
  • Bauer D, Haroutunian V, Meador-Woodruff JH, et al. Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia. Schizophr Res. 2010;117:92–98. doi:10.1016/j.schres.2009.07.025
  • Shan D, Lucas EK, Drummond JB, et al. Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia. Schizophr Res. 2013;144:1–8. doi:10.1016/j.schres.2012.12.019
  • Rao JS, Kellom M, Reese EA, et al. Dysregulated glutamate and dopamine transporters in postmortem frontal cortex from bipolar and schizophrenic patients. J Affect Disord. 2012;136:63–71. doi:10.1016/j.jad.2011.08.017
  • Ohnuma T, Tessler S, Arai H, Faull RL, McKenna PJ, Emson PC. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Brain Res Mol Brain Res. 2000;85(1–2):24–31. doi:10.1016/S0169-328X(00)00222-9
  • Meyer T, Ludolph AC, Morkel M, Hagemeier C, Speer A. Genomic organization of the human excitatory amino acid transporter gene GLT-1. Neuroreport. 1997;8:775–777. doi:10.1097/00001756-199702100-00039
  • Mallolas J, Hurtado O, Castellanos M, et al. A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke. J Exp Med. 2006;203(3):711–717. doi:10.1084/jem.20051979
  • Zafra F, Gomeza J, Olivares L, Aragón C, Giménez C. Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. Eur J Neurosci. 1995;7(6):1342–1352. doi:10.1111/j.1460-9568.1995.tb01125.x
  • Danysz W, Parsons AC. Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol Rev. 1998;50:597–664.
  • Waziri R, Baruah S, Sherman AD. Abnormal serine-glycine metabolism in the brains of schizophrenics. Schizophr Res. 1993;8(3):233–243. doi:10.1016/0920-9964(93)90021-A
  • Heresco-Levy U, Javitt DC. Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis. Schizophr Res. 2004;66(2–3):89–96. doi:10.1016/S0920-9964(03)00129-4
  • Williams JB, Mallorga PJ, Conn PJ, Pettibone DJ, Sur C. Effects of typical and atypical antipsychotics on human glycine transporters. Schizophr Res. 2004;71(1):103–112. doi:10.1016/j.schres.2004.01.013
  • Tsai G, Lane HY, Yang P, Chong MY, Lange N. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry. 2004;55:452–456. doi:10.1016/j.biopsych.2003.09.012
  • Nelson N. The family of Na+/Cl- neurotransmitter transporters. J Neurochem. 1998;71(5):1785–1803. doi:10.1046/j.1471-4159.1998.71051785.x
  • Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261–276. doi:10.1093/schbul/13.2.261
  • van der Gaag M, Hoffman T, Remijsen M, et al. The five-factor model of the positive and negative syndrome scale II: a ten-fold cross-validation of a revised model. Schizophr Res. 2006;85:280–287. doi:10.1016/j.schres.2006.03.021
  • Dumais A, Lesage AD, Lalovic A, et al. Is violent method of suicide a behavioral marker of lifetime aggression? Am J Psychiatry. 2005;162(7):1375–1378. doi:10.1176/appi.ajp.162.7.1375
  • Morita Y, Ujike H, Tanaka Y, et al. The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(1):54–58. doi:10.1002/ajmg.b.30565
  • Matsumoto Y, Suzuki A, Ishii G, Oshino S, Otani K, Goto K. The −181 A/C polymorphism in the excitatory amino acid transporter-2 gene promoter affects the personality trait of reward dependence in healthy subjects. Neurosci Lett. 2007;427(2):99–102. doi:10.1016/j.neulet.2007.09.015
  • Poletti S, Radaelli D, Bosia M, et al. Effect of glutamate transporter EAAT2 gene variants and gray matter deficits on working memory in schizophrenia. Eur Psychiatry. 2014;29(4):219–225. doi:10.1016/j.eurpsy.2013.07.003
  • NCBI. Reference SNP (refSNP) Cluster Report: rs4354668. Available from: https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=4354668. Accessed July 11, 2018.
  • Zhang B, Guan F, Chen G, et al. Common variants in SLC1A2 and schizophrenia: association and cognitive function in patients with schizophrenia and healthy individuals. Schizophr Res. 2015;169(1–3):128–134. doi:10.1016/j.schres.2015.10.012
  • Deng X, Shibata H, Ninomiya H, et al. Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. BMC Psychiatry. 2004;4:21. doi:10.1186/1471-244X-4-21
  • Nagai Y, Ohnuma T, Karibe J, et al. No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia. Neurosci Lett. 2009;463(3):223–227. doi:10.1016/j.neulet.2009.07.092
  • Deng X, Sagata N, Takeuchi N, et al. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. BMC Psychiatry. 2008;8:58. doi:10.1186/1471-244X-8-58
  • Tsai SJ, Cheng CY, Hong CJ, Liao DL, Liou YJ. Polymorphisms in glycine transporter with schizophrenia. Neuropsychopharmacol Hung. 2006;8(1):17–21.
  • Kang WS, Park HJ, Park JK, Cho AR, Kim JW. Association study between solute carrier family 6, member 9 (SLC6A9) gene and schizophrenia in Korean population (abstract). 10th World Congress of Biological Psychiatry. 2011. doi: 10.3284/wfsbp.2011.1
  • Abel KM, Drake R, Goldstein JM. Sex differences in schizophrenia. Int Rev Psychiatry. 2010;22(5):417–428. doi:10.3109/09540261.2010.515205
  • Ochoa S, Usall J, Cobo J, Labad X, Kulkarni J. Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review schizophrenia research and treatment. Schizophr Res Treat. 2012;2012:916198.
  • Qin W, Liu C, Sodhi M, Lu H. Meta-analysis of sex differences in gene expression in schizophrenia. BMC Syst Biol. 2016;10(1):100–106. doi:10.1186/s12918-016-0304-1
  • Spangaro M, Bosia M, Zanoletti A, et al. Cognitive dysfunction and glutamate reuptake: effect of EAAT2 polymorphism in schizophrenia. Neurosci Lett. 2012;522(2):151–155. doi:10.1016/j.neulet.2012.06.030
  • Spangaro M, Bosia M, Zanoletti A, et al. Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia. Pharmacogenomics. 2014;15(7):925–932. doi:10.2217/pgs.14.42
  • Dallaspezia S, Poletti S, Lorenzi C, et al. Influence of an interaction between lithium salts and a functional polymorphism in SLC1A2 on the history of illness in bipolar disorder. Mol Diagn Ther. 2012;16(5):303–309. doi:10.1007/s40291-012-0004-5
  • Shao L, Vawter MP. Shared gene expression alterations in schizophrenia and bipolar disorder. Biol Psychiatry. 2008;64(2):89–97. doi:10.1016/j.biopsych.2007.11.010
  • Kim K, Lee SG, Kegelman TP, et al. Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol. 2011;226(10):2484–2493. doi:10.1002/jcp.22609
  • Łoza B. Nowe wymiary leczenia schizofrenii. Psychiatria. 2005;1:1–8.
  • Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D. Searching for a consensus five-factor model of the positive and negative syndrome scale for schizophrenia. Schizophr Res. 2012;137(1–3):246–250. doi:10.1016/j.schres.2012.01.031
  • Hor K, Taylor M. Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol. 2010;24:81–90. doi:10.1177/1359786810385490
  • Kim SW, Kim SJ, Mun JW, et al. Psychosocial factors contributing to suicidal ideation in hospitalized schizophrenia patients in Korea. Psychiatry Invest. 2010;7(2):79–85. doi:10.4306/pi.2010.7.2.79