Management of Treatment-Resistant Depression: Challenges and Strategies

References

• Aan Het Rot M, Collins KA, Murrough JW, et al. Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. Biol Psychiatry. 2010;67(2):139–145. doi:10.1016/j.biopsych.2009.08.03819897179
   PubMed Web of Science ®Google Scholar
• Abraham G, Milev R, Stuart Lawson J. T3 augmentation of SSRI resistant depression. J Affect Disord. 2006;91(2–3):211–215. doi:10.1016/j.jad.2006.01.01316483669
   PubMed Web of Science ®Google Scholar
• APA. Practice guideline for the treatment of patients with major depressive disorder. Available from: https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/mdd.pdf. Accessed 18, 2020.
   Google Scholar
• APA Committee on Electroconvulsive Therapy. The Practice of Electroconvulsive Therapy: Recommendations for Treatment, Training and Privileging: A Task Force Report of the American Psychiatric Association; 2001; APA.
   Google Scholar
• Aronson R, Offman HJ, Joffe RT, Naylor CD. Triiodothyronine augmentation in the treatment of refractory depression. A meta-analysis. Arch Gen Psychiatry. 1996;53(9):842–848. doi:10.1001/archpsyc.1996.018300900900138792761
   PubMed Web of Science ®Google Scholar
• Baeken C, Vanderhasselt MA, Remue J, et al. Intensive HF-rTMS treatment in refractory medication-resistant unipolar depressed patients. J Affect Disord. 2013;151(2):625–631. doi:10.1016/j.jad.2013.07.00823896317
   PubMed Web of Science ®Google Scholar
• Bauer M, Pfennig A, Severus E, Whybrow PC, Angst J, Moller HJ, D. World Federation of Societies of Biological Psychiatry. Task Force on Unipolar Depressive. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders. World J Biol Psychiatry. 2013;14(5):334–385. doi:10.3109/15622975.2013.80419523879318
   PubMed Web of Science ®Google Scholar
• Bauer M, Pretorius HW, Constant EL, Earley WR, Szamosi J, Brecher M. Extended-release quetiapine as adjunct to an antidepressant in patients with major depressive disorder: results of a randomized, placebo-controlled, double-blind study. J Clin Psychiatry. 2009;70(4):540–549. doi:10.4088/JCP.08m0462919358791
   PubMed Web of Science ®Google Scholar
• Baumann P, Nil R, Souche A, et al. A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation. J Clin Psychopharmacol. 1996;16(4):307–314. doi:10.1097/00004714-199608000-000068835706
   PubMed Web of Science ®Google Scholar
• Benadhira R, Thomas F, Bouaziz N, et al. A randomized, sham-controlled study of maintenance rTMS for treatment-resistant depression (TRD). Psychiatry Res. 2017;258:226–233. doi:10.1016/j.psychres.2017.08.02928844559
   PubMed Web of Science ®Google Scholar
• Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47(4):351–354. doi:10.1016/S0006-3223(99)00230-910686270
   PubMed Web of Science ®Google Scholar
• Berman RM, Marcus RN, Swanink R, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2007;68(6):843–853. doi:10.4088/JCP.v68n060417592907
   PubMed Web of Science ®Google Scholar
• Berman RM, Thase ME, Trivedi MH, et al. Long-term safety and tolerability of open-label aripiprazole augmentation of antidepressant therapy in major depressive disorder. Neuropsychiatr Dis Treat. 2011;7:303–312. doi:10.2147/NDT.S1833321655344
   PubMed Web of Science ®Google Scholar
• Blumberger DM, Vila-Rodriguez F, Thorpe KE, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial. Lancet. 2018;391(10131):1683–1692. doi:10.1016/S0140-6736(18)30295-229726344
   PubMed Web of Science ®Google Scholar
• Brunoni AR, Chaimani A, Moffa AH, et al. Repetitive transcranial magnetic stimulation for the acute treatment of major depressive episodes: a systematic review with network meta-analysis. JAMA Psychiatry. 2017;74(2):143–152. doi:10.1001/jamapsychiatry.2016.364428030740
   PubMed Web of Science ®Google Scholar
• Carhart-Harris RL, Bolstridge M, Rucker J, et al. Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry. 2016;3(7):619–627. doi:10.1016/S2215-0366(16)30065-727210031
   PubMed Web of Science ®Google Scholar
• Carreno FR, Frazer A. Vagal nerve stimulation for treatment-resistant depression. Neurotherapeutics. 2017;14(3):716–727. doi:10.1007/s13311-017-0537-828585221
   PubMed Web of Science ®Google Scholar
• Cattaneo A, Ferrari C, Uher R, et al. Absolute measurements of macrophage migration inhibitory factor and interleukin-1-beta mRNA levels accurately predict treatment response in depressed patients. Int J Neuropsychopharmacol. 2016;19(10):pii: pyw045.
   Web of Science ®Google Scholar
• Chistyakov AV, Rubicsek O, Kaplan B, Zaaroor M, Klein E. Safety, tolerability and preliminary evidence for antidepressant efficacy of theta-burst transcranial magnetic stimulation in patients with major depression. Int J Neuropsychopharmacol. 2010;13(3):387–393. doi:10.1017/S146114571000002720128955
   PubMed Web of Science ®Google Scholar
• Cimpianu CL, Strube W, Falkai P, Palm U, Hasan A. Vagus nerve stimulation in psychiatry: a systematic review of the available evidence. J Neural Transm (Vienna). 2017;124(1):145–158. doi:10.1007/s00702-016-1642-227848034
   PubMed Web of Science ®Google Scholar
• Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet. 2009;373(9665):746–758. doi:10.1016/S0140-6736(09)60046-519185342
   PubMed Web of Science ®Google Scholar
• Cipriani A, Hawton K, Stockton S, Geddes JR. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ. 2013;346:f3646. doi:10.1136/bmj.f364623814104
   PubMed Web of Science ®Google Scholar
• Conway CR, George MS, Sackeim HA. Defining treatment-resistant depression-reply. JAMA Psychiatry. 2017;74(7):759. doi:10.1001/jamapsychiatry.2017.0970
   Web of Science ®Google Scholar
• Crossley NA, Bauer M. Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials. J Clin Psychiatry. 2007;68(6):935–940. doi:10.4088/JCP.v68n061717592920
   PubMed Web of Science ®Google Scholar
• Crown WH, Finkelstein S, Berndt ER, et al. The impact of treatment-resistant depression on health care utilization and costs. J Clin Psychiatry. 2002;63(11):963–971. doi:10.4088/JCP.v63n110212444808
   PubMed Web of Science ®Google Scholar
• Daly EJ, Singh JB, Fedgchin M, et al. Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial. JAMA Psychiatry. 2018;75(2):139–148. doi:10.1001/jamapsychiatry.2017.373929282469
   PubMed Web of Science ®Google Scholar
• Daskalakis ZJ, Dimitrova J, McClintock SM, et al. Magnetic seizure therapy (MST) for major depressive disorder. Neuropsychopharmacology. 2019;45(2):276–282.31486777
   PubMed Web of Science ®Google Scholar
• Deng ZD, Lisanby SH, Peterchev AV. Electric field depth-focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs. Brain Stimul. 2013;6(1):1–13. doi:10.1016/j.brs.2012.02.00522483681
   PubMed Web of Science ®Google Scholar
• Deng ZD, Lisanby SH, Peterchev AV. Coil design considerations for deep transcranial magnetic stimulation. Clin Neurophysiol. 2014;125(6):1202–1212. doi:10.1016/j.clinph.2013.11.03824411523
   PubMed Web of Science ®Google Scholar
• Drevets WC, Furey ML. Replication of scopolamine’s antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial. Biol Psychiatry. 2010;67(5):432–438. doi:10.1016/j.biopsych.2009.11.02120074703
   PubMed Web of Science ®Google Scholar
• El-Khalili N, Joyce M, Atkinson S, et al. Extended-release quetiapine fumarate (quetiapine XR) as adjunctive therapy in major depressive disorder (MDD) in patients with an inadequate response to ongoing antidepressant treatment: a multicentre, randomized, double-blind, placebo-controlled study. Int J Neuropsychopharmacol. 2010;13(7):917–932. doi:10.1017/S146114571000001520175941
   PubMed Web of Science ®Google Scholar
• Faridhosseini F, Sadeghi R, Farid L, Pourgholami M. Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta-analysis of randomized placebo-controlled trials. Hum Psychopharmacol. 2014;29(3):216–223. doi:10.1002/hup.v29.324911574
   PubMed Web of Science ®Google Scholar
• Fava M, Memisoglu A, Thase ME, et al. Opioid modulation with buprenorphine/samidorphan as adjunctive treatment for inadequate response to antidepressants: a randomized double-blind placebo-controlled trial. Am J Psychiatry. 2016;173(5):499–508. doi:10.1176/appi.ajp.2015.1507092126869247
   PubMed Web of Science ®Google Scholar
• Fekadu A, Wooderson S, Donaldson C, et al. A multidimensional tool to quantify treatment resistance in depression: the Maudsley staging method. J Clin Psychiatry. 2009;70(2):177–184. doi:10.4088/JCP.08m0430919192471
   PubMed Web of Science ®Google Scholar
• Fitzgerald PB, Grace N, Hoy KE, Bailey M, Daskalakis ZJ. An open label trial of clustered maintenance rTMS for patients with refractory depression. Brain Stimul. 2013;6(3):292–297. doi:10.1016/j.brs.2012.05.00322683273
   PubMed Web of Science ®Google Scholar
• Fitzgerald PB, Hoy KE, Elliot D, Susan McQueen RN, Wambeek LE, Daskalakis ZJ. Accelerated repetitive transcranial magnetic stimulation in the treatment of depression. Neuropsychopharmacology. 2018;43(7):1565–1572. doi:10.1038/s41386-018-0009-929467437
   PubMed Web of Science ®Google Scholar
• Fitzgerald PB, Hoy KE, Herring SE, Clinton AM, Downey G, Daskalakis ZJ. Pilot study of the clinical and cognitive effects of high-frequency magnetic seizure therapy in major depressive disorder. Depress Anxiety. 2013;30(2):129–136. doi:10.1002/da.2200523080404
   PubMed Web of Science ®Google Scholar
• Freeman MP. Relapse prevention after recovery in patients with persistent major depressive disorder-an active pursuit. JAMA Psychiatry. 2019. doi:10.1001/jamapsychiatry.2019.3637
   Web of Science ®Google Scholar
• Furey ML, Drevets WC. Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. Arch Gen Psychiatry. 2006;63(10):1121–1129. doi:10.1001/archpsyc.63.10.112117015814
   PubMed Web of Science ®Google Scholar
• Gaynes BN, Lloyd SW, Lux L, et al. Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis.”. J Clin Psychiatry. 2014;75(5):477–489. doi:10.4088/JCP.13r0881524922485
   PubMed Web of Science ®Google Scholar
• George MS. Transcranial magnetic stimulation for the treatment of depression. Expert Rev Neurother. 2010;10(11):1761–1772. doi:10.1586/ern.10.9520977332
   PubMed Web of Science ®Google Scholar
• George MS, Lisanby SH, Avery D, et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Arch Gen Psychiatry. 2010;67(5):507–516. doi:10.1001/archgenpsychiatry.2010.4620439832
   PubMed Web of Science ®Google Scholar
• George MS, Wassermann EM, Williams WA, et al. Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. Neuroreport. 1995;6(14):1853–1856. doi:10.1097/00001756-199510020-000088547583
   PubMed Web of Science ®Google Scholar
• George MS, Wassermann EM, Williams WA, et al. Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation (rTMS) of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996;8(2):172–180.9081553
   PubMed Web of Science ®Google Scholar
• Group UER. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;361(9360):799–808.12642045
   PubMed Web of Science ®Google Scholar
• Gunduz-Bruce H, Silber C, Kaul I, et al. Trial of SAGE-217 in patients with major depressive disorder. N Engl J Med. 2019;381(10):903–911. doi:10.1056/NEJMoa181598131483961
   PubMed Web of Science ®Google Scholar
• Guzzetta F, Tondo L, Centorrino F, Baldessarini RJ. Lithium treatment reduces suicide risk in recurrent major depressive disorder. J Clin Psychiatry. 2007;68(3):380–383. doi:10.4088/JCP.v68n030417388706
   PubMed Web of Science ®Google Scholar
• Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62. doi:10.1136/jnnp.23.1.5614399272
   PubMed Web of Science ®Google Scholar
• Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC. Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 2007;64(2):193–200. doi:10.1001/archpsyc.64.2.19317283286
   PubMed Web of Science ®Google Scholar
• Hoflich G, Kasper S, Hufnagel A, Ruhrmann S, Moller HJ. Application of transcranial magnetic stimulation in treatment of drug-resistant major depression: a report of two cases. Human Psychopharmacol. 1993;8(5):361–365. doi:10.1002/hup.470080510
   Web of Science ®Google Scholar
• Holtzheimer PE 3rd, McDonald WM, Mufti M, et al. Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression. Depress Anxiety. 2010;27(10):960–963. doi:10.1002/da.v27:1020734360
   PubMed Web of Science ®Google Scholar
• Holtzheimer PE, Kelley ME, Gross RE, et al. Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry. 2012;69(2):150–158. doi:10.1001/archgenpsychiatry.2011.145622213770
   PubMed Web of Science ®Google Scholar
• Holzer M, Padberg F. Intermittent theta burst stimulation (iTBS) ameliorates therapy-resistant depression: a case series. Brain Stimul. 2010;3(3):181–183. doi:10.1016/j.brs.2009.10.00420633448
   PubMed Web of Science ®Google Scholar
• Howland RH. New developments with vagus nerve stimulation therapy. J Psychosoc Nurs Ment Health Serv. 2014;52(3):11–14.
   Web of Science ®Google Scholar
• Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71(2):171–186. doi:10.1097/PSY.0b013e3181907c1b19188531
   PubMed Web of Science ®Google Scholar
• Hoy KE, Fitzgerald PB. Magnetic seizure therapy for treatment-resistant depression. Expert Rev Med Devices. 2011;8(6):723–732. doi:10.1586/erd.11.5522029469
   PubMed Web of Science ®Google Scholar
• Husain MM, Rush AJ, Fink M, et al. Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): a Consortium for Research in ECT (CORE) report. J Clin Psychiatry. 2004;65(4):485–491. doi:10.4088/JCP.v65n040615119910
   PubMed Web of Science ®Google Scholar
• Ibrahim L, Diazgranados N, Luckenbaugh DA, et al. Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(4):1155–1159. doi:10.1016/j.pnpbp.2011.03.01921466832
   PubMed Web of Science ®Google Scholar
• Ijaz S, Davies P, Williams CJ, Kessler D, Lewis G, Wiles N. Psychological therapies for treatment-resistant depression in adults.”. Cochrane Database Syst Rev. 2018;5:CD010558.29761488
   PubMed Web of Science ®Google Scholar
• Ionescu DF, Luckenbaugh DA, Niciu MJ, et al. Effect of baseline anxious depression on initial and sustained antidepressant response to ketamine. J Clin Psychiatry. 2014;75(9):e932–e938. doi:10.4088/JCP.14m0904925295436
   PubMed Web of Science ®Google Scholar
• Ionescu DF, Luckenbaugh DA, Niciu MJ, Richards EM, Zarate CA Jr. A single infusion of ketamine improves depression scores in patients with anxious bipolar depression. Bipolar Disord. 2015;17(4):438–443. doi:10.1111/bdi.2015.17.issue-425400146
   PubMed Web of Science ®Google Scholar
• Ionescu DF, Niciu MJ, Richards EM, Zarate CA Jr. Pharmacologic treatment of dimensional anxious depression: a review. Prim Care Companion CNS Disord. 2014;16(3).
   Google Scholar
• Iosifescu DV, Nierenberg AA, Mischoulon D, et al. An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. J Clin Psychiatry. 2005;66(8):1038–1042. doi:10.4088/JCP.v66n081216086620
   PubMed Web of Science ®Google Scholar
• Janicak PG, O’Reardon JP, Sampson SM, et al. Transcranial magnetic stimulation in the treatment of major depressive disorder: a comprehensive summary of safety experience from acute exposure, extended exposure, and during reintroduction treatment. J Clin Psychiatry. 2008;69(2):222–232. doi:10.4088/JCP.v69n020818232722
   PubMed Web of Science ®Google Scholar
• Kaster TS, Daskalakis ZJ, Noda Y, et al. Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial. Neuropsychopharmacology. 2018;43(11):2231–2238. doi:10.1038/s41386-018-0121-x29946106
   PubMed Web of Science ®Google Scholar
• Kato N. Neurophysiological mechanisms of electroconvulsive therapy for depression. Neurosci Res. 2009;64(1):3–11. doi:10.1016/j.neures.2009.01.01419321135
   PubMed Web of Science ®Google Scholar
• Kayser S, Bewernick BH, Matusch A, Hurlemann R, Soehle M, Schlaepfer TE. Magnetic seizure therapy in treatment-resistant depression: clinical, neuropsychological and metabolic effects. Psychol Med. 2015;45(5):1073–1092. doi:10.1017/S003329171400224425420474
   PubMed Web of Science ®Google Scholar
• Keitner GI, Garlow SJ, Ryan CE, et al. A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression. J Psychiatr Res. 2009;43(3):205–214. doi:10.1016/j.jpsychires.2008.05.00318586273
   PubMed Web of Science ®Google Scholar
• Keitner GI, Ryan CE, Solomon DA. Realistic expectations and a disease management model for depressed patients with persistent symptoms. J Clin Psychiatry. 2006;67(9):1412–1421. doi:10.4088/JCP.v67n091217017828
   PubMed Web of Science ®Google Scholar
• Keller MB, Shapiro RW, Lavori PW, Wolfe N. Recovery in major depressive disorder: analysis with the life table and regression models. Arch Gen Psychiatry. 1982;39(8):905–910. doi:10.1001/archpsyc.1982.042900800250047103679
   PubMed Web of Science ®Google Scholar
• Kellner CH, Husain MM, Knapp RG, et al. A novel strategy for continuation ECT in geriatric depression: phase 2 of the PRIDE study. Am J Psychiatry. 2016;173(11):1110–1118. doi:10.1176/appi.ajp.2016.1601011827418381
   PubMed Web of Science ®Google Scholar
• Kelly TF, Lieberman DZ. Long term augmentation with T3 in refractory major depression. J Affect Disord. 2009;115(1–2):230–233. doi:10.1016/j.jad.2008.09.02219108898
   PubMed Web of Science ®Google Scholar
• Kennedy SH, Giacobbe P. Treatment resistant depression–advances in somatic therapies. Ann Clin Psychiatry. 2007;19(4):279–287. doi:10.1080/1040123070167522218058285
   PubMedGoogle Scholar
• Kennedy SH, Giacobbe P, Rizvi SJ, et al. Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years. Am J Psychiatry. 2011;168(5):502–510. doi:10.1176/appi.ajp.2010.1008118721285143
   PubMed Web of Science ®Google Scholar
• Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry. 1994;51(3):199–214. doi:10.1001/archpsyc.1994.039500300350048122957
   PubMed Web of Science ®Google Scholar
• Leiknes KA, Jarosh-von Schweder L, Hoie B. Contemporary use and practice of electroconvulsive therapy worldwide. Brain Behav. 2012;2(3):283–344. doi:10.1002/brb3.3722741102
   PubMed Web of Science ®Google Scholar
• Levkovitz Y, Isserles M, Padberg F, et al. Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial. World Psychiatry. 2015;14(1):64–73. doi:10.1002/wps.2019925655160
   PubMed Web of Science ®Google Scholar
• Li CT, Chen MH, Juan CH, et al. Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study. Brain. 2014;137(Pt 7):2088–2098. doi:10.1093/brain/awu10924817188
   PubMed Web of Science ®Google Scholar
• Lieb J, Karmali R, Horrobin D. Elevated levels of prostaglandin E2 and thromboxane B2 in depression. Prostaglandins Leukot Med. 1983;10(4):361–367. doi:10.1016/0262-1746(83)90048-36574523
   PubMedGoogle Scholar
• Lisanby SH. Update on magnetic seizure therapy: a novel form of convulsive therapy. J ECT. 2002;18(4):182–188. doi:10.1097/00124509-200212000-0000312468992
   PubMed Web of Science ®Google Scholar
• Lontis ER, Voigt M, Struijk JJ. Focality assessment in transcranial magnetic stimulation with double and cone coils. J Clin Neurophysiol. 2006;23(5):462–471. doi:10.1097/01.wnp.0000229944.63011.a117016158
   PubMed Web of Science ®Google Scholar
• Lozano AM, Giacobbe P, Hamani C, et al. A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression. J Neurosurg. 2012;116(2):315–322. doi:10.3171/2011.10.JNS10212222098195
   PubMed Web of Science ®Google Scholar
• Lozano AM, Mayberg HS, Giacobbe P, Hamani C, Craddock RC, Kennedy SH. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry. 2008;64(6):461–467. doi:10.1016/j.biopsych.2008.05.03418639234
   PubMed Web of Science ®Google Scholar
• Luscher B, Shen Q, Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry. 2011;16(4):383–406.21079608
   PubMed Web of Science ®Google Scholar
• Maeda F, Keenan JP, Tormos JM, Topka H, Pascual-Leone A. Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation. Clin Neurophysiol. 2000;111(5):800–805. doi:10.1016/S1388-2457(99)00323-510802449
   PubMed Web of Science ®Google Scholar
• Mahmoud RA, Pandina GJ, Turkoz I, et al. Risperidone for treatment-refractory major depressive disorder: a randomized trial. Ann Intern Med. 2007;147(9):593–602. doi:10.7326/0003-4819-147-9-200711060-0000317975181
   PubMed Web of Science ®Google Scholar
• Malhi GS, Parker GB, Crawford J, Wilhelm K, Mitchell PB. Treatment-resistant depression: resistant to definition? Acta Psychiatr Scand. 2005;112(4):302–309. doi:10.1111/acp.2005.112.issue-416156838
   PubMed Web of Science ®Google Scholar
• Marcus RN, McQuade RD, Carson WH, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a second multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2008;28(2):156–165. doi:10.1097/JCP.0b013e31816774f918344725
   PubMed Web of Science ®Google Scholar
• Mathew SJ, Murrough JW, Aan Het Rot M, Collins KA, Reich DL, Charney DS. Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial.”. Int J Neuropsychopharmacol. 2010;13(1):71–82. doi:10.1017/S146114570900016919288975
   PubMed Web of Science ®Google Scholar
• Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45(5):651–660. doi:10.1016/j.neuron.2005.02.01415748841
   PubMed Web of Science ®Google Scholar
• McDonald A, Walter G. The portrayal of ECT in American movies. J ECT. 2001;17(4):264–274. doi:10.1097/00124509-200112000-0000611731728
   PubMed Web of Science ®Google Scholar
• McElhiney MC. The Autobiographical Memory Interview-Short Form In: Psychiatry DoB. New York: New York State Psychiatric Institute; 2001.
   Google Scholar
• McGirr A, Van den Eynde F, Tovar-Perdomo S, Fleck MP, Berlim MT. Effectiveness and acceptability of accelerated repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant major depressive disorder: an open label trial. J Affect Disord. 2015;173:216–220. doi:10.1016/j.jad.2014.10.06825462419
   PubMed Web of Science ®Google Scholar
• McGrath PJ, Stewart JW, Fava M, et al. Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry. 2006;163(9):1531–1541. doi:10.1176/ajp.2006.163.9.153116946177
   PubMed Web of Science ®Google Scholar
• McGrath PJ, Stewart JW, Harrison W, Quitkin FM. Treatment of tricyclic refractory depression with a monoamine oxidase inhibitor antidepressant. Psychopharmacol Bull. 1987;23(1):169–172.3602314
   PubMedGoogle Scholar
• McLachlan G. Treatment resistant depression: what are the options? BMJ. 2018;363:k5354. doi:10.1136/bmj.k535430563939
   PubMed Web of Science ®Google Scholar
• Meltzer-Brody S, Colquhoun H, Riesenberg R, et al. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, Phase 3 trials. Lancet. 2018;392(10152):1058–1070. doi:10.1016/S0140-6736(18)31551-430177236
   PubMed Web of Science ®Google Scholar
• Mueller TI, Leon AC. Recovery, chronicity, and levels of psychopathology in major depression. Psychiatr Clin North Am. 1996;19(1):85–102. doi:10.1016/S0193-953X(05)70275-68677222
   PubMed Web of Science ®Google Scholar
• Murrough JW, Perez AM, Pillemer S, et al. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry. 2013;74(4):250–256. doi:10.1016/j.biopsych.2012.06.02222840761
   PubMed Web of Science ®Google Scholar
• Mutz J, Vipulananthan V, Carter B, Hurlemann R, Fu CHY, Young AH. Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis. BMJ. 2019;364:l1079. doi:10.1136/bmj.l107930917990
   PubMed Web of Science ®Google Scholar
• Na KS, Lee KJ, Lee JS, Cho YS, Jung HY. Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:79–85. doi:10.1016/j.pnpbp.2013.09.00624056287
   PubMed Web of Science ®Google Scholar
• Naguy A. Brexanolone and postpartum depression: what does it have to do with GABA? Arch Womens Ment Health. 2019;22(6):833–834. doi:10.1007/s00737-019-00986-031302763
   PubMed Web of Science ®Google Scholar
• Naguy A, Alamiri B, Al Awadhi DS. Treatment-resistant depression: A plea to mull over! Asian J Psychiatr. 2018;36:69–70. doi:10.1016/j.ajp.2018.06.01429979996
   PubMed Web of Science ®Google Scholar
• Nelson JC, Baumann P, Delucchi K, Joffe R, Katona C. A systematic review and meta-analysis of lithium augmentation of tricyclic and second generation antidepressants in major depression. J Affect Disord. 2014;168:269–275. doi:10.1016/j.jad.2014.05.05325069082
   PubMed Web of Science ®Google Scholar
• Newton-Howes G, Tyrer P, Johnson T. Personality disorder and the outcome of depression: meta-analysis of published studies. Br J Psychiatry. 2006;188:13–20. doi:10.1192/bjp.188.1.1316388064
   PubMed Web of Science ®Google Scholar
• Newton-Howes G, Tyrer P, Johnson T, et al. Influence of personality on the outcome of treatment in depression: systematic review and meta-analysis. J Pers Disord. 2014;28(4):577–593. doi:10.1521/pedi_2013_27_07024256103
   PubMed Web of Science ®Google Scholar
• Nierenberg AA, Amsterdam JD.Treatment-resistant depression: definition and treatment approaches. J Clin Psychiatry. 1990;51(Suppl):39–47.
   PubMedGoogle Scholar
• Nierenberg AA, Fava M, Trivedi MH, et al. A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. Am J Psychiatry. 2006;163(9):1519–1530. doi:10.1176/ajp.2006.163.9.151916946176
   PubMed Web of Science ®Google Scholar
• O’Reardon JP, Blumner KH, Peshek AD, Pradilla RR, Pimiento PC. Long-term maintenance therapy for major depressive disorder with rTMS. J Clin Psychiatry. 2005;66(12):1524–1528. doi:10.4088/JCP.v66n120516401152
   PubMed Web of Science ®Google Scholar
• O’Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry. 2007;62(11):1208–1216. doi:10.1016/j.biopsych.2007.01.01817573044
   PubMed Web of Science ®Google Scholar
• Pagnin D, de Queiroz V, Pini S, Cassano GB. Efficacy of ECT in depression: a meta-analytic review. J ECT. 2004;20(1):13–20. doi:10.1097/00124509-200403000-0000415087991
   PubMed Web of Science ®Google Scholar
• Papakostas GI, Fava M, Thase ME. Treatment of SSRI-resistant depression: a meta-analysis comparing within- versus across-class switches. Biol Psychiatry. 2008;63(7):699–704. doi:10.1016/j.biopsych.2007.08.01017919460
   PubMed Web of Science ®Google Scholar
• Parker G, Roy K, Hadzi-Pavlovic D, Pedic F. Psychotic (delusional) depression: a meta-analysis of physical treatments. J Affect Disord. 1992;24(1):17–24. doi:10.1016/0165-0327(92)90056-C1347545
   PubMed Web of Science ®Google Scholar
• Parker GB, Malhi GS, Crawford JG, Thase ME. Identifying “paradigm failures” contributing to treatment-resistant depression. J Affect Disord. 2005;87(2–3):185–191. doi:10.1016/j.jad.2005.02.01515979725
   PubMed Web of Science ®Google Scholar
• Pascual-Leone A, Catala MD, Pascual-Leone A. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood. Neurology. 1996;46(2):499–502. doi:10.1212/WNL.46.2.4998614521
   PubMed Web of Science ®Google Scholar
• Peselow ED, Filippi AM, Goodnick P, Barouche F, Fieve RR. The short- and long-term efficacy of paroxetine HCl: A. Data from a 6-week double-blind parallel design trial vs. imipramine and placebo. Psychopharmacol Bull. 1989;25(2):267–271.2532373
   PubMedGoogle Scholar
• Petersen T, Papakostas GI, Posternak MA, et al. Empirical testing of two models for staging antidepressant treatment resistance. J Clin Psychopharmacol. 2005;25(4):336–341. doi:10.1097/01.jcp.0000169036.40755.1616012276
   PubMed Web of Science ®Google Scholar
• Post RM. The new news about lithium: an underutilized treatment in the United States. Neuropsychopharmacology. 2018;43(5):1174–1179. doi:10.1038/npp.2017.23828976944
   PubMed Web of Science ®Google Scholar
• Prange AJ Jr, Wilson IC, Rabon AM, Lipton MA. Enhancement of imipramine antidepressant activity by thyroid hormone. Am J Psychiatry. 1969;126(4):457–469. doi:10.1176/ajp.126.4.4574185164
   PubMed Web of Science ®Google Scholar
• Prudic J, Haskett RF, Mulsant B, et al. Resistance to antidepressant medications and short-term clinical response to ECT. Am J Psychiatry. 1996;153(8):985–992.8678194
   PubMed Web of Science ®Google Scholar
• Raison CL, Rutherford RE, Woolwine BJ, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2013;70(1):31–41. doi:10.1001/2013.jamapsychiatry.422945416
   PubMed Web of Science ®Google Scholar
• Richards EM, Mathews DC, Luckenbaugh DA, et al. A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression. Psychopharmacology (Berl). 2016;233(6):1119–1130. doi:10.1007/s00213-015-4195-426728893
   PubMed Web of Science ®Google Scholar
• Roth Y, Zangen A, Hallett M. A coil design for transcranial magnetic stimulation of deep brain regions. J Clin Neurophysiol. 2002;19(4):361–370. doi:10.1097/00004691-200208000-0000812436090
   PubMed Web of Science ®Google Scholar
• Rush AJ, Gullion CM, Basco MR, Jarrett RB, Trivedi MH. The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychol Med. 1996;26(3):477–486. doi:10.1017/S00332917000355588733206
   PubMed Web of Science ®Google Scholar
• Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905–1917. doi:10.1176/ajp.2006.163.11.190517074942
   PubMed Web of Science ®Google Scholar
• Sackeim HA. Central issues regarding the mechanisms of action of electroconvulsive therapy: directions for future research. Psychopharmacol Bull. 1994;30(3):281–308.7878177
   PubMedGoogle Scholar
• Sackeim HA. The definition and meaning of treatment-resistant depression. J Clin Psychiatry. 2001;62(Suppl 16):10–17.
   PubMedGoogle Scholar
• Sackeim HA, Aaronson ST, Bunker MT, et al. The assessment of resistance to antidepressant treatment: rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF). J Psychiatr Res. 2019;113:125–136. doi:10.1016/j.jpsychires.2019.03.02130974339
   PubMed Web of Science ®Google Scholar
• Sackeim HA, Haskett RF, Mulsant BH, et al. Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial. JAMA. 2001;285(10):1299–1307. doi:10.1001/jama.285.10.129911255384
   PubMed Web of Science ®Google Scholar
• Samoudi AM, Tanghe E, Martens L, Joseph W. Deep transcranial magnetic stimulation: improved coil design and assessment of the induced fields using MIDA model. Biomed Res Int. 2018;(2018:7061420.29967781
   PubMed Web of Science ®Google Scholar
• Sanacora G, Gueorguieva R, Epperson CN, et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry. 2004;61(7):705–713. doi:10.1001/archpsyc.61.7.70515237082
   PubMed Web of Science ®Google Scholar
• Shelton RC, Tollefson GD, Tohen M, et al. A novel augmentation strategy for treating resistant major depression. Am J Psychiatry. 2001;158(1):131–134. doi:10.1176/appi.ajp.158.1.13111136647
   PubMed Web of Science ®Google Scholar
• Souery D, Amsterdam J, de Montigny C, et al. Treatment resistant depression: methodological overview and operational criteria. Eur Neuropsychopharmacol. 1999;9(1–2):83–91. doi:10.1016/S0924-977X(98)00004-210082232
   PubMed Web of Science ®Google Scholar
• Souery D, Oswald P, Massat I, et al., D. Group for the Study of Resistant. Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study. J Clin Psychiatry. 2007;68(7):1062–1070. doi:10.4088/JCP.v68n071317685743
   PubMed Web of Science ®Google Scholar
• Strawbridge R, Arnone D, Danese A, Papadopoulos A, Herane Vives A, Cleare AJ. Inflammation and clinical response to treatment in depression: A meta-analysis. Eur Neuropsychopharmacol. 2015;25(10):1532–1543. doi:10.1016/j.euroneuro.2015.06.00726169573
   PubMed Web of Science ®Google Scholar
• Suppa A, Huang YZ, Funke K, et al. Ten years of theta burst stimulation in humans: established knowledge, unknowns and prospects. Brain Stimul. 2016;9(3):323–335. doi:10.1016/j.brs.2016.01.00626947241
   PubMed Web of Science ®Google Scholar
• Thase ME, Frank E, Mallinger AG, Hamer T, Kupfer DJ. Treatment of imipramine-resistant recurrent depression, III: efficacy of monoamine oxidase inhibitors. J Clin Psychiatry. 1992;53(1):5–11.
   PubMed Web of Science ®Google Scholar
• Thase ME, Rush AJ. Treatment resistant depression In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press Ltd.; 1995:1081–1097.
   Google Scholar
• Thase ME, Rush AJ, Howland RH, et al. Double-blind switch study of imipramine or sertraline treatment of antidepressant-resistant chronic depression. Arch Gen Psychiatry. 2002;59(3):233–239. doi:10.1001/archpsyc.59.3.23311879161
   PubMed Web of Science ®Google Scholar
• Ustun TB, Kessler RC. Global burden of depressive disorders: the issue of duration. Br J Psychiatry. 2002;181:181–183. doi:10.1192/bjp.181.3.18112204918
   PubMed Web of Science ®Google Scholar
• van Bronswijk S, Moopen N, Beijers L, Ruhe HG, Peeters F. Effectiveness of psychotherapy for treatment-resistant depression: a meta-analysis and meta-regression. Psychol Med. 2019;49(3):366–379. doi:10.1017/S003329171800199X30139408
   PubMed Web of Science ®Google Scholar
• Wilkinson ST, Agbese E, Leslie DL, Rosenheck RA. Identifying recipients of electroconvulsive therapy: data from privately insured Americans. Psychiatr Serv. 2018;69(5):542–548. doi:10.1176/appi.ps.20170036429385954
   PubMed Web of Science ®Google Scholar
• Williams NR, Sudheimer KD, Bentzley BS, et al. High-dose spaced theta-burst TMS as a rapid-acting antidepressant in highly refractory depression. Brain. 2018;141(3):e18. doi:10.1093/brain/awx37929415152
   PubMed Web of Science ®Google Scholar
• Wisner KL, Stika CS, Ciolino JD. The first food and drug administration-indicated drug for postpartum depression-brexanolone. JAMA Psychiatry. 2019;76:1001. doi:10.1001/jamapsychiatry.2019.1546
   Web of Science ®Google Scholar
• Xu Y, Hackett M, Carter G, et al. Effects of low-dose and very low-dose ketamine among patients with major depression: a systematic review and meta-analysis. Int J Neuropsychopharmacol. 2016;19(4).
   Web of Science ®Google Scholar
• Zall H, Therman PG, Myers JM. Lithium carbonate: a clinical study. Am J Psychiatry. 1968;125(4):549–555. doi:10.1176/ajp.125.4.5495711819
   PubMed Web of Science ®Google Scholar
• Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 2018;23(4):801–811. doi:10.1038/mp.2017.25529532791
   PubMed Web of Science ®Google Scholar
• Zhou X, Ravindran AV, Qin B, et al. Comparative efficacy, acceptability, and tolerability of augmentation agents in treatment-resistant depression: systematic review and network meta-analysis. J Clin Psychiatry. 2015;76(4):e487–e498. doi:10.4088/JCP.14r0920425919841
   PubMed Web of Science ®Google Scholar
• Berlim MT, van den Eynde F, Tovar-Perdomo S, Daskalakis ZJ. Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials. Psychol Med. 2014;44(2):225–39.23507264
   PubMed Web of Science ®Google Scholar