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Review

Profile of brivaracetam and its potential in the treatment of epilepsy

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Pages 2967-2973 | Published online: 30 Nov 2015

References

  • PeruccaPGilliamFGAdverse effects of antiepileptic drugsLancet Neurol201211979280222832500
  • LeporiniCDe SarroGRussoEAdherence to therapy and adverse drug reactions: is there a link?Expert Opin Drug Saf201413Suppl 1S41S5525171158
  • Lyseng-WilliamsonKALevetiracetam: a review of its use in epilepsyDrugs201171448951421395360
  • Mendoza-TorreblancaJGVanoye-CarloAPhillips-FarfánBVCarmona-AparicioLGómez-LiraGSynaptic vesicle protein 2A: basic facts and role in synaptic functionEur J Neurosci201338113529353924102679
  • KendaBMMatagneACTalagaPEDiscovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activityJ Med Chem200447353054914736235
  • LynchBALambengNNockaKThe synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetamProc Natl Acad Sci U S A2004101269861986615210974
  • GillardMFuksBLeclercqKMatagneABinding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant propertiesEur J Pharmacol20116641–3364421575627
  • KaminskiRMMatagneALeclercqKSV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsyNeuropharmacology200854471572018207204
  • MatagneAMargineanuDGKendaBMichelPKlitgaardHAnti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2ABr J Pharmacol200815481662167118500360
  • BialerMJohannessenSILevyRHPeruccaETomsonTWhiteHSProgress report on new antiepileptic drugs: a summary of the Twelfth Eilat Conference (EILAT XII)Epilepsy Res20151118514125769377
  • MumoliLPalleriaCGaspariniSBrivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizuresDrug Des Devel Ther2015957195725
  • DetraitERLeclercqKLoscherWBrivaracetam does not alter spatial learning and memory in both normal and amygdala-kindled ratsEpilepsy Res2010911748320678901
  • DupuisNMatagneAStaelensLAnti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature ratsEpilepsia201556580080525818358
  • WasterlainCGBaldwinRNaylorDEThompsonKWSuchomelovaLNiquetJRational polytherapy in the treatment of acute seizures and status epilepticusEpilepsia201152Suppl 8707121967369
  • TaiKKTruongDDBrivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonusJ Neural Transm (Vienna)2007114121547155117690949
  • NygaardHBKaufmanACSekine-KonnoTBrivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer’s disease mouse modelAlzheimers Res Ther2015712525945128
  • ZonaCPieriMCarunchioICurcioLKlitgaardHMargineanuDGBrivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in cultureEpilepsy Res2010881465419914041
  • KöhlingRVoltage-gated sodium channels in epilepsyEpilepsia200243111278129512423377
  • RogawskiMALöscherWThe neurobiology of antiepileptic drugsNature Reviews Neuroscience20045755356415208697
  • Sargentini-MaierMLEspiePCoquetteAStockisAPharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjectsDrug Metab Dispos2008361364517908923
  • Sargentini-MaierMLRolanPConnellJThe pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy malesBr J Clin Pharmacol200763668068817223857
  • RolanPSargentini-MaierMLPigeoletEStockisAThe pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy menBr J Clin Pharmacol2008661717518341673
  • Sargentini-MaierMLSokalskiABoulangerPJacobsTStockisABrivaracetam disposition in renal impairmentJ Clin Pharmacol201252121927193322235139
  • StockisASargentini-MaierMLHorsmansYBrivaracetam disposition in mild to severe hepatic impairmentJ Clin Pharmacol201353663364123649964
  • von RosenstielPBrivaracetam (UCB 34714)Neurotherapeutics200741848717199019
  • StockisAWatanabeSRouitsEMatsugumaKIrieSBrivaracetam single and multiple rising oral dose study in healthy Japanese participants: influence of CYP2C19 genotypeDrug Metab Pharmacokinet201429539439924717838
  • FrenchJACostantiniCBrodskyAvon RosenstielPGroupNSAdjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trialNeurology201075651952520592253
  • Van PaesschenWHirschEJohnsonMFalterUvon RosenstielPEfficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial-onset seizures: a phase IIb, randomized, controlled trialEpilepsia2013541899722813235
  • RyvlinPWerhahnKJBlaszczykBJohnsonMELuSAdjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trialEpilepsia2014551475624256083
  • BitonVBerkovicSFAbou-KhalilBSperlingMRJohnsonMELuSBrivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trialEpilepsia2014551576624446953
  • KwanPTrinkaEVan PaesschenWRektorIJohnsonMELuSAdjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trialEpilepsia2014551384624116853
  • KleinPSchiemannJSperlingMRA randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizuresEpilepsia Epub20151016
  • TianXYuanMZhouQWangXThe efficacy and safety of brivaracetam at different doses for partial-onset epilepsy: a meta-analysis of placebo-controlled studiesExpert Opinion on Pharmacotherapy201516121755176726165169
  • MaJHuangSYouCAdjunctive brivaracetam for patients with refractory partial seizures: a meta-analysis of randomized placebo-controlled trialsEpilepsy Res2015114596526088886
  • CrespelAGelissePReedRCManagement of juvenile myoclonic epilepsyEpilepsy Behav201328Suppl 1S81S8623756489
  • Kasteleijn-Nolst TrenitéDGSchmitzBJanzDConsensus on diagnosis and management of JME: from founder’s observations to current trendsEpilepsy Behav201328Suppl 1S87S9023756490
  • Kasteleijn-Nolst TrenitéDGGentonPParainDEvaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity modelNeurology200769101027103417785672
  • MagauddaAGelissePGentonPAntimyoclonic effect of levetiracetam in 13 patients with Unverricht-Lundborg disease: clinical observationsEpilepsia200445667868115144434
  • MuonaMBerkovicSFDibbensLMA recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsyNat Genet2015471394625401298
  • MagauddaAFerlazzoENguyenVHGentonPUnverricht-Lundborg disease, a condition with self-limited progression: long-term follow-up of 20 patientsEpilepsia200647586086616686650
  • FranceschettiSMichelucciRCanafogliaLProgressive myoclonic epilepsies: definitive and still undetermined causesNeurology201482540541124384641
  • KälviäinenGGentonPAndermannEBrivaracetm in patients with Unverricht-Lundborg Disease: results from two randomized, placebo-controlled, double-blind studiesEpilepsia Conference Proceedings: 28th International Epilepsy CongressJune 28-July 2, 2009Budapest Abstract
  • RosillonDAstrucBHulhovenREffect of brivaracetam on cardiac repolarisation – a thorough QT studyCurr Med Res Opin20082482327233718601811
  • CalabròRSItalianoDMilitiDBramantiPLevetiracetam-associated loss of libido and anhedoniaEpilepsy Behav201224228328422560189
  • CalabròRSFerlazzoEItalianoDBramantiPDose-dependent oxcarbazepine-related anorgasmiaEpilepsy Behav201017228728820089459
  • CalabròRSBramantiPItalianoDFerlazzoETopiramate-induced erectile dysfunctionEpilepsy Behav200914356056119189861
  • BialerMJohannessenSILevyRHPeruccaETomsonTWhiteHSProgress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX)Epilepsy Res200983114319008076
  • StockisAChanteuxHRosaMRolanPBrivaracetam and carbamazepine interaction in healthy subjects and in vitroEpilepsy Res2015113192725986188
  • StockisAWatanabeSFauchouxNInteraction between brivaracetam (100 mg/day) and a combination oral contraceptive: a randomized, double-blind, placebo-controlled studyEpilepsia2014553e27e3124512385
  • PalleriaCCoppolaACitraroRPerspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosisExpert Opin Pharma cother2015161523552371