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Review

Aggression in autism spectrum disorder: presentation and treatment options

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Pages 1525-1538 | Published online: 23 Jun 2016

References

  • American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders: DSM-5Spring Hill, TNManMag2003
  • HastingsRPKovshoffHWardNJdegli EspinosaFBrownTRemingtonBSystems analysis of stress and positive perceptions in mothers and fathers of pre-school children with autismJ Autism Dev Disord200535563564416177837
  • LecavalierLLeoneSWiltzJThe impact of behaviour problems on caregiver stress in young people with autism spectrum disordersJ Intellect Disabil Res200650317218316430729
  • AmanMSinghNAberrant Behavior Checklist: ManualEast Aurora, NYSlosson Educational Publications1986
  • KaartinenMPuuraKHelminenMSalmelinRPelkonenEJuujärviPReactive aggression among children with and without autism spectrum disorderJ Autism Dev Disord201444102383239123263769
  • FarmerCButterEMazurekMOAggression in children with autism spectrum disorders and a clinic-referred comparison groupAutism201519328129124497627
  • HartleySSikoraDMcCoyRPrevalence and risk factors of maladaptive behaviour in young children with autistic disorderJ Intellect Disabil Res2008521081982918444989
  • LoveJRCarrJELeBlancLAFunctional assessment of problem behavior in children with autism spectrum disorders: a summary of 32 outpatient casesJ Autism Dev Disord200939236337218704671
  • McClintockKHallSOliverCRisk markers associated with challenging behaviours in people with intellectual disabilities: a meta-analytic studyJ Intellect Disabil Res200347640541612919191
  • TsakanikosECostelloHHoltGSturmeyPBourasNBehaviour management problems as predictors of psychotropic medication and use of psychiatric services in adults with autismJ Autism Dev Disord20073761080108517053989
  • KanneSMMazurekMOAggression in children and adolescents with ASD: prevalence and risk factorsJ Autism Dev Disord201141792693720960041
  • MatsonJLRivetTTThe effects of severity of autism and PDD-NOS symptoms on challenging behaviors in adults with intellectual disabilitiesJ Dev Phys Disabil20082014151
  • NICHD Early Child Care Research NetworkTrajectories of physical aggression from toddlerhood to middle childhood: predictors, correlates, and outcomesMonogr Soc Res Child Dev2004694vii1129
  • EisenhowerASBakerBLBlacherJPreschool children with intellectual disability: syndrome specificity, behaviour problems, and maternal well-beingJ Intellect Disabil Res200549965767116108983
  • ReeseRMRichmanDMBelmontJMMorsePFunctional characteristics of disruptive behavior in developmentally disabled children with and without autismJ Autism Dev Disord200535441942816134028
  • DominickKCDavisNOLainhartJTager-FlusbergHFolsteinSAtypical behaviors in children with autism and children with a history of language impairmentRes Dev Disabil200728214516216581226
  • LuiselliJKAggression and noncomplianceApplied Behavior Analysis for Children with Autism Spectrum DisordersBerlin, GermanySpringer2009175187
  • Dryden-EdwardsRCCombrinck-GrahamLDevelopmental Disabilities from Childhood to Adulthood: What Works for Psychiatrists in Community and Institutional SettingsBaltimore, MDJHU Press2010
  • DagnanDWestonCPhysical intervention with people with intellectual disabilities: the influence of cognitive and emotional variablesJ Appl Res Intellect Disabil2006192219222
  • StithSMLiuTDaviesLCRisk factors in child maltreatment: a meta-analytic review of the literatureAggress Violent Behav20091411329
  • Otero-LópezJMCastroCVillardefrancosESantiagoMJJob dissatisfaction and burnout in secondary school teachers: student’s disruptive behaviour and conflict management examinedEur J Educ Psychol20092299111
  • NeeceCLGreenSABakerBLParenting stress and child behavior problems: a transactional relationship across timeAm J Intellect Dev Disabil20121171486622264112
  • HodgettsSNicholasDZwaigenbaumLHome sweet home? Families’ experiences with aggression in children with autism spectrum disordersFocus Autism Dev Disabil2013283166174
  • PowersMDPalmieriMJD’EramoKSPowersKMEvidence-based treatment of behavioral excesses and deficits for individuals with autism spectrum disordersEvidence-based Practices and Treatments for Children with AutismNew York, NYSpringer20115592
  • SooryaLCarpenterLRomanczykRApplied behavior analysis. Textbook of Autism Spectrum DisordersArlington, VAAmerican Psychiatric Publishing2011525536
  • CooperJOHeronTEHewardWLApplied Behavior Analysis2nd edNew York, NYPearson2007
  • WongCOdomSLHumeKAEvidence-based practices for children, youth, and young adults with autism spectrum disorder: a comprehensive reviewJ Autism Dev Disord20154571951196625578338
  • RothMEGillisJMReedFDA meta-analysis of behavioral interventions for adolescents and adults with autism spectrum disordersJ Behav Educ2014232258286
  • IwataBADorseyMFSliferKJBaumanKERichmanGSToward a functional analysis of self-injuryJ Appl Behav Anal19942721978063622
  • PaclawskyjTRMatsonJLRushKSSmallsYVollmerTRQuestions about behavioral function (QABF): a behavioral checklist for functional assessment of aberrant behaviorRes Dev Disabil200021322322910939320
  • IwataBADeLeonIGRoscoeEMReliability and validity of the functional analysis screening toolJ Appl Behav Anal201346127128424114099
  • NewcomerLLLewisTJFunctional behavioral assessment: an investigation of assessment reliability and effectiveness of function-based interventionsJ Emot Behav Disord2004123168181
  • HerzingerCVCampbellJMComparing functional assessment methodologies: a quantitative synthesisJ Autism Dev Disord20073781430144517004118
  • BadgettNFalcomataTSA comparison of methodologies of brief functional analysisDev Neurorehabil201518422423323869515
  • QuerimACIwataBARoscoeEMSchlichenmeyerKJOrtegaJVHurlKEFunctional analysis screening for problem behavior maintained by automatic reinforcementJ Appl Behav Anal2013461476024114084
  • HardingJWWackerDPBergWKLeeJFDolezalDConducting functional communication training in home settings: a case study and recommendations for practitionersBehav Anal Pract2009212120936098
  • FersterCBPositive reinforcement and behavioral deficits of autistic childrenChild Dev19613243745613699189
  • MatsonJLDixonDRMatsonMLAssessing and treating aggression in children and adolescents with developmental disabilities: a 20-year overviewEduc Psychol2005252–3151181
  • GerhardtPFWeissMJDelmolinoLTreatment of severe aggression in an adolescent with autism: non-contingent reinforcement and functional communication trainingBehav Anal Today200444386
  • CarrJECoriatySWilderDAA review of “noncontingent” reinforcement as treatment for the aberrant behavior of individuals with developmental disabilitiesRes Dev Disabil200021537739111100801
  • CarrEGDurandVMReducing behavior problems through functional communication trainingJ Appl Behav Anal19851821111262410400
  • BraithwaiteKLRichdaleALFunctional communication training to replace challenging behaviors across two behavioral outcomesBehav Interv20001512136
  • SchieltzKMWackerDPHardingJWIndirect effects of functional communication training on non-targeted disruptive behaviorJ Behav Educ2011201153223487563
  • KurtzPFBoelterEWJarmolowiczDPChinMDHagopianLPAn analysis of functional communication training as an empirically supported treatment for problem behavior displayed by individuals with intellectual disabilitiesRes Dev Disabil20113262935294221696917
  • BlankenshipKEricksonCAMcDougleCJPharmacotherapy of autism and related disordersPsychiatr Ann2010404203209
  • McCrackenJTMcGoughJShahBRisperidone in children with autism and serious behavioral problemsN Engl J Med2002347531432112151468
  • OwenRSikichLMarcusRNAripiprazole in the treatment of irritability in children and adolescents with autistic disorderPediatrics200912461533154019948625
  • CenterWatchDrug Information: FDA-Approved DrugsSilver Spring, MDUS Food and Drug Administration2009 Available from: http://www.centerwatch.com/drug-information/fda-approved-drugs/year/2009Accessed April 26, 2016
  • HorriganJPBarnhillLJRisperidone and explosive aggressive autismJ Autism Dev Disord19972733133239229261
  • McDougleCJHolmesJPCarlsonDCPeltonGHCohenDJPriceLHA double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disordersArch Gen Psychiatry19985576336419672054
  • SheaSTurgayACarrollARisperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disordersPediatrics20041145e634e64115492353
  • Research Units on Pediatric Psychopharmacology Autism NetworkRisperidone treatment of autistic disorder: longer-term benefits and blinded discontinuation after 6 monthsAm J Psychiatry200516271361136915994720
  • AmanMRettigantiMNagarajaHNTolerability, safety, and benefits of risperidone in children and adolescents with autism: 21-month follow-up after 8-week placebo-controlled trialJ Child Adolesc Psychopharmacol201525648249326262903
  • EricksonCAStiglerKAPoseyDJMcDougleCJAripiprazole in autism spectrum disorders and fragile X syndromeNeurotherapeutics20107325826320643378
  • StiglerKAPoseyDJMcDougleCJAripiprazole for maladaptive behavior in pervasive developmental disordersJ Child Adolesc Psychopharmacol200414345546315650503
  • Valicenti-McDermottMRDembHClinical effects and adverse reactions of off-label use of aripiprazole in children and adolescents with developmental disabilitiesJ Child Adolesc Psychopharmacol200616554956017069544
  • StiglerKADienerJTKohnAEAripiprazole in pervasive developmental disorder not otherwise specified and Asperger’s disorder: a 14-week, prospective, open-label studyJ Child Adolesc Psychopharmacol200919326527419519261
  • MarcusRNOwenRKamenLA placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorderJ Am Acad Child Adolesc Psychiatry200948111110111919797985
  • MarcusRNOwenRManosGAripiprazole in the treatment of irritability in pediatric patients (aged 6–17 years) with autistic disorder: results from a 52-week, open-label studyJ Child Adolesc Psychopharmacol201121322923621663425
  • HoJGCaldwellRLMcDougleCJThe effects of aripiprazole on electrocardiography in children with pervasive developmental disordersJ Child Adolesc Psychopharmacol201222427728322849533
  • LallyJMacCabeJHAntipsychotic medication in schizophrenia: a reviewBr Med Bull2015114116917925957394
  • LiXBTangYLWangCYde LeonJClozapine for treatment-resistant bipolar disorder: a systematic reviewBipolar Disord201517323524725346322
  • IfteniPCorrellCUNielsenJBurteaVKaneJMManuPRapid clozapine titration in treatment-refractory bipolar disorderJ Affect Disord201416616817225012427
  • PoyrazCATuranŞDemirelÖFUsta SağlamNGYıldızNDuranAEffectiveness of ultra-rapid dose titration of clozapine for treatment-resistant bipolar mania: case seriesTher Adv Psychopharmacol20155423724226301080
  • PoyrazCAÖzdemirASağlamNGRapid clozapine titration in patients with treatment refractory schizophreniaPsychiatr Q201687231532226433727
  • ChenNCBedairHSMcKayBBowersMBJrMazureCClozapine in the treatment of aggression in an adolescent with autistic disorderJ Clin Psychiatry200162647948011465533
  • GobbiGPulvirentiLLong-term treatment with clozapine in an adult with autistic disorder accompanied by aggressive behaviourJ Psychiatry Neurosci200126434034111590976
  • LambreySFalissardBMartin-BarreroMEffectiveness of clozapine for the treatment of aggression in an adolescent with autistic disorderJ Child Adolesc Psychopharmacol2010201798020166802
  • BeherecLLambreySQuiliciGRosierAFalissardBGuillinORetrospective review of clozapine in the treatment of patients with autism spectrum disorder and severe disruptive behaviorsJ Clin Psychopharmacol201131334134421508854
  • AyubMSaeedKMunshiTANaeemFClozapine for psychotic disorders in adults with intellectual disabilitiesCochrane Database Syst Rev20159CD01062526397173
  • MaayanLCorrellCUWeight gain and metabolic risks associated with antipsychotic medications in children and adolescentsJ Child Adolesc Psychopharmacol201121651753522166172
  • HorriganJPBarnhillLJCourvoisieHEOlanzapine in PDDJ Am Acad Child Adolesc Psychiatry1997369116611679291716
  • HollanderEWassermanSSwansonENA double-blind placebo-controlled pilot study of olanzapine in childhood/adolescent pervasive developmental disorderJ Child Adolesc Psychopharmacol200616554154817069543
  • PotenzaMNHolmesJPKanesSJMcDougleCJOlanzapine treatment of children, adolescents, and adults with pervasive developmental disorders: an open-label pilot studyJ Clin Psychopharmacol199919137449934941
  • KemnerCWillemsen-SwinkelsSHde JongeMTuynman-QuaHvan EngelandHOpen-label study of olanzapine in children with pervasive developmental disorderJ Clin Psychopharmacol200222545546012352267
  • FidoAAl-SaadSOlanzapine in the treatment of behavioral problems associated with autism: an open-label trial in KuwaitMed Princ Pract200817541541818685284
  • MartinAKoenigKScahillLBregmanJOpen-label quetiapine in the treatment of children and adolescents with autistic disorderJ Child Adolesc Psychopharmacol1999929910710461820
  • FindlingRLMcNamaraNKGraciousBLQuetiapine in nine youths with autistic disorderJ Child Adolesc Psychopharmacol200414228729415319025
  • CorsonAHBarkenbusJEPoseyDJStiglerKAMcDougleCJA retrospective analysis of quetiapine in the treatment of pervasive developmental disordersJ Clin Psychiatry200465111531153615554768
  • HardanAYJouRJHandenBLRetrospective study of quetiapine in children and adolescents with pervasive developmental disordersJ Autism Dev Disord200535338739116119479
  • GoforthHWRaoMSImprovement in behaviour and attention in an autistic patient treated with ziprasidoneAust N Z J Psychiatry200337677577614636398
  • DuggalHSZiprasidone for maladaptive behavior and attention-deficit/hyperactivity disorder symptoms in autistic disorderJ Child Adolesc Psychopharmacol200717226126417489724
  • McDougleCJKemDLPoseyDJCase series: use of ziprasidone for maladaptive symptoms in youths with autismJ Am Acad Child Adolesc Psychiatry200241892192712164181
  • MaloneRPDelaneyMAHymanSBCaterJRZiprasidone in adolescents with autism: an open-label pilot studyJ Child Adolesc Psychopharmacol200717677979018315450
  • DominickKWinkLKMcDougleCJEricksonCAA retrospective naturalistic study of ziprasidone for irritability in youth with autism spectrum disorderJ Child Adolesc Psychopharmacol201525539740126091194
  • TaylorDZiprasidone in the management of schizophreniaCNS Drugs200317642343012697001
  • KarlssonPDenckerENybergSPharmacokinetics, dopamine D2 and serotonin 5-HT2A receptor occupancy and safety profile of paliperidone ER, in healthy volunteersEur Neuropsychopharmacol200515Suppl 3S38
  • StiglerKAEricksonCAMullettJEPoseyDJMcDougleCJPaliperidone for irritability in autistic disorderJ Child Adolesc Psychopharmacol2010201757820166801
  • StiglerKAMullettJEEricksonCAPoseyDJMcDougleCJPaliperidone for irritability in adolescents and young adults with autistic disorderPsychopharmacology (Berl)2012223223724522549762
  • LoebelABramsMGoldmanRSLurasidone for the treatment of irritability associated with autistic disorderJ Autism Dev Disord20164641153116326659550
  • EngelhardtDMPolizosPWaizerJHoffmanSPA double-blind comparison of fluphenazine and haloperidol in outpatient schizophrenic childrenJ Autism Child Schizophr1973321281374583792
  • CampbellMAndersonLTMeierMA comparison of haloperidol and behavior therapy and their interaction in autistic childrenJ Am Acad Child Psychiatry1978174640655370186
  • CampbellMAndersonLTSmallAMPerryRGreenWHCaplanRThe effects of haloperidol on learning and behavior in autistic childrenJ Autism Dev Disord19821221671757174605
  • AndersonLTCampbellMAdamsPSmallAMPerryRShellJThe effects of haloperidol on discrimination learning and behavioral symptoms in autistic childrenJ Autism Dev Disord19891922272392663834
  • PerryRCampbellMAdamsPLong-term efficacy of haloperidol in autistic children: continuous versus discontinuous drug administrationJ Am Acad Child Adolesc Psychiatry198928187922914841
  • ArmenterosJLAdamsPBCampbellMEisenbergZWHaloperidol-related dyskinesias and pre- and perinatal complications in autistic childrenPsychopharmacol Bull19953123633697491393
  • HirotaTVeenstra-VanderweeleJHollanderEKishiTAntiepileptic medications in autism spectrum disorder: a systematic review and meta-analysisJ Autism Dev Disord201444494895724077782
  • HubandNFerriterMNathanRJonesHAntiepileptics for aggression and associated impulsivityCochrane Database Syst Rev20102CD00349920166067
  • HellingsJAWeckbaughMNickelEJA double-blind, placebo-controlled study of valproate for aggression in youth with pervasive developmental disordersJ Child Adolesc Psychopharmacol200515468269216190799
  • LewitzkaUSeverusEBauerRRitterPMüller-OerlinghausenBBauerMThe suicide prevention effect of lithium: more than 20 years of evidence-a narrative reviewInt J Bipolar Disord2015313226183461
  • CampbellMFishBKoreinJShapiroTCollinsPKohCLithium and chlorpromazine: a controlled crossover study of hyperactive severely disturbed young childrenJ Autism Child Schizophr1972232342634567547
  • KerbeshianJBurdLFisherWLithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatologyJ Clin Psychopharmacol1987764014053429701
  • SteingardRBiedermanJLithium responsive manic-like symptoms in two individuals with autism and mental retardationJ Am Acad Child Adolesc Psychiatry19872669329352892825
  • SiegelMBeresfordCABunkerMPreliminary investigation of lithium for mood disorder symptoms in children and adolescents with autism spectrum disorderJ Child Adolesc Psychopharmacol201424739940225093602
  • Deepmala SlatteryJKumarNClinical trials of N-acetylcysteine in psychiatry and neurology: a systematic reviewNeurosci Biobehav Rev20155529432125957927
  • BerkMMalhiGSGrayLJDeanOMThe promise of N-acetylcysteine in neuropsychiatryTrends Pharmacol Sci201334316717723369637
  • JamesSJMelnykSJerniganSMetabolic endophenotype and related genotypes are associated with oxidative stress in children with autismAm J Med Genet B Neuropsychiatr Genet2006141B894795616917939
  • EricksonCAMcDougleCJStiglerKAPoseyDJGlutamatergic function in autismHeresco-LevyUGlutamate in Neuropsychiatric DisordersTrivandrum, KeralaResearch Signpost2008
  • HardanAYFungLKLiboveRAA randomized controlled pilot trial of oral N-acetylcysteine in children with autismBiol Psychiatry2012711195696122342106
  • GhanizadehAMoghimi-SaraniEA randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disordersBMC Psychiatry20131319623886027
  • NikooMRadniaHFarokhniaMMohammadiMRAkhondzadehSN-acetylcysteine as an adjunctive therapy to risperidone for treatment of irritability in autism: a randomized, double-blind, placebo-controlled clinical trial of efficacy and safetyClin Neuropharmacol2015381111725580916
  • PoseyDJMcDougleCJThe pharmacotherapy of target symptoms associated with autistic disorder and other pervasive developmental disordersHarv Rev Psychiatry200082456310902094
  • PankseppJSahleyTLPossible brain opioid involvement in disrupted social intent and language development of autismSchoplerEMesibovGBNeurobiological Issues in AutismNew York, NYPlenum Press1987
  • CampbellMAndersonLTSmallAMNaltrexone in autistic children: behavioral symptoms and attentional learningJ Am Acad Child Adolesc Psychiatry1993326128312918282676
  • RoyARoyMDebSUnwinGRoyAAre opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic reviewJ Intellect Disabil Res201559429330624589346
  • AdlerBAWinkLKEarlyMDrug-refractory aggression, self-injurious behavior, and severe tantrums in autism spectrum disorders: a chart review studyAutism201519110210624571823
  • SchubartJRCamachoFLeslieDPsychotropic medication trends among chidren and adolescents with autism psectrum disorder in the Medicaid programAutism201418663163724165274
  • WinkLKPedapatiEVHornPSMcDougleCJEricksonCAMultiple antipsychotic medication use in autism spectrum disorderJ Child Adolesc Psychopharmacol Epub10142015
  • GallegoJANielsenJDe HertMKaneJMCorrellCUSafety and tolerability of antipsychotic polypharmacyExpert Opin Drug Saf201211452754222563628
  • GhaleihaAAsadabadiMMohammadiMRMemantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trialInt J Neuropsychopharmacol201316478378922999292
  • GhaleihaAMohammadiEMohammadiMRRiluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trialPaediatr Drugs201315650551423821414
  • MohammadiMRYadegariNHassanzadehEDouble-blind, placebo-controlled trial of risperidone plus amantadine in children with autism: a 10-week randomized studyClin Neuropharmacol201336617918424201232
  • WinkLKEricksonCAStiglerKAMcDougleCJRiluzole in autistic disorderJ Child Adolesc Psychopharmacol201121437537921823915
  • EricksonCAChambersJEMemantine for disruptive behavior in autistic disorderJ Clin Psychiatry2006676100016848669
  • EricksonCAVeenstra-VanderweeleJMMelmedRDSTX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label studyJ Autism Dev Disord201444495896424272415
  • BronsardVPaulCPreySWhat are the best outcome measures for assessing quality of life in plaque type psoriasis? A systematic review of the literatureJ Eur Acad Dermatol Venereol201024Suppl 2172220443996
  • StiglerKAMcDougleCJPharmacotherapy of irritability in pervasive developmental disordersChild Adolesc Psychiatr Clin N Am2008174739752viiviii18775367
  • Centers for Disease Control and PreventionAutism Spectrum Disorder, Data and StatisticsAtlanta, GACenters for Disease Control and Prevention2014 Available from: http://www.cdc.gov/ncbddd/autism/data.htmlAccessed April 26, 2016
  • MinshawiNWinkLKShafferRA randomized, placebo-controlled trial of D-cycloserine for the enhancement of social skills training in autism spectrum disordersMol Autism201672126753090