Safety, tolerability, and efficacy of fixed combination therapy with dorzolamide hydrochloride 2% and timolol maleate 0.5% in glaucoma and ocular hypertension

References

• AllinghamRRDamjiKFFreedmanSMoroiSEShafranovGShieldsMBAn overview of glaucomaShields’ Textbook of Glacuoma5th edPhiladelphiaLippincott Williams & Wilkins200512
   Google Scholar
• FolbergRKumarVAbbasAKFaustoNThe EyeRobbins and Cotran Pathologic Basis of Disease7th edPhiladelphiaElsevier Saunders200514211447
   Google Scholar
• LeskeMCOpen-angle glaucoma – an epidemiologic overviewOphthalmic Epidemiol2007Jul–Aug14416617217896292
   PubMed Web of Science ®Google Scholar
• QuigleyHABromanATThe number of people with glaucoma worldwide in 2010 and 2020Br J Ophthalmol200690326226716488940
   PubMed Web of Science ®Google Scholar
• RudnickaARMt-IsaSOwenCGCookDGAshbyDVariations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysisInvest Ophthalmol Vis Sci200647104254426117003413
   PubMed Web of Science ®Google Scholar
• KhouriASRealiniTFechtnerRDNetlandPAFixed-combination drugsGlaucoma Medical Therapy, Principles and Management2nd edNew YorkOxford University Press2008139150
   Google Scholar
• KassMAHeuerDKHigginbothamEJThe Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucomaArch Ophthalmol20021206701713 discussion 829–73012049574
   PubMed Web of Science ®Google Scholar
• KobeltGHealth economics, economic evaluation, and glaucomaJ Glaucoma200211653153912483101
   PubMed Web of Science ®Google Scholar
• BoyleJEGhoshKGieserDKAdamsonsIAA randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol and dorzolamide. Dorzolamide-Timolol Study GroupOphthalmology199810510194519519787368
   PubMed Web of Science ®Google Scholar
• ClaxtonAJCramerJPierceCA systematic review of the associations between dose regimens and medication complianceClin Ther20012381296131011558866
   PubMed Web of Science ®Google Scholar
• StrohmaierKSnyderEDuBinerHAdamsonsIThe efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components. Dorzolamide-Timolol Study GroupOphthalmology199810510193619449787367
   PubMed Web of Science ®Google Scholar
• GreenbergRNOverview of patient compliance with medication dosing: a literature reviewClin Ther1984655925996383611
   PubMed Web of Science ®Google Scholar
• HigginbothamEJConsiderations in glaucoma therapy: fixed combinations versus their component medicationsClin Ophthalmol201041920169043
   PubMedGoogle Scholar
• IchhpujaniPKatzLJEfficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertensionDrug, Healthcare and Patient Safety201027383
   Google Scholar
• RazeghinejadMRSawchynAKKatzLJFixed combinations of dorzolamide-timolol and brimonidine-timolol in the management of glaucomaExpert Opin Pharmacother201011695996820307220
   PubMed Web of Science ®Google Scholar
• Food and Drug AdministrationGeneric Drug Roundup: Feb 2009 http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/ucm089346.pdf. Published 2009 Feb 2Accessed 2009 Oct 2
   Google Scholar
• Baiza-DuranLMAlvarez-DelgadoJContreras-RubioAYThe efficacy and safety of two fixed combinations: timolol-dorzolamide-brimonidine versus timolol-dorzolamide. A prospective, randomized, double-masked, multi-center, 6-month clinical trialAnn Ophthalmol (Skokie)2009413–417417820214051
   PubMedGoogle Scholar
• FramptonJEPerryCMTopical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertensionDrugs Aging2006231297799517154662
   PubMed Web of Science ®Google Scholar
• HoffmanBBKatzungBGAdrenoceptor antagonist drugsBasic and Clinical PharmacologyNew YorkMcGraw-Hill2007141158
   Google Scholar
• Food and Drug AdministrationOverview: Dorzolamide Hydrochloride and Timolol Maleate http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=DORZOLAMIDE%20HYDROCHLORIDE%20AND%20TIMOLOL%20MALEATE&CFID=50418758&CFTOKEN=18f5006a032ce6b8-B14B17B2-EB11-C82D-B8C8A0BAEEFB9D7B. Updated 2009 Oct 19Accessed 2009 Oct 19
   Google Scholar
• HutnikCNeimaDIbrahimFTolerability and effectiveness of preservative-free dorzolamide-timolol (preservative-free COSOPT) in patients with open-angle glaucoma or ocular hypertensionClin Ophthalmol2010458159020668720
   PubMedGoogle Scholar
• SheddenAAdamsonsIAGetsonAJComparison of the efficacy and tolerability of preservative-free and preservative-containing formulations of the dorzolamide/timolol fixed combination (COSOPT) in patients with elevated intraocular pressure in a randomized clinical trialGraefes Arch Clin Exp Ophthalmol201052 [Epub ahead of print]
   Web of Science ®Google Scholar
• Azarga [package insert–prescribing information]Hemel Hempstead, UKAlcon Laboratories (UK) Ltd2008
   Google Scholar
• JanulevicieneIBrinzolamide 1%/timolol 0.5%: safety and efficacy of a new fixed-combination IOP-lowering product for glaucomaCurr Med Res Opin201026112575257820868340
   PubMed Web of Science ®Google Scholar
• MundorfTKRauchmanSHWilliamsRDNotivolRA patient preference comparison of Azarga (brinzolamide/timolol fixed combination) vs Cosopt (dorzolamide/timolol fixed combination) in patients with open-angle glaucoma or ocular hypertensionClin Ophthalmol20082362362819668763
   PubMedGoogle Scholar
• VoldSDEvansRMStewartRHWaltersTMallickSA one-week comfort study of BID-dosed brinzolamide 1%/timolol 0.5% ophthalmic suspension fixed combination compared to BID-dosed dorzolamide 2%/timolol 0.5% ophthalmic solution in patients with open-angle glaucoma or ocular hypertensionJ Ocul Pharmacol Ther200824660160519049301
   PubMed Web of Science ®Google Scholar
• Merck Sharp & Dohme v Alcon Code of Practice Review20105114125
   Google Scholar
• ClineschmidtCMWilliamsRDSnyderEAdamsonsIAA randomized trial in patients inadequately controlled with timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Dorzolamide-Timolol Combination Study GroupOphthalmology199810510195219599787369
   PubMed Web of Science ®Google Scholar
• ColemanALLernerFBernsteinPWhitcupSMA 3-month randomized controlled trial of bimatoprost (LUMIGAN) versus combined timolol and dorzolamide (Cosopt) in patients with glaucoma or ocular hypertensionOphthalmology2003110122362236814644719
   PubMed Web of Science ®Google Scholar
• DayDGSharpeEDBeischelCJJenkinsJNStewartJAStewartWCSafety and efficacy of bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% fixed combinationEur J Ophthalmol200515333634215945001
   PubMed Web of Science ®Google Scholar
• ChiselitaDAntohiIMedvichiRDanielescuCComparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, randomized, masked, cross-over design studyOftalmologia2005493394516408674
   PubMedGoogle Scholar
• FechtnerRDAiraksinenPJGetsonAJLinesCRAdamsonsIAEfficacy and tolerability of the dorzolamide 2%/timolol 0.5% combination (COSOPT) versus 0.005% (XALATAN) in the treatment of ocular hypertension or glaucoma: results from two randomized clinical trialsActa Ophthalmol Scand2004821424814982045
   PubMedGoogle Scholar
• KonstasAGKozobolisVPTsironiSMakridakiIEfremovaRStewartWCComparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatmentOphthalmology200811519910318166407
   PubMed Web of Science ®Google Scholar
• ParmaksizSYukselNKarabasVLOzkanBDemirciGCaglarYA comparison of travoprost, latanoprost, and the fixed combination of dorzolamide and timolol in patients with pseudoexfoliation glaucomaEur J Ophthalmol2006161738016496249
   PubMed Web of Science ®Google Scholar
• SuzukiERJrFranklinLMda SilvaLJFigueiredoCRNettoJABatistaWDComparison of the efficacy and safety of travoprost with a fixed-combination of dorzolamide and timolol in patients with open-angle glaucoma or ocular hypertensionCurr Med Res Opin20062291799180516968583
   PubMed Web of Science ®Google Scholar
• FrancisBADuLTBerkeSEhrenhausMMincklerDSComparing the fixed combination dorzolamide-timolol (Cosopt) to concomitant administration of 2% dorzolamide (Trusopt) and 0.5% timolol – a randomized controlled trial and a replacement studyJ Clin Pharm Ther200429437538015271105
   PubMed Web of Science ®Google Scholar
• HutzelmannJOwensSSheddenAAdamsonsIVargasEComparison of the safety and efficacy of the fixed combination of dorzolamide/timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study. International Clinical Equivalence Study GroupBr J Ophthalmol19988211124912539924327
   PubMed Web of Science ®Google Scholar
• SallKNGreffLJJohnson-PrattLRDorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy and tolerabilityOphthalmology2003110361562412623832
   PubMed Web of Science ®Google Scholar
• SolishAMDeLuccaPTCasselDAKolodnyAHHustadCMSkobierandaFDorzolamide/timolol fixed combination versus concomitant administration of brimonidine and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measuresJ Glaucoma200413214915715097262
   PubMed Web of Science ®Google Scholar
• ZabriskieNNetlandPAComparison of brimonidine/latanoprost and timolol/dorzolamide: two randomized, double-masked, parallel clinical trialsAdv Ther20032029210012836809
   PubMed Web of Science ®Google Scholar
• CvenkelBStewartJANelsonLAStewartWCDorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertensionCurr Eye Res200833216316818293187
   PubMed Web of Science ®Google Scholar
• KonstasAGKozobolisVPLallosNChristodoulakisEStewartJAStewartWCDaytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%Eye (Lond)200418121264126915218522
   PubMed Web of Science ®Google Scholar
• ShinDHFeldmanRMSheuWPEfficacy and safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressureOphthalmology2004111227628215019375
   PubMed Web of Science ®Google Scholar
• ArcieriESArcieriRSPereiraACAndreoEGFinottiIGSa FilhoWFComparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressureCurr Med Res Opin200723468368917407624
   PubMed Web of Science ®Google Scholar
• NixonDRYanDBChartrandJPPiemontesiRLSimonyiSHollanderDAThree-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapyCurr Med Res Opin20092571645165319476406
   PubMed Web of Science ®Google Scholar
• MartinezASanchezMIntraocular pressure lowering effect of dorzolamide/timolol fixed combination in patients with glaucoma who were unresponsive to prostaglandin analogs/prostamidesCurr Med Res Opin200723359559917355740
   PubMed Web of Science ®Google Scholar
• OzkurtYOralYKaracanOComezADoganOKComparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgeryEye Contact Lens2008341212318180678
   PubMed Web of Science ®Google Scholar
• MigliorSGrundenJWKwokKEfficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolol in open-angle glaucoma or ocular hypertensionEye (Lond)20102471234124220019759
   PubMed Web of Science ®Google Scholar
• TeusMAMigliorSLaganovskaGEfficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertensionClin Ophthalmol2009362963619997566
   PubMedGoogle Scholar
• HatanakaMReisASanoMESusannaRJrAdditive intraocular pressure reduction effect of fixed combination of maleate timolol 0.5%/dorzolamide 2% (Cosopt) on monotherapy with latanoprost (Xalatan) in patients with elevated intraocular pressure: a prospective, 4-week, open-label, randomized, controlled clinical trialJ Glaucoma201019533133519730119
   PubMed Web of Science ®Google Scholar
• CrichtonACHarasymowyczPHutnikCMEffectiveness of dorzolamide-timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line studyJ Ocul Pharmacol Ther201026550351120874498
   PubMed Web of Science ®Google Scholar
• Cosopt [package insert–prescribing information]Whitehouse Station, NJMerck & Co., Inc2009
   Google Scholar
• BeckersHJSchoutenJSWebersCAvan der ValkRHendrikseFSide effects of commonly used glaucoma medications: comparison of tolerability, chance of discontinuation, and patient satisfactionGraefes Arch Clin Exp Ophthalmol2008246101485149018575878
   PubMed Web of Science ®Google Scholar
• AmmarDAKahookMYThe effects of combination glaucoma medications on ocular surface epithelial cellsAdv Ther2009261097097519921496
   PubMed Web of Science ®Google Scholar
• SantosVMCastroRALimaCCMoraesMBSugaiTASkin eruption and thrombocytopaenia in a woman with glaucoma: a case reportWest Indian Med J201059110210520931926
   PubMed Web of Science ®Google Scholar
• YehJKravitzDFrancisBRational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucomaClin Ophthalmol20082238939919668730
   PubMedGoogle Scholar
• RylanderNRVoldSDCost analysis of glaucoma medicationsAm J Ophthalmol2008145110611318154755
   PubMed Web of Science ®Google Scholar