Standard Amblyopia Therapy in Adults with Longstanding Amblyopia Improves Visual Acuity and Contrast Sensitivity

References

• von Noorden GK. Amblyopia: a multidisciplinary approach. Proctor lecture. Invest Ophthalmol Vis Sci. 1985;26(12):1704–1716.
   PubMed Web of Science ®Google Scholar
• Michaels DD. Visual Optics and Refraction: A Clinical Approach. St Louis, MO: C.V. Mosby Co.; 1980.
   Google Scholar
• London R, Wick B. Patients with amblyopia and strabismus. In: Benjamin WJ, editor. Borish’s Clinical Refraction. 2 ed. St. Louis, MO: Butterworth-Heinemann; 2006:1461–1478.
   Google Scholar
• Fu Z, Hong H, Su Z, Lou B, Pan CW, Liu H. Global prevalence of amblyopia and disease burden projections through 2040: a systematic review and meta-analysis. Br J Ophthalmol. 2020;104(8):1164–1170.
   PubMed Web of Science ®Google Scholar
• Pediatric Eye Disease Investigator Group Writing C. A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol. 2002;120(3):268–278.
   PubMedGoogle Scholar
• Hertle RW, Scheiman MM, Beck RW, et al. Stability of visual acuity improvement following discontinuation of amblyopia treatment in children aged 7 to 12 years. Arch Ophthalmol. 2007;125(5):655–659.
   PubMedGoogle Scholar
• Holmes JM, Edwards AR, Beck RW, et al. A randomized pilot study of near activities versus non-near activities during patching therapy for amblyopia. J Aapos. 2005;9(2):129–136.
   PubMed Web of Science ®Google Scholar
• Holmes JM, Kraker RT, Beck RW, et al. A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children. Ophthalmology. 2003;110(11):2075–2087.
   PubMed Web of Science ®Google Scholar
• Loudon SE, Simonsz HJ. The history of the treatment of amblyopia. Strabismus. 2005;13(2):93–106.
   PubMedGoogle Scholar
• Wallace DK, Edwards AR. A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children. Ophthalmology. 2006;113(6):904–912.
   PubMed Web of Science ®Google Scholar
• Holmes JM, Lazar EL, Melia BM, et al. Effect of age on response to amblyopia treatment in children. Arch Ophthalmol. 2011;129(11):1451–1457.
   PubMedGoogle Scholar
• Holmes JM, Repka MX, Kraker RT, Clarke MP. The treatment of amblyopia. Strabismus. 2006;14(1):37–42.
   PubMedGoogle Scholar
• Morishita H, Hensch TK. Critical period revisited: impact on vision. Curr Opin Neurobiol. 2008;18(1):101–107.
   PubMed Web of Science ®Google Scholar
• Levi DM. Linking assumptions in amblyopia. Vis Neurosci. 2013;30(5–6):277–287.
   PubMed Web of Science ®Google Scholar
• Levi DM, Li RW. Perceptual learning as a potential treatment for amblyopia: a mini-review. Vision Res. 2009;49(21):2535–2549.
   PubMed Web of Science ®Google Scholar
• Levi DM, Li RW. Improving the performance of the amblyopic visual system. Philos Trans R Soc Lond B Biol Sci. 2009;364(1515):399–407.
   PubMed Web of Science ®Google Scholar
• Hess RF, Mansouri B, Thompson B. A new binocular approach to the treatment of amblyopia in adults well beyond the critical period of visual development. Restor Neurol Neurosci. 2010;28(6):793–802.
   PubMed Web of Science ®Google Scholar
• Li J, Thompson B, Deng D, Chan LY, Yu M, Hess RF. Dichoptic training enables the adult amblyopic brain to learn. Curr Biol. 2013;23(8):R308–309.
   PubMed Web of Science ®Google Scholar
• Tsirlin I, Colpa L, Goltz HC, Wong AM. Behavioral training as new treatment for adult amblyopia: a meta-analysis and systematic review. Invest Ophthalmol Vis Sci. 2015;56(6):4061–4075.
   PubMed Web of Science ®Google Scholar
• Gao TY, Guo CX, Babu RJ, et al. Effectiveness of a binocular video game vs placebo video game for improving visual functions in older children, teenagers, and adults with amblyopia: a randomized clinical trial. JAMA Ophthalmol. 2018;136(2):172–181.
   PubMed Web of Science ®Google Scholar
• Holmes JM, Manh VM, Lazar EL, et al. Effect of a binocular iPad game vs part-time patching in children aged 5 to 12 years with amblyopia: a randomized clinical trial. JAMA Ophthalmol. 2016;134(12):1391–1400.
   PubMed Web of Science ®Google Scholar
• Holmes JM, Manny RE, Lazar EL, et al.; Pediatric Eye Disease Investigator G. A randomized trial of binocular dig rush game treatment for amblyopia in children aged 7 to 12 years. Ophthalmology. 2019;126(3):456–466.
   PubMed Web of Science ®Google Scholar
• Sharbatoghli L, Hashemi H, Mohamadi A, et al. Visual acuity improvement in adult anisometropic amblyopes after active vision therapy. Clinical Optometry. 2020;12:183–187.
   PubMed Web of Science ®Google Scholar
• Simonsz-Toth B, Joosse MV, Besch D. Refractive adaptation and efficacy of occlusion therapy in untreated amblyopic patients aged 12 to 40 years. Graefes Arch Clin Exp Ophthalmol. 2019;257(2):379–389.
   PubMed Web of Science ®Google Scholar
• Hou F, Huang CB, Tao L, Feng L, Zhou Y, Lu ZL. Training in contrast detection improves motion perception of sinewave gratings in amblyopia. Invest Ophthalmol Vis Sci. 2011;52(9):6501–6510.
   PubMed Web of Science ®Google Scholar
• Caloroso E, Rouse MW. Clinical Management of Strabismus. Boston: Butterworth-Heinemann; 2007.
   Google Scholar
• Gao TY, Anstice N, Babu RJ, et al. Optical treatment of amblyopia in older children and adults is essential prior to enrolment in a clinical trial. Ophthalmic Physiol Opt. 2018;38(2):129–143.
   PubMed Web of Science ®Google Scholar
• Moseley MJ, Fielder AR, Stewart CE. The optical treatment of amblyopia. Optom Vis Sci. 2009;86(6):629–633.
   PubMed Web of Science ®Google Scholar
• Wang J, Feng L, Wang Y, Zhou J, Hess RF. Binocular benefits of optical treatment in anisometropic amblyopia. J Vis. 2018;18(4):6.
   PubMed Web of Science ®Google Scholar
• Hou F, Lesmes L, Bex P, Dorr M, Lu ZL. Using 10AFC to further improve the efficiency of the quick CSF method. J Vis. 2015;15(9):1–18.
   Web of Science ®Google Scholar
• Lesmes LA, Lu ZL, Baek J, Albright TD. Bayesian adaptive estimation of the contrast sensitivity function: the quick CSF method. J Vis. 2010;10(3):1–21.
   Web of Science ®Google Scholar
• Stewart CE, Moseley MJ, Stephens DA, Fielder AR. Treatment dose-response in amblyopia therapy: the Monitored Occlusion Treatment of Amblyopia Study (MOTAS). Invest Ophthalmol Vis Sci. 2004;45(9):3048–3054.
   PubMed Web of Science ®Google Scholar
• Wallace DK, Lazar EL, Crouch ER, et al. Time course and predictors of amblyopia improvement with 2 hours of daily patching. JAMA Ophthalmol. 2015;133(5):606–609.
   PubMed Web of Science ®Google Scholar
• Pediatric Eye Disease Investigator Group Writing C. The Course of Moderate Amblyopia Treated with Patching in Children: experience of the Amblyopia Treatment Study. Am J Ophthalmol. 2003;136(4):620–629.
   PubMed Web of Science ®Google Scholar
• Loudon SE, Polling JR, Simonsz HJ. A preliminary report about the relation between visual acuity increase and compliance in patching therapy for amblyopia. Strabismus. 2002;10(2):79–82.
   PubMedGoogle Scholar
• Bavelier D, Levi DM, Li RW, Dan Y, Hensch TK. Removing brakes on adult brain plasticity: from molecular to behavioral interventions. J Neurosci. 2010;30(45):14964–14971.
   PubMed Web of Science ®Google Scholar
• Polat U, Ma-Naim T, Spierer A. Treatment of children with amblyopia by perceptual learning. Vision Res. 2009;49(21):2599–2603.
   PubMed Web of Science ®Google Scholar
• Hernandez-Rodriguez CJ, Fukumitsu H, Ruiz-Fortes P, Soto-Negro R, Merino-Suarez M, Pinero DP. Efficacy of perceptual learning-based vision training as an adjuvant to occlusion therapy in the management of amblyopia: a pilot study. Vision. 2021;5(1):54.
   Google Scholar
• Awan M, Proudlock FA, Gottlob I. A randomized controlled trial of unilateral strabismic and mixed amblyopia using occlusion dose monitors to record compliance. Invest Ophthalmol Vis Sci. 2005;46(4):1435–1439.
   PubMed Web of Science ®Google Scholar
• Stewart CE, Fielder AR, Stephens DA, Moseley MJ. Treatment of unilateral amblyopia: factors influencing visual outcome. Invest Ophthalmol Vis Sci. 2005;46(9):3152–3160.
   PubMed Web of Science ®Google Scholar
• Arditi A, Cagenello R. On the statistical reliability of letter-chart visual acuity measurements. Invest Ophthalmol Vis Sci. 1993;34(1):120–129.
   PubMed Web of Science ®Google Scholar