1,554
Views
44
CrossRef citations to date
0
Altmetric
Review

Escitalopram for the management of major depressive disorder: a review of its efficacy, safety, and patient acceptability

Pages 853-861 | Published online: 04 Dec 2012

References

  • WaughJGoaKLEscitalopram: a review of its use in the management of major depressive and anxiety disordersCNS Drugs200317534336212665392
  • SanchezCBergqvistPBBrennumLTEscitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activitiesPsychopharmacology (Berl)2003167435336212719960
  • ChenFLarsenMBSanchezCWiborgOThe S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitorsEur Neuropsychopharmacol200515219319815695064
  • MorkAKreilgaardMSanchezCThe R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving ratsNeuropharmacology200345216717312842122
  • El MansariMSanchezCChouvetGRenaudBHaddjeriNEffects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brainNeuropsychopharmacology20053071269127715702136
  • KimuraMEscitalopram oxalateJ Jpn Soc Hosp Pharm201248371375
  • MurdochDKeamSJEscitalopram: a review of its use in the management of major depressive disorderDrugs200565162379240416266205
  • OwensMJKnightDLNemeroffCBSecond-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetineBiol Psychiatry200150534535011543737
  • DhillonSScottLJPloskerGLEscitalopram: a review of its use in the management of anxiety disordersCNS Drugs200620976379016953656
  • ChenFLarsenMBNeubauerHASanchezCPlengePWiborgOCharacterization of an allosteric citalopram-binding site at the serotonin transporterJ Neurochem2005921212815606893
  • NeubauerHAHansenCGWiborgODissection of an allosteric mechanism on the serotonin transporter: a cross-species studyMol Pharmacol20066941242125016434615
  • SanchezCBogesoKPEbertBReinesEHBraestrupCEscitalopram versus citalopram: the surprising role of the R-enantiomerPsychopharmacology (Berl)2004174216317615160261
  • KleinNSacherJGeiss-GranadiaTHigher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT studyPsychopharmacology (Berl)2007191233333917235610
  • SpinaESantoroVD’ArrigoCClinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an updateClin Ther20083071206122718691982
  • WadeAMichael LemmingOBang HedegaardKEscitalopram 10 mg/day is effective and well tolerated in a placebo-controlled study in depression in primary careInt Clin Psychopharmacol20021739510211981349
  • BurkeWJGergelIBoseAFixed-dose trial of the single isomer SSRI escitalopram in depressed outpatientsJ Clin Psychiatry200263433133612000207
  • LepolaUMLoftHReinesEHEscitalopram 10–20 mg/day) is effective and well tolerated in a placebo-controlled study in depression in primary careInt Clin Psychopharmacol200318421121712817155
  • LalitVAppayaPMHegdeRPEscitalopram versus citalopram and sertraline: a double-blind controlled, multi-centric trial in Indian patients with unipolar major depressionIndian J Psychiatry200446433334121206792
  • MooreNVerdouxHFantinoBProspective, multicentre, randomized, double-blind study of the efficacy of escitalopram versus citalopram in outpatient treatment of major depressive disorderInt Clin Psychopharmacol200520313113715812262
  • OuJJXunGLWuRREfficacy and safety of escitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, randomized, double-blind, flexible-dose studyPsychopharmacology (Berl)20112132–363964620340011
  • YevtushenkoVYBelousAIYevtushenkoYGGusininSEBuzikOJAgibalovaTVEfficacy and tolerability of escitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, prospective, randomized, double-blind, active-controlled study in adult outpatientsClin Ther200729112319233218158074
  • MontgomerySHansenTKasperSEfficacy of escitalopram compared to citalopram: a meta-analysisInt J Neuropsychopharmacol201114226126820875220
  • TrkuljaVIs escitalopram really relevantly superior to citalopram in treatment of major depressive disorder? A meta-analysis of head-to-head randomized trialsCroat Med J2010511617320162747
  • BoulengerJPHuusomAKFloreaIBaekdalTSarchiaponeMA comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patientsCurr Med Res Opin20062271331134116834832
  • BaldwinDSCooperJAHuusomAKHindmarchIA double-blind, randomized, parallel-group, flexible-dose study to evaluate the tolerability, efficacy and effects of treatment discontinuation with escitalopram and paroxetine in patients with major depressive disorderInt Clin Psychopharmacol200621315916916528138
  • HirayasuYA dose-response and non-inferiority study evaluating the efficacy and safety of escitalopram in patients with major depressive disorder: a placebo- and paroxetine-controlled, double-blind, comparative studyJpn J Clin Psychopharmacol201114883899
  • Mochida Pharmacoceutical COL. Interview Form LEXAPRO Tab. 10 mg3rd ed Available from: http://di.mt-pharma.co.jp/file/if/f_lex.pdf2012Accessed November 15, 2012 Japanese
  • Deliberation Result Report of LEXAPRO Tab. 10 mgPharmaceutical Food Station Examination Management Section, Ministry of Health, Labour and WelfareJapan2011 Available from: http://www.info.pmda.go.jp/shinyaku/P201100076/79000500_22300AMX00517_A100_1.pdf2011Accessed November 29, 2012 Japanese
  • MaoPXTangYLJiangFEscitalopram in major depressive disorder: a multicenter, randomized, double-blind, fixed-dose, parallel trial in a Chinese populationDepress Anxiety2008251465417149753
  • VenturaDArmstrongEPSkrepnekGHHaim ErderMEscitalopram versus sertraline in the treatment of major depressive disorder: a randomized clinical trialCurr Med Res Opin200723224525017288677
  • KhanABoseAAlexopoulosGSGommollCLiDGandhiCDouble-blind comparison of escitalopram and duloxetine in the acute treatment of major depressive disorderClin Drug Investig2007277481492
  • WadeAGembertKFloreaIA comparative study of the efficacy of acute and continuation treatment with escitalopram versus duloxetine in patients with major depressive disorderCurr Med Res Opin20072371605161417559755
  • BielskiRJVenturaDChangCCA double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorderJ Clin Psychiatry20046591190119615367045
  • MontgomerySAHuusomAKBothmerJA randomised study comparing escitalopram with venlafaxine XR in primary care patients with major depressive disorderNeuropsychobiology2004501576415179022
  • HirayasuYA long-term administration study of escitalopram in patients with major depressive disordersJpn J Clin Psychopharmacol201114901912
  • HirayasuYA long-term administration study of escitalopram in elderly patients with major depressive disorderJpn J Clin Psychopharmacol201114901912
  • GorwoodPWeillerELemmingOKatonaCEscitalopram prevents relapse in older patients with major depressive disorderAm J Geriatr Psychiatry200715758159317586783
  • KornsteinSGBoseALiDSaikaliKGGandhiCEscitalopram maintenance treatment for prevention of recurrent depression: a randomized, placebo-controlled trialJ Clin Psychiatry200667111767177517196058
  • Cipralex®/Lexapro® (escitalopram)Product Monograph-Issue 8-June 2009CopenhagenH. Lundbeck A/S2009
  • Lexapro® (escitalopram oxalate) tablets and oral solution [US prescribing information]St Louis, MOForest Laboratories, Inc2011 Available from: http://www.frx.com/pi/lexapro_pi.pdfAccessed May 10, 2011
  • KennedySHAndersenHFThaseMEEscitalopram in the treatment of major depressive disorder: a meta-analysisCurr Med Res Opin200925116117519210149
  • GunnellDSaperiaJAshbyDSelective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA’s safety reviewBMJ2005330748838515718537
  • PedersenAGEscitalopram and suicidality in adult depression and anxietyInt Clin Psychopharmacol200520313914315812263
  • BechPTanghojPCialdellaPAndersenHFPedersenAGEscitalopram dose-response revisited: an alternative psychometric approach to evaluate clinical effects of escitalopram compared to citalopram and placebo in patients with major depressionInt J Neuropsychopharmacol20047328329015320956
  • AshtonAKMahmoodAIqbalFImprovements in SSRI/SNRI-induced sexual dysfunction by switching to escitalopramJ Sex Marital Ther200531325726216020143
  • GersingKTaylorLMereadithCOutcome and adverse events for escitalopram and sertraline in a real-world setting [abstract no NR815] American Psychiatric AssociationAnnual Meeting 2005 New Research AbstractsAtlanta, GA20052126
  • ClaytonAWightmanDModellJGEffects in MDD on sexual functioning of bupropion XL, escitalopram, and placebo in depressed patiets [abstract no NR-818] American Psychiatric AssociationAnnual Meeting 2005 New Research AbstractsAtlanta (GA)20052126
  • LoVecchioFWattsDWinchellJKnightJMcDowellTOutcomes after supratherapeutic escitalopram ingestionsJ Emerg Med2006301171916434330
  • SeifertSAMeissnerGKEscitalopram overdose: a case series [abstract no 72]J Toxicol200442495496
  • OlsenDDartRRobinettMSevere serotonin syndrome from escitalopram overdose [abstract no 72]J Toxicol Clin Toxicol200442744745
  • CiprianiAFurukawaTASalantiGComparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysisLancet2009373966574675819185342
  • PatrickGCombsGGavaganTInitiating antidepressant therapy? Try these 2 drugs firstJ Fam Pract200958736536919607774
  • KasperSBaldwinDSLarsson LonnSBoulengerJPSuperiority of escitalopram to paroxetine in the treatment of depressionEur Neuropsychopharmacol200919422923719185467
  • LamRWAndersenHFWadeAGEscitalopram and duloxetine in the treatment of major depressive disorder: a pooled analysis of two trialsInt Clin Psychopharmacol200823418118718545055
  • MurdochDKeamSJEscitalopram: a review of its use in the management of major depressive disorderDrugs2005651623802404