797
Views
22
CrossRef citations to date
0
Altmetric
Original Research

Metformin Improves the Depression Symptoms of Women with Polycystic Ovary Syndrome in a Lifestyle Modification Program

, ORCID Icon, , , , ORCID Icon, , & ORCID Icon show all
Pages 737-746 | Published online: 15 Apr 2020

References

  • Baldani DP, Skrgatic L, Ougouag R. Polycystic ovary syndrome: important underrecognised cardiometabolic risk factor in reproductive-age women. Int J Endocrinol. 2015;2015:786362. doi:10.1155/2015/786362
  • Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet (London, England). 2007;370(9588):685–697. doi:10.1016/S0140-6736(07)61345-2
  • Teede HJ, Misso ML, Costello MF, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018;110(3):364–379. doi:10.1016/j.fertnstert.2018.05.004
  • Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013;6:1–13. doi:10.2147/CLEP.S37559
  • Pfieffer ML. Polycystic ovary syndrome: diagnosis and management. Clin Med Res. 2019;44:30–35.
  • Ali AT. Polycystic ovary syndrome and metabolic syndrome. Ceska Gynekol. 2015;80(4):279–289.
  • Azziz R. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature. J Clin Endocrinol Metab. 2006;91(3):781–785. doi:10.1210/jc.2005-2153
  • Franks S. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria. J Clin Endocrinol Metab. 2006;91(3):786–789. doi:10.1210/jc.2005-2501
  • Skiba MA, Islam RM, Bell RJ, Davis SR. Understanding variation in prevalence estimates of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2018;24(6):694–709. doi:10.1093/humupd/dmy022
  • Guraya SS. Prevalence and ultrasound features of polycystic ovaries in young unmarried Saudi females. J Microsc Ultrastruct. 2013;1:30–34. doi:10.1016/j.jmau.2013.06.002
  • Al Bassam NM, Ali S, Rahman SR. Polycystic ovarian syndrome (PCOS), awareness among female students, qassim university, Qassim Region, Saudi Arabia. Int J Res Granthaalayah. 2018;6:395–406.
  • Mehrabian F, Khani B, Kelishadi R, Ghanbari E. The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria. Endokrynol Pol. 2011;62(3):238–242.
  • Ding T, Hardiman PJ, Petersen I, et al. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis. Oncotarget. 2017;8(56):96351–96358. doi:10.18632/oncotarget.19180
  • Coffey S, Bano G, Mason HD. Health-related quality of life in women with polycystic ovary syndrome: a comparison with the general population using the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and the short form-36 (SF-36). Gynecol Endocrinol. 2006;22(2):80–86. doi:10.1080/09513590600604541
  • Barnard L, Ferriday D, Guenther N, et al. Quality of life and psychological well being in polycystic ovary syndrome. Hum Reprod. 2007;22(8):2279–2286. doi:10.1093/humrep/dem108
  • Li Y, Li Y, Yu Ng EH, et al. Polycystic ovary syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from a meta-analysis. Fertil Steril. 2011;96(2):452–458. doi:10.1016/j.fertnstert.2011.05.072
  • Deeks AA, Gibson-Helm ME, Paul E, Teede HJ. Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression? Hum Reprod. 2011;26(6):1399–1407. doi:10.1093/humrep/der071
  • Cooney LG, Dokras A. Depression and anxiety in polycystic ovary syndrome: etiology and treatment. Curr Psychiatry Rep. 2017;19(11):83. doi:10.1007/s11920-017-0834-2
  • Chaudhari AP, Mazumdar K, Mehta PD. Anxiety, depression, and quality of life in women with polycystic ovarian syndrome. Indian J Psychol Med. 2018;40(3):239–246. doi:10.4103/IJPSYM.IJPSYM_561_17
  • Farkas J, Rigo A, Demetrovics Z. Psychological aspects of the polycystic ovary syndrome. Gynecol Endocrinol. 2014;30(2):95–99. doi:10.3109/09513590.2013.852530
  • Hung J-H, Hu L-Y, Tsai S-J, et al. Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study. PLoS One. 2014;9(5):e97041. doi:10.1371/journal.pone.0097041
  • Watson K, Nasca C, Aasly L, McEwen B, Rasgon N. Insulin resistance, an unmasked culprit in depressive disorders: promises for interventions. Neuropharmacol. 2018;136:327–334. doi:10.1016/j.neuropharm.2017.11.038
  • Sartorius N. Depression and diabetes. Dialogues Clin Neurosci. 2018;20(1):47–52.
  • Mathur R, Levin O, Azziz R. Use of ethinylestradiol/drospirenone combination in patients with the polycystic ovary syndrome. Ther Clin Risk Manag. 2008;4:487–492. doi:10.2147/TCRM.S6864
  • Wang R, Kim BV, Van Wely M, et al. Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis. bmj. 2017;356:j138.
  • Abu Hashim H, Foda O, Ghayaty E. Combined metformin-clomiphene in clomiphene-resistant polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand. 2015;94(9):921–930. doi:10.1111/aogs.12673
  • Palomba S, Falbo A, Zullo F, Orio JF. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev. 2009;30(1):1–50.
  • Fux Otta C, Wior M, Iraci GS, et al. Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial. Gynecol Endocrinol. 2010;26(3):173–178. doi:10.3109/09513590903215581
  • Macut D, Bjekic-Macut J, Rahelic D, Doknic M. Insulin and the polycystic ovary syndrome. Diabetes Res Clin Pract. 2017;130:163–170. doi:10.1016/j.diabres.2017.06.011
  • Kurzthaler D, Hadziomerovic-Pekic D, Wildt L, Seeber BE. Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects. Reprod Biol Endocrinol. 2014;12(1):98. doi:10.1186/1477-7827-12-98
  • Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017;60(9):1577–1585. doi:10.1007/s00125-017-4342-z
  • Castro Cabezas M, van Wijk JP, Elte JW, Klop B. Effects of metformin on the regulation of free fatty acids in insulin resistance: a double-blind, placebo-controlled study. J Nutr Metab. 2012;2012:394623. doi:10.1155/2012/394623
  • Kashani L, Omidvar T, Farazmand B, et al. Does pioglitazone improve depression through insulin-sensitization? Results of a randomized double-blind metformin-controlled trial in patients with polycystic ovarian syndrome and comorbid depression. Psychoneuroendocrinology. 2013;38(6):767–776. doi:10.1016/j.psyneuen.2012.08.010
  • Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics. 2001;107(4):E55. doi:10.1542/peds.107.4.e55
  • Guo M, Mi J, Jiang QM, et al. Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus. Clin Exp Pharmacol Physiol. 2014;41(9):650–656.
  • Shivavedi N, Kumar M, Tej G, Nayak PK. Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. Brain Res. 2017;1674:1–9. doi:10.1016/j.brainres.2017.08.019
  • Khedr SA, Elmelgy AA, El-Kharashi OA, et al. Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-jun repression. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(4):407–422. doi:10.1007/s00210-018-1466-8
  • Hahn S, Benson S, Elsenbruch S, et al. Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality. Hum Reprod. 2006;21(7):1925–1934. doi:10.1093/humrep/del069
  • Moll E, van Wely M, Lambalk CB, Bossuyt PM, van der Veen F. Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo. Hum Reprod. 2012;27(11):3273–3278. doi:10.1093/humrep/des310
  • Sirota I, Stein DE, Vega M, Keltz MD. Insulin Resistance and β-cell Function Calculated by Homeostasis Model Assessment in Lean, Overweight, and Obese Women with Polycystic Ovary Syndrome. J Reprod Med. 2016;61:3–10.
  • Louwers Y, Lao O, Fauser BC, Kayser M, Laven JS. The impact of self-reported ethnicity versus genetic ancestry on phenotypic characteristics of polycystic ovary syndrome (PCOS). J Clin Endocrinol Metab. 2014;99(10):E2107–E2116.
  • Huang Z, Yong EL. Ethnic differences: is there an Asian phenotype for polycystic ovarian syndrome? Best Pract Res Clin Obstet Gynaecol. 2016;37:46–55. doi:10.1016/j.bpobgyn.2016.04.001
  • Wang R, Mol BWJ. The Rotterdam criteria for polycystic ovary syndrome: evidence-based criteria? Hum Reprod. 2017;32(2):261–264. doi:10.1093/humrep/dew287
  • Carlson RV, Boyd KM, Webb DJ. The revision of the declaration of Helsinki: past, present and future. Br J Clin Pharmacol. 2004;57(6):695–713. doi:10.1111/j.1365-2125.2004.02103.x
  • Lenze EJ, Sheffrin M, Driscoll HC, et al. Incomplete response in late-life depression: getting to remission. Dialogues Clin Neurosci. 2008;10(4):419–430.
  • AlHadi AN, AlAteeq DA, Al-Sharif E, et al. An arabic translation, reliability, and validation of patient health questionnaire in a Saudi sample. Ann Gen Psychiatry. 2017;16(1):32. doi:10.1186/s12991-017-0155-1
  • Sawaya H, Atoui M, Hamadeh A, Zeinoun P, Nahas Z. Adaptation and initial validation of the patient health questionnaire - 9 (PHQ-9) and the generalized anxiety disorder - 7 questionnaire (GAD-7) in an Arabic speaking Lebanese psychiatric outpatient sample. Psychiatry Res. 2016;239:245–252. doi:10.1016/j.psychres.2016.03.030
  • Coons SJ, Alabdulmohsin SA, Draugalis JR, Hays RD. Reliability of an Arabic version of the RAND-36 health survey and its equivalence to the US-English version. Med Care. 1998;36(3):428–432. doi:10.1097/00005650-199803000-00018
  • Al-Jumaili AA, Al-Rekabi MD, Sorofman B. Evaluation of instruments to assess health literacy in Arabic language among Iraqis. Res Social Adm Pharm. 2015;11(6):803–813. doi:10.1016/j.sapharm.2015.02.002
  • Morris NS, MacLean CD, Chew LD, Littenberg B. The single item literacy screener: evaluation of a brief instrument to identify limited reading ability. BMC Fam Pract. 2006;7(1):21. doi:10.1186/1471-2296-7-21
  • Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–613. doi:10.1046/j.1525-1497.2001.016009606.x
  • Kroenke K, Spitzer RL, Williams JB, Monahan PO, Lowe B. Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med. 2007;146(5):317–325. doi:10.7326/0003-4819-146-5-200703060-00004
  • Wang CP, Lorenzo C, Habib SL, Jo B, Espinoza SE. Differential effects of metformin on age related comorbidities in older men with type 2 diabetes. J Diabetes Complications. 2017;31(4):679–686. doi:10.1016/j.jdiacomp.2017.01.013
  • Aswar U, Chepurwar S, Shintre S, Aswar M. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep PR. 2017;69(2):358–364. doi:10.1016/j.pharep.2016.12.004
  • Moulton CD, Hopkins CWP, Ismail K, Stahl D. Repositioning of diabetes treatments for depressive symptoms: A systematic review and meta-analysis of clinical trials. Psychoneuroendocrinology. 2018;94:91–103. doi:10.1016/j.psyneuen.2018.05.010
  • Tu HP, Lin C-H, Hsieh H-M, et al. Prevalence of anxiety disorder in patients with type 2 diabetes: a nationwide population-based study in Taiwan 2000–2010. Psychiatr Q. 2017;88(1):75–91. doi:10.1007/s11126-016-9436-0
  • Reddy BR, Maitra S, Jhelum P, et al. Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats. J Biosci. 2016;41(3):407–417. doi:10.1007/s12038-016-9627-8
  • Erensoy H, Niafar M, Ghafarzadeh S, Aghamohammadzadeh N, Nader ND. A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome. Gynecol Endocrinol. 2019;35(1):72–75. doi:10.1080/09513590.2018.1498476
  • Benson S, Arck PC, Tan S, et al. Disturbed stress responses in women with polycystic ovary syndrome. Psychoneuroendocrinology. 2009;34(5):727–735. doi:10.1016/j.psyneuen.2008.12.001
  • Kawamura S, Maesawa C, Nakamura K, et al. Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population. Neuropsychiatr Dis Treat. 2011;7:655–662. doi:10.2147/NDT.S25504
  • Cesta CE, Kuja-Halkola R, Lehto K, Iliadou AN, Landen M. Polycystic ovary syndrome, personality, and depression: A twin study. Psychoneuroendocrinology. 2017;85:63–68. doi:10.1016/j.psyneuen.2017.08.007
  • Day F, Karaderi T, Jones MR, et al. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 2018;14(12):e1007813. doi:10.1371/journal.pgen.1007813
  • Srinivasan S, Yee SW, Giacomini KM. Pharmacogenetics of antidiabetic drugs. Adv Pharmacol. 2018;83:361–389. doi:10.1016/bs.apha.2018.04.005
  • Song DK, Hong YS, Sung YA, Lee H. Insulin resistance according to beta-cell function in women with polycystic ovary syndrome and normal glucose tolerance. PLoS One. 2017;12(5):e0178120. doi:10.1371/journal.pone.0178120
  • Glintborg D, Mumm H, Hougaard D, Ravn P, Andersen M. Ethnic differences in Rotterdam criteria and metabolic risk factors in a multiethnic group of women with PCOS studied in Denmark. Clin Endocrinol (Oxf). 2010;73(6):732–738. doi:10.1111/j.1365-2265.2010.03873.x
  • Welt CK, Arason G, Gudmundsson JA, et al. Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations. J Clin Endocrinol Metab. 2006;91(11):4361–4368. doi:10.1210/jc.2006-1191
  • Wang Y, Liu B, Yang Y, et al. Metformin exerts antidepressant effects by regulated DNA hydroxymethylation. Epigenomics. 2019;11(6):655–667. doi:10.2217/epi-2018-0187
  • Keshavarzi S, Kermanshahi S, Karami L, et al. Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: the role of CREB/BDNF and Akt/GSK3 signaling pathways. Neurotoxicol. 2019;72:74–84. doi:10.1016/j.neuro.2019.02.004
  • Vandenbroucke JP. Observational research, randomised trials, and two views of medical science. PLoS Med. 2008;5(3):e67. doi:10.1371/journal.pmed.0050067