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REVIEW

Prospect of Exosome in Ligament Healing: A Systematical Review

ORCID Icon, , ORCID Icon &
Pages 91-101 | Received 09 Oct 2023, Accepted 13 Dec 2023, Published online: 27 Dec 2023

References

  • Leong NL, Kator JL, Clemens TL, James A, Enomoto-Iwamoto M, Jiang J. Tendon and ligament healing and current approaches to tendon and ligament regeneration. J Ortho Res. 2020;38(1):7–12. doi:10.1002/jor.24475
  • Wu F, Nerlich M, Docheva D. Tendon injuries: basic science and new repair proposals. EFORT Open Rev. 2017;2(7):332–342. doi:10.1302/2058-5241.2.160075
  • Dagget MC, Busch K, Ferretti A, Monaco E, Bruni G, Saithna A. Percutaneous anterior cruciate ligament repair with needle arthroscopy and biological augmentation. Arthrosc Techniq. 2021;10(2):e289–e295. doi:10.1016/j.eats.2020.10.006
  • Wu XD, Kang L, Tian J, et al. Exosome derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway. Mater Today Bio. 2022;15:100319. doi:10.1016/j.mtbio.2022.100319
  • Chamberlain CS, Clements AE, Kink JA, et al. Extracellular vesicle-educated macrophages promote early achilles tendon healing. Stem Cells. 2019;37:682. doi:10.1002/stem.2988
  • Zhang M, Liu H, Cui Q, et al. Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon. Stem Cell Res Ther. 2020;11(402):1–15. doi:10.1186/s13287-020-01918-x
  • Batista JP, Chahla J, Dalmau-Pastor M, Maestu R, Kunze KN, Guelfi M. Arthroscopic anterior cruciate ligament repair with and without suture augmentation: technical note. J ISAKOS. 2021;6:251–256. doi:10.1136/jisakos-2020-000508
  • Setiawati R, Utomo DN, Rantam FA, Ifran NN, Budhiparama NC. Early graft tunnel healing after anterior cruciate ligament reconstruction with intratunnel injection of bone marrow mesenchymal stem cells and vascular endothelial growth factor. Orthop J Sports Med. 2017;5(6):1–8. doi:10.1177/2325967117708548
  • Shen H, Lane RA. Extracellular vesicle from inflammation-primed adipose-derived stem cells enhance Achilles tendon repair by reducing inflammation and promoting intrinsic healing. BioRxiv. 2023;15(6):617–627.
  • Nwachukwu BU, Patel BH, Lu Y, Allen AA, Williams RJ. Anterior cruciate ligament repair outcomes: an update systematic review of recent literature. Arthros J. 2019;2019:3023208.
  • Miao C, Zhou W, Wang X, Fang J. The research progress of exosomes in osteoarthritis, with particular emphasis on the mediating roles of miRNAs and Inc RNAs. Front Pharmacol. 2021;12:685623. doi:10.3389/fphar.2021.685623
  • Isola A, Chen S. Exosomes: the messengers of health and disease. Curr Neuropharmacol. 2016;15(1):157–165. doi:10.2174/1570159X14666160825160421
  • Malekpour K, Hazrati A, Zahar M, et al. The potential use of mesenchymal stem cells and their derived exosomes for orthopedic diseases treatment. Stem Cell Rep. 2022;18:933–951. doi:10.1007/s12015-021-10185-z
  • Rezaie J, Feghhi M, Etemadi T. A review on exosomes application in clinical trials: perspective, questions and challenges. Cell Commun Signal. 2022;20(145):1–13.
  • Tian J, chen W, Xiong Y, et al. Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis. Bioact Mater. 2022;22:326–342. doi:10.1016/j.bioactmat.2022.10.001
  • Sunwoo JY, Eliasberg CD, Carballo CB, Rodeo SA. The role of the macrophage in tendinopathy and tendon healing. J Orthop Res. 2020;38(8):1666–1675. doi:10.1002/jor.24667
  • Rhatomy S, Prasetyo TE, Setyawan R, et al. Prospect of stem cells conditioned medium (secretome) in ligament and tendon healing: a systematic review. Stem Cells Transl Med. 2020;9:895–902. doi:10.1002/sctm.19-0388
  • Hsueh YH, Buddakosai W, Le PN, et al. Therapeutic effect of induced pluripotent stem cell-derived extracellular vesicles in an vitro and in vivo osteoarthritis model. J Orthop Translat. 2022;38:141–155. doi:10.1016/j.jot.2022.10.004
  • Shen H, Yoneda S, Abu-Amer Y, Guilak F, Gelberman RH. Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair. J Orthop Res. 2020;38(1):117–127. doi:10.1002/jor.24406
  • Ye T, Chen Z, Zhang J, et al. Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity. Bioact Mater. 2022;21:194–208. doi:10.1016/j.bioactmat.2022.08.007
  • Cui H, He Y, Chen S, Zhang D, Yu Y, Fan C. Macrophage-derived miRNA-containing exosomes induce peritendinous fibrosis after tendon injury through the miR-21-5p/Smad7 pathway. Mol Ther Nucleic Acids. 2019;14:115–130.
  • Trzyna A, Banaś-Ząbczyk A. Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy. Biomolecule. 2021;11:878. doi:10.3390/biom11060878
  • Villatoro AJ, Del M, Martín-Astorga C, Alcoholado C, Del Mar Sánchez-Martín M, Becerra J. Proteomic analysis of the secretome and exosomes of feline adipose-derived mesenchymal stem cells. Animals. 2021;11:295. doi:10.3390/ani11020295
  • Fu G, Lu L, Pan Z, Fan A, Yin F. Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells. Regenerative Med. 2021;16(4):359–372. doi:10.2217/rme-2021-0004
  • Zhuang J, Hang R, Sun R, et al. Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration. Front Chem. 2022;2022:1.
  • Wang Y, Yu D, Liu Z, et al. Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Ther. 2017;8(189). doi:10.1186/s13287-017-0632-0
  • Li R, Li D, Wang H, et al. Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF. Stem Cell Res Ther. 2022;13(1). doi:10.1186/s13287-022-02975-0
  • Li Z, Li Q, Tong K, et al. BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats. Stem Cell Res Ther. 2022;13:1.
  • Al Halawani A, Mithieux SM, Yeo GC, Hosseini-Beheshti E, Weiss AS. Extracellular vesicles: interplay with the extracellular matrix and modulated cell responses. Int J Mol Sci. 2022;23:3389. doi:10.3390/ijms23063389
  • Noonin C, Thongboonkerd V. Exosome-inflammasome crosstalk and their roles in inflammatory responses. Theranostics. 2021;11(9):4436–4451. doi:10.7150/thno.54004
  • Zou M, Wang J, Shao Z. Therapeutic potential of exosomes in tendon and tendon-bone healing: a systematic review of preclinical studies. J Funct Biomater. 2023;14(6):299. doi:10.3390/jfb14060299
  • Song K, Jiang T, Pan P, Yao Y, Jiang Q. Exosomes from tendon derived stem cells promote tendon repair through miR-144-3p-regulated tenocyte proliferation and migration. Stem Cell Res Ther. 2022;13(80):1–18. doi:10.1186/s13287-022-02723-4
  • Asadpour A, Yahaya BH, Bicknell K, Cottrell GS, Widera D. Uncovering the gray zone: mapping the global landscape of direct-to-consumer businesses offering interventions based on secretomes, extracellular vesicles, and exosome. Stem Cell Res Ther. 2023;14(111):1–7.