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Case Report

Pharmacogenetics of antipsychotic adverse effects: Case studies and a literature review for clinicians

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Pages 965-973 | Published online: 15 Jan 2008

References

  • BarnesTRE1992Clinical assessment of the extrapyramidal side effects of antipsychotic drugsJ of Psychopharmacology621421
  • BasileVSMasellisMBadriF1999Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophreniaNeuropsychopharmacology21172710379516
  • BasileVSOzdemirVMasellisM2000A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophreniaMol Psychiatry54101710889552
  • BasileVSOzdemirVMasellisM2001Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophreniaMol Psychiatry6230411317228
  • BlasiGBertolinoA2006Imaging genomics and response to treatment with antipsychotics in schizophreniaNeuroRx31173016490418
  • BradfordD2002CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendantsPharmacogenomics32294311972444
  • BrockmollerJKirchheinerJSchmiderJ2002The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatmentClinical Pharmacology and Therapeutics724385212386646
  • CaseyDE2004Pathophysiology of antipsychotic drug-induced movement disordersThe Journal of Clinical Psychiatry65 Suppl 925815189109
  • ChouWHYanFXde LeonJ2000Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illnessJ Clin Psychopharmacol202465110770465
  • ChouinardG2004New nomenclature for drug-induced movement disorders including tardive dyskinesiaThe Journal of Clinical Psychiatry65 Suppl 991515189106
  • DahlM-L2002Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?Clinical Pharmacokinetics414537012083975
  • de LeonJArmstrongSCCozzaKL2005The dosing of atypical antipsychoticsPsychosomatics462627315883149
  • de LeonJArmstrongSCCozzaKL2006Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19Psychosomatics4711216384802
  • de LeonJSusceMTMurray-CarmichaelE2006The amplichip CYP450 genotyping test-integrating a new clinical toolMol Diag Ther1013551
  • de LeonJSusceMTPanRM2005aThe CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuationJournal of Clinical Psychiatry66152715669884
  • de LeonJSusceMTPanRM2005bPolymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illnessJournal of Clinical Psychopharmacology254485616160620
  • del TaccaMLattanziLLastellaM2005Genotype A1/A2 associated with neuroleptic malignant syndromeBipolar Disorders7390116026494
  • DoradoPBereczRPenas-LledoEM2006Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugsCurrent Drug Targets716718017168842
  • EichhammerPAlbusMBorrmann-HassenbachM2000Association of dopamine D3-receptor gene variants with neuroleptic induced akathisia in schizophrenic patients: a generalization of Steen’s study on DRD3 and tardive dyskinesiaAmerican Journal of Medical Genetics (Neuropsychiatric Genetics)961879110893495
  • EllingrodVLSchultzSKArndtS2000Association between cytochrome P4502D6 (CYP2D6) genotype, antipsychotic exposure, and abnormal involuntary movement scale (AIMS) scorePsychiatr Genet1091110909122
  • EllingrodVLSchultzSKArndtS2002Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6Pharmacotherapy2214161912432967
  • EllingrodVLPerryPJRingoldJC2005Weight gain associated with the -759 C/T polymorphism of the 5HT2C receptor and olanzapineAm J Med Genetics Part B (Neuropsychiatric Genetics)134B768
  • EllingrodVLBishopJRMolineJ2007Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophreniaPsychopharmacology Bulletin40576217285096
  • FreudenreichOGoffDC2002Antipsychotic combination therapy in schizophrenia: A review of efficacy and risks of current combinationsActa Psychiatrica Scandinavica1063233012366465
  • Garcia-BarceloMMLamLCUngvariGS2001Dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patientsJ Neural Transm108671711478419
  • GovTrack, us, HR. 493–110th Congress2007Genetic Information Nondiscrimination Act of 2007, GovTrack.us (database of federal legislation)Accessed Jul 12, 2007 URL: http://www.govtrack.us/congress/bill.xpd?bill=h110-493
  • GuyW1976Abnormal involuntary movement scaleECDEU assessment manual for psychopharmacologyWashington, DCU.S. Public Health Service5347
  • HaroJMSalvador-CarullaL2006The SOHO (Schizophrenia Outpatient Health Outcome) study: implications for treatment of schizophreniaCNS Drugs2029330116599647
  • InadaTDobashiISugitaT1997Search for a susceptibility locus to tardive dyskinesiaHum Psychopharmacol Clin Exp12359
  • Ingelman-SundbergM2004Pharmacogenetics of cytochrome P450 and its applications in drug therapy, the past, present and futureTrends in Pharmacological Sciences2419320015063083
  • JanssenLPRisperdal® prescribing information [online]Accessed 19 March 2007 URL: http://www.risperdal.com/active/janus/en_US/assets/common/company/pi/risperdal.pdf
  • JeanneteauFFunalotBJankovicJ2006A functional variant of the dopamine D3 receptor is associated with risk and age at onset of essential tremorPNAS10310753816809426
  • JoyCBAdamsCELawrieSM2006Haloperidol versus placebo for schizophreniaCochrane Database of Systematic Reviews4CD003082
  • KaiserRTremblayP-BKlufmollerF2002Relationship between adverse effects of antipsychotic treatment and dopamine D[sub2] receptor polymorphisms in patients with schizophreniaMolecular Psychiatry769512192613
  • KapitanyTMeszarosKLenzingerE1998Genetic polymorphism for drug metabolism (CYP2D6) and tardive dyskinesia in schizophreniaSchizophr Res3210169713905
  • KapurSSeemanP2001Does fast dissociation from the dopamine D2 receptor explain the action of atypical antipsychotics?Am J Psychiatry158360911229973
  • KirchheinerJNickchenKBauerM2004Pharmacogenetics of anti-depressants and antipsychotics: the contribution of allelic variations to the phenotype of drug responseMolecular Psychiatry94427315037866
  • KishidaIKawanishiCFurunoC2004Association in Japanese patients between neuroleptic malignant syndrome and functional polymorphisms of the dopamine D2 receptor geneMolecular Psychiatry9293815094790
  • LambertBLCunninghamFEMillerDR2006Diabetes risk associated with use of olanzapine, quetiapine and risperidone in veterans health administration patients with schizophreniaAmerican Journal of Epidemiology1646728116943266
  • LaneHYLeeCCLiuYC2005Pharmacogenetic studies of response to risperidone and other newer atypical antipsychoticsPharmacogenomics61394915882132
  • LererBSegmanRHFangerauH2002Pharmacogenetics of tardive dyskinesia. Combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphismNeuropsychopharmacology271051912062911
  • LererBSegmanRHTanE-C2005Combined analysis of 635 patients confirms an age related association of serotonin 2A receptor gene with tardive dyskinesia and specificity for non-orofacial subtypeInternational Journal of Neuropsychopharmacology84112515857569
  • LererBSegmanRH2006Pharmacogenetics of antipsychotic therapy: pivotal research issues and the prospects for clinical implementationDialogues in Clinical Neuroscience8859416640118
  • LiebermanJAStroupTSMcEvoyJP2005Effectiveness of anti-psychotic drugs in patients with chronic schizophreniaN Engl J Med35312092316172203
  • LlerenaABereczRDoradoP2004QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrationsJournal of Psychopharmacology181899315260906
  • MalhotraAKMurphyGMJrKennedyJL2004Pharmacogenetics of psychotropic drug responseAm J Psychiatry1617809615121641
  • MiharaKKondoTSuzukiA2001No relationship between –141C Ins/Del polymorphism in the promoter region of dopamine D2 receptor and extrapyramidal adverse effects of selective dopamine D2 antagonists in schizophrenic patients: a preliminary studyPsychiatry Research10133811223117
  • MiharaKKondoTSuzukiA2003Relationship between functional dopamine D2 and D3 receptors gene polymorphism and neuroleptic malignant syndromeAmerican Journal of Medical Genetics Neuropsychiatric Genetics1175760
  • MiharaKSuzukiAKondoT2001Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidolAmerican Journal of Medical Genetics (Neuropsychiatric Genetics)105271411353448
  • MillerDDEllingrodVLHolmanTL2005Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphismAmerican Journal of Medical Genetics Part B. Neuropsychiatric Genetics133B97100
  • MillerDDMcEvoyJPDavisS2005Clinical correlates of tardive dyskinesia in schizophrenia: baseline data from CATIE schizophrenia trialSchizophrenia Research80334316171976
  • MorleyKIHallWD2004Using pharmacogenetics and pharmacogenomics in the treatment of psychiatric disorders: some ethical and economic considerationsJournal of Molecular Medicine82213014598045
  • MullerDJKennedyJL2006Genetics of antipsychotic treatment emergent weight gain in schizophreniaPharmacogenomics78638716981847
  • MurrayM2006Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agentsJournal of Pharmacy and Pharmacology588718516805946
  • NewcomerJW2006Medical risk in patients with bipolar disorder and schizophreniaJ Clin Psychiatry67 Suppl 9253016965186
  • OhmoriOSuzukiTKojimaH1998Tardive dyskinesia and debriso-quine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenicsSchizophr Res32107139713906
  • OlfsonMBlancoCLiuL2006National Trends in the outpatient treatment of children and adolescents with antipsychotic drugsArchives of General Psychiatry636798516754841
  • OlfsonMMarcusSCCorey-LisleP2006Hyperlipidemia following treatment with antipsychotic medicationsAm J Psychiatry1631821517012695
  • OzdemirVWilliams-JonesBCooperD2007Mapping translational research in personalized therapeuticsPharmacogenomics87785
  • RegenoldWTThaparRKMaranoC2002Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug useJournal of Affective Disorders70192612113916
  • ReynoldsGPTemplemanLAZhangZJ2005The role of 5-HT2C receptor in the pharmacogenetics of antipsychotic drug treatmentProgress in Neuro-Psychopharmacology and Biological Psychiatry291021815953671
  • ReynoldsGTemplemanLAGodlewskaBR2006Pharmacogenetics of schizophreniaExpert Opinion on Pharmacotherapy714294016859426
  • RietschelMKraussHMullerDJ2000Dopamine D3 receptor variant and tardive dyskinesiaEur Arch Psychiatry Clin Neurosci25031510738862
  • RyanMCCollinsPThakoreJH2003Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophreniaThe American Journal of Psychiatry160284912562574
  • SachseCBrockmollerJBaueS1997Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequencesAm J Hum Genet60284959012401
  • SchulzeTGSchumacherJMullerDJ2001Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophreniaAm J Med Genet10549850111496364
  • ScordoMGSpinaEFacciolàG1999Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidonePsychopharmacology147300610639689
  • SegmanRNeemanTHeresco-LevyU1999Genotypic association between the dopamine D3 receptor and tardive dyskinesia in chronic schizophreniaMol Psychiatry42475310395214
  • SegmanRHHeresco-LevyUFinkelB2001Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophreniaMol Psychiatry6225911317227
  • ShirzadiAAGhaemiSN2006Side effects of atypical antipsychotics: extrapyramidal symptoms and the metabolic syndromeHarvard Review of Psychiatry141526416787887
  • SiposFRKehoePGBurnsT2006The cardiovascular and respiratory health of people with schizophreniaActa Psychiatrica Scandinavica113245616638069
  • SrivastavaVVarmaPGPrasadS2006Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV role of dopaminergic pathway gene polymorphismsPharmacogenetics and Genomics161111716424823
  • StahlSMGradyMM2004A critical review of atypical antipsychotic utilization: comparing monotherapy with polypharmacy and augmentationCurrent Medicinal Chemistry113132714965234
  • SteenVMLovlieRMacEwanT1997Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patientsMol Psychiatry2139459106238
  • SuzukiAKondoTOtaniK2001Association of the Taq1 polymorphism of the dopamine D2 receptor gene with predisposition to neuroleptic malignant syndromeAm J Psychiatry15817141611579007
  • Swainston-HarrisonTPerryCM2004Aripiprazole: a review of its use in schizophrenia and schizoaffective disorderDrugs6417153615257633
  • TanECChongSAMahendranR2001Susceptibility to neuroleptic-induced tardive dyskinesia and the T102C polymorphism in the serotonin type 2A receptorBiol Psychiatry50144711526996
  • TecottLHSunLMAkanaSF1995Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptorsNature37454267700379
  • TemplemanLAReynoldsGPArranzB2005Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosisPharmacogenetics and Genomics1519520015864111
  • TiwariAKDesphandeSNRaoAR2005Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III Lack of association of CYP3A4 and CYP2D6 gene polymorphismsSchizophrenia Research7521615820320
  • Van BruntDLGibsonPJRamseyJL2003Outpatient use of major antipsychotic drugs in ambulatory care settings, Medgenmed [computer file]Medscape General Medicine516Accessed 15 August 2007 URL: http://www.medscape.com/viewarticle/45898414600653
  • WilkaitisJMulvihillTNasrallahHASchatzbergAFNemeroffCB2004Classic antipsychotic medicationsAmerican psychiatric publishing textbook of psychopharmacology3rd edAmerican Psychiatric Publishing437
  • WilkinsonGR2005Drug metabolism and variability among patients in drug responseN Engl J Med35221
  • Williams-JonesBOzdemirV2007Challenges for corporate ethics in marketing genetic tests. Journal of Business Ethics advance online publicationaccessed 7/12/07 http://www.springerlink.com/content/g6w320149833347h/?p=90f320134a9f4804b5bca7f6d3c3f60b&pi=0
  • YoungRMLawfordBRBarnesM2004Prolactin levels in anti-psychotic treatment of patients with schizophrenia carrying the DRD2 alleleBritish Journal of Psychiatry1851475115286066
  • ZaiCCHwangRWDe LucaV2006Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patientsInternational Journal of Neuropsychopharmacology7113

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