812
Views
27
CrossRef citations to date
0
Altmetric
Special Report

Phytotherapy for diabetic dyslipidemia: evidence from clinical trials

Pages 311-319 | Published online: 18 Jan 2017

References

  • Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetesrelated complications. Phys. Ther. 88, 1254–1264 (2008).
  • Arca M, Pigna G, Favoccia C. Mechanisms of diabetic dyslipidemia: relevance for atherogenesis. Curr. Vasc. Pharmacol. 10, 684–686 (2012).
  • Ghorbani A, Varedi M, Hadjzadeh MR, Omrani GH. Type-1 diabetes induces depot-specific alterations in adipocyte diameter and mass of adipose tissues in the rat. Exp. Clin. Endocrinol. Diabetes 118, 442–448 (2010).
  • Ghorbani A, Omrani GH, Hadjzadeh MR, Varedi M. Proinsulin C-peptide inhibits lipolysis in diabetic rat adipose tissue through phosphodiestrase-3B enzyme. Horm. Metab. Res. 45, 221–225 (2012).
  • Vijayaraghavan K. Treatment of dyslipidemia in patients with Type 2 diabetes. Lipids Health Dis. 9, 144 (2010).
  • Karalis DG. The role of lipid-lowering therapy in preventing coronary heart disease in patients with Type 2 diabetes. Clin. Cardiol. 31, 241–248 (2008).
  • Harper CR, Jacobson TA. Avoiding statin myopathy: understanding key drug interactions. Clin. Lipidol. 6, 665–674 (2011).
  • Sorrentino MJ. An update on statin alternatives and adjuncts. Clin. Lipdol. 7, 721–730 (2012).
  • Solano MP, Goldberg RB. Management of dyslipidemia in diabetes. Cardiol. Rev. 14, 125–135 (2006).
  • Leiherer A, Mündlein A, Drexel H. Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vasc. Pharmacol. 58, 3–20 (2013).
  • Ghorbani A, Rakhshandeh H. The Most Effective Herbs for Diabetes. Mashhad University of Medical Sciences Publisher, Mashhad, Iran (2012).
  • Shafiee-Nick R, Ghorbani A, Vafaee F, Rakhshandeh H. Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Adv. Pharmacol. Sci. 2012, 6 (2012).
  • Barnes J, Anderson LA, Phillipson JD. Herbal medicines. Pharmaceutical Press, London, UK, 279–289 (2007).
  • Hajzadeh MR, Tavakol Afshari J, Ghorbani A, Shakeri MT. The effects of aqueous extract of garlic (Allium sativum L.) on laryngeal cancer cells (Hep-2) and L929 cells in vitro. J. Med. Plants 5, 41–48 (2006).
  • Ashraf R, Aamir K, Shaikh AR, Ahmed T. Effects of garlic on dyslipidemia in patients with Type 2 diabetes mellitus. J. Ayub Med. Coll. Abbottabad 17, 60–64 (2005).
  • Mirunalini S, Krishnaveni M, Ambily. Effects of raw garlic (Allium sativum) on hyperglycemia in patients with Type 2 diabetes mellitus. Pharmacologyonline 2, 968–974 (2011). Consumption of three cloves of garlic once daily led to a 56, 8, 17 and 21% decrease of fasting blood glucose (FBG), triglyceride, cholesterol and LDL, respectively.
  • Varma M, Sharma DK, Paaneri S, Mishra A, Sinha ARS, Varma V. Potential clinical benefits of garlic (Allium sativum). J. Environ. Res. Dev. 5, 652–655 (2011).
  • Sobenin IA, Nedosugova LV, Filatova LV, Balabolkin MI, Gorchakova TV, Orekhov AN. Metabolic effects of time-released garlic powder tablets in Type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta Diabetol. 45, 1–6 (2008).
  • Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in Type 2 diabetes patients. Pak. J. Pharm. Sci. 24, 565–570 (2011).
  • Borrelli F, Capasso R, Izzo AA. Garlic (Allium sativum L.): adverse effects and drug interactions in humans. Mol. Nutr. Food Res. 51, 1386–1397 (2007).
  • Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 3, 245–248 (1996). Controlled trial of 76 Type 2 diabetic patients that demonstrated Aloe vera decreases FBG by 49% and triglycerides by 52%.
  • Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine 3, 241–243 (1996).
  • Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic Type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta. Med. 78, 311–316 (2012).
  • Aronson JK. Meyler’s Side Effects of Herbal Medicines. Elsevier, Oxford, UK (2009).
  • Aro A, Uusitupa M, Hersio K, Korhonen T, Siitonen O. Improved diabetic control and hypocholesterolaemic effect induced by long-term dietary supplementation with guar gum in Type 2 (insulin-independent) diabetes. Diabetologia 21, 29–33 (1981).
  • Ebeling P, Yki-Jarvinen H, Aro A, Helve E, Sinisalo M, Koivisto VA. Glucose and lipid metabolism and insulin sensitivity in Type 1 diabetes: the effect of guar gum. Am. J. Clin. Nutr. 48, 98–103 (1988).
  • Groop PH, Aro A, Stenman S, Groop L. Long-term effects of guar gum in subjects with non-insulin dependent diabetes mellitus. Am. J. Clin. Nutr. 58, 513–518 (1993).
  • Sels JP, Flendrig JA, Postmes TH. The influence of guar-gum bread on the regulation of diabetes mellitus Type II in elderly patients. Br. J. Nutr. 57, 177–183 (1987).
  • Smith U, Holm G. Effect of a modified guar gum preparation on glucose and lipid levels in diabetics and healthy volunteers. Atherosclerosis 45, 1–10 (1982).
  • Fuessl HS, Williams G, Adrian TE, Bloom SR. Guar sprinkled on food: effect on glycaemic control, plasma lipids and gut hormones in non-insulin dependent diabetic patients. Diabetic Med. 4, 463–468 (1987).
  • Lalor BC, Bhatnagar D, Winocour PH et al. Placebo-controlled trial of the effects of guar gum and metformin on fasting blood glucose and serum lipids in obese, Type 2 diabetic patients. Diabetic Med. 7, 242–245 (1990).
  • Niemi MK, Keinänen-Kiukaanniemi SM, Salmela PI. Long-term effects of guar gum and microcrystalline cellulose on glycaemic control and serum lipids in Type 2 diabetes. Eur. J. Clin. Pharmacol. 34, 427–429 (1988).
  • Soni Y. Effect of Cyamopsis tetragonoloba (guar) on lipid profile in diabetic and non-diabetic subjects. J. Postgrad. Med. Inst. 25, 199–205 (2011).
  • Uusitupa M, Siitonen O, Savolainen K, Silvasti M, Penttila I, Parviainen M. Metabolic and nutritional effects of long-term use of guar gum in the treatment of noninsulin dependent diabetes of poor metabolic control. Am. J. Clin. Nutr. 49, 345–351 (1989).
  • Uusitupa M, Sodervik H, Silvasti M, Karttunen P. Effects of a gel forming dietary fiber, guar gum, on the absorption of glibenclamide and metabolic control and serum lipids in patients with non-insulin-dependent (Type 2) diabetes. Int. J. Clin. Pharmacol. Ther. Toxicol. 28, 153–157 (1990).
  • Vuorinen-Markkola H, Sinisalo M, Koivisto VA. Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins. Am. J. Clin. Nutr. 56, 1056–1560 (1992).
  • McIvor ME, Cummings CC, Mendeloff AI. Long-term ingestion of guar gum is not toxic in patients with noninsulin-dependent diabetes mellitus. Am. J. Clin. Nutr. 41, 891–894 (1985).
  • Iyer U, Joshi A, Dhruv S. Impact of amla (Embilica officinalis) supplementation on the glycemic and lipidemic status of Type 2 diabetic subjects. J. Herbal Med. Toxicol. 3, 15–21 (2009). Controlled clinical trial that demonstrated considerable decrease of triglyceride (23%) and FBG (35%) following 2 months treatment with Amla (35 g/day).
  • Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and Type 2 diabetic patients. Int. J. Food Sci. Nutr. 62, 609–616 (2011).
  • Najmi A, Haque SF, Khan RA, Nasiruddin M. Therapeutic effect of Nigella sativa oil on different clinical and biochemical parameters in metabolic syndrome. Internet J. Pharmacol. 5(2), 8 (2008).
  • Kaatabi H, Bamosa AO, Lebda FM, Al Elq AH, Al-Sultan AI. Favorable impact of Nigella sativa seeds on lipid profile in Type 2 diabetic patients. J. Family Community Med. 19, 155–161 (2012).
  • Sharma NK, Ahirwar D, Jhade D, Gupta S. Medicinal and phamacological potential of Nigella sativa: a review. Ethnobotanical Rev. 13, 946–955 (2009).
  • Bazzano LA. Effects of soluble dietary fiber on low-density lipoprotein cholesterol and coronary heart disease risk. Curr. Atheroscler. Rep. 10, 473–477 (2008).
  • Anderson JW, Allgood LD, Turner J, Oeltgen PR, Daggy BP. Effects of psyllium on glucose and serum lipid responses in men with Type 2 diabetes and hypercholesterolemia. Am. J. Clin. Nutr. 70, 466–473 (1999).
  • Cicero AFG, Derosa G, Bove M, Imola F, Borghi C, Gaddi AV. Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet. Mediterr. J. Nutr. Metab. 3, 47–54 (2010).
  • Sierra M, Garcia JJ, Fern á ndez N, Diez MJ, Calle AP. Therapeutic effects of psyllium in Type 2 diabetic patients. Eur. J. Clin. Nutr. 56, 830–842 (2002).
  • Sartore G, Reitano R, Barison A et al. The effects of psyllium on lipoproteins in Type II diabetic patients. Eur. J. Clin. Nutr. 63, 1269–1271 (2009).
  • Ziai SA, Larijani B, Akhoondzadeh S et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J. Ethnopharmacol. 102, 202–207 (2005).
  • Fallah Hoseini H, Larijani B, Heshmat R et al. The efficacy of Silybum marianum (L.) gaertn. (Silymarin) in the treatment of Type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother. Res. 20, 1036–1039 (2006).
  • Ramezani M, Azar Abadi M, Falah Hosseini H, Abdi H, Baher GR, Hosseini MA. The effect of Silybum marinum (L.) gaertn. seed extract on glycemic control in Type II diabetic patient’s candidate for insulin therapy visiting endocrinology clinic in Baqiyatallah hospital in the years of 2006. J. Med. Plants 7, 79–84 (2008). Randomized, double-blind placebo clinical trial that demonstrated significant hypolipidemic and hypoglycemic effects of Silybum marianum (200 mg three times a day for 4 months) on diabetic patients.
  • Duke JA, Bogenschutz-Godwin MJ, duCellier J, Duke PA. Handbook of Medicinal Herbs. CRC Press, NY, USA (2002).
  • Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot. Essent. Fatty Acids 56, 379–384 (1997).
  • Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in Type 2 diabetes mellitus: a double blind placebo controlled study. J. Assoc. Physicians India 49, 1057–1061 (2001).
  • Kassaian N, Azadbakht L, Forghani B, Amini M. Effect of fenugreek seeds on blood glucose and lipid profiles in Type 2 diabetic patients. Int. J. Vitam. Nutr. Res. 79, 34–39 (2009).
  • Mitra A, Bhattacharya D. Dose-dependent effects of fenugreek composite in diabetes with dyslipidaemia. Indian J. Pract. Doctor 3, 2006-08–2006-09 (2006).
  • Moosa AS, Rashid MU, Asadi AZ, Ara N, Uddin M, Ferdaus A. Hypolipidemic effects of fenugreek seed powder. Bangl. J. Pharmacol. 1, 64–67 (2006).
  • Sharma RD. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr. Res. 6, 1353–1364 (1986).
  • Sharma RD, Raghuran TC. Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr. Res. 10, 731–739 (1990). Crossover trial of Type 2 diabetic subjects that showed fenugreek seeds significantly decrease triglyceride, cholesterol, LDL, VLDL and FBG.
  • Sharma RD, Raghuran TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in Type I diabetes. Eur. J. Clin. Nutr. 44, 301–306 (1990).
  • Fu-rong L, Lin S, You Q, Lan G, Heng L, Yi D. Clinical observation on Trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of Type 2 diabetes mellitus. Chin. J. Integr. Med. 14, 56–60 (2008).
  • Chen HL, Sheu WH, Tai TS, Liaw YP, Chen YC. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in Type 2 diabetic subjects – a randomized double-blind trial. J. Am. Coll. Nutr. 22, 36–42 (2003).
  • Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM. Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med. 44, 20–23 (2002).
  • Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G, Azizi F. Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in Type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Diabetes Res. Clin. Pract. 96, 384–354 (2012).
  • Fallah Hoseini H, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani B. The clinical investigation of Citrullus colocynthis (L.) Schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo-controlled clinical trial. Phytother. Res. 23, 1186–1189 (2009).
  • Fallah Hoseini H, Kianbakht S, Heshmat R. Cynara scolymus L. in treatment of hypercholesterolemic Type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. J. Med. Plant. 11, 58–65 (2012).
  • Upadhyay UM, Goyal RK. Efficacy of Enicostemma littorale in Type 2 diabetic patients. Phytother. Res. 18, 233–235 (2004).
  • Ludvik B, Neuffer B, Pacini G. Efficacy of Ipomoea batatas (Caiapo) on diabetes control in Type 2 diabetic subjects treated with diet. Diabetes Care 27, 436–440 (2004).
  • Adamson I, Okafor C, Abu-Bakare A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of Type II diabetics. West Afr. J. Med. 9, 108–115 (1990).
  • Akhtar MS, Khan S, Bashir S, Salman M. Effect of Lodoicea sechellarum Labill (sea coconut) fruit on blood glucose and lipid profile in Type 2 diabetic and normal human volunteers. Diabetologia Croatica 38, 87–93 (2009).
  • Andallu B, Suryakantham V, Srikanthi BL, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with Type 2 diabetes. Clin. Chim. Acta 314, 47–53 (2001). Clinical trial that demonstrated Morus indica lowers LDL (23%) and FBG (27%), and increases HDL (18%) in diabetic patients.
  • Rai V, Mani UV, Iyer UM. Effect of ocimum sanctum leaf powder in blood lipoproteins, glycated proteins and total amino acids in patients with non-insulin-dependent diabetes mellitus. J. Nutr. Env. Med. 7, 113–118 (1997).
  • El-Sayed MK. Effects of Portulaca oleracea L. seeds in treatment of Type-2 diabetes mellitus patients as adjunctive and alternative therapy. J. Ethnopharmacol. 137, 643–651 (2011).
  • Vosough-Ghanbari S, Rahimi R, Kharabaf S et al. Effects of Satureja khuzestanica on serum glucose, lipids and markers of oxidative stress in patients with Type 2 diabetes mellitus: a double-blind randomized controlled trial. eCAM 7, 465–470 (2010).
  • Bei WJ, Guo J, Wu HY, Cao Y. Lipidregulating effect of traditional Chinese medicine: mechanisms of actions. Evid. Based Complement. Alternat. Med. 2012, 10 (2012).
  • Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids 29, 189–193 (1994).
  • Shrivastava A, Chaturvedi U, Singh SV, Saxena JK, Bhatia G. A mechanism based pharmacological evaluation of efficacy of Allium sativum in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. Asian J. Pharm. Clin. Res. 5, 123–126 (2012).
  • Al-Naqeep G, Ismail M, Yazan LS. Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression. J. Funct. Food 1, 298–303 (2009).
  • Anila L, Vijayalakshmi NR. Flavonoids from Emblica officinalis and Mangifera indica – effectiveness for dyslipidemia. J. Ethnopharmacol. 79, 81–87 (2002).
  • Gunness P, Gidley MJ. Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides. Food Funct. 1, 149–155 (2010).
  • Chaturvedi U, Shrivastava A, Bhadauria S, Saxena JK, Bhatia G. A mechanism based pharmacological evaluation of efficacy of Trigonella-foenom graecum (fenugreek) seeds in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. J. Cardiovasc. Pharmacol. doi:10.1097/ FJC.0b013e31828b7822 (2013) (Epub ahead of print).
  • Vijayakumar MV, Pandey V, Mishra GC, Bhat MK. Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor. Obesity 18, 667–674 (2010).
  • Minekus M, Jelier M, Xiao JZ et al. Effect of partially hydrolyzed guar gum (PHGG) on the bioaccessibility of fat and cholesterol. Biosci. Biotechnol. Biochem. 69, 932–938 (2005).
  • Sobolova L, Skottova N, Vecera R, Urbanek K. Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. Pharmacol. Res. 53, 104–112 (2006).
  • Nomaguchia K, Tanakaa M, Misawaa E et al. Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity. Obesity Res. Clin. Pract. 5, e190–e201 (2011).
  • Elboudwarej O, Hojjat H, Safarpoor S, Vazirian S, Ahmadi S. Dysfunctional HDL and cardiovascular disease risk in individuals with diabetic dyslipidemia. J. Diabetes Metab. S4, 001 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.