References
- Siegel R , NaishadhamD, JemalA. Cancer statistics, 2012.CA Cancer J. Clin.62(1), 10–29 (2012).
- Sell S . Detection of cancer by tumor-markers in the blood – a view to the future.Crit. Rev. Oncog.4(4), 419–433 (1993).
- Nicholson JK , LindonJC, HolmesE. ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica29(11), 1181–1189 (1999).
- Gowda GAN , ZhangSC, GuHW, AsiagoV, ShanaiahN, RafteryD. Metabolomics-based methods for early disease diagnostics.Expert Rev. Mol. Diagn.8(5), 617–633 (2008).
- Fiehn O . Metabolomics – the link between genotypes and phenotypes.Plant. Mol. Biol.48(1–2), 155–171 (2002).
- Raftery D , GowdaGAN. An approaching new wave of multicomponent biomarker diagnostics?J. Urol.179(6), 2089–2090 (2008).
- Warburg O . On the origin of cancer cells.Science123(3191), 309–314 (1956).
- DeBerardinis RJ , MancusoA, DaikhinEet al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl Acad. Sci. USA 104(49), 19345–19350 (2007).
- Johnson RA , WichernDW. Applied Multivariate Statistical Analysis (5th Edition). Prentice Hall, NJ, USA (2001).
- Kim YS , MaruvadaP. Frontiers in metabolomics for cancer research: proceedings of a National Cancer Institute workshop.Metabolomics4(2), 105–113 (2008).
- Wishart DS , TzurD, KnoxCet al. HMDB: the human metabolome database. Nucleic Acids Res. 35, D521–D526 (2007).
- Ye T , MoHP, ShanaiahN, GowdaGAN, ZhangSC, RafteryD. Chemoselective (15)N tag for sensitive and high-resolution nuclear magnetic resonance profiling of the carboxyl-containing metabolome.Anal. Chem.81(12), 4882–4888 (2009).
- Gu HW , PanZZ, XiBW, AsiagoV, MusselmanB, RafteryD. Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: application to the detection of breast cancer.Anal. Chim. Acta686(1–2), 57–63 (2011).
- Issaq HJ , FoxSD, ChanKC, VeenstraTD. Global proteomics and metabolomics in cancer biomarker discovery.J. Sep. Sci.34(24), 3484–3492 (2011).
- Spratlin JL , SerkovaNJ, EckhardtSG. Clinical applications of metabolomics in oncology: a review.Clin. Cancer Res.15(2), 431–440 (2009).
- Giskeodegard GF , GrindeMT, SitterBet al. Multivariate modeling and prediction of breast cancer prognostic factors using MR metabolomics. J. Proteome Res. 9(2), 972–979 (2010).
- Asiago VM , AlvaradoLZ, ShanaiahNet al. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res. 70(21), 8309–8318 (2010).
- DeFeo EM , WuCL, McDougalWS, ChengLL. A decade in prostate cancer: from NMR to metabolomics.Nat. Rev. Urol.8(6), 301–311 (2011).
- Kline EE , TreatEG, AvernaTA, DavisMS, SmithAY, SillerudLO. Citrate concentrations in human seminal fluid and expressed prostatic fluid determined via H-1 nuclear magnetic resonance spectroscopy outperform prostate specific antigen in prostate cancer detection.J. Urol.176(5), 2274–2279 (2006).
- Sreekumar A , PoissonLM, RajendiranTMet al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457(7231), 910–914 (2009).