Association Study of Genetic Polymorphisms in GABRD with Treatment Response and Dose in Methadone Maintenance Treatment

References

• Kleber HD . Methadone maintenance 4 decades later: thousands of lives saved but still controversial. JAMA300(19), 2303–2305 (2008).
   PubMed Web of Science ®Google Scholar
• Kreek MJ , BorgL , DucatE , RayB. Pharmacotherapy in the treatment of addiction: methadone. J. Addict. Dis.29(2), 200–216 (2010).
   PubMed Web of Science ®Google Scholar
• Li Y , KantelipJP , Gerritsen-vanSchieveen P , DavaniS. Interindividual variability of methadone response: impact of genetic polymorphism. Mol. Diagn. Ther.12(2), 109–124 (2008).
   PubMed Web of Science ®Google Scholar
• Somogyi AA , BarrattDT , AliRL , CollerJK. Pharmacogenomics of methadone maintenance treatment. Pharmacogenomics15(7), 1007–1027 (2014).
   PubMed Web of Science ®Google Scholar
• Fonseca F , TorrensM. Pharmacogenetics of methadone response. Mol. Diagn. Ther.22(1), 57–78 (2018).
   PubMed Web of Science ®Google Scholar
• Packiasabapathy S , AruldhasBW , HornNet al. Pharmacogenomics of methadone: a narrative review of the literature. Pharmacogenomics21(12), 871–887 (2020).
   PubMed Web of Science ®Google Scholar
• Simpson DD . Treatment for drug abuse: follow-up outcomes and length of time spent. Arch. Gen. Psychiatr.38(8), 875–880 (1981).
   PubMed Web of Science ®Google Scholar
• Trafton JA , MinkelJ , HumphreysK. Determining effective methadone doses for individual opioid-dependent patients. PLoS Med.3(3), e80 (2006).
   PubMed Web of Science ®Google Scholar
• Bao YP , LiuZM , EpsteinDH , DuC , ShiJ , LuL. A meta analysis of retention in methadone maintenance by dose and dosing strategy. Am. J. Drug Alcohol Abuse35(1), 28–33 (2009).
   PubMed Web of Science ®Google Scholar
• Eap CB , BuclinT , BaumannP. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin. Pharmacokinet.41(14), 1153–1193 (2002).
   PubMed Web of Science ®Google Scholar
• Bart G , LenzS , StrakaRJ , BrundageRC. Ethnic and genetic factors in methadone pharmacokinetics: a population pharmacokinetic study. Drug Alcohol Depend.145, 185–193 (2014).
   PubMed Web of Science ®Google Scholar
• Levran O , PelesE , RandesiMet al. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. Pharmacogenomics14(7), 755–768 (2013).
   PubMed Web of Science ®Google Scholar
• Ahmad T , ValentovicMA , RankinGO. Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics. Biochem. Pharmacol.153, 196–204 (2018).
   PubMed Web of Science ®Google Scholar
• Dennis BB , BaworM , ThabaneL , SohaniZ , SamaanZ. Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis. PLoS ONE9(1), e86114 (2014).
   PubMed Web of Science ®Google Scholar
• Crettol S , BessonJ , Croquette-KrokarMet al. Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry32(7), 1722–1727 (2008).
   PubMed Web of Science ®Google Scholar
• Peng S , JiangH , DuJet al. Methadone dosage and plasma levels, SNPs of OPRM1 gene and age of first drug use were associated with outcomes of methadone maintenance treatment. Front. Genet.9, 450 (2018).
   PubMed Web of Science ®Google Scholar
• Fang CP , WangSC , TsouHHet al. Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. J. Hum. Genet.65(4), 381–386 (2020).
   PubMed Web of Science ®Google Scholar
• Oneda B , CrettolS , BochudMet al. beta-Arrestin2 influences the response to methadone in opioid-dependent patients. Pharmacogenomics J.11(4), 258–266 (2011).
   PubMed Web of Science ®Google Scholar
• Xi ZX , SteinEA. Increased mesolimbic GABA concentration blocks heroin self-administration in the rat. J. Pharmacol. Exp. Ther.294(2), 613–619 (2000).
   PubMed Web of Science ®Google Scholar
• Kalivas PW , O’BrienC. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology33(1), 166–180 (2008).
   PubMed Web of Science ®Google Scholar
• Schlussman SD , BuonoraM , BrownsteinAJ , ZhangY , HoA , KreekMJ. Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects. Brain Res.1523, 49–58 (2013).
   PubMed Web of Science ®Google Scholar
• Gipson CD , KupchikYM , KalivasPW. Rapid, transient synaptic plasticity in addiction. Neuropharmacology76 Pt B, 276–286 (2014).
   PubMed Web of Science ®Google Scholar
• Taylor AM , CastonguayA , GhoghaAet al. Neuroimmune regulation of GABAergic neurons within the ventral tegmental area during withdrawal from chronic morphine. Neuropsychopharmacology41(4), 949–959 (2016).
   PubMed Web of Science ®Google Scholar
• Tracy ME , BanksML , SheltonKL. Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology (Berl)233(4), 715–725 (2016).
   PubMed Web of Science ®Google Scholar
• Stephens DN , KingSL , LambertJJ , BelelliD , DukaT. GABA(A) receptor subtype involvement in addictive behaviour. Genes Brain Behav.16(1), 149–184 (2017).
   PubMed Web of Science ®Google Scholar
• Loh EW , TangNL , LeeDT , LiuSI , StadlinA. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population. Am. J. Med. Genet. B Neuropsychiatr. Genet.144B(4), 439–443 (2007).
   PubMed Web of Science ®Google Scholar
• Levran O , LondonoD , O’HaraKet al. Heroin addiction in African Americans: a hypothesis-driven association study. Genes Brain Behav.8(5), 531–540 (2009).
   PubMed Web of Science ®Google Scholar
• Enoch MA , HodgkinsonCA , YuanQ , ShenPH , GoldmanD , RoyA. The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. Biol. Psychiatry67(1), 20–27 (2010).
   PubMed Web of Science ®Google Scholar
• Li D , SulovariA , ChengC , ZhaoH , KranzlerHR , GelernterJ. Association of gamma-aminobutyric acid A receptor alpha2 gene (GABRA2) with alcohol use disorder. Neuropsychopharmacology39(4), 907–918 (2014).
   PubMed Web of Science ®Google Scholar
• Chen CH , HuangCC , LiaoDL. Association analysis of GABRB3 promoter variants with heroin dependence. PLoS ONE9(4), e102227 (2014).
   PubMedGoogle Scholar
• Kim YS , YangM , MatWKet al. GABRB2 haplotype association with heroin dependence in Chinese population. PLoS ONE10(11), e0142049 (2015).
   PubMed Web of Science ®Google Scholar
• Levran O , PelesE , RandesiMet al. Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. Prog. Neuropsychopharmacol. Biol. Psychiatry64, 118–123 (2016).
   PubMed Web of Science ®Google Scholar
• Sun Y , ZhangY , ZhangDet al. GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers. Trans. Psychiatry8(1), 138 (2018).
   PubMedGoogle Scholar
• Feng Y , KapornaiK , KissEet al. Association of the GABRD gene and childhood-onset mood disorders. Genes Brain Behav.9(6), 668–672 (2010).
   PubMed Web of Science ®Google Scholar
• Pu M , ZhangZ , XuZet al. Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response. Pharmacogenomics14(3), 277–288 (2013).
   PubMed Web of Science ®Google Scholar
• Xie X , LiuH , ZhangJet al. Association between genetic variations of NMDA receptor NR3 subfamily genes and heroin addiction in male Han Chinese. Neurosci. Lett.631, 122–125 (2016).
   PubMed Web of Science ®Google Scholar
• GTEx Consortium . The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science348(6235), 648–660 (2015).
   PubMed Web of Science ®Google Scholar
• Barrett JC , FryB , MallerJ , DalyMJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics21(2), 263–265 (2005).
   PubMed Web of Science ®Google Scholar
• Shi YY , HeL. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res.15(2), 97–98 (2005).
   PubMed Web of Science ®Google Scholar
• Parker JG , WanatMJ , SodenMEet al. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. J. Neurosci.31(47), 17103–17112 (2011).
   PubMed Web of Science ®Google Scholar
• Wei W , ZhangN , PengZ , HouserCR , ModyI. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci.23(33), 10650–10661 (2003).
   PubMed Web of Science ®Google Scholar
• Dibbens LM , FengHJ , RichardsMCet al. GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. Hum. Mol. Genet.13(13), 1315–1319 (2004).
   PubMed Web of Science ®Google Scholar
• Maguire EP , MacphersonT , SwinnyJDet al. Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants. J. Neurosci.34(3), 823–838 (2014).
   PubMed Web of Science ®Google Scholar
• Mihalek RM , BowersBJ , WehnerJMet al. GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcohol. Clin. Exp. Res.25(12), 1708–1718 (2001).
   PubMed Web of Science ®Google Scholar
• Nie H , RewalM , GillTM , RonD , JanakPH. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc. Natl Acad. Sci. USA108(11), 4459–4464 (2011).
   PubMed Web of Science ®Google Scholar
• Rewal M , JurdR , GillTM , HeDY , RonD , JanakPH. Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. J. Neurosci.29(2), 543–549 (2009).
   PubMed Web of Science ®Google Scholar
• Anstee QM , KnappS , MaguireEPet al. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat. Commun.4, 2816 (2013).
   PubMed Web of Science ®Google Scholar
• Xie X , GuJ , ZhuangDet al. Association between GABA receptor delta subunit gene polymorphisms and heroin addiction. Neurosci. Lett.755, 135905 (2021).
   PubMed Web of Science ®Google Scholar
• Bell J , BurrellT , IndigD , GilmourS. Cycling in and out of treatment; participation in methadone treatment in NSW, 1990-2002. Drug Alcohol Depend.81(1), 55–61 (2006).
   PubMed Web of Science ®Google Scholar
• Lehotay DC , GeorgeS , EtterMLet al. Free and bound enantiomers of methadone and its metabolite, EDDP in methadone maintenance treatment: relationship to dosage? Clin. Biochem. 38(12), 1088–1094 (2005).
   PubMed Web of Science ®Google Scholar
• Wang RY , ChenHJ , HuangCLet al. Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population. PLoS ONE13(7), e0201408 (2018).
   PubMed Web of Science ®Google Scholar
• Duan S , JinZ , LiuXet al. Tobacco and alcohol use among drug users receiving methadone maintenance treatment: a cross-sectional study in a rural prefecture of Yunnan Province, Southwest China. BMJ Open7(3), e014643 (2017).
   PubMed Web of Science ®Google Scholar
• Zhong BL , XuYM , XieWX , LuJ , YuWB , YanJ. Alcohol drinking in Chinese methadone-maintained clients: a self-medication for depression and anxiety?J. Addict. Med.13(4), 314–321 (2019).
   PubMed Web of Science ®Google Scholar