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ORIGINAL ARTICLE

Effects of perilymphatic pressure, sodium nitroprusside, and bupivacaine on cochlear fluid pH of guinea pigs

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Pages 1219-1224 | Received 18 Jun 2015, Accepted 21 Jul 2015, Published online: 01 Sep 2015

References

  • Ikeda K, Kusakari J, Takasaka T, Saito Y. Early effects of acetazolamide on anionic activities of the guinea pig endolymph: evidence for active function of carbonic anhydrase in the cochlea. Hear Res 1987;31:211–16.
  • Arakawa E, Marcus DC, Thalmann R. Dependence of endocochlear potential on vascular pH. Hear Res 1987;31:1–7.
  • Nimura Y, Mori Y, Inui T, Sohma Y, Takenaka H, Kubota T. Effects of CO2/HCO3–in perilymph on the endocochlear potential in guinea pigs. J Physiol Sci 2007;57:15–22.
  • Suzuki M, Wakayama T, Kotani R. Regulation of Cochlear Fluids pH: (I) The Role of Carbon Dioxide. Open Otorhinolaryngol J 2015;8:8–14.
  • Suzuki M, Wakayama T, Kotani R. Regulation of Cochlear Fluids pH: (II) The Role of Bicarbonate. Open Otorhinolaryngol J 2015;8:1–7.
  • Nakashima T, Suzuki T, Yanagita N. Cochlear blood flow under increased inner ear pressure. Ann Otol Rhinol Laryngol 1991;100:394–7.
  • Ohlsén KA, Didier A, Baldwin D, Miller JM, Nuttall AL. Cochlear blood flow in response to dilating agents. Hear Res 1992;58:19–25.
  • Nakashima T, Nuttall AL, Miller JM. Effects of vasodilating agents on cochlear blood flow in mice. Hear Res 1994;80:241–6.
  • Kristensen JD, Karlsten R, Gordh T. Spinal cord blood flow after intrathecal injection of ropivacaine and bupivacaine. Br J Clin Pharmacol 1998;42:685–90.
  • Hussain SSM, Ren TY, Nuttall JM, Miller JM. The Effects of bupivacaine on cochlear blood flow and input output functions of the ear in guinea pig. Abstr Assoc Res Otolaryngol 1995;18:153.
  • Suzuki M, Kikuchi T, Ikeda K. Endocochlear potential and endolymphatic K+ changes induced by gap junction blockers. Acta Otolaryngol 2004;124:902–6.
  • Tasaki I, Davis H, Eldredge DH. Exploration of cochlear potentials in guinea pigs with a microelectrode. J Acoust Soc Am 1954;26:765–73.
  • Takumida M, Anniko M. Direct evidence of nitric oxide production in the guinea pig organ of Cort. Acta Otolaryngol 2001;121:68–71.
  • Kong WJ, Ren T, Nuttall AL. Electrophysiological and morphological evaluation of the acute ototoxicity of sodium nitroprusside. Hear Res 1996;99:22–30.
  • Jiang ZG, Shi X, Zhao H, Si JQ, Nuttall AL. Basal nitric oxide production contributes to membrane potential and vasotone regulation of guinea pig in vitro spiral modiolar artery. Hear Res 2004;189:92–100.
  • Wang T. Nitric oxide regulates HCO3–and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule. Am J Physiol 1997;272:F242–8.
  • Tojo A, Guzman NJ, Garg LC, Tisher CC, Madsen KM. Nitic oxide inhibits bafilomycin-sensitive H+–ATPase activity in rat cortical collecting duct. Am J Physiol 1994;267:F509–15.
  • Stankovic KM, Brown D, Alper SL, Adams JC. Localization of pH regulating proteins H+ ATPase and Cl–/HCO3– exchanger in the guinea pig inner ear. Hear Res 1997;114:21–34.
  • Wangemann P, Nakaya K, Wu T, Maganti RJ, Itza EM, Sannemann JD, et al. Loss of cochlear HCO3– secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome. Am J Physiol Renal Physiol 2007;292:F1345–53.
  • Royaux IE, Belyantseva IA, Wu T, Kachar B, Everett LA, Marcus DC, et al. Localization and functional studies of pendrin in the mouse inner ear provide insight about the etiology of deafness in Pendred syndrome. JARP 2003;4:394–404.

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