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Research Article

Upregulation of N-acetylaspartic Acid Induces Oxidative Stress to Contribute in Disease Pathophysiology

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Pages 305-309 | Received 19 Dec 2010, Published online: 25 Feb 2011

REFERENCES

  • Baslow, M. H. (2000). Functions of N-Acetyl-l-aspartate and N-acetyl-L- aspartylglutamate in the vertebrate brain. Journal of Neurochemistry, 75, 453–459.
  • Bennet, M. J., Gibson, K. M., Sherwood, W. G., Divry, P., Rolland, M. O., (1993). Reliable prenatal diagnosis of Canavan disease (aspartoacylase deficiency): Comparison of enzymatic and metabolite analysis. Journal of Inherited Metabolic Disease, 16, 831–836.
  • Bhatnagar, M., Sharma, D., & Salvi, M. (2009). Neuroprotective effects of Withania somnifera: A possible mechanism. Journal Neurochemical Research, 34, 1975–1983.
  • Delaney, B. (2010). Acute oral toxicity of N-acetyl-l-aspartic acid (NAA) in rats. Food and Chemical Toxicology, 48, 1761.
  • Goldstein, F. B. (1969). The enzymatic synthesis of N-acetyl-L-aspartic acid by subcellular preparations of the rat brain. Journal of Biological Chemistry, 244, 4257–4260.
  • Hession, A. O., Esrey, E. G., Croes, R. A., & Maxwell, C. A. (2008). N-acetylglutamate and N-acetylaspartate in soybeans (Glycine max L.), maize (Zea maize L.), and other foodstuffs. Journal of Agricultural Food and Chemical, 56, 9121–9126.
  • Kaya, N., Fimtiaz, F., Colak, D., Al-Sayed, M., Al-Odaib, A., Al-Zahrani, F., (2008). Genome-wide gene expression profiling and mutation analysis of Saudi patients with Canavan disease. Genetics in Medicine, 10, 675–684.
  • Konov, S. (2007). HIV treatment bulletin conference reports. Retrieved on January 14, 2011 from http://www.aegis.com/files/i-base/2007/htbmay07.pdf
  • Lee, D.-H., & Pfeifer, G. P. (2007). Mutagenesis induced by the nitric oxide donor sodium nitroprusside in mouse cells. Mutagenesis, 22, 63–67.
  • Lin, W., Wei, X., Xue, H., Kelimu, M., Tao, R., Song, Y., (2000). Study on DNA strand breaks induced by sodium nitroprusside, a nitric oxide donor, in vivo and in vitro. Mutation Research, 466, 187–195.
  • Lin, W., Xue, H., Liu, S., He, Y., Fu, J., & Zhou, Z. (1998). Genotoxicity of nitric oxide produced from sodium nitroprusside. Mutation Research, 413, 121–127.
  • Nakano, T., Terato, H., Asagoshi, K., Masaoka, A., Mukuta, M., Ohyama, Y., (2003). DNA protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage. Journal of Biological Chemistry, 278, 25264–25272.
  • Nguyen, T., Brunson, D., Crespi, C. L., Penman, B. W., Wishnok, J. S., & Tannenbaum, S. R. (1992). DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proceedings of the National Academy of Sciences of the United States of America, 89, 3030–3034.
  • Okumura, F., Lenschow, D. J., & Zhang, D.-E. (2008). Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation. Journal of Biological Chemistry, 283, 24484–24488.
  • Pederzolli, C. D., Mescka, C. P., Magnusson, A. S., Deckmann, K. B., de Souza Streck, E., & Sgaravatti, A. M. (2010). N-acetylaspartic acid impairs enzymatic antioxidant defenses and enhances hydrogen peroxide concentration in rat brain. Metabolic Brain Disease, 25, 251–259.
  • Pederzolli, C. D., Mescka, C. P., Scapin, F., Rockenbach, F. J., Sgaravatti, A. M., Sgarbi, M. B., (2007). N-acetylaspartic acid promotes oxidative stress in cerebral cortex of rats. International Developmental Neuroscience, 25, 317–324.
  • Rajasankar, S., Manivasagam, T., Sankar, V., Prakash, S., Muthusamy, R., Krishnamurti, A., (2009). Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse. Journal of Ethnopharmacology, 125, 369–373.
  • Richter, E., Abramova, M., & Surendran, S. (2011). Parkinson's disease: Molecular changes and therapeutic approaches. In S. Surendran (ed.), Neurochemistry of metabolic diseases, lysosomal storage diseases, phenylketonuria and Canavan disease. New York: Nova Science. Retrieved on January 14, 2011 from https://www.novapublishers.com/catalog/product_info.php?products_id=21889
  • Sager, T. N., Thomsen, C., Valsborg, J. S., Laursen, H., & Hansen, A. J. (1999). Astroglia contain a specific transport mechanism for N-Acetyl-L-Aspartate. Journal of Neurochemistry, 73, 807–811.
  • Surendran, S. (2005). Canavan disease: Genomic interaction and metabolic levels. EXCLI Journal, 4, 77–86.
  • Surendran, S. (2008). N-acetyl aspartate induces nitric oxide to result neurodegeneration in Canavan disease. Bioscience Hypotheses, 1, 228–229.
  • Surendran, S. (2009). Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility. Molecular Biology Reports, 36, 201–206.
  • Surendran, S. (2010). Upregulation of N-acetylaspartic acid resulting nitric oxide toxicity induces aspartoacylase mutations and protein interaction to cause pathophysiology seen in Canavan disease. Medical Hypotheses, 75, 533–534.
  • Surendran, S., Bamforth, F. J., Chan, A., Tyring, S. K., Goodman, S. I., & Matalon, R. (2003). Mild elevation of N-acetylaspartic acid and macrocephaly: Diagnostic problem. Journal of Child Neurology, 18, 809–812.
  • Surendran, S., Kaya, N., & Ozand, P. (2011). Canavan disease: Molecular pathology, phenotype and therapeutic approaches. In S. Surendran (ed.) Neurochemistry of metabolic diseases, lysosomal storage diseases, phenylketonuria and Canavan disease. New York: Nova Science. Retrieved on January 14, 2011 from https://www.novapublishers.com/catalog/product_info.php?products_id=21889
  • Surendran, S., & Kondapaka, S. (2005). Altered expression of neuronal nitric oxide synthase in the duodenum longitudinal muscle-myenteric plexus (LM-MP) of obesity induced diabetes mouse: Implications on enteric neurodegeneration. Biochemical and Biophysical Research Communications, 338, 919–922.
  • Surendran, S., & Kumaresan, G. (2007). Neurochemical changes and therapeutic approaches in Canavan disease. In S. Surendran (ed.), Neurochemistry of metabolic diseases, lysosomal storage diseases, phenylketonuria and Canavan disease. Trivandrum, India: Transworld Research Network, 119–132.
  • Surendran, S., Matalon, R., & Tyring, S. K. (2006). Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: Implications on diabetic neuropathy. Biochemical and Biophysical Research Communications, 345, 973–975.
  • Surendran, S., & Rajasankar, S. (2010). Parkinson's disease: Oxidative stress and therapeutic approaches. Neurological Sciences, 31, 531–540.
  • Suzuki, T., Yamada, M., Ide, H., Kanaori, K., Tajima, K., Morii, T., (2000). Identification and characterization of a reaction product of 2’-deoxyoxanosine with glycine. Chemical Research in Toxicology, 13, 227–230.
  • Tacke, U., Olbrich, H., Sass, J. O., Fekete, A., Horvath, J., Ziyeh, S., (2005). Possible genotype-phenotype correlations in children with mild clinical course of Canavan disease. Neuropediatrics, 36, 252–255.
  • Taylor, D. L., Davies, S. E. C., Obrenovitch, T. P., Urenjak, J., Richards, D. A., Clark, J. B., (1994). Extracellular N-acetylaspartate in the rat brain: In vivo determination of basal levels and changes evoked by high K+. Journal of Neurochemistry, 62, 2349–2355.

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