Resolution of Dysarthria in Multiple Sclerosis by Treatment with Weak Electromagnetic Fields

References

• Acuna-Castroviejo D., Rosenstein R. E., Romeo H. E., Cardinali D. P. Changes in gamma-aminobutyric acid high affinity binding to cerebral cortex membranes after pinealectomy or melatonin administration to rats. Neuroendocrinology 1986a; 43: 24–31
   PubMed Web of Science ®Google Scholar
• Acuna-Castroviejo D., Lowenstein P. R., Rosenstein R. E., Cardinali D. P. Diumal rhythm of benzodiazepine binding in rat cerebral cortex: disruption by pinealectomy. Journal of Pineal Research 1986b; 3: 101–109
   PubMed Web of Science ®Google Scholar
• Achar V. S., Welch K. M. A., Chabi E., Banosh K., Meyer J. S. Cerebrospinal fluid gamma-aminobutyric acid in neurological disease. Neurology 1976; 26: 777–780
   PubMed Web of Science ®Google Scholar
• Aldegunde M., Miquez I., Veira J. Effects of pinealectomy on regional brain serotonin metabolism. International Journal of Neuroscience 1985; 26: 9–13
   PubMed Web of Science ®Google Scholar
• Anton-Tay F. Melatonin: effects on brain function. Advances in Biochemical Psychopharmacology 1974; 11: 315–324
   PubMedGoogle Scholar
• Anton-Tay F., Chou C., Anton S., Wurtman R. J. Brain serotonin concentration; elevation following intraperitoneal administration of melatonin. Science 1968; 162: 277–278
   PubMed Web of Science ®Google Scholar
• Anton-Tay F., Diaz J. L., Fernandez-Guardiola A. On the effect of melatonin upon human brain. Its possible therapeutic implications. Life Sciences 1973; 10: 841–850
   Google Scholar
• Armstrong D. L., Hay M., Terrian D. M. Modulation of cerebellar granule cell activity by iontophoretic application of serotonergic agents. Brain Research Bulletin 1987; 19: 699–704
   PubMed Web of Science ®Google Scholar
• Bairy N., Pimental P. A., Langenberg P. W. A double-blind trial of clonazepam in the treatment of parkinsonian dysarthria. Neurology 1988; 38: 255–258
   PubMed Web of Science ®Google Scholar
• Bauer H. J. Problems of symptomatic therapy in multiple sclerosis. Neurology 1978; 28: 8–20
   PubMed Web of Science ®Google Scholar
• Bawin S. M., Adey W. R. Sensitivity of calcium binding in cerebral tissue to weak environmental electric fields oscillating at low frequency. Proceedings of the National Academy of Sciences, USA 1976; 73: 1999–2003
   PubMed Web of Science ®Google Scholar
• Bishop G. A., Ho R. H. The distribution and origin of serotonin immunoreactivity in the rat cerebellum. Brain Research 1985; 331: 195–207
   PubMed Web of Science ®Google Scholar
• Blackman C. F. Stimulation of brain tissue in vitro by extremely low frequency, low intensity, sinusoidal electromagnetic fields. Electromagnetic fields and neurobehavioral function, M. E. O'Connor, R. H. Lovely. Alan R. Liss, New York 1988
   Google Scholar
• Calne D. B., Klawans H. L. Pathophysiology and pharmacotherapy of tremor. Pharmacology and Therapy 1977; 2: 113–123
   Web of Science ®Google Scholar
• Cardinali D. P. Changes in hypothalamic neurotransmitter uptake following pinealectomy. superior cervical ganglionectomy or melatonin administration to rats. Neuroendocrinology 1975; 19: 91–95
   PubMed Web of Science ®Google Scholar
• Cardinali D. P., Vacas M. I., Estevez-Boyer E. Specific binding for melatonin in bovine brain. Endocrinology 1979; 105: 437–441
   PubMed Web of Science ®Google Scholar
• Chan-Palay V. Cerebellar dentate nucleus: organization, cytology and transmitters. Springer Verlag, Heidelberg 1977; 199–207
   Google Scholar
• Charcot J. M. Lectures on the diseases of the nervous system. New Sydenham Society, London 1877; Vol. 1
   Google Scholar
• Claveria L. E., Curzon C, Harrison M. J. G., Kantamaneni B. D. Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1974; 37: 715–718
   PubMed Web of Science ®Google Scholar
• Costa E., Guidotti A., Toffano C. Molecular mechanisms mediating the action of diazepam on GAB A receptors. British Journal of Psychiatry 1978; 133: 239–248
   PubMed Web of Science ®Google Scholar
• Cotzias G. C., Tang L. C., Miller S. T., Ginos J. Z. Melatonin and abnormal movements induced by L-dopa in mice. Science 1971; 173: 450–452
   PubMed Web of Science ®Google Scholar
• Darley F. L., Aronson A. E., Brown J. R. Motor speech disorders. W. B. Saunders Company, Philadelphia 1975; 229–249
   Google Scholar
• Davidson D., Pullar I. A., Mawdsley C., Kinloch N., Yates C. M. Monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry 1977; 40: 741–745
   PubMed Web of Science ®Google Scholar
• Defeadis F. V. Amino acids as central neurotransmitters. Annual Review of Pharmacology & Toxicology 1975; 15: 105–130
   Web of Science ®Google Scholar
• DeJong R. N. The neurologic examination, 4th edition. Harper & Row, Philadelphia 1979; 318–328
   Google Scholar
• Demaine C., Semm P. The avian pineal gland as an independent magnetic sensor. Neuroscience Letters 1985; 62: 119–122
   PubMed Web of Science ®Google Scholar
• Demaine C., Semm P. Magnetic fields abolish the nychthemeral rhythmicity of responses of Purkinje cells to the pineal hormone melatonin in the pigeon's cerebellum. Neuroscience Letters 1986; 72: 158–162
   PubMed Web of Science ®Google Scholar
• Dixey R., Rein G. (3H) Noradrenaline release potentiated in a clonal cell line by low intensity pulsed magnetic fields. Nature 1982; 206: 253–256
   Google Scholar
• Fahn S., Cote L. J. Regional distribution of gamma-aminobutyric acid in brain of the rhesus monkey. Journal of Neurochemistry 1968; 15: 209–213
   PubMed Web of Science ®Google Scholar
• Ghez C. The cerebellum. Principles of neural science, E. R. Kandel, J. H. Schwartz, T. M. Jessel. Elsevier, New York 1991; 626–646
   Google Scholar
• Gilman S., Bloedel J., Leehtenberg R. Disorders of the cerebellum. F. A. Davis, Philadelphia 1981
   Google Scholar
• Giesser B. Multiple sclerosis. Current concepts in management. Drugs 1985; 29: 88–95
   PubMed Web of Science ®Google Scholar
• Harrer G., Fischbach R. Uher die wirkung hestimmter aminosauren auf das ergebniss des unberwarmungstests bein multiple sclerose kranken. Journal of Neural Transmission 1973; 34: 205–214
   PubMed Web of Science ®Google Scholar
• Hermann A. B., Gorman A. L. F. Effects of 4-aminopyridine on potassium currents in a molluscan neuron. Journal of General Physiology 1981; 78: 63–86
   PubMed Web of Science ®Google Scholar
• Hokfelt T., Fuxe K. Cerebellar monomine nerve terminals, a new type of afferent fibers to the cortex cerebelli. Experimental Brain Research 1969; 9: 63–72
   PubMed Web of Science ®Google Scholar
• Hyyppa M. T., Jolma T., Riekkinen P., Rinne U. K. Effects of L-tryptophan on central indoleamine metabolism and short-lasting neurologic disturbances in multiple sclerosis. Journal of Neural Transmission 1975; 37: 297–305
   PubMed Web of Science ®Google Scholar
• Izumi K., Donaldson J., Minnich J., Barbeau A. Quabain-induced seizures in rats: modification by melatonin and melanocyte-stimulating hormone. Canadian Journal of Physiology and Pharmacology 1973; 51: 572–578
   PubMed Web of Science ®Google Scholar
• Jacobs B. L., Fomal C. A. 5-HT and motor control: a hypothesis. Trends in Neurosciences 1993; 16: 346–352
   PubMed Web of Science ®Google Scholar
• Jaffe K. A., Laszewski B. L., Carr D. B., Phillips R. D. Chronic exposure to a 60-Hz electric field: effects on synaptic transmission and peripheral nerve function in the rat. Bioelectromagnetics 1980; 1: 131–147
   PubMedGoogle Scholar
• Jenner P., Chadwick D., Reynolds E. D., Marsden C. D. Altered 5-HT metabolism with clonazepam, diazepam, and diphenylhydantoin. Journal of Pharmacy & Pharmacology 1975; 27: 707–710
   PubMed Web of Science ®Google Scholar
• Johansson B., Ross B. E. 5-hydroxyindoleacetic acid and homovanillic acid in CSF of patients with neurological disease. European Neurology 1977; 11: 37–45
   Web of Science ®Google Scholar
• Kisser W., Harrer G. Amino acid determinations in serum of patients with multiple sclerosis. Wiener Klinische Wochenschrift 1974; 86: 80–82
   PubMed Web of Science ®Google Scholar
• Kremer M., Russell W. R., Smyth G. E. A mid-brain syndrome following head injury. Journal of Neurology Neurosurgery and Psychiatry 1947; 10: 49–40
   PubMed Web of Science ®Google Scholar
• Kuroda H., Ogawa N., Yamawaki Y., Nukina I., Ofuji T., Yamamoto M., Otsuki S. Cerebrospinal fluid GAB A levels in various neurological and psychiatric diseases. Journal of Neurology Neurosurgery and Psychiatry 1982; 45: 257–260
   PubMed Web of Science ®Google Scholar
• Laudon M., Nir I., Zisapel N. Melatonin receptors in discrete brain areas of the male rat. Impact of aging on density and on circadian rhythmicity. Neuroendocrinology 1988; 48: 577–583
   PubMed Web of Science ®Google Scholar
• Lechtenberg R., Gilman S. Speech disorders in cerebellar disease. Annals of Neurology 1978; 3: 785–290
   Web of Science ®Google Scholar
• Lowenstein P. R., Rosenstein R., Cardinali D. P. Melatonin reverses pinealectomy-induced decrease of henzodiazepine binding in rat cerebral cortex. Neurochemistry International 1985; 7: 675–681
   PubMed Web of Science ®Google Scholar
• Luca N., Hategan D. Determination of serotonin content and ceruloplasmin activity of blood and CSF amino acid level in multiple sclerosis. Review Roumanian Medicine—Neurology and Psychiatry 1986; 21: 153–159
   Google Scholar
• Markianos M., Sfagos C. Altered serotonin uptake kinetics in multiple sclerosis. Journal of Neurology 1988; 235: 236–237
   PubMed Web of Science ®Google Scholar
• Maura G., Roccatagliata E., Ulivi M., Raiteri M. Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HT, and 5-HT, receptors. European Journal of Pharmacology 1988; 145: 31–38
   PubMed Web of Science ®Google Scholar
• Miledi R. Transmitter release induced by injection of calcium ions into nerve terminals. Proceedings of the Royal Society of Biological Sciences 1973; 183: 421–428
   PubMed Web of Science ®Google Scholar
• Monaco F., Fumero S., Mondino A., Mutani R. Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases. Journal of Neurology, Neurosurgery and Psychiatry 1979; 42: 640–441
   PubMed Web of Science ®Google Scholar
• Moszkowska A., Kordon C., Ebels I. Biochemical fractions and mechanisms involved in the pined modulation of pituitary gonadotropin release. The pineal gland, G. E. W. Wolstenholme, J. Knight. Churchill Livingstone, London 1971; 241–258
   Google Scholar
• Obata K., Takeda K. Release of gamma-aminobutyric acid into the fourth ventricle induced by stimulation of the cat's cerebellum. Journal of Neurochemistry 1969; 16: 1043–1047
   PubMed Web of Science ®Google Scholar
• Olsen R. W. GABA-benzodiazepine-barbiturate receptor interactions. Journal of Neurochemistry 1981; 37: 1–13
   PubMed Web of Science ®Google Scholar
• Ossenkopp K. P., Cain D. P. Inhibitory effects of acute exposure to low-intensity 60-Hz magnetic fields on electrically kindled seizures in rats. Brain Research 1988; 442: 255–260
   PubMed Web of Science ®Google Scholar
• Pazo J. H. Effects of melatonin on spontaneous and evoked neuronal activity in the mesencephalic reticular formation. Brain Research Bulletin 1979; 4: 725–730
   PubMed Web of Science ®Google Scholar
• Plaitakis A., Nicklas W. J., Berl S. Thiamine deficiency: selective impairment of the cerebellar serotonergic system. Neurology 1978; 28: 691–498
   PubMed Web of Science ®Google Scholar
• Poser C. M. Diseases of the myelin sheath. A texrbook of neurology, H. H. Merritt. Lea & Febiger, Philadelphia 1973; 683–705
   Google Scholar
• Pryse-Phillips W., Murray T. J. Essential neurology. Medical Examination Publishing Co., Inc, New York 1978; 188–191
   Google Scholar
• Rascol A., Clanet M., Montastruc J. L., Delage W., Guiraud-Chaumeil B. L-5-hydroxytrophan in the cerebelalr syndrome treatment. Biomedicine 1981; 35: 112–113
   PubMedGoogle Scholar
• Reichardt L. F., Kelly R. B. A molecular description of nerve terminal function. Annual Review of Biochemistry 1983; 52: 871–926
   PubMed Web of Science ®Google Scholar
• Rosen A. D. Magnetic field influence on acetylcholine release at the neuromuscular junction. American Journal of Physiology 1992; 262: C1418–C1422, (cell physiol. 31)
   PubMed Web of Science ®Google Scholar
• Rosen A. D., Lubowsky J. Magnetic fields influence on central nervous system function. Experimental Neurology 1987; 95: 679–487
   PubMed Web of Science ®Google Scholar
• Rosenstein R. E., Cardinali D. P. Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland. Brain Research 1986; 398: 403–406
   PubMed Web of Science ®Google Scholar
• Rudick R. A., Goodkin D. E., Ransohoff R. M. Pharmacotherapy of multiple sclerosis: current status. Cleveland Clinic Journal of Medicine 1992; 59: 267–277
   PubMed Web of Science ®Google Scholar
• Rudolph K., Win-Justice A., Krauchi K., Feer H. Static magnetic fields decrease nocturnal pineal cAMP in the rat. Brain Research 1988; 446: 159–160
   PubMed Web of Science ®Google Scholar
• Rusovan A., Kanje M. D600, a Ca++ antagonist, prevents stimulation of nerve regeneration by magnetic fields. NeuroReport 1992a; 3: 813–814
   PubMed Web of Science ®Google Scholar
• Rusovan A., Kanje M. Magnetic fields stimulate peripheral nerve regeneration in hypophysectomized rats. NeuroReport 1992b; 3: 1039–1041
   PubMed Web of Science ®Google Scholar
• Rusovan A., Kanje M., Mild K. H. The stimulatory effect of magnetic fields on regeneration of the rat sciatic nerve is frequency dependent. Experimental Neurology 1992; 117: 81–84
   PubMed Web of Science ®Google Scholar
• Russell J. W., Windebank A. J., Harper C. M. Treatment of stable chronic demyelinating polyneuropathy with 3,4-diaminopyridine. Mayo Clinic Proceedings 1995; 70: 532–539
   PubMed Web of Science ®Google Scholar
• Sallanon M., Claustrat B., Touret M. Presence of melatonin in various cat brainstem nuclei determined by radioimmunoassay. Acta Endocrinologica 1982; 101: 161–165
   PubMedGoogle Scholar
• Sandyk R. Successful treatment of cerebellar tremor with clonazepam. Clinical Pharmacy 1985; 4: 615–618
   PubMedGoogle Scholar
• Sandyk R. L-tryptophan in neuropsychiatric disorders: a review. International Journal of Neuroscience 1992a; 63: 127–144
   Google Scholar
• Sandyk R. The pineal gland and multiple sclerosis. (Editorial). International Journal of Neuroscience 1992b; 63: 206–215
   Web of Science ®Google Scholar
• Sandyk R. Demyelination as an epiphenomenon in multiple sclerosis. International Journal of Neuroscience 1993; 72: 141–148
   PubMedGoogle Scholar
• Sandyk R., Dann L. C. Weak electromagnetic fields attenuate tremor in multiple sclerosis. International Journal of Neuroscience 1994; 79: 199–212
   PubMed Web of Science ®Google Scholar
• Sandyk R., Iacono R. P., Fisher H. Posttraumatic cerebellar syndrome: response to L-tryptophan. International Journal of Neuroscience 1989; 47: 301–302
   PubMed Web of Science ®Google Scholar
• Schmidt R. F. Grundriss der neurophysiologie. Springer-Verlag, Berlin 1972; 83–87
   Google Scholar
• Semm P., Vollrath L. Alterations in the spontaneous activity of cells in the guinea pig pineal gland and visual system produced by pineal indoles. Journal of Neural Transmission 1982; 53: 265–275
   PubMed Web of Science ®Google Scholar
• Semm P., Vollrath L. Electrical responses of homing pigeon and guinea pig Purkinje cells to pineal indoleamines applied by microelectrophoresis. Journal of Comparative Physiology 1984; 154: 675–681
   Web of Science ®Google Scholar
• Semm P. Neurobiological investigations on the magnetic sensitivity of the pineal gland in rodents and pigeons. Comparative Biochemistry and Physiology 1983; 76A: 683–689
   Web of Science ®Google Scholar
• Semm P., Nohr D., Demaine C., Wiltschko W. Neural basis of the magnetic compass: interactions of visual, magnetic and vestibular inputs in the pigeon's brain. Journal of Comparative Physiology 1982; 155: 283–288
   Web of Science ®Google Scholar
• Shinnar S., Maciewicz R. J., Shofer R. J. A raphe projection to cat cerebellar cortex. Brain Research 1975; 97: 139–144
   PubMed Web of Science ®Google Scholar
• Sibley W. A. The diagnosis and course of multiple sclerosis. Neurobehavioral aspects of multiple sclerosis, S. M. Rao. Oxford University Press, New York 1990
   Google Scholar
• Smith A. R., Kappers J. A. Effect of pinealectomy, gonadectomy, pCPA and pineal extracts on the rat parvocellular neurosecretory hypothalamic system: a fluorescence histochemical investigation. Brain Research 1975; 86: 353–371
   PubMed Web of Science ®Google Scholar
• Sonninen V., Riekkinen P., Rinne U. K. Acid monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Neurology 1973; 23: 760–763
   PubMed Web of Science ®Google Scholar
• Sperber D., Dransfield K., Maret G., Weisenseel M. H. Oriented growth of pollen tubes in strong magnetic field. Naturwissenschaften 1981; 68: 40–43
   Web of Science ®Google Scholar
• Strahlendorf J. C., Barnes C. D. Modulation of cerebellar neuronal activity by raphe stimulation. Brain Research 1979; 169: 565–569
   PubMed Web of Science ®Google Scholar
• Strahlendorf J. C., Hubbard G. D. Serotonergic interactions with rat cerebellar Purkinje cells. Brain Research Bulletin 1983; 11: 265–269
   PubMed Web of Science ®Google Scholar
• Strahlendorf J. C., Lee M., Strahlendorf H. K. Effects of serotonin on cerebellar Purkinjee cells are dependent on the baseline firing rate. Experimental Brain Research 1984; 56: 50–58
   PubMed Web of Science ®Google Scholar
• Sugden D., Morris R. D. Changes in regional brain levels of tryptophan, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, dopamine and noradrenaline after pinealectomy. Journal of Neurochemistry 1979; 32: 1593–1594
   PubMed Web of Science ®Google Scholar
• Tabaddor K., Wolfson L. I., Sharpless N. S. Ventricular fluid homovanillic acid and 5-hydroxyin-doleacetic acid concentrations in patients with movement disorders. Neurology 1978; 28: 1249–1253
   PubMed Web of Science ®Google Scholar
• Takeuchi Y., Kimura H., Sano Y. Immunohistochemical demonstration of serotonin-containing nerve fibers in the cerebellum. Cell Tissue Research 1982; 226: 1–12
   PubMed Web of Science ®Google Scholar
• Trelles L., Trelles J. O., Castro C., Altamirano J., Benzaquen M. Successful treatment of two cases of intention tremor with clonazepam. Annals of Neurology 1984; 16: 621
   PubMed Web of Science ®Google Scholar
• Trouillas P., Brudon F., Adeleine P. Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. Archives of Neurology 1988; 45: 1217–1222
   PubMed Web of Science ®Google Scholar
• Trouillas P., Gaval P., Robert J. M., Adeleine P., Jouvet M. Regression de l'ataxie cerebelleuse humaine sous administration a long terme de 5-hydroxytryptophan. C. R. Academie Science (Paris) 1981; 292: 111–119
   Google Scholar
• Van Diemen H. A. M., Polman C. H., Van Dongen M. M. M. M., Nauta J. J. P., Strijen R. L. M., Van Loenen A. C., Bertelsmann F. W., Koetsier J. C. 4-aminopyridine induces functional improvement in multiple sclerosis patients: a neuropsychiological study. Journal of the Neurological Sciences 1993; 116: 220–226
   PubMed Web of Science ®Google Scholar
• Van Woert M. H., Chung Hwang E. Treatment of myoclonus. Disorders of movement, A. Barbeau. MTP Press, LancasterEngland 1981; 59–80
   Google Scholar
• Walton J. N. Brain's diseases of the nervous system. Oxford University Press, Oxford 1977; 550
   Google Scholar
• Welker H. A., Semm P., Willig R. P., Commentz J. C., Wiltschko W., Vollrath L. Effects of an artificial magnetic field on serotonin N-acetyltransferase activity and melatonin content of the rat pineal gland. Experimental Brain Research 1983; 50: 42–32
   Web of Science ®Google Scholar
• Wilson B. W., Chess E. K., Anderson L. E. 60-Hz electric-field effects on pineal melatonin rhythms: time course for onset and recovery. Bioelectromagnetics 1986; 7: 239–242
   PubMed Web of Science ®Google Scholar
• Wilson B. W., Stevens R. G., Anderson L. E. Neuroendocrine mediated effects of electromagnetic field exposure: possible role of the pineal gland. Life Sciences 1989; 45: 1319–1332
   PubMed Web of Science ®Google Scholar
• Zeise M. L., Semm P. Melatonin lowers excitability of guinea pig hippocampal neurons in vitro. Journal of Comparative Physiology 1985; 157: 23–29
   PubMed Web of Science ®Google Scholar