Tryptophan Availability and the Susceptibility to Stress in Multiple Sclerosis: A Hypothesis

References

• Abou-Saleh M. T., Coppen A. J. Classification of depressive illness: clinico-psychological correlates. Journal of Affective Disorder 1984; 6: 53–66
   PubMed Web of Science ®Google Scholar
• Ackenheil M. Hormone response to stress in mental illness. Handbook of biological psychiatry, H. M. Van Praag, M. H. Lader, O. J. Rafaelson, E. J. Sachar. Marcel Dekker, New York 1980; 195–215, (part 111)
   Google Scholar
• Ader R., Felten D., Cohen N. Interactions between the brain and the immune system. Annual Review of Pharmacology and Toxicology 1990; 30: 561–602
   PubMed Web of Science ®Google Scholar
• Ashcroft G. W., Crawford T. B. B., Cundall R. L., Davidson D. L., Dobson J., Dow R. C., Eccleston D., Loose R. W., Pullar I. A. 5-hydroxytryptamine metabolism in affective illness: the effect of tryptophan administration. Psychological Medicine 1973; 3: 326–332
   PubMedGoogle Scholar
• Beaulieu S., Paolo T. D., Barden N. Implication of the serotonergic system in the decreased ACTH response to stress after lesion of the amygdaloid central nucleus. Progress in Neuropsychopharmacology and Biological Psychiatry 1985; 9: 665–669
   PubMedGoogle Scholar
• Bender D. A., Totoe L. High doses of vitamin B6 in the rat are associated with inhibition of hepatic tryptophan metabolism and increased uptake of tryptophan into the brain. Journal of Neurochemistry 1984; 43: 733–736
   PubMedGoogle Scholar
• Birkmeyer W., Iselstoeger H., Seemann D. Hormonstatus und Verlaufsform der Multiple Sklerose. Klinische Medizine 1955; 10: 550–554
   Google Scholar
• Blalock J. E. A molecular basis for bidirectional communication between the immune system and neuroendocrine systems. Physiological Reviews 1989; 69: 1–32
   PubMed Web of Science ®Google Scholar
• Blalock J. E. Molecular mechanisms of bidirectional communication between the immune and neuroendocrine systems. International Journal of Neuroscience 1990; 51: 363–364
   PubMed Web of Science ®Google Scholar
• Bliss E. L., Ailion J., Zwanziger J. Metabolism of norepinephrine, serotonin and dopamine in rat brain with stress. Journal of Pharmacology and Experimental Therapeutics 1968; 164: 122–134
   PubMed Web of Science ®Google Scholar
• Brickner R. M., Simon D. J. Emotional stress in relation to attacks of multiple sclerosis. Association for Research in Nervous Disorders Proceedings 1950; 28: 143–146
   PubMedGoogle Scholar
• Chelmicka-Schorr E., Arnason B. G. Nervous system-immune system interactions and their role in multiple sclerosis. Annals of Neurology 1994; 36: S29–S32, (suppl)
   Google Scholar
• Chouinard G., Young S. N., Annable L., Sourkes T. L. Tryptophan-nicotinamide combination in depression. Lancet 1977; 1: 249
   PubMedGoogle Scholar
• Claustrat B., Chazot G., Brun J., Jordan D., Sassolas G. A chronobiological study of melatonin and Cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biological Psychiatry 1984; 19: 1215–1228
   PubMed Web of Science ®Google Scholar
• Claveria L. E., Curzon G., Harrison M. J. G., Kantamaneni B. D. Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1974; 37: 715–718
   PubMed Web of Science ®Google Scholar
• Coppen A. J., Eccleston E. G., Peet M. Total and free tryptophan concentration in the plasma of depressive subjects. Lancet 1973; 2: 60–63
   PubMed Web of Science ®Google Scholar
• Coppen A. J., Doogan D. P. Serotonin and its place in the pathogenesis of depression. Journal of Clinical Psychiatry 1988; 49: 4–11, (suppl. 8)
   PubMedGoogle Scholar
• Curzon G., Green Ar. Effect of hydrocortisone on rat brain 5-hydroxytryptamine. Life Sciences 1968; 7: 657
   PubMed Web of Science ®Google Scholar
• Curzon G., Joseph M. H., Knott P. J. Effects of immobilization and food deprivation on rat brain tryptophan metabolism. Journal of Neurochemistry 1972; 19: 1967–1974
   PubMed Web of Science ®Google Scholar
• Davidson D., Pullar I. A., Mawdsley C, Kinloch N., Yates C. M. Monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry 1977; 40: 741–745
   PubMed Web of Science ®Google Scholar
• DeKloat E. R., Sybesma H., Reul H. H. Selective control by corticosterone of serotonin 1 receptor capacity in raphe-hippocampal system. Neuroendocrinology 1986; 42: 513–521
   PubMedGoogle Scholar
• Demeyer M. K., Shea P. A., Hendrie H. C., Yoshimura N. N. Plasma tryptophan and five other amino acids in depressed and normal subjects. Archives of General Psychiatry 1981; 38: 642–646
   PubMedGoogle Scholar
• Eccleston D., Aschcroft G. W., Crawford T. B. B., Stanton J. B., Wood D., McTurk P. H. Effect of tryptophan administration on 5-HIAA in cerebrospinal fluid in man. Journal of Neurology Neurosurgery and Psychiatry 1970; 33: 269–272
   PubMedGoogle Scholar
• Fernstrom J. D., Wurtman R. J. Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 1971; 173: 149–152
   PubMed Web of Science ®Google Scholar
• Femstrom J. D., Wurtman R. J. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 1972; 178: 414–416
   PubMedGoogle Scholar
• Fernstrom J. D., Faller D. V. Neutral amino acids in the brain: changes in response to food ingestion. Journal of Neurochemistry 1978; 30: 1531–1538
   PubMed Web of Science ®Google Scholar
• Francis G. S., Antel J. P., Duquette P. Inflammatory demyelinating diseases of the CNS. Neurology in clinical practice, W. G. Bradley, B. Daroff, G. M. Fenichel, C. D. Marsden. Butterworth, Boston 1990; 1154
   Google Scholar
• Franklin G., Nelson L., Haeton R. Stress and its relationship to acute exacerbation in MS. Journal of Neurological Rehabilitation 1988; 2: 7–11
   Google Scholar
• Freire-Garabal M., Nunez-Iglesias M. J., Balboa J. L., Fernandez-Rial J. C., Rey-Mendez M. Effects of buspirone on the immune response to stress in mice. Pharmacology Biochemistry and Behavior 1995; 51: 821–825
   PubMedGoogle Scholar
• Frohman L. A. Neurotransmitters as regulators of endocrine function. Neuroendocrinology, D. T. Krieger, J. C. Hughes. Sinauer Associates, Inc, Sunderland, Massachusetts 1980; 44–57
   Google Scholar
• Fuller R. W. Serotonergic stimulation of pituitary-adrenocortical function in rats. Neuroendocrinology 1981; 32: 118–124
   PubMed Web of Science ®Google Scholar
• Fuller R. W., Snoddy H. D., Clemens J. A. The effect of quipazine, a serotonin receptor agonist, on serum corticosterone concentration in rats. Endocrine Research Communications 1978; 5: 161–171
   PubMed Web of Science ®Google Scholar
• Gard P. R., Hand Jey S. L., Parsons A. D. A multivariate investigation of postpartum mood disturbances. British Journal of Psychiatry 1986; 148: 567–575
   PubMed Web of Science ®Google Scholar
• Grant I., Brown G., Harris T. Severely threatening events and marked life difficulties preceding onset or exacerbation of MS. Journal of Neurology Neurosurgery and Psychiatry 1989; 52: 8–13
   PubMed Web of Science ®Google Scholar
• Growdon J. H., Cohen E. L., Wurtman R. J. Treatment of brain disease with dietary precursors of neurotransmitters. Annals of Internal Medicine 1977; 86: 337–339
   PubMedGoogle Scholar
• Hamon M., Bourgoin S., Artaud F., El Mestikawy S. The respective roles of tryptophan uptake and tryptophan hydroxylase in the regulation of serotonin synthesis in the central nervous system. Journal of Physiology (Paris) 1981; 77: 269–279
   PubMed Web of Science ®Google Scholar
• Handley S. L., Dunn T. L., Waldron G. Tryptophan, Cortisol, and puerperal mood. British Journal of Psychiatry 1980; 136: 498–508
   PubMed Web of Science ®Google Scholar
• Hedaya R. J. Pharmacokinetic factors in the clinical use of tryptophan. Journal of Clinical Psychopharmacology 1984; 4: 347–348
   PubMedGoogle Scholar
• Hillier J., Hillier J. G., Redfern P. H. Liver tryptophan pyrrolase activity and metabolism of brain 5HT in rat. Nature 1975; 253: 566–569
   PubMedGoogle Scholar
• Hollister L. E., Davis K. L., Morrison Davis B. Hormones in the treatment of psychiatric disorders. Neuroendocrinology, D. T. Krieger, J. C. Hughes. Sinauer Associates, Inc, Sunderland, Massachusetts 1980; 167–175
   Google Scholar
• Hyyppa M. T., Jolma T., Riekkinen P., Rinne U. K. Effects of L-tryptophan on central indoleamine metabolism and short-lasting neurologic disturbances in multiple sclerosis. Journal of Neural Transmission 1975; 37: 297–304
   PubMed Web of Science ®Google Scholar
• Imura H., Nakai Y., Yoshimi T. Effect of 5-hydroxytryptophan on growth hormone and ACTH release in man. Journal of Clinical Endocrinology and Metabolism 1973; 36: 204–211
   PubMed Web of Science ®Google Scholar
• Johansson B., Ross B. E. 5-hydroxyindoleacetic acid and homovanillic acid in CSF of patients with neurological disease. European Neurology 1977; 11: 37–45
   Web of Science ®Google Scholar
• Jones M. T., Hillhouse E. W., Burden J. Effect of various putative neurotransmitters on the secretion of corticotrophin releasing hormone from the rat hypothalamus in vitro. A model of the neurotransmitters involved. Journal of Endocrinology 1976; 69: 1–20
   PubMed Web of Science ®Google Scholar
• Joseph M. H., Kennett G. A. Corticosteroid response to stress depends upon increased tryptophan availability. Psychopharmacology 1983; 79: 79–81
   PubMedGoogle Scholar
• Kennett G. A., Joseph M. H. Stress induced increases in 5HT release, measured in vivo, depend upon increased tryptophan availability. Neuroscienmce Letters 1981a; 7: S56, (suppl)
   Google Scholar
• Kennett G. A., Joseph M. H. The functional importance of increased brain tryptophan in the serotonergic response to restraint stress. Neuropharmacology 1981b; 20: 39–43
   PubMedGoogle Scholar
• Kisser W., Harrer G. Amino acid determinations in serum of patients with multiple sclerosis. Wiener Klinische Wochenschrift 1974; 86: 80–82
   PubMed Web of Science ®Google Scholar
• Kopin I. J. Catecholamines, adrenal hormones, and stress. Neuroendocrinology, D. T. Krieger, J. C. Hughes. Sinauer Associates, Inc, Sunderland, Massachusetts 1980; 159–166
   Google Scholar
• Lewis D. A., Sherman B. M. Serotonergic stimulation of adrenocorticotrophin secretion in man. Journal of Clinical Endocrinology and Metabolism 1984; 58: 458–467
   PubMed Web of Science ®Google Scholar
• Luga N., Hategan D. Determination of serotonin content and ceruloplasmin activity of blood and CSF amino acid level in multiple sclerosis. Review Roumanian Medicine–Neurology and Psychiatry 1986; 24: 153–159
   Google Scholar
• Lynch H. J., Deng M. H. Pineal responses to stress. Journal of Neural Transmission 1986; 21: 461–473, (suppl)
   Google Scholar
• Madaras B. K., Cohen E. L., Messing R., Munro H. N., Wurtman R. J. Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan. Nature 1973; 244: 34–35
   PubMedGoogle Scholar
• Meltzer M. Y., Lowry M. T. The serotonin hypothesis of depression. Psychopharmacology: the third generation in progress, M. Y. Meltzer. Raven Press, New York 1987; 513–526
   Google Scholar
• Moller S. E. Evaluation of the relative potency of individual competing amino acids to tryptophan transport in endogenously depressed patients. Psychiatry Research 1980; 3: 141–150
   PubMedGoogle Scholar
• Monaco F., Fumero S., Mondino A., Mutani R. Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases. Journal of Neurology, Neurosurgery and Psychiatry 1979; 42: 640–641
   PubMed Web of Science ®Google Scholar
• Mueller G. P., Twohy C. P., Chen H. T., Advis J. P., Meites J. Effects of L-tryptophan and restraint stress on hypothalamic and brain serotonergic turnover and pituitary TSH and prolactin release in rats. Life Sciences 1976; 18: 715–724
   PubMedGoogle Scholar
• Natelson B. H., Janocko L., Jacoby J. H. An interaction between dietary tryptophan and stress in exacerbating gastric disease. Physiology and Behavior 1981; 26: 197–200
   PubMed Web of Science ®Google Scholar
• Neckers L., Sze P. Y. Regulaton of 5-hydroxytryptamine metabolism in mouse brain by adrenal corticosteroids. Brain Research 1975; 93: 123–132
   PubMedGoogle Scholar
• Pardridge W. M. Kinetics of competitive inhibition of neutral amino acid transport across the blood brain barrier. Journal of Neurochemistry 1977; 28: 10–18
   Google Scholar
• Paykel E. S. Contribution of life events to causation of psychiatric illness. Psychological Medicine 1978; 8: 245–253
   PubMed Web of Science ®Google Scholar
• Perez-Cruet J., Tagliamonte A., Tagliamonte P., Gessa G. L. Changes in brain serotonin metabolism associated with fasting and satiation in rats. Life sciences 1972; 11: 31–39
   Google Scholar
• Plonk J. W., Bivens C. H., Feldman J. M. Inhibition of hypoglycemia-induced Cortisol secretion by the serotonin antagonist cyproheptadine. Journal of Clinical Endocrinology and Metabolism 1974; 38: 836–845
   PubMedGoogle Scholar
• Poser C. M. Multiple sclerosis. Observations and reflections–a personal memoir. Journal of the Neurological Sciences 1992; 107: 127–140
   PubMed Web of Science ®Google Scholar
• Reichlin S. Neuroendocrine-immune interactions. New England Journal of Medicine 1993; 329: 1246–1253
   PubMed Web of Science ®Google Scholar
• Richardson Morton K. D., Van de Kar L. D., Lorens S. A. Stress-induced renin and corticosterone release: effect of dorsal raphe lesions and 5-HT2 antagonist. Federation Proceedings 1986; 45: 674
   Google Scholar
• Rose D. P. The influence of sex, age and breast cancer on tryptophan metabolism. Clinica Chimica Acta 1967; 18: 221–215
   PubMed Web of Science ®Google Scholar
• Roszman T. L., Jackson J. C., Cross R. J., Titus M. J., Markesbery W. R., Brooks W. H. Neuroanatomic and neurotransmitter influences on immune function. Journal of Immunology 1985; 135: 769S–772S
   PubMed Web of Science ®Google Scholar
• Rudick R. A., Goodkin D. E., Ransohoff R. M. Pharmacotherapy of multiple sclerosis: current status. Cleveland Clinic Journal of Medicine 1992; 59: 267–277
   PubMed Web of Science ®Google Scholar
• Sachar E. J. Hormonal changes in stress and mental illness. Neuroendocrinology, D. T. Krieger, J. C. Hughes. Sinauer Associates, Inc, Sunderland, Massachusetts 1980; 177–183
   Google Scholar
• Sandyk R. Premenstrual exacerbation of symptoms in multiple sclerosis is attenuated by treatment with weak electromagnetic fields. International Journal of Neuroscience, (in press)
   Google Scholar
• Sandyk R., Consroe P., Iacono R. P. L-tryptophan in drug-induced movement disorder with insomnia. New England Journal of Medicine 1986; 314: 1257
   PubMed Web of Science ®Google Scholar
• Schapira K., Poskanzer D. C., Newell D. J., Miller H. Marriage, pregnancy and multiple sclerosis. Brain 1966; 89: 419–428
   PubMed Web of Science ®Google Scholar
• Shaw D. M., Tidmarsh S. F., Karajgi B. M. Tryptophan, affective disorder and stress. Journal of Affective Disease 1980; 2: 321–325
   PubMedGoogle Scholar
• Sonninen V., Riekkinen P., Rinne U. K. Acid monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Neurology 1973; 23: 760–763
   PubMed Web of Science ®Google Scholar
• Sourkes T. L. Pathways of stress in the CNS. Progress in Neuropsychopharmacology and Biological Psychiatry 1983; 7: 389–411
   PubMedGoogle Scholar
• Squires R. F. Hyperthermia and L-tryptophan-induced increases in serotonin turnover in rat brain. Advances in Biochemical Psychopharmacology 1974; 10: 207–211
   PubMedGoogle Scholar
• Stein G., Milton F., Bebbington P., Wood K., Coppen A. Relationship between mood disturbances and free and total plasma tryptophan in postpartum women. British Medical Journal 1976; 2: 457
   PubMed Web of Science ®Google Scholar
• Tabaddor K., Wolfson L. I., Sharpless N. S. Ventricular fluid homovanillic acid and 5-hydroxyin-doleacetic acid concentrations in patients with movement disorders. Neurology 1978; 28: 1249–1253
   PubMed Web of Science ®Google Scholar
• Tagliamonte A., Tagliamonte P., Perez-Cruet J., Stern S., Gessa G. L. Effect of psychotrophic drugs on tryptophan concentration in rat brain. Journal of Pharmacology and Experimental Therapeutics 1971; 177: 475–480
   PubMedGoogle Scholar
• Teasdale G. M., Smith P. A., Wilkinson R., Latner A. L., Miller H. Endocrine activity in multiple sclerosis. Lancet 1967; I: 64–68
   Google Scholar
• Tyrrell J. B., Forsham P. H. Glucocorticoids and adrenal androgens. Basic and clinical endocrinology, F. S. Greenspan, P. H. Forsham. Lange Medical, Los Altos, California 1976; 272–283
   Google Scholar
• Vermes I., Smelik P. G., Mulder A. H. Effects of hypophysectomy, adrenalectomy and corticosterone treatment on uptake and release of putative central neurotransmitters by rat hypothalamic tissue in vitro. Life Sciences 1976; 19: 1719–1728
   PubMedGoogle Scholar
• Warren S., Greenhill S., Warren K. Emotional stress and the development of MS: case-control evidence of a relationship. Journal of Chronic Disease 1982; 35: 821–831
   PubMedGoogle Scholar
• Wurtman R. J. The pineal as a neuroendocrine transducer. Neuroendocrinology, D. T. Krieger, J. C. Hughes. Sinauer Associates, Inc, Sunderland, Massachusetts 1980a; 102–108
   Google Scholar
• Wurtman R. J. Nutritional control of brain tryptophan and serotonin. Biochenical and medical aspects of tryptophan metabolism, O. Hayashi, Y. Ishimura, R. Kido. Elsevier/North Holland, Amsterdam 1980b; 31–46
   Google Scholar
• Wurtman R. J. Nutrients that modify brain function. Scientific American 1982; 246: 42–51
   Google Scholar
• Yehuda R., Meyer J. S. A role for serotonin in the hypothalamic-adrenal response to insulin stress. Neuroendocrinology 1984; 38: 25–32
   PubMed Web of Science ®Google Scholar
• Young S. N. The clinical psychopharmacology of tryptophan. Nutrition and the brain, R. J. Wurtman, J. J. Wurtman. Raven Press, New York 1986; vol. 7: 49–88
   Google Scholar