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Anatomical Pathology

Immunocytochemical localisation of caspase-3 in pancreatic islets from type 2 diabetic subjects

Pages 432-437 | Received 23 Sep 2009, Accepted 10 Mar 2010, Published online: 15 Jul 2010

References

  • Martin SJ, Green DR. Protease activation during apoptosis: death by thousand cuts? Cell 1995; 82: 349–352.
  • Cohen GM. Caspases: the excursions of apoptosis. Biochem J 1997; 326: 1–16.
  • Hirata H, Takahashi A, Kobayashi S, et al Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med 1998; 187: 587–600.
  • Tewari M, Quan LT, O'Rourke K, et al Yama/CPP32ß, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 1995; 81: 801–809.
  • Gown AM, Willingham MC. Improved detection of apoptotic cells in archival paraffin sections: Immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 2002; 50: 449–454.
  • Cell Signaling Technology. Cleaved Caspase-3 (Asp 175) Antibody. Publication #9661. Beverly, MA: Cell Signaling Technology, 2006; 1–7.
  • Butler AE, Jansen J, Bonner-Weir S, et al β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102–110.
  • Cnop M, Welsh N, Jonas JC, et al Mechanisms of pancreatic-β cell death in type 1 and type 2 diabetes. Diabetes 2005; 54: s97–s107.
  • Tomita T, Iwata K. Gelatinases and inhibitors of gelatinases in pancreatic islets and islet cell tumors. Mod Pathol 1997; 10: 47–54.
  • Tomita T. Metallothionein in pancreatic endocrine tumors. Mod Pathol 2000; 13: 389–395.
  • Tomita T. Immunocytochemical localization of caspase-3 for pancreatic islets from type 1 diabetic subjects. Islets (in press).
  • Tomita T. Caspase-3 immunocytochemical staining for pancreatic endocrine tumors. Hum Pathol 2009; 40: 1050–1052.
  • Milliga CE, Prevette D, Yagimura H, et al Peptide inhibitors of the ICE proteinase family arrest programmed cell death of motor neurons in vivo and in vitro. Neuron 1995; 15: 385–393.
  • Enari M, Talanian RV, Wong WW, Nagata S. Sequential activation of ICE-like and CPP32-like proteinases during Fas-mediated apoptosis. Nature 1996; 380: 723–726.
  • Yamada K, Ichikawa F, Ishikawa-Shigemoto S, et al Essential role of caspase-3 in apoptosis of mouse β cells transfected with human Fas. Diabetes 1999; 48: 478–483.
  • Marchetti P, DelGuerra S, Marselli L, et al Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by Metform. J Clin Endocrinol Metab 2004; 89: 5535–5541.
  • Tomita T. New markers for pancreatic islets and islet cell tumors. Pathol Int 2002; 52: 425–432.
  • Tomita T. Amylin in pancreatic islets and pancreatic endocrine neoplasms. Pathol Int 2003; 53: 591–595.
  • Birdal-Hansen T, Moore WGI, Bodden MK, et al Matrix metallopro-teinases – Review. Crit Rev Oral Biol 1993; 4: 197–250.
  • Perez SE, Cano DA, Dao-Pick T, et al Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes 2005; 54: 694–701.
  • Westermark P, Wernstedt C, Wilander E, Slettern K. A novel peptide in the calcitonin gene-related peptide family as amyloid fibril in the endocrine pancreas. Biochem Bioph Res Commun 1986; 140: 827–831.
  • Jansen J, Ashley RH, Harrison D, McIntyre R, Butler PC. The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate sized toxic amyloid particles. Diabetes 1999; 8: 491–498.
  • Zhang S, Lie J, Dragnunow M, Cooper GSJ. Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a cascade and JNK1. J Biol Chem 2003; 278: 52810–52819.
  • Kloppel G. Islet histopathology in diabetes mellitus. In: Kloppel G, Heinz P, editors. Pancreatic Pathology. Edinburgh: Churchill Livingstone, 1984; 154–192.
  • Westermark P, Wilander E. The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 1978; 15: 417–421.
  • Hoppener JWM, Ahren B. Islet amyloid and type 2 diabetes mellitus. N Eng J Med 2000; 343: 411–419.
  • Laakso M, Lehto S. Epidemiology of macrovascular heart disease in diabetes. Diabetes Rev 1997; 5: 294–315.
  • National Institutes of Health. Kidney Disease of Diabetes. NIH Publication No. 3925. Bethesda, MD: NIH, 1995.
  • Tomita T. Cleaved caspase-3 immunocytochemical staining for pancreatic islets and pancreatic endocrine tumors: a potential marker for biological malignancy. Islets 2010; 2: 82–88.

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