Norovirus non-structural protein p20 leads to impaired restitution of epithelial defects by inhibition of actin cytoskeleton remodelling

References

• Green KY, Ando T, Balayan MS, Berke T, Clarke IN, Estes MK. Taxonomy of the caliciviruses. J Infect Dis 2000;181(Suppl 2):S322–30.
   Google Scholar
• McClung HJ, Butler DG, Kerzner B, Gall DG, Hamilton JR. Transmissible gastroenteritis. Mucosal ion transport in acute viral enteritis. Gastroenterology 1976;70:1091–5.
   PubMedGoogle Scholar
• Davidson GP, Gall DG, Petric M, Butler DG, Hamilton JR. Human rotavirus enteritis induced in conventional piglets. Intestinal structure and transport. J Clin Invest 1977:60: 1402–9.
   PubMed Web of Science ®Google Scholar
• Ball JM, Tian P, Zeng CQ, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 1996:272:101–4.
   PubMed Web of Science ®Google Scholar
• Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998:43:435–41.
   PubMed Web of Science ®Google Scholar
• Stockmann M, Fromm M, Schmitz H, Schmidt W, Riecken EO, Schulzke JD. Duodenal biopsies of HIV-infected patients with diarrhoea exhibit epithelial barrier defects but no active secretion. Aids 1998;12:43–51.
   PubMed Web of Science ®Google Scholar
• Schmitz H, Rokos K, Florian P, Gitter AH, Fromm M, Scholz P, Supernatants of HIV-infected immune cells affect the barrier function of human HT-29/B6 intestinal epithelial cells. Aids 2002. 16:983–91.
   Google Scholar
• Asanaka M, Atmar RL, Ruvolo V, Crawford SE, Neill FH, Estes MK. Replication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci USA 2005;102:10327–32.
   PubMedGoogle Scholar
• Guix S, Asanaka M, Katayama K, Crawford SE, Neill FH, Atmar RL, Estes MK. Norwalk Virus RNA is infectious in mammalian cells. J Virol 2007;81:12238–48.
   PubMedGoogle Scholar
• Chang KO, Sosnovtsev SV, Belliot G, King AD, Green KY. Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line. Virology 2006;353:463–73.
   PubMed Web of Science ®Google Scholar
• Wobus CE, Karst SM, Thackray LB, Chang KO, Sosnovtsev SV, Belliot G, Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biol 2004;2:e432.
   PubMed Web of Science ®Google Scholar
• Lambden PR, Caul EO, Ashley CR, Clarke IN. Sequence and genome organization of a human small round-structured (Norwalk-like) virus. Science 1993:259:516–19.
   PubMedGoogle Scholar
• Jiang X, Wang M, Wang K, Estes MK. Sequence and genomic organization of Norwalk virus. Virology 1993;195:51–61.
   PubMed Web of Science ®Google Scholar
• Glass PJ, White LJ, Ball JM, Leparc-Goffart I, Hardy ME, Estes MK. Norwalk virus open reading frame 3 encodes a minor structural protein. J Virol 2000;74:6581–91.
   PubMed Web of Science ®Google Scholar
• Liu B, Clarke IN, Lambden PR. Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis. J Virol 1996;70: 2605–10.
   PubMedGoogle Scholar
• Seah EL, Marshall JA, Wright PJ. Open reading frame 1 of the Norwalk-like virus Camberwell: completion of sequence and expression in mammalian cells. J Virol 1999;73: 10531–5.
   PubMedGoogle Scholar
• Hardy ME, Crone TJ, Brower JE, Ettayebi K. Substrate specificity of the Norwalk virus 3C-like proteinase. Virus Res 2002;89:29–39.
   PubMed Web of Science ®Google Scholar
• Belliot G, Sosnovtsev SV, Mitra T, Hammer C, Garfield M, Green KY. In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells. J Virol 2003;77:10957–74.
   PubMed Web of Science ®Google Scholar
• Dodd DA, Giddings TH Jr, Kirkegaard K. Poliovirus 3A protein limits interleukin-6 (IL-6), IL-8, and beta interferon secretion during viral infection. J Virol 2001;75:8158–65.
   PubMed Web of Science ®Google Scholar
• Neznanov N, Kondratova A, Chumakov KM, Angres B, Zhumabayeva B, Agol VI, Gudkov AV. Poliovirus protein 3A inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface. J Virol 2001;75:10409–20.
   PubMed Web of Science ®Google Scholar
• Mitic LL, Van Itallie CM, Anderson JM. Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am J Physiol Gastrointest Liver Physiol 2000;279:G250–4.
   PubMed Web of Science ®Google Scholar
• Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 2002;156:1099–111.
   PubMed Web of Science ®Google Scholar
• Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology 2005;128:987–1001.
   PubMed Web of Science ®Google Scholar
• Gitter AH, Schulzke JD, Sorgenfrei D, Fromm M. Ussing chamber for high-frequency transmural impedance analysis of epithelial tissues. J Biochem Biophys Methods 1997; 35:81–8.
   PubMedGoogle Scholar
• Gunzel D, Florian P, Richter JF, Troeger H, Schulzke JD, Fromm M, Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. Am J Physiol Regul Integr Comp Physiol 2006;290: R1496–507.
   Google Scholar
• Sun Z, Wang X, Wallen R, Deng X, Du X, Hallberg E, Andersson R. The influence of apoptosis on intestinal barrier integrity in rats. Scand J Gastroenterol 1998;33:415–22.
   PubMed Web of Science ®Google Scholar
• Gitter AH, Bendfeldt K, Schulzke JD, Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. Faseb J 2000;14:1749–53.
   PubMed Web of Science ®Google Scholar
• Bojarski C, Gitter AH, Bendfeldt K, Mankertz J, Schmitz H, Wagner S, Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis. J Physiol 2001;535:541–52.
   PubMed Web of Science ®Google Scholar
• Gitter AH, Wullstein F, Fromm M, Schulzke JD. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 2001;121:1320–8.
   PubMed Web of Science ®Google Scholar
• Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, Nusrat A. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 2003;171:6164–72.
   PubMed Web of Science ®Google Scholar
• Inai T, Kobayashi J, Shibata Y. Claudin-1 contributes to the epithelial barrier function in MDCK cells. Eur J Cell Biol 1999;78:849–55.
   PubMed Web of Science ®Google Scholar
• Mankertz J, Hillenbrand B, Tavalali S, Huber O, Fromm M, Schulzke JD. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun 2004;314:1001–7.
   Google Scholar
• Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, Schulzke JD. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 2000;113:2085–90.
   PubMed Web of Science ®Google Scholar
• Amasheh S, Meiri N, Gitter AH, Schoneberg T, Mankertz J, Schulzke JD, Fromm M. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 2002;115:4969–76.
   PubMed Web of Science ®Google Scholar
• Heller F, Florian P, Bojarski C, Richter J, Christ M, Hillenbrand B, Mankertz J, Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005;129:550–64.
   PubMed Web of Science ®Google Scholar
• Zeissig S, Fromm A, Mankertz J, Zeitz M, Fromm M, Schulzke JD. Restoration of ENaC expression by glucocorticoid receptor transfection in human HT-29/B6 colon cells. Biochem Biophys Res Commun 2006;344:1065–70.
   PubMedGoogle Scholar
• Kvietys PR, Specian RD, Grisham MB, Tso P. Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion. Am J Physiol 1991;261:G384–91.
   Google Scholar
• Mammen JM, Matthews JB. Mucosal repair in the gastrointestinal tract. Crit Care Med 2003;31(8 Suppl):S532–7.
   Google Scholar
• Grossmann J, Walther K, Artinger M, Rummele P, Woenckhaus M, Scholmerich J. Induction of apoptosis before shedding of human intestinal epithelial cells. Am J Gastroenterol 2002;97:1421–8.
   PubMed Web of Science ®Google Scholar
• Braucher RE, Kirsner JB. Regeneration of colon mucosa in lagre lesions: a morphological and histochemical study. Gastroenterology 1966;50:372–5.
   PubMedGoogle Scholar
• Wilson AJ, Gibson PR. Epithelial migration in the colon: filling in the gaps. Clin Sci (Lond) 1997;93:97–108.
   PubMed Web of Science ®Google Scholar
• Nusrat A, Delp C, Madara JL, Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells. J Clin Invest 1992;89:1501–11.
   PubMed Web of Science ®Google Scholar
• Bement WM, Forscher P, Mooseker MS. A novel cytoskeletal structure involved in purse string wound closure and cell polarity maintenance. J Cell Biol 1993;121:565–78.
   PubMed Web of Science ®Google Scholar
• Fenteany G, Janmey PA, Stossel TP. Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr Biol 2000;10:831–8.
   PubMed Web of Science ®Google Scholar
• Meyer zum Buschenfelde D, Hoschutzky H, Tauber R, Huber O. Molecular mechanisms involved in TFF3 peptide-mediated modulation of the E-cadherin/catenin cell adhesion complex. Peptides 2004;25:873–83.
   PubMed Web of Science ®Google Scholar
• Nusrat A, Parkos CA, Liang TW, Carnes DK, Madara JL. Neutrophil migration across model intestinal epithelia: monolayer disruption and subsequent events in epithelial repair. Gastroenterology 1997;113:1489–500.
   PubMed Web of Science ®Google Scholar
• Rosenblatt J, Raff MC, Cramer LP. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol 2001; 11:1847–57.
   Web of Science ®Google Scholar
• Florian P, Schoneberg T, Schulzke JD, Fromm M, Gitter AH. Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions. J Physiol 2002;545:485–99.
   Google Scholar
• Turner JR. ‘Putting the squeeze’ on the tight junction: understanding cytoskeletal regulation. Semin Cell Dev Biol 2000;11:301–8.
   Google Scholar
• Charlton CA, Volkman LE. Sequential rearrangement and nuclear polymerization of actin in baculovirus-infected Spodoptera frugiperda cells. J Virol 1991;65:1219–27.
   PubMedGoogle Scholar
• Melamed I, Stein L, Roifman CM. Epstein-Barr virus induces actin polymerization in human B cells. J Immunol 1994;153:1998–2003.
   PubMedGoogle Scholar
• Wu RF, Gu Y, Xu YC, Mitola S, Bussolino F, Terada LS. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. J Virol 2004;78: 779–89.
   PubMedGoogle Scholar
• Moser LA, Carter M, Schultz-Cherry S. Astrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication. J Virol 2007;81:11937–45.
   Google Scholar
• Zeissig S, Bojarski C, Buergel N, Mankertz J, Zeitz M, Fromm M, Schulzke JD. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 2004;53: 1295–302.
   PubMed Web of Science ®Google Scholar