96
Views
87
CrossRef citations to date
0
Altmetric
Original Article

Differential Cell Kinetics in the Ileum and Colon of Germfree Rats

, &
Pages 445-451 | Received 05 Feb 1993, Accepted 04 Oct 1993, Published online: 08 Jul 2009

References

  • Meslin J C, Sacquet E, Raibaud P. Action d'une flore micro-bienne qui ne déconjugue pas les sals biliares sur la morphologie et le renouvellement cellulaire de la muquese de l'r;intestine grele du rat. Ann Biol Anim Biochem Biophys 1974; 14: 709–20
  • Heneghan J G. Enterocyte kinetics, mucosal surface area and mucus in gnobiotics. Zen-tralbl Bakteriol 1979; 19–27, Fliedner T, Heit H, Niethammer D, Pflieger H, editors. Clinical and experimental gnobiotics. Suppl 7
  • Lipkin M. Proliferation and differentiation of gastrointestinal cells in normal and diseased states. Physiology of the gastrointestinal tract, L R Johnson. Raven Press, New York 1981; 145–68
  • Uribe A, Johansson C. Initial kinetic changes of prostaglandin E2-induced hyperplasia occur in the villous compartments. Gastroenterology 1988; 94: 1335–42
  • Baumgartner A, Koelz H R, Halter F. Indomethacin and turnover of gastric mucosal cells in the rat. Am J Physiol 1986; 250: G830–5
  • Uribe A. Indomethacin accelerates clearance of labeled cells and increases DNA synthesis in gastrointestinal mucosa of the rat. Dig Dis Sci 1992; 37: 403–8
  • Rao R K. Biologically active peptides in the gastrointestinal lumen. Life Sci 1991; 48: 1685–704
  • Frei E, Whang J, Scoggins R B, et al. The stathmokinetic effect of vincristine. Cancer Res 1964; 24: 1918–24
  • Norin K E, Gustafsson B E, Midvedt T. Strain differences in faecal tryptic activity of germfree and conventional rats. Lab Anim 1986; 20: 67–9
  • Wright N, Morley A, Appleton D. Variation in the duration of mitoses in the crypt of Lieberkühn of the rat: a cytokinetic study using vincristine. Cell Tissue Kinet 1972; 5: 351–64
  • Clarke R M. A comparison of metaphase arresting agents and tritiated thymidine in measurement of the rate of entry into mitoses in the crypt of Lieberkühn of the rat. Cell Tissue Kinet 1971; 4: 263
  • Cleaver J E. Population kinetics in animals tissues. In: Thymidine metabolism and cell kinetics. Amsterdam: North Holland 1964; 7: 184–234
  • Cairnie A B, Bentley R E. Cell proliferation studies in the intestinal epithelium of the rat. Exp Cell Res 1967; 46: 428–40
  • Tannock F. A comparison of the relative efficiencies of various metaphase arrest agents. Exp Cell Res 1965; 47: 345–56
  • Senior P V, Pritchett C J, Sunter J P, . Stathmokinetic studies on intestinal crypts following 70% resection of the small bowel or transplantation of 10–20 mm of small bowel to the exterior abdominal wall. Mechanisms of intestinal adaptation, J WL Robinson, R H Dowling, E O Riecken, et al. MTP Press Limited, Lancaster 1982; 337–51
  • Rijke R PC. Growth control in normal experimental animals. Cell proliferation in the gastrointestinal tract, D R Appleton, J P Sunter, A J Watson. Pitman Medical Limited, Kent 1980; 57–65
  • Abrams G A, Bauer H, Sprinz H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. Lab Invest 1963; 12: 355–64
  • Guenet J L, Sacquet E, Gueneau G, et al. Action de la microflore totale du rat sur l'activité mitotique des cryptes de Lieberkühn. C R Acad Sci (Paris) 1970; 270: 3070–87
  • Gordon H A, Bruckner-Kardos E. Effect of normal microbial flora on intestinal surface area. Am J Physiol 1961; 201: 175–8
  • Al-Muhktar M YT, Polak J M, Bloom S R, . The search for appropriate measurements of proliferative and morphological status in studies on intestinal adaptation. Mechanisms of intestinal adaptation, J WL Robinson, R H Dowling, E O Riecken, et al. MTP Press Limited, Lancaster 1982; 3–25
  • Altman G G. Influence of bile and pancreatic secretions on the size of the intestinal villi in the rat. Am J Anat 1971; 1132: 167–78
  • Uribe A, Midtvedt T, Jaramillo E, et al. Epithelial cell proliferation in the proximal small intestine of germfree rats. Acta Chir Scand 1991; 562: 87–92, Suppl
  • Bloom S R, Polak J M. The hormonal pattern of intestinal adaptation: a major role for enteroglucagon. Scand J Gastroenterol 1982; 74: 93–104
  • Johnson L R. Regulation of gastrointestinal growth. Physiology of the gastrointestinal tract, L R Johnson. Raven Press, New York 1987; 301–33
  • Ranken R, Wilson R, Bealmear P M. Increased turnover of intestinal mucosal cells of germfree mice induced by cholic acid. Proc Soc Exp Biol Med 1971; 138: 270–2
  • Lesher S, Wallburg H E, Sacher G A. Generation cycle in the duodenal crypt cells of germfree and conventional mice. Nature 1964; 202: 884–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.