264
Views
146
CrossRef citations to date
0
Altmetric
Original Article

A Double-Blind Placebo-Controlled Trial with Loperamide in Irritable Bowel Syndrome

, &
Pages 463-468 | Received 26 Apr 1995, Accepted 08 Nov 1995, Published online: 08 Jul 2009

References

  • Talley N J, Zinsmeister A R, van Dyke C, Melton L J, III. Epidemiology of colonic symptoms and the irritable bowel syndrome. Gastroenterology 1991; 101: 927–34
  • Whitehead W E, Engle B J, Schuster M M. Irritable bowel syndrome. Physiological and psychological differences between diarrhoea-predominant and constipation-predominant patients. Dig Dis 1980; 35: 404–13
  • Thompson W G. Pathogenesis of the irritable bowel. First United European Gastroenterology Week, AthensGreece, September, 1992, 47–58, lectures
  • Kellow J E, Borody T J, Philips S F, Tucker R L, Haddad A C. Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology 1986; 91: 386–95
  • Kumar D, Wingate D L. The irritable bowel syndrome: A paroxysmal motor disorder. Lancet 1985; 2: 973–7
  • Kellow J E, Gill R C, Wingate D L. Prolonged ambient recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 1990; 98: 1208–18
  • Kruis W, Thieme C H, Weinzierl, Schüssler P, Holl J. A diagnostic score for the irritable bowel syndrome. Gastroenterology 1984; 87: 1–7
  • Manning A P, Thompson W G, Heaton K W, Morris A F. Towards positive diagnosis of the irritable bowel. Br Med J 1978; 2: 653–4
  • Lancaster-Smith M J, Prote P J, Pinto T, Andersen J A, Schiff A A. Influence of drug treatment on the irritable bowel syndrome and its interaction with psychoneurotic morbidity. Acta Psych Scand 1982; 66: 33–41
  • Thompson W G, Heaton K W. Functional bowel disorders in apparently healthy people. Gastroenterology 1980; 79: 283–8
  • Hardcastle J, Hardcastle P T, Cookson J. Inhibitory actions of loperamide on absorptive processes in rat small intestine. Gut 1986; 27: 686–94
  • Moriarty K J. ABC of colorectal disease. The irritable bowel syndrome. BMJ 1992; 304: 1166–9
  • Drossman D A, McKee D C, Sandler R S, Mitchell C M, Craner E M, Lowman B C, et al. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and non-patients with irritable bowel syndrome. Gastroenterology 1988; 95: 701–8
  • Mendeloff A I, Monk M, Siegel C I, Lilienfeldt A. Illness, experiences and life stresses in patients with irritable colon and with ulcerative colitis. An epidemiological study of ulcerative colitis and regional enteritis in Baltimore, 1960–64. N Engl J Med 1970; 282: 14–7
  • Palmer R L, Crisp A H, Sonhill E. Psychological characteristics of patients with irritable bowel syndrome. Postgrad Med J 1974; 50: 416–9
  • Young S J, Alpers D H, Norland C C, Woodruff R A. Psychiatric illness and the irritable bowel syndrome. Practical implications for the primary physician. Gastroenterology 1976; 70: 162–6
  • Cohen S. Neuromuscular disorders of the gastrointestinal tract. Hosp Pract 1983; 1: 121–31
  • Whitehead W E, Crowell M D, Robinson V C, Heller B R, Schuster M M. Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut 1992; 33: 825–39
  • Lüttecke K. A three-part controlled study of trimebutine in the treatment of irritable colon syndrome. Curr Res Opin 1980; 6: 437–43
  • Toussaint J. Etude en simple aveugle de la trimebutine et de la mebeverine dans le colon irritable et la dyspepsie. Acta Ther 1981; 7: 261–8
  • Whitehead W E, Bosmajian L, Zonderman A B. Symptoms of psychologic distress associated with irritable bowel syndrome. Comparison of community and medical clinic samples. Gastroenterology 1988; 95: 709–14
  • Corazze G R, Varira D, Milletti S, Vanziri S, Gasparrini G. Controlled clinical evaluation of pinaverium bromide and trimebutine in functional disorders of the colon. Acta Ther 1983; 9: 383–9
  • Copé R. Etude clinique comparative de. l'associacion clinidium (br)-chlordiazepoxide et de la trimebutine dans le traitment de colopatie functionelle. Med Chir Dig 1981; 10: 713–7
  • Klein K B. Controlled treatment trials in the irritable bowel syndrome: A critique. Gastroenterology 1988; 95: 232–341
  • Harvey R F, Mauad E C, Brown A M. Prognosis in the irritable bowel syndrome: A five-year prospective study. Lancet 1987; 1: 963–5
  • Svendsen J H, Munck L K, Andersen J R. Irritable bowel syndrome—prognosis and diagnostic safety. A 5-year follow up study. Scand J Gastroenterol 1985; 20: 415–8
  • Holmes K M, Salter R H. Irritable bowel syndrome. A safe diagnosis. Br Med J 1982; 285: 1533–4
  • Weber F H, McCallum R W. Clinical approaches to irritable bowel syndrome. Lancet 1992; 340: 1477–52
  • Van Nueten J M, Janssen P AJ, Fontaine J. Loperamide (R 18 553), a novel type of anti-diarrheal agent. Part 3. In vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneimittelforschung 1974; 24: 1641–5
  • Mainguet P, Fiasse R. Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection. Gut 1977; 18: 575–9
  • Hodges J L, Lehman E L. Basic concepts of probability and statistics. Holden-Day Inc, San Francisco 1964; 318–22
  • Beyme F. Psychotherapy of the irritable colon syndrome. Hexagon 1985; 2: 11–6
  • Creed F, Guthrie E. Psychological factors in the irritable bowel syndrome. Gut 1987; 28: 1307–18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.