Pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl₄

References

• Ballet F. (1990). Hepatic circulation: potential for therapeutic intervention. Pharmacol Ther 47:281–328.
   PubMed Web of Science ®Google Scholar
• Boudinot FD, Jusko WJ. (1984). Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis. J Pharm Sci 73:774–780.
   PubMed Web of Science ®Google Scholar
• Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254.
   PubMed Web of Science ®Google Scholar
• Chiou WL. (1978). Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm 6:539–546.
   PubMedGoogle Scholar
• Chrungoo VJ, Singh K, Singh J. (1997). Differential biochemical response of freshly isolated rat hepatocytes to paracetamol, carbon tetrachloride and d-galactosamine toxicity. Indian J Exp Biol 35:603−610.
   Google Scholar
• Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res 10:1093–1095.
   PubMed Web of Science ®Google Scholar
• Decker K, Keppler D. (1974). Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev Physiol Biochem Pharmacol 71:77–106.
   Web of Science ®Google Scholar
• Duggleby RG. (1995). Analysis of enzyme progress curves by nonlinear regression. Meth Enzymol 249:61–90.
   PubMed Web of Science ®Google Scholar
• Fisher MB, Campanale K, Ackermann BL, VandenBranden M, Wrighton SA. (2000). In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug Metab Dispos 28:560–566.
   PubMed Web of Science ®Google Scholar
• Gibaldi M, Perrier D (Editors-in-chief). (1982). Pharmacokinetics (2nd ed.). New York: Marcel-Dekker.
   Google Scholar
• Gregus Z, Madhu C, Goon D, Klaassen CD. (1988). Effect of galactosamine-induced hepatic UDP-glucuronic acid depletion on acetaminophen elimination in rats. Dispositional differences between hepatically and extrahepatically formed glucuronides of acetaminophen and other chemicals. Drug Metab Dispos 16:527–533.
   PubMed Web of Science ®Google Scholar
• Ichimura F, Deguchi Y, Yokogawa K, Nakashima E. (1987). The effects of valproate on plasma concentration of phenytoin in normal and d-galactosamine-treated rats. Chem Pharm Bull 35:2030–2037.
   PubMed Web of Science ®Google Scholar
• Kaderlik KR, Mulder GJ, Shaddock JG, Casciano DA, Teitel CH, Kadlubar FF. (1994). Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes. Carcinogenesis 15:1711–1716.
   PubMed Web of Science ®Google Scholar
• Kang HE, Choi KY, Lee MG. (2008). Determination of an agent for the inflammatory liver disease, liquiritigenin, in rat plasma, urine, and various tissue homogenates by high-performance liquid chromatography. In: Proceedings of the Spring International Convention of the Pharmaceutical Society of Korea, Jeju, South Korea, April 30–May 3 2008; Abstract 342.
   Google Scholar
• Kang HE, Cho YK, Jung HY, Choi KY, Sohn SI, Baek SR, Lee MG. (2009a). Pharmacokinetics and first-pass effects of liquiritigenin in rats: low bioavailability is primarily due to extensive gastrointestinal first-pass effect. Xenobiotica 39:465–475.
   PubMed Web of Science ®Google Scholar
• Kang HE, Jung HY, Cho YK, Kim SH, Sohn SI, Baek SR, Lee MG. (2009b). Pharmacokinetics of liquiritigenin in mice, rats, rabbits, and dogs, and animal scale-up. J Pharm Sci 98:4327–4342.
   PubMed Web of Science ®Google Scholar
• Kang HE, Chung HJ, Kim HS, Lee JW, Lee MG. (2010a). Pharmacokinetic interaction between liquiritigenin (LQ) and DDB: increased glucuronidation of LQ in the liver possibly due to increased hepatic blood flow rate by DDB. Eur J Pharm Sci 39:181–189.
   PubMed Web of Science ®Google Scholar
• Kang HE, Sohn SI, Baek SR, Lee JW, Lee MG. (2010b). Liquiritigenin pharmacokinetics in a rat model of diabetes mellitus induced by streptozotocin: greater formation of glucuronides in the liver, especially M2, due to increased hepatic uridine 5′-diphosphoglucuronic acid level. Metabolism, in press.
   Web of Science ®Google Scholar
• Keppler DO, Rudigier JF, Bischoff E, Decker KF. (1970). The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem 17:246–253.
   PubMedGoogle Scholar
• Kim SG, Cho MK. (1996). Expression of glutathione S-transferases Ya, Yb1, Yb2, Yc1 and Yc2 and microsomal epoxide hydrolase gene by thiazole, benzothiazole and benzothiadiazole. Biochem Pharmacol 52:1831−1841.
   Web of Science ®Google Scholar
• Kim SC, Byun SH, Yang CH, Kim CY, Kim JW, Kim SG. (2004). Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage). Toxicology 197:239–251.
   PubMed Web of Science ®Google Scholar
• Kim YW, Ki SH, Lee JR, Lee SJ, Kim CW, Kim SC, Kim SG. (2006). Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Chem Biol Interact 161:125–138.
   PubMed Web of Science ®Google Scholar
• Kim YW, Kang HE, Lee MG, Hwang SJ, Kim SC, Lee CH, Kim SG. (2009). Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes. Am J Physiol Gastrointest Liver Physiol 296:G372–G381.
   PubMed Web of Science ®Google Scholar
• Klaassen CD, Plaa GL. (1968). Effect of carbon tetrachloride on the metabolism, storage, and excretion of sulfobromophthalein. Toxicol Appl Pharmacol 12:132–139.
   PubMed Web of Science ®Google Scholar
• Kumaravelu P, Dakshinamoorthy DP, Subramaniam S, Devaraj H, Devaraj NS. (1995). Effect of eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver. Biochem Pharmacol 49:1703–1707.
   PubMed Web of Science ®Google Scholar
• Lee JH, Lee MG. (2008). Telithromycin pharmacokinetics in rat model of diabetes mellitus induced by alloxan or streptozotocin. Pharm Res 25:1915–1924.
   PubMed Web of Science ®Google Scholar
• Makin AJ, Hughes RD, Williams R. (1997). Systemic and hepatic hemodynamic changes in acute liver injury. Am J Physiol 272(3 Pt 1):G617–G625.
   Google Scholar
• Mitruka BM, Rawnsley HM (Editors-in-chief). (1981). Clinical biomedical and hematological reference values in normal experimental animals and normal humans (2nd ed). New York: Masson Publishing.
   Google Scholar
• Øie S, Guentert TW. (1982). Comparison of equilibrium time in dialysis experiments using spiked plasma or spiked buffer. J Pharm Sci 71:127–128.
   PubMed Web of Science ®Google Scholar
• Richardson TA, Sherman M, Kalman D, Morgan ET. (2006). Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney. Drug Metab Dispos 34:351−353.
   Web of Science ®Google Scholar
• Shimamura H, Nakai S, Yamamoto K, Hitomi N, Yumioka E. (1990). Biliary and urinary metabolites of liquiritigenin in rats. Jpn J Pharmacogn 44:265–268.
   Google Scholar
• Shimamura H, Suzuki H, Hanano M, Suzuki A, Sugiyama Y. (1993). Identification of tissues responsible for the conjugative metabolism of liquiritigenin in rats: an analysis based on metabolite kinetics. Biol Pharm Bull 16:899–907.
   PubMed Web of Science ®Google Scholar
• Wang F, Wen T, Chen XY, Wu H. (2008). Protective effects of pirfenidone on D-galactosamine and lipopolysaccharide-induced acute hepatotoxicity in rats. Inflamm Res 57:183–188.
   PubMed Web of Science ®Google Scholar
• Watkins JB, Klaassen CD. (1982a). Determination of hepatic uridine 5′-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol. J Pharmacol Methods 7:145–151.
   PubMedGoogle Scholar
• Watkins JB, Klaassen CD. (1982b). Effect of inducers and inhibitors of glucuronidation on the biliary excretion and choleretic action of valproic acid in the rat. J Pharmacol Exp Ther 220:305–310.
   PubMed Web of Science ®Google Scholar
• Wilkinson GR, Shand DG. (1975). Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377–390.
   PubMed Web of Science ®Google Scholar