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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 12
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General Xenobiochemistry

Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126

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Pages 1031-1043 | Received 11 May 2011, Accepted 05 Jul 2011, Published online: 04 Oct 2011

References

  • Badawi AF, Cavalieri EL, Rogan EG. (2000). Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A1, 1A2 and 1B1 and 2- and 4-hydroxylation of 17beta-estradiol in female Sprague-Dawley rats. Carcinogenesis 21:1593–1599.
  • Bandiera S, Safe S, Okey AB. (1982). Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor. Chem Biol Interact 39:259–277.
  • Bhattacharyya KK, Brake PB, Eltom SE, Otto SA, Jefcoate CR. (1995). Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. J Biol Chem 270:11595–11602.
  • Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, Mendrick DL, Zacharewski TR. (2006). Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice. Toxicol Sci 94:398–416.
  • Bui PH, Hankinson O. (2009). Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. Mol Pharmacol 76:1031–1043.
  • Bui PH, Imaizumi S, Beedanagari SR, Reddy ST, Hankinson O. (2010). Human cytochrome P450, CYP2S1, metabolizes cyclooxygenase-and lipoxygenase-derived eicosanoids. Drug Metab Dispos 39:180–190.
  • Chen JJ, Chen GS, Bunce NJ. (2003). Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons. Environ Toxicol 18:115–119.
  • Chirulli V, Longo V, Marini S, Mazzaccaro A, Fiorio R, Gervasi PG. (2005). CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs. Life Sci 76:2535–2546.
  • Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, Stoilov I. (2003). Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem Biophys 414:91–100.
  • Crunkhorn SE, Plant KE, Gibson GG, Kramer K, Lyon J, Lord PG, Plant NJ. (2004). Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth. Biochem Pharmacol 67:107–118.
  • Deb S, Bandiera SM. (2009). Characterization and expression of extrahepatic CYP2S1. Expert Opin Drug Metab Toxicol 5:367–380.
  • Deb S, Bandiera SM. (2010). Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats: its regulation by aryl hydrocarbon receptor agonists. Toxicology 267:91–98.
  • Dere E, Boverhof DR, Burgoon LD, Zacharewski TR. (2006). In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue. BMC Genomics 7:80.
  • Dewa Y, Nishimura J, Jin M, Kawai M, Saegusa Y, Harada T, Shibutani M, Mitsumori K. (2009). Molecular expression analysis of beta-naphthoflavone-induced hepatocellular tumors in rats. Toxicol Pathol 37:446–455.
  • Diliberto JJ, Burgin D, Birnbaum LS. (1997). Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice. Biochem Biophys Res Commun 236:431–433.
  • Ding X, Kaminsky LS. (2003). Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149–173.
  • Harris MW, Moore JA, Vos JG, Gupta BN. (1973). General biological effects of TCDD in laboratory animals. Environ Health Perspect 5:101–109.
  • Honkakoski P, Zelko I, Sueyoshi T, Negishi M. (1998). The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652–5658.
  • Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M. (1999). Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19:6318–6322.
  • Kim S, Dere E, Burgoon LD, Chang CC, Zacharewski TR. (2009). Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci 112:229–244.
  • Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T, Lehmann JM. (1998). An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73–82.
  • Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW. (2010). Acute toxicity of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environ Int 36:918–923.
  • Lan NC, Karin M, Nguyen T, Weisz A, Birnbaum MJ, Eberhardt NL, Baxter JD. (1984). Mechanisms of glucocorticoid hormone action. J Steroid Biochem 20:77–88.
  • LeCluyse EL. (2001). Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chem Biol Interact 134:283–289.
  • McKillop D, Case DE. (1991). Mutagenicity, carcinogenicity and toxicity of beta-naphthoflavone, a potent inducer of P448. Biochem Pharmacol 41:1–7.
  • Mei Q, Richards K, Strong-Basalyga K, Fauty SE, Taylor A, Yamazaki M, Prueksaritanont T, Lin JH, Hochman J. (2004). Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2. J Pharm Sci 93:2488–2496.
  • Nagata K, Ogino M, Shimada M, Miyata M, Gonzalez FJ, Yamazoe Y. (1999). Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. Arch Biochem Biophys 362:242–253.
  • Nannelli A, Chirulli V, Longo V, Gervasi PG. (2008). Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. Toxicology 252:105–112.
  • Nannelli A, Rossignolo F, Tolando R, Rossato P, Longo V, Gervasi PG. (2009). Effect of beta-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig. Toxicology 265:69–79.
  • Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. (2004). Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279:23847–23850.
  • Nishida CR, Lee M, de Montellano PR. (2010). Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1. Mol Pharmacol 78:497–502.
  • Rivera SP, Saarikoski ST, Hankinson O. (2002). Identification of a novel dioxin-inducible cytochrome P450. Mol Pharmacol 61:255–259.
  • Rivera SP, Wang F, Saarikoski ST, Taylor RT, Chapman B, Zhang R, Hankinson O. (2007). A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia. J Biol Chem 282:10881–10893.
  • Rylander T, Neve EP, Ingelman-Sundberg M, Oscarson M. (2001). Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Biochem Biophys Res Commun 281:529–535.
  • Saarikoski ST, Rivera SP, Hankinson O, Husgafvel-Pursiainen K. (2005). CYP2S1: a short review. Toxicol Appl Pharmacol 207:62–69.
  • Safe S. (1990). Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21:51–88.
  • Safe SH. (1994). Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24:87–149.
  • Saito K, Kobayashi K, Mizuno Y, Fukuchi Y, Furihata T, Chiba K. (2010). Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes. Drug Metab Pharmacokinet 25:108–111.
  • Schramm H, Robertson LW, Oesch F. (1985). Differential regulation of hepatic glutathione transferase and glutathione peroxidase activities in the rat. Biochem Pharmacol 34:3735–3739.
  • Sesardic D, Cole KJ, Edwards RJ, Davies DS, Thomas PE, Levin W, Boobis AR. (1990). The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues. Biochem Pharmacol 39:499–506.
  • Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson J, Ibbotson SH. (2003). Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet 361:1336–1343.
  • Stephen FD, Drahushuk AT, Olson JR. (1997). Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C. Toxicology 124:39–51.
  • Sueyoshi T, Negishi M. (2001). Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 41:123–143.
  • Tsuchiya Y, Nakajima M, Takagi S, Taniya T, Yokoi T. (2006). MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res 66:9090–9098.
  • Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE. (2006). The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93:223–241.
  • Vondrácek J, Svihálková-Sindlerová L, Pencíková K, Krcmár P, Andrysík Z, Chramostová K, Marvanová S, Valovicová Z, Kozubík A, Gábelová A, Machala M. (2006). 7H-Dibenzo[c,g]carbazole and 5,9-dimethyldibenzo[c,g]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial ‘stem-like’ cells. Mutat Res 596:43–56.
  • Zhang H, LeCulyse E, Liu L, Hu M, Matoney L, Zhu W, Yan B. (1999). Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch Biochem Biophys 368:14–22.

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