Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 7
102
Views
10
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Similarities in diesel exhaust particles induced alterations in expression of cytochrome P-450 and glutathione S-transferases in rat lymphocytes and lungs

, , , , &
Pages 624-632 | Received 31 Oct 2011, Accepted 14 Dec 2011, Published online: 21 Feb 2012

References

  • Al-Humadi NH, Siegel PD, Lewis DM, Barger MW, Ma JY, Weissman DN, Ma JK. (2002). Alteration of intracellular cysteine and glutathione levels in alveolar macrophages and lymphocytes by diesel exhaust particle exposure. Environ Health Perspect 110:349–353.
  • Baldwin SJ, Bramhall JL, Ashby CA, Yue L, Murdock PR, Hood SR, Ayrton AD, Clarke SE. (2006). Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan). Drug Metab Dispos 34:1063–1069.
  • Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST, Wilson SJ, Boman C, Cassee FR, Frew AJ, Kelly FJ, Sandström T, Blomberg A. (2006). Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Respir J 27:359–365.
  • Bonvallot V, Baeza-Squiban A, Baulig A, Brulant S, Boland S, Muzeau F, Barouki R, Marano F. (2001). Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression. Am J Respir Cell Mol Biol 25:515–521.
  • Dey A, Dhawan A, Kishore Seth P, Parmar D. (2005). Evidence for cytochrome P450 2E1 catalytic activity and expression in rat blood lymphocytes. Life Sci 77:1082–1093.
  • Dey A, Parmar D, Dayal M, Dhawan A, Seth PK. (2001). Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression. Life Sci 69:383–393.
  • Dinsdale D, Verschoyle RD. (2001). Cell-specific loss of cytochrome P450 2B1 in rat lung following treatment with pneumotoxic and non-pneumotoxic trialkylphosphorothioates. Biochem Pharmacol 61:493–501.
  • Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77.
  • Furman GM, Silverman DM, Schatz RA. (1998). Inhibition of rat lung mixed-function oxidase activity following repeated low-level toluene inhalation: possible role of toluene metabolites. J Toxicol Environ Health Part A 54:633–645.
  • Gerde P, Muggenburg BA, Thornton-Manning JR, Lewis JL, Pyon KH, Dahl AR. (1997). Benzo[a]pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis 18:1825–1832.
  • Haas CE, Brazeau D, Cloen D, Booker BM, Frerichs V, Zaranek C, Frye RF, Kufel T. (2005). Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction. Eur J Clin Pharmacol 61:583–593.
  • Habig WH, Pabst MJ, Jakoby WB. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130–7139.
  • Hannon-Fletcher MP, Barnett YA. (2008). Lymphocyte cytochrome P450 expression: inducibility studies in male Wistar rats. Br J Biomed Sci 65:1–6.
  • Hatanaka N, Yamazaki H, Kizu R, Hayakawa K, Aoki Y, Iwanari M, Nakajima M, Yokoi T. (2001). Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust. Carcinogenesis 22:2033–2038.
  • Hemminki K, Söderling J, Ericson P, Norbeck HE, Segerbäck D. (1994). DNA adducts among personnel servicing and loading diesel vehicles. Carcinogenesis 15:767–769.
  • Hirano S, Furuyama A, Koike E, Kobayashi T.. (2003). Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells. Toxicology 187:161–70.
  • Irigaray P, Belpomme D. (2010). Basic properties and molecular mechanisms of exogenous chemical carcinogens. Carcinogenesis 31:135–148.
  • Ma JY, Ma JK. (2002). The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymes. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 20:117–147.
  • Kawabata Y, Iwai K, Udagawa T, Tukagoshi K, Higuchi K. (1986). Effects of diesel soot on unscheduled DNA synthesis of tracheal epithelium and lung tumor formation. Dev Toxicol Environ Sci 13:213–222.
  • Kawabata Y, Udagawa T, Higuchi K, Yamada H, Hashimoto H, Iwai K. (1988). Lung injury and carcinogenesis following transtracheal instillation of diesel soot particle to the lung. J Japan Soc Air Pollut 23:32–40.
  • Koike E, Hirano S, Furuyama A, Kobayashi T. (2004). cDNA microarray analysis of rat alveolar epithelial cells following exposure to organic extract of diesel exhaust particles. Toxicol Appl Pharmacol 201:178–185.
  • Kuljukka-Rabb T, Peltonen K, Isotalo S, Mikkonen S, Rantanen L, Savela K. (2001). Time- and dose-dependent DNA binding of PAHs derived from diesel particle extracts, benzo[a]pyrene and 5-methychrysene in a human mammary carcinoma cell line (MCF-7). Mutagenesis 16:353–358.
  • Lee C, Watt KC, Chang AM, Plopper CG, Buckpitt AR, Pinkerton KE. (1998). Site-selective differences in cytochrome P450 isoform activities. Comparison of expression in rat and rhesus monkey lung and induction in rats. Drug Metab Dispos 26:396–400.
  • Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE. (2004). Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol 173:3467–3481.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275.
  • Omura S, Koike E, Kobayashi T. (2009). Microarray analysis of gene expression in rat alveolar epithelial cells exposed to fractionated organic extracts of diesel exhaust particles. Toxicology 262:65–72.
  • Osier M, Oberdörster G. (1997). Intratracheal inhalation vs intratracheal instillation: differences in particle effects. Fundam Appl Toxicol 40:220–227.
  • Parmar D, Dhawan A, Dayal M, Seth PK. (1998). Immunochemical and biochemical evidence for expression of Phenobarbital and 3-methylcholanthrene-inducibleisoenzymes of cytochrome P450 in rat brain. Int J Toxicol 17:619–30.
  • Piskorska-Pliszczynska J, Keys B, Safe S, Newman MS. (1986). The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons. Toxicol Lett 34:67–74.
  • Puntarulo S, Cederbaum AI. (1998). Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes. Free Radic Biol Med 24:1324–1330.
  • Ramanathan R, Das NP, Tan CH. (1994). Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. Free Radic Biol Med 16:43–48.
  • Rengasamy A, Barger MW, Kane E, Ma JK, Castranova V, Ma JY. (2003). Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats. J Toxicol Environ Health Part A 66:153–167.
  • Sagai M, Saito H, Ichinose T, Kodama M, Mori Y. (1993). Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Radic Biol Med 14:37–47.
  • Sato H, Sone H, Sagai M, Suzuki K T, Aoki Y.. (2000). Increase in mutation frequency in lung of Big Blue rat by exposure to diesel exhaust. Carcinogenesis 21:653–661.
  • Satoh K. (1978). Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 90:37–43.
  • Saurabh K, Sharma A, Yadav S, Parmar D. (2010). Polycyclic aromatic hydrocarbon metabolizing cytochrome P450s in freshly prepared uncultured rat blood lymphocytes. Biochem Pharmacol 79:1182–1188.
  • Takano H, Yanagisawa R, Ichinose T, Sadakane K, Inoue K, Yoshida S, Takeda K, Yoshino S, Yoshikawa T, Morita M. (2002). Lung expression of cytochrome P450 1A1 as a possible biomarker of exposure to diesel exhaust particles. Arch Toxicol 76:146–151.
  • Totlandsdal AI, Cassee FR, Schwarze P, Refsnes M, Låg M. (2010). Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells. Part Fibre Toxicol 7:41.
  • Ueng TH, Hwang WP, Chen RM, Wang HW, Kuo ML, Park SS, Guengerich FP. (1998). Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues. J Toxicol Environ Health Part A 54:509–527.
  • Wan J, Diaz-Sanchez D. (2007). Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles. Inhal Toxicol 19 Suppl 1:177–182.
  • Wisniowski PE, Spech RW, Wu M, Doyle NA, Pasula R, Martin WJ 2nd. (2000). Vitronectin protects alveolar macrophages from silica toxicity. Am J Respir Crit Care Med 162:733–739.
  • Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T. (2000). Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Mutat Res 472:129–138.
  • Zhao H, Barger MW, Ma JK, Castranova V, Ma JY. (2006). Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Environ Health Perspect 114:1253–1258.
  • Zhao HW, Barger MW, Ma JK, Castranova V, Ma JY. (2004). Effects of exposure to diesel exhaust particles (DEP) on pulmonary metabolic activation of mutagenic agents. Mutat Res 564:103–113.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.