Effects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats

References

• Adeneye AA, Amole OO, Adeneye AK. (2006). Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 77:511–514.
   PubMed Web of Science ®Google Scholar
• Bailey DG, Malcolm J, Arnold O, Spence JD. (1998). Grapefruit juice-drug interactions. Br J Clin Pharmacol 46:101–110.
   PubMed Web of Science ®Google Scholar
• Calixto JB, Santos AR, Cechinel Filho V, Yunes RA. (1998). A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential. Med Res Rev 18:225–258.
   PubMed Web of Science ®Google Scholar
• Elvin-Lewis M. (2001). Should we be concerned about herbal remedies. J Ethnopharmacol 75:141–164.
   PubMed Web of Science ®Google Scholar
• Evi LP, Gadegbeku KE, Agbonon A, Aklikokou K, Moukha S, Creppy EE, Gbéassor M. (2008). Toxicological assessment on extracts of Phyllanthus amarus Schum and Thonn. Sci Res Essay 3:410–415.
   Google Scholar
• Franke RM, Baker SD, Mathijssen RH, Schuetz EG, Sparreboom A. (2008). Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. Clin Pharmacol Ther 84:704–709.
   PubMed Web of Science ®Google Scholar
• Hamdy DA, Brocks DR. (2010). High performance liquid chromatographic assay for the simultaneous determination of midazolam and ketoconazole in plasma. J Pharm Biomed Anal 53:617–622.
   Google Scholar
• Hari Kumar KB, Kuttan R. (2006). Inhibition of drug metabolizing enzymes (cytochrome P450) in vitro as well as in vivo by Phyllanthus amarus Schum & Thonn. Biol Pharm Bull 29:1310–1313.
   PubMed Web of Science ®Google Scholar
• Kobayashi K, Urashima K, Shimada N, Chiba K. (2002). Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochem Pharmacol 63:889–896.
   PubMed Web of Science ®Google Scholar
• Kotegawa T, Laurijssens BE, Von Moltke LL, Cotreau MM, Perloff MD, Venkatakrishnan K, Warrington JS, Granda BW, Harmatz JS, Greenblatt DJ. (2002). In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat. J Pharmacol Exp Ther 302:1228–1237.
   PubMed Web of Science ®Google Scholar
• Krithika R, Mohankumar R, Verma RJ, Shrivastav PS, Mohamad IL, Gunasekaran P, Narasimhan S. (2009). Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. Chem Biol Interact 181:351–358.
   PubMed Web of Science ®Google Scholar
• Kumar KB, Kuttan R. (2004). Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice. J Radiat Res 45:133–139.
   PubMed Web of Science ®Google Scholar
• Lam YWF, Huang S-M, Hall SD. (2006). Herbal Supplements-Drug Interactions Scientific and Regulatory Perspectives. New York: Taylor & Francis Group.
   Google Scholar
• Lin JH, Lu AY. (1998). Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet 35:361–390.
   PubMed Web of Science ®Google Scholar
• Mohri K, Uesawa Y, Sagawa K. (2000). Effects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice. Drug Metab Dispos 28:482–486.
   PubMed Web of Science ®Google Scholar
• Murugaiyah V, Chan KL. (2006). Antihyperuricemic lignans from the leaves of Phyllanthus niruri. Planta Med 72:1262–1267.
   PubMed Web of Science ®Google Scholar
• Naaz F, Javed S, Abdin MZ. (2007). Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice. J Ethnopharmacol 113:503–509.
   PubMed Web of Science ®Google Scholar
• Nakajima M, Suzuki T, Sasaki T, Yokoi T, Hosoyamada A, Yamamoto T, Kuroiwa Y. (1999). Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans. Ther Drug Monit 21:507–513.
   PubMed Web of Science ®Google Scholar
• Notka F, Meier G, Wagner R. (2004). Concerted inhibitory activities of Phyllanthus amarus on HIV replication in vitro and ex vivo. Antiviral Res 64:93–102.
   PubMed Web of Science ®Google Scholar
• Obianime AW, Uche FI. (2008). The phytochemical screening and the effects of methanolic extract of Phyllanthus amarus leaf on the biochemical parameters of male guinea pigs. J Appl Sci Environ 12:73–77.
   Google Scholar
• Pal D, Mitra AK. (2006). MDR- and CYP3A4-mediated drug–herbal interactions. Life Sci 78:2131–2145.
   PubMed Web of Science ®Google Scholar
• Rajeshkumar NV, Joy KL, Kuttan G, Ramsewak RS, Nair MG, Kuttan R. (2002). Antitumour and anticarcinogenic activity of Phyllanthus amarus extract. J Ethnopharmacol 81:17–22.
   PubMed Web of Science ®Google Scholar
• Sripanidkulchai B, Tattawasart U, Laupatarakasem P, Vinitketkumneun U, Sripanidkulchai K, Furihata C, Matsushima T. (2002). Antimutagenic and anticarcinogenic effects of Phyllanthus amarus. Phytomedicine 9:26–32.
   PubMed Web of Science ®Google Scholar
• Taesotikul T, Dumrongsakulchai W, Wattanachai N, Navinpipat V, Somanabandhu A, Tassaneeyakul W, Tassaneeyakul W. (2011). Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. Drug Metab Pharmacokinet 26:154–161.
   PubMed Web of Science ®Google Scholar
• Tassaneeyakul W, Birkett DJ, McManus ME, Tassaneeyakul W, Veronese ME, Andersson T, Tukey RH, Miners JO. (1994). Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol 47:1767–1776.
   PubMed Web of Science ®Google Scholar
• Tassaneeyakul W, Guo LQ, Fukuda K, Ohta T, Yamazoe Y. (2000a). Inhibition selectivity of grapefruit juice components on human cytochromes P450. Arch Biochem Biophys 378:356–363.
   PubMed Web of Science ®Google Scholar
• Tassaneeyakul W, Vannaprasaht S, Yamazoe Y. (2000b). Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice. Br J Clin Pharmacol 49:139–144.
   PubMed Web of Science ®Google Scholar
• Venkataramanan R, Komoroski B, Strom S. (2006). In vitro and in vivo assessment of herb drug interactions. Life Sci 78:2105–2115.
   PubMed Web of Science ®Google Scholar
• Yadav NP, Pal A, Shanker K, Bawankule DU, Gupta AK, Darokar MP, S Khanuja SP. (2008). Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus. Phytomedicine 15:1053–1061.
   PubMed Web of Science ®Google Scholar
• Zhang W, Tan TM, Lim LY. (2007). Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats. Drug Metab Dispos 35:110–115.
   PubMed Web of Science ®Google Scholar
• Zhou S, Yung Chan S, Cher Goh B, Chan E, Duan W, Huang M, McLeod HL. (2005). Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet 44:279–304.
   PubMed Web of Science ®Google Scholar
• Zhou SF. (2008). Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 9:310–322.
   PubMed Web of Science ®Google Scholar