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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 2
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Topics in Xenobiochemistry

A response to “radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary”

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Pages 226-227 | Received 09 May 2012, Accepted 23 Jun 2012, Published online: 25 Jul 2012

References

  • Gao H, Obach RS. (2011). Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals. Curr Drug Metab 12:578–586.
  • Lappin G, Seymour M. (2010). Addressing metabolite safety during first-in-man studies using ¹4C-labeled drug and accelerator mass spectrometry. Bioanalysis 2:1315–1324.
  • Obach RS, Nedderman AN, Smith DA. (2012). Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary? Xenobiotica 42:46–56.
  • Roffey SJ, Obach RS, Gedge JI, Smith DA. (2007). What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs. Drug Metab Rev 39:17–43.
  • White RE, Evans DC, Hop CECA, Moore DJ, Prakash C, Surapaneni S, Tse FLS. (2013). Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary. Xenobiotica 43:219–225.

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