Xenobiotica, Volume 43, Issue 2 (2013)

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Xenobiotica, Volume 43, Issue 2 (2013)

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General Xenobiochemistry

Article
Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms
Rui-Hua Dong, Zhong-Ze Fang, Liang-Liang Zhu, Guang-Bo Ge, Xiao-Bao Li, Cui-Min Hu, Yun-Feng Cao, Yang-Liu Xia, Ling Yang & Ze-Yuan Liu
Pages: 133-139
Published online: 20 Jul 2012
AbstractforDeep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms | Full Text | References | PDF (831.6 KB) | Supplemental
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Article
Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips
Régis Baudoin, Jean Matthieu Prot, Grégory Nicolas, Jessy Brocheton, Céline Brochot, Cécile Legallais, Henri Benech & Eric Leclerc
Pages: 140-152
Published online: 25 Jul 2012
AbstractforEvaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips | Full Text | References | PDF (1 MB)
  • 755 Views
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Article
Prediction of drug concentration-time profiles of therapeutic proteins in humans from animals
Iftekhar Mahmood
Pages: 153-160
Published online: 25 Jul 2012
AbstractforPrediction of drug concentration-time profiles of therapeutic proteins in humans from animals | Full Text | References | PDF (791 KB)
  • 361 Views
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Article
2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner
Alejandro Mejia-Garcia, Esmeralda M. Sanchez-Ocampo, Silvia Galindo-Gomez, Mineko Shibayama, Octavio Reyes-Hernandez, Simon Guzman-Leon, Frank J. Gonzalez & Guillermo Elizondo
Pages: 161-168
Published online: 27 Jul 2012
Abstractfor2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner | Full Text | References | PDF (985 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application
James M. Mathews, Sherri S. Brown, Purvi R. Patel, Sherry R. Black, Troy T. Banks, Amy S. Etheridge, Timothy R. Fennell, Rodney W. Snyder, Chad R. Blystone & Suramya Waidyanatha
Pages: 169-181
Published online: 25 Jul 2012
AbstractforMetabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application | Full Text | References | PDF (830.6 KB)
  • 299 Views
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Article
Absorption of TAK-491, a new angiotensin II receptor antagonist, in animals
Naohiro Kawaguchi, Takuya Ebihara, Toshiyuki Takeuchi, Akio Morohashi, Hitomi Yamasaki, Yoshihiko Tagawa, Junzo Takahashi, Takahiro Kondo & Satoru Asahi
Pages: 182-192
Published online: 07 Aug 2012
AbstractforAbsorption of TAK-491, a new angiotensin II receptor antagonist, in animals | Full Text | References | PDF (755.9 KB)
  • 435 Views
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Article
Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug–drug interactions in humans
Kyeong-Ryoon Lee, Sung Heum Choi, Jin-Sook Song, Eun-Young Kwak, Yoon-Jee Chae, So Hee Im, Byung Hoi Lee, Hyewon Seo, Woon-Ki Cho, Min-Sun Kim, Nak Jeong Kim, Sung-Hoon Ahn & Myung Ae Bae
Pages: 193-200
Published online: 03 Aug 2012
AbstractforPharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug–drug interactions in humans | Full Text | References | PDF (718.1 KB)
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Molecular Toxicology

Article
Metabolic profiling of TRPV1 antagonists of the benzothiazole amide series: implications for in vitro genotoxicity assessment
Johan Bylund, Carl Petersson, Anders Lindgren, Susanne Olofsson & Stefan Czene
Pages: 201-210
Published online: 07 Aug 2012
AbstractforMetabolic profiling of TRPV1 antagonists of the benzothiazole amide series: implications for in vitro genotoxicity assessment | Full Text | References | PDF (1,021.8 KB)
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Pharmacogenetics

Article
Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism
Wei Pan, Soo-Kyung Bae, Eon-Jeong Shim, Sung-Eun Park, Sang-Seop Lee, Soo-Jin Park, Chang-Woo Yeo, Hong-Hao Zhou, Ji-Hong Shon & Jae-Gook Shin
Pages: 211-218
Published online: 25 Jul 2012
AbstractforEffects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism | Full Text | References | PDF (683.1 KB) | Supplemental
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Topics in Xenobiochemistry

Article
Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary
Ronald E. White, David C. Evans, Cornelis E. C. A. Hop, David J. Moore, Chandra Prakash, Sekhar Surapaneni & Francis L. S. Tse
Pages: 219-225
Published online: 18 Jul 2012
AbstractforRadiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary | Full Text | References | PDF (606.2 KB)
  • 970 Views
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Article
A response to “radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary”
R. Scott Obach, Angus N. Nedderman & Dennis A. Smith
Pages: 226-227
Published online: 25 Jul 2012
CitationforA response to “radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary” | Full Text | References | PDF (569.1 KB)
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